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168 results

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Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Pharmacological prevention and treatment of opioid-induced constipation in cancer patients: A systematic review and meta-analysis.
Kistemaker KRJ, Sijani F, Brinkman DJ, de Graeff A, Burchell GL, Steegers MAH, van Zuylen L. Kistemaker KRJ, et al. Cancer Treat Rev. 2024 Apr;125:102704. doi: 10.1016/j.ctrv.2024.102704. Epub 2024 Mar 1. Cancer Treat Rev. 2024. PMID: 38452708 Free article. Review.
Both for prevention and treatment of OIC osmotic (e.g. polyethylene glycol) and stimulant (e.g. bisacodyl) laxatives are widely used. Newer drugs such as the peripherally acting -opioid receptor antagonists (PAMORAs) and naloxone in a fixed combination with oxycodone have …
Both for prevention and treatment of OIC osmotic (e.g. polyethylene glycol) and stimulant (e.g. bisacodyl) laxatives are widely used. …
Efficacy of drugs in chronic idiopathic constipation: a systematic review and network meta-analysis.
Luthra P, Camilleri M, Burr NE, Quigley EMM, Black CJ, Ford AC. Luthra P, et al. Lancet Gastroenterol Hepatol. 2019 Nov;4(11):831-844. doi: 10.1016/S2468-1253(19)30246-8. Epub 2019 Aug 29. Lancet Gastroenterol Hepatol. 2019. PMID: 31474542 Free article.
Based on an endpoint of failure to achieve three or more complete spontaneous bowel movements (CSBMs) per week, the stimulant diphenyl methane laxatives bisacodyl and sodium picosulfate, at a dose of 10 mg once daily, were ranked first at 4 weeks (RR 0.55, 95% CI 0.48-0.63 …
Based on an endpoint of failure to achieve three or more complete spontaneous bowel movements (CSBMs) per week, the stimulant diphenyl metha …
Comparison of efficacy of pharmacological treatments for chronic idiopathic constipation: a systematic review and network meta-analysis.
Nelson AD, Camilleri M, Chirapongsathorn S, Vijayvargiya P, Valentin N, Shin A, Erwin PJ, Wang Z, Murad MH. Nelson AD, et al. Gut. 2017 Sep;66(9):1611-1622. doi: 10.1136/gutjnl-2016-311835. Epub 2016 Jun 10. Gut. 2017. PMID: 27287486 Free article.
Bisacodyl, NaP, prucalopride and velusetrag were superior to placebo for the 3 CSBM/week end point. ...CONCLUSIONS: Current drugs for CIC show similar efficacy. Bisacodyl may be superior to prescription medications for delta(b) in the number of SBM/week in CIC....
Bisacodyl, NaP, prucalopride and velusetrag were superior to placebo for the 3 CSBM/week end point. ...CONCLUSIONS: Current drugs for …
Comparison of efficacies of vegetable oil based and polyethylene glycol based bisacodyl suppositories in treating patients with neurogenic bowel dysfunction after spinal cord injury: a meta-analysis.
Yi Z, Jie C, Wenyi Z, Bin X, Hongzhu J. Yi Z, et al. Turk J Gastroenterol. 2014 Oct;25(5):488-92. doi: 10.5152/tjg.2014.6708. Turk J Gastroenterol. 2014. PMID: 25417608 Free article. Review.
BACKGROUND/AIMS: We performed a meta-analysis to compare the efficacies of vegetable oil based bisacodyl (VOB) and polyethylene glycol based bisacodyl (PGB) suppositories in treating patients with neurogenic bowel dysfunction (NBD) after spinal cord injury (SCI). .. …
BACKGROUND/AIMS: We performed a meta-analysis to compare the efficacies of vegetable oil based bisacodyl (VOB) and polyethylene glyco …
High amplitude propagated contractions with Glycerin versus Bisacodyl: A within-subject comparison in children undergoing colonic manometry.
Mansi S, Bahia G, Patel D, Dorfman L, El-Chammas K, Fei L, Liu C, Santucci NR, Graham K, Kaul A. Mansi S, et al. Neurogastroenterol Motil. 2023 May;35(5):e14544. doi: 10.1111/nmo.14544. Epub 2023 Feb 27. Neurogastroenterol Motil. 2023. PMID: 37096635 Free PMC article. Clinical Trial.
We aimed to compare the HAPC characteristics with Bisacodyl and Glycerin in children undergoing CM for constipation. METHODS: This is a prospective single-center cross-over study of children aged 2-18 years undergoing CM. All patients received both Glycerin and Bisacody …
We aimed to compare the HAPC characteristics with Bisacodyl and Glycerin in children undergoing CM for constipation. METHODS: This is …
Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study.
Wilkinson-Smith V, Scott M, Menys A, Wiklendt L, Marciani L, Atkinson D, Sansone S, Zdanaviciene A, Coupland C, Knowles CH, Dinning P, Taylor SA, Gowland P, Hoad CL, Corsetti M, Spiller RC. Wilkinson-Smith V, et al. Gut. 2024 Dec 10;74(1):35-44. doi: 10.1136/gutjnl-2024-332755. Gut. 2024. PMID: 39438126 Free PMC article. Clinical Trial.
Patients then proceeded to Part 2: a randomised cross-over study of 10-days bisacodyl 10 mg daily versus hyoscine 20 mg three times per day, assessing daily pain and constipation. ...Abnormally large colons predicted significantly delayed evacuation after macrogol challeng …
Patients then proceeded to Part 2: a randomised cross-over study of 10-days bisacodyl 10 mg daily versus hyoscine 20 mg three times p …
Oral bisacodyl is effective and well-tolerated in patients with chronic constipation.
Kamm MA, Mueller-Lissner S, Wald A, Richter E, Swallow R, Gessner U. Kamm MA, et al. Clin Gastroenterol Hepatol. 2011 Jul;9(7):577-83. doi: 10.1016/j.cgh.2011.03.026. Epub 2011 Mar 25. Clin Gastroenterol Hepatol. 2011. PMID: 21440672 Clinical Trial.
Compared with baseline, there was a statistically significant improvement in the overall Patient Assessment of Constipation quality of life (PAC-QOL) score and all subscales (satisfaction, physical discomfort, psychosocial discomfort, worries and concerns) in the bisacodyl …
Compared with baseline, there was a statistically significant improvement in the overall Patient Assessment of Constipation quality of life …
High-resolution manometry reveals different effect of polyethylene glycol, bisacodyl, and prucalopride on colonic motility in healthy subjects: An acute, open label, randomized, crossover, reader-blinded study with potential clinical implications.
Corsetti M, Thys A, Harris A, Pagliaro G, Deloose E, Demedts I, Tack J. Corsetti M, et al. Neurogastroenterol Motil. 2021 May;33(5):e14040. doi: 10.1111/nmo.14040. Epub 2020 Dec 10. Neurogastroenterol Motil. 2021. PMID: 33301221 Clinical Trial.
Only bisacodyl and prucalopride are expected to directly stimulate the colonic motility in humans in vivo. ...CONCLUSIONS & INFERENCES: In humans, PEG, prucalopride, and bisacodyl have distinct effects on colonic motility. This information has clinical implicati …
Only bisacodyl and prucalopride are expected to directly stimulate the colonic motility in humans in vivo. ...CONCLUSIONS & INFER …
Combination of bisacodyl suppository and 1 L polyethylene glycol plus ascorbic acid is a non-inferior and comfortable regimen compared to 2 L polyethylene glycol plus ascorbic acid.
Kim SH, Kim ER, Kim K, Kim TJ, Hong SN, Chang DK, Kim YH. Kim SH, et al. Dig Endosc. 2020 May;32(4):600-607. doi: 10.1111/den.13548. Epub 2019 Nov 11. Dig Endosc. 2020. PMID: 31574170 Clinical Trial.
(P = 0.00). CONCLUSIONS: One liter PEG-Asc with bisacodyl suppository resulted in an equivalent bowel-cleansing outcome with reduced patient discomfort compared to 2 L PEG-Asc. Therefore, PEG-Asc with bisacodyl suppository represents a potential alternative and incr …
(P = 0.00). CONCLUSIONS: One liter PEG-Asc with bisacodyl suppository resulted in an equivalent bowel-cleansing outcome with reduced …
Comparison of bisacodyl and sodium picosulphate in the treatment of chronic constipation.
Kienzle-Horn S, Vix JM, Schuijt C, Peil H, Jordan CC, Kamm MA. Kienzle-Horn S, et al. Curr Med Res Opin. 2007 Apr;23(4):691-9. doi: 10.1185/030079907x178865. Curr Med Res Opin. 2007. PMID: 17407625 Clinical Trial.
Patients were treated daily for 4 weeks (bisacodyl, 5-10 mg daily: 70 patients; sodium picosulphate, 5-10 mg daily: 74 patients). ...There was a trend for better tolerability in patients receiving bisacodyl treatment based on the number of drug-related adverse event …
Patients were treated daily for 4 weeks (bisacodyl, 5-10 mg daily: 70 patients; sodium picosulphate, 5-10 mg daily: 74 patients). ... …
168 results