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MPTP induces dystonia and parkinsonism. Clues to the pathophysiology of dystonia.
Perlmutter JS, Tempel LW, Black KJ, Parkinson D, Todd RD. Perlmutter JS, et al. Among authors: black kj. Neurology. 1997 Nov;49(5):1432-8. doi: 10.1212/wnl.49.5.1432. Neurology. 1997. PMID: 9371934
The pathophysiology of dystonia is unclear, but several clues implicate striatal dopamine dysfunction. ...The time course of dystonia and parkinsonism is analogous to lower limb dystonia as the first, frequently transient, symptom of Parkinson's disease in hu …
The pathophysiology of dystonia is unclear, but several clues implicate striatal dopamine dysfunction. ...The time course of dysto
Spatial reorganization of putaminal dopamine D2-like receptors in cranial and hand dystonia.
Black KJ, Snyder AZ, Mink JW, Tolia VN, Revilla FJ, Moerlein SM, Perlmutter JS. Black KJ, et al. PLoS One. 2014 Feb 10;9(2):e88121. doi: 10.1371/journal.pone.0088121. eCollection 2014. PLoS One. 2014. PMID: 24520350 Free PMC article.
An automated algorithm located the peak location of [(18)F]spiperone binding within the striatum, relative to a brain atlas, in each of 14 patients with cranial dystonia and 8 patients with hand dystonia. The mean (left and right) |x|, y, and z coordinates of peak s …
An automated algorithm located the peak location of [(18)F]spiperone binding within the striatum, relative to a brain atlas, in each of 14 p …
Decreased [18F]spiperone binding in putamen in idiopathic focal dystonia.
Perlmutter JS, Stambuk MK, Markham J, Black KJ, McGee-Minnich L, Jankovic J, Moerlein SM. Perlmutter JS, et al. Among authors: black kj. J Neurosci. 1997 Jan 15;17(2):843-50. doi: 10.1523/JNEUROSCI.17-02-00843.1997. J Neurosci. 1997. PMID: 8987805 Free PMC article.
In this study we have investigated the pathophysiology of two idiopathic focal dystonias: hand cramp with excessive cocontractions of agonist and antagonist hand or forearm muscles during specific tasks, such as writing, and facial dystonia manifested by involuntary …
In this study we have investigated the pathophysiology of two idiopathic focal dystonias: hand cramp with excessive cocontractions of …
PET measurement of dopamine D2 receptor-mediated changes in striatopallidal function.
Black KJ, Gado MH, Perlmutter JS. Black KJ, et al. J Neurosci. 1997 May 1;17(9):3168-77. doi: 10.1523/JNEUROSCI.17-09-03168.1997. J Neurosci. 1997. PMID: 9096151 Free PMC article.
We speculate that the U91356a-PET technique may prove useful in detecting functional abnormalities of D2-mediated dopaminergic function in diseases such as parkinsonism, dystonia, Tourette syndrome, or schizophrenia....
We speculate that the U91356a-PET technique may prove useful in detecting functional abnormalities of D2-mediated dopaminergic function in d …
Diminished regional cerebral blood flow response to vibration in patients with blepharospasm.
Feiwell RJ, Black KJ, McGee-Minnich LA, Snyder AZ, MacLeod AM, Perlmutter JS. Feiwell RJ, et al. Among authors: black kj. Neurology. 1999 Jan 15;52(2):291-7. doi: 10.1212/wnl.52.2.291. Neurology. 1999. PMID: 9932946
OBJECTIVE: To determine whether patients with blepharospasm have abnormal sensorimotor processing similar to patients with writer's cramp. BACKGROUND: Blepharospasm is a focal dystonia manifest by involuntary, excessive blinking and squeezing of the eyes. Altered sensorimo …
OBJECTIVE: To determine whether patients with blepharospasm have abnormal sensorimotor processing similar to patients with writer's cramp. B …
Severe imipramine-induced myoclonus in a patient with psychotic bipolar depression, catatonia, and schizencephaly.
Black KJ, Kilzieh N. Black KJ, et al. Ann Clin Psychiatry. 1994 Mar;6(1):45-9. doi: 10.3109/10401239409148839. Ann Clin Psychiatry. 1994. PMID: 7951645
We report a case of exceptionally severe myoclonus developing at therapeutic doses and modest serum levels of imipramine. The patient went on to experience dystonia and catatonia. Both of these were in typical settings (after haloperidol and with psychotic bipolar depressi …
We report a case of exceptionally severe myoclonus developing at therapeutic doses and modest serum levels of imipramine. The patient went o …
Putamen volume in idiopathic focal dystonia.
Black KJ, Ongür D, Perlmutter JS. Black KJ, et al. Neurology. 1998 Sep;51(3):819-24. doi: 10.1212/wnl.51.3.819. Neurology. 1998. PMID: 9748033
OBJECTIVE: To determine whether the volume of the putamen is abnormal in patients with idiopathic focal dystonia. BACKGROUND: The cause of adult-onset focal dystonia is unknown, but substantial evidence suggests that the putamen may be abnormal in this condition. .. …
OBJECTIVE: To determine whether the volume of the putamen is abnormal in patients with idiopathic focal dystonia. BACKGROUND: The cau …
Decreased [18F]spiperone binding in putamen in dystonia.
Perlmutter JS, Stambuk MK, Markham J, Black KJ, McGee-Minnich L, Jankovic J, Moerlein SM. Perlmutter JS, et al. Among authors: black kj. Adv Neurol. 1998;78:161-8. Adv Neurol. 1998. PMID: 9750913 No abstract available.