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Comparative Investigation of Frankincense Nutraceuticals: Correlation of Boswellic and Lupeolic Acid Contents with Cytokine Release Inhibition and Toxicity against Triple-Negative Breast Cancer Cells.

Schmiech M, Lang SJ, Ulrich J, Werner K, Rashan LJ, Syrovets T, Simmet T. Schmiech M, et al. Nutrients. 2019 Oct 2;11(10):2341. doi: 10.3390/nu11102341. Nutrients. 2019. PMID: 31581678 Free PMC article.

Sixteen frankincense nutraceuticals were characterized by high-performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS), revealing major differences in boswellic and lupeolic acid compositions and total contents, which varied from 0.4% to 35.7%. …

Sixteen frankincense nutraceuticals were characterized by high-performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS), …

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Boswellic acid exerts potent anticancer effects in HCT-116 human colon cancer cells mediated via induction of apoptosis, cell cycle arrest, cell migration inhibition and inhibition of PI3K/AKT signalling pathway.

Wang D, Ge S, Bai J, Song Y. Wang D, et al. J BUON. 2018 Mar-Apr;23(2):340-345. J BUON. 2018. PMID: 29745074 Free article.

PURPOSE: Boswellic acid is an important plant-derived natural product with tremendous pharmacological potential and has been reported to inhibit the growth of several types of cancer cells. ...Besides, boswellic acid altered the Bax/Bcl-2 ratio …

PURPOSE: Boswellic acid is an important plant-derived natural product with tremendous pharmacological potential and has been r …

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Boswellic acid sensitizes gastric cancer cells to Cisplatin-induced apoptosis via p53-mediated pathway.

Al-Bahlani S, Burney IA, Al-Dhahli B, Al-Kharusi S, Al-Kharousi F, Al-Kalbani A, Ahmed I. Al-Bahlani S, et al. BMC Pharmacol Toxicol. 2020 Sep 1;21(1):64. doi: 10.1186/s40360-020-00442-1. BMC Pharmacol Toxicol. 2020. PMID: 32867831 Free PMC article.

BACKGROUND: Cisplatin (CDDP) is an effective anticancer drug for Gastric cancer (GC) that induces apoptosis by altering pro- (p53) and anti-apoptotic (Akt and NFkB) proteins; however, chemoresistance remains a big challenge. Additional compounds with promising anticancer e …

BACKGROUND: Cisplatin (CDDP) is an effective anticancer drug for Gastric cancer (GC) that induces apoptosis by altering pro- (p53) an …

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Inhibitory effect of 11-carbonyl-beta-boswellic acid on non-small cell lung cancer H446 cells.

Huang G, Yang J, Zhang L, Cao L, Zhang M, Niu X, Zhou Z, Zhang X, Li P, Liu JF. Huang G, et al. Biochem Biophys Res Commun. 2018 Sep 18;503(4):2202-2205. doi: 10.1016/j.bbrc.2018.06.137. Epub 2018 Jul 4. Biochem Biophys Res Commun. 2018. PMID: 29953860

BACKGROUND: The anti-lung tumor potential of 11-carbonyl-beta-boswellic acid was investigated. MATERIALS & METHODS: The inhibitory effects of 11-carbonyl-beta-boswellic acid on non-small cell lung cancer (NSCLC) was assessed by proliferation …

BACKGROUND: The anti-lung tumor potential of 11-carbonyl-beta-boswellic acid was investigated. MATERIALS & METHODS: The in …

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An Update on Pharmacological Potential of Boswellic Acids against Chronic Diseases.

Roy NK, Parama D, Banik K, Bordoloi D, Devi AK, Thakur KK, Padmavathi G, Shakibaei M, Fan L, Sethi G, Kunnumakkara AB. Roy NK, et al. Int J Mol Sci. 2019 Aug 22;20(17):4101. doi: 10.3390/ijms20174101. Int J Mol Sci. 2019. PMID: 31443458 Free PMC article. Review.

Natural compounds, in recent years, have attracted significant attention for their use in the prevention and treatment of diverse chronic diseases as they are devoid of major toxicities. Boswellic acid (BA), a series of pentacyclic triterpene molecules, is isolated …

Natural compounds, in recent years, have attracted significant attention for their use in the prevention and treatment of diverse chronic di …

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Acetyl-11-keto-beta-boswellic acid inhibits proliferation and induces apoptosis of gastric cancer cells through the phosphatase and tensin homolog /Akt/ cyclooxygenase-2 signaling pathway.

Sun MX, He XP, Huang PY, Qi Q, Sun WH, Liu GS, Hua J. Sun MX, et al. World J Gastroenterol. 2020 Oct 14;26(38):5822-5835. doi: 10.3748/wjg.v26.i38.5822. World J Gastroenterol. 2020. PMID: 33132637 Free PMC article.

Cyclooxygenase (COX)-2 plays an important role in the carcinogenesis and progression of gastric cancer. Acetyl-11-keto-beta-boswellic acid (AKBA) is a promising drug for cancer therapy, but its effects and mechanism of action on human gastric cancer …

Cyclooxygenase (COX)-2 plays an important role in the carcinogenesis and progression of gastric cancer. Acetyl-11-keto-beta-boswel …

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3-acetyl-11-keto-beta-boswellic acid decreases the malignancy of taxol resistant human ovarian cancer by inhibiting multidrug resistance (MDR) proteins function.

Jin L, Yingchun W, Zhujun S, Yinan W, Dongchen W, Hui Y, Xi Y, Wanzhou Z, Buluan Z, Jinhua W. Jin L, et al. Biomed Pharmacother. 2019 Aug;116:108992. doi: 10.1016/j.biopha.2019.108992. Epub 2019 May 23. Biomed Pharmacother. 2019. PMID: 31129513 Free article.

OBJECTIVE: Recurrence of ovarian cancer is mainly due to multidrug resistance (MDR). 3-acetyl-11-keto-beta-boswellic acid (AKBA) could reverse the multidrug resistance in human ileocecal adenocarcinoma cells, but whether AKBA could modulate acquired MDR in ov …

OBJECTIVE: Recurrence of ovarian cancer is mainly due to multidrug resistance (MDR). 3-acetyl-11-keto-beta-boswellic acid …

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Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities.

Efferth T, Oesch F. Efferth T, et al. Semin Cancer Biol. 2020 Feb 4:S1044-579X(20)30034-1. doi: 10.1016/j.semcancer.2020.01.015. Online ahead of print. Semin Cancer Biol. 2020. PMID: 32027979 Review.

We conducted a systematic review on the anti-inflammatory and anti-cancer activities of Boswellia species and their chemical ingredients (e.g. 3-O-acetyl-11-keto-beta boswellic acid, alpha- and beta-boswellic acids, 11-keto-beta-boswellic aci …

We conducted a systematic review on the anti-inflammatory and anti-cancer activities of Boswellia species and their chemical ingredie …

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Acetyl-11-Keto-beta-Boswellic Acid Exerts the Anti-Cancer Effects via Cell Cycle Arrest, Apoptosis Induction and Autophagy Suppression in Non-Small Cell Lung Cancer Cells.

Lv M, Shao S, Zhang Q, Zhuang X, Qiao T. Lv M, et al. Onco Targets Ther. 2020 Jan 23;13:733-744. doi: 10.2147/OTT.S236346. eCollection 2020. Onco Targets Ther. 2020. PMID: 32158225 Free PMC article.

OBJECTIVE: Acetyl-11-keto-beta-boswellic acid (AKBA) is a triterpenoid, which is the main component of boswellic acid from Boswellia Serrata, a medicinal plant that has shown immense potential in anti-cancer therapy. ...Furthermore, AKBA also in …

OBJECTIVE: Acetyl-11-keto-beta-boswellic acid (AKBA) is a triterpenoid, which is the main component of boswellic aci …

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Synthesis of new boswellic acid derivatives as potential antiproliferative agents.

Shamraiz U, Hussain H, Ur Rehman N, Al-Shidhani S, Saeed A, Khan HY, Khan A, Fischer L, Csuk R, Badshah A, Al-Rawahi A, Hussain J, Al-Harrasi A. Shamraiz U, et al. Nat Prod Res. 2020 Jul;34(13):1845-1852. doi: 10.1080/14786419.2018.1564295. Epub 2019 Jan 29. Nat Prod Res. 2020. PMID: 30691289

In the current investigation, a series of heterocyclic derivatives of boswellic acids were prepared along with new monomers of 3-O-acetyl-11-keto-beta-boswellic acid (AKBA, 1) 11-keto-beta-boswellic acid (KBA, 2) and several new bis-AKBA and KBA …

In the current investigation, a series of heterocyclic derivatives of boswellic acids were prepared along with new monomers of 3-O-ac …

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