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107 results

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Page 1
State-of-the-art evidence in the treatment of systemic sclerosis.
Pope JE, Denton CP, Johnson SR, Fernandez-Codina A, Hudson M, Nevskaya T. Pope JE, et al. Nat Rev Rheumatol. 2023 Apr;19(4):212-226. doi: 10.1038/s41584-023-00909-5. Epub 2023 Feb 27. Nat Rev Rheumatol. 2023. PMID: 36849541 Free PMC article. Review.
Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease with multi-organ involvement, fibrosis and vasculopathy. ...Bosentan can reduce the development of new digital ulcers. Trial data for other manifestations are mostly lacking. ...
Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease with multi-organ involvement, fibrosis and vasculopathy. ... …
[Update Raynaud Phenomenon].
Caspary L. Caspary L. Dtsch Med Wochenschr. 2025 Jun;150(12):661-667. doi: 10.1055/a-2365-0537. Epub 2025 May 19. Dtsch Med Wochenschr. 2025. PMID: 40388975 Review. German.
The socioeconomic effect of RP is small in most of the patients; as far as they aren't engaged in professions with cold exposition, ability to work is not restricted. However, if systemic sclerosis (SSc) is the underlying disease of RP, disability rates are considerable du …
The socioeconomic effect of RP is small in most of the patients; as far as they aren't engaged in professions with cold exposition, ability …
Treatment recommendations for the systemic pharmacological treatment of systemic sclerosis digital ulcers: Results from the World Scleroderma Foundation Ad Hoc Committee.
Maltez N, Ross L, Baron M, Alunno A, Campochiaro C, Suliman YA, Schoones JW, Allanore Y, Del Galdo F, Denton CP, Distler O, Frech T, Furst DE, Giuggioli D, Khanna D, Krieg T, Kuwana M, Matucci-Cerinic M, Moinzadeh P, Pope J, Chung L, Hughes M. Maltez N, et al. J Scleroderma Relat Disord. 2025 Aug 19;10(3):23971983251340559. doi: 10.1177/23971983251340559. Online ahead of print. J Scleroderma Relat Disord. 2025. PMID: 40852405 Free article.
INTRODUCTION: Digital ulcers are an important disease manifestation of systemic sclerosis and are associated with significant morbidity. ...Phosphodiesterase 5 inhibitors and intravenous iloprost were recommended for the management of acute digital …
INTRODUCTION: Digital ulcers are an important disease manifestation of systemic sclerosis and are associated with signi …
Bosentan: a review of its use in the management of digital ulcers associated with systemic sclerosis.
Dhillon S. Dhillon S. Drugs. 2009 Oct 1;69(14):2005-24. doi: 10.2165/10489160-000000000-00000. Drugs. 2009. PMID: 19747014 Review.
Bosentan (Tracleer) is an orally administered dual endothelin-1 (ET-1) receptor antagonist approved in the EU for reducing the number of new digital ulcers in patients with systemic sclerosis and ongoing digital ulcer disease. Oral bos …
Bosentan (Tracleer) is an orally administered dual endothelin-1 (ET-1) receptor antagonist approved in the EU for reducing the number …
Raynaud, digital ulcers and calcinosis in scleroderma.
Nitsche A. Nitsche A. Reumatol Clin. 2012 Sep-Oct;8(5):270-7. doi: 10.1016/j.reuma.2012.02.006. Epub 2012 Jul 25. Reumatol Clin. 2012. PMID: 22835924 Free article. Review.
Raynaud, digital ulcers and calcinosis are frequent manifestations of patients with systemic sclerosis. Digital ulcers are seen in more than half of the patients with scleroderma. Hospitalizations, ischemic complications and impairment of …
Raynaud, digital ulcers and calcinosis are frequent manifestations of patients with systemic sclerosis. Digital …
Classification, categorization and essential items for digital ulcer evaluation in systemic sclerosis: a DeSScipher/European Scleroderma Trials and Research group (EUSTAR) survey.
Blagojevic J, Bellando-Randone S, Abignano G, Avouac J, Cometi L, Czirják L, Denton CP, Distler O, Frerix M, Guiducci S, Huscher D, Jaeger VK, Lóránd V, Maurer B, Nihtyanova S, Riemekasten G, Siegert E, Tarner IH, Vettori S, Walker UA, Allanore Y, Müller-Ladner U, Del Galdo F, Matucci-Cerinic M; EUSTAR co-workers. Blagojevic J, et al. Arthritis Res Ther. 2019 Jan 24;21(1):35. doi: 10.1186/s13075-019-1822-1. Arthritis Res Ther. 2019. PMID: 30678703 Free PMC article.
BACKGROUND: A consensus on digital ulcer (DU) definition in systemic sclerosis (SSc) has been recently reached (Suliman et al., J Scleroderma Relat Disord 2:115-20, 2017), while for their evaluation, classification and categorisation, it is still missi …
BACKGROUND: A consensus on digital ulcer (DU) definition in systemic sclerosis (SSc) has been recently reached (Suliman …
Bosentan in systemic sclerosis.
Heresi GA, Minai OA. Heresi GA, et al. Drugs Today (Barc). 2008 Jun;44(6):415-28. doi: 10.1358/dot.2008.44.6.1220138. Drugs Today (Barc). 2008. PMID: 18596996 Review.
Pulmonary compromise, including pulmonary arterial hypertension and interstitial lung disease, is currently the leading cause of death in patients with SSc. Digital ulcers are common complications which lead to substantial morbidity and functional limitation. ... …
Pulmonary compromise, including pulmonary arterial hypertension and interstitial lung disease, is currently the leading cause of death in pa …
Digital ulcers in scleroderma patients: A retrospective observational study.
De Cata A, Inglese M, Molinaro F, De Cosmo S, Rubino R, Bernal M, Mazzoccoli G. De Cata A, et al. Int J Immunopathol Pharmacol. 2016 Jun;29(2):180-7. doi: 10.1177/0394632015606846. Epub 2015 Dec 18. Int J Immunopathol Pharmacol. 2016. PMID: 26684622 Free PMC article.
BACKGROUND: The guidelines for digital ulcers (DUs) management in systemic sclerosis (SSc) indicate the use of iloprost to induce wound healing and bosentan to prevent the onset of new DU. ...CONCLUSION: The treatment with iloprost plus bosentan …
BACKGROUND: The guidelines for digital ulcers (DUs) management in systemic sclerosis (SSc) indicate the use of iloprost …
Bosentan Does Not Affect Renal Resistive Index in Scleroderma/Systemic Sclerosis Patients.
Di Poi E, Colussi G, Bertoni M, Giovannini I, Tolusso B, Ferraccioli GF, Gremese E, De Vita S, Romano G. Di Poi E, et al. Kidney Blood Press Res. 2023;48(1):728-737. doi: 10.1159/000534642. Epub 2023 Nov 8. Kidney Blood Press Res. 2023. PMID: 37939680 Free PMC article.
This study aimed to determine the impact of bosentan, a nonselective endothelin-1 receptor antagonist, on RRI and kidney function in SSc patients with recurrent digital ulcers. ...DISCUSSION/CONCLUSION: In conclusion, in patients with SSc complicated by di …
This study aimed to determine the impact of bosentan, a nonselective endothelin-1 receptor antagonist, on RRI and kidney function in …
Low occurrence of digital ulcers in scleroderma patients treated with bosentan for pulmonary arterial hypertension: a retrospective case-control study.
Cozzi F, Pigatto E, Rizzo M, Favaro M, Zanatta E, Cardarelli S, Riato L, Punzi L. Cozzi F, et al. Clin Rheumatol. 2013 May;32(5):679-83. doi: 10.1007/s10067-013-2172-z. Epub 2013 Jan 24. Clin Rheumatol. 2013. PMID: 23344686
Digital ulcers (DU) are one of the most common and debilitating manifestations of vasculopathy in systemic sclerosis (SSc). ...The occurrence of DU, defined as loss of tissue of varying degrees in the epidermis, dermis and subcutaneous tissue, was determined …
Digital ulcers (DU) are one of the most common and debilitating manifestations of vasculopathy in systemic sclerosis (S …
107 results