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Page 1
Mechanism of 5-lipoxygenase inhibition by acetyl-11-keto-beta-boswellic acid.
Safayhi H, Sailer ER, Ammon HP. Safayhi H, et al. Mol Pharmacol. 1995 Jun;47(6):1212-6. Mol Pharmacol. 1995. PMID: 7603462
The formation of 5-lipoxygenase (EC 1.13.11.34) products from endogenous substrate by intact rat neutrophilic granulocytes and from exogenous arachidonic acid by rat granulocyte 105,000 x g supernatants and affinity chromatography-purified human leukocyte 5- …
The formation of 5-lipoxygenase (EC 1.13.11.34) products from endogenous substrate by intact rat neutrophilic granulocytes and …
Acetyl-11-keto-beta-boswellic acid (AKBA): structure requirements for binding and 5-lipoxygenase inhibitory activity.
Sailer ER, Subramanian LR, Rall B, Hoernlein RF, Ammon HP, Safayhi H. Sailer ER, et al. Br J Pharmacol. 1996 Feb;117(4):615-8. doi: 10.1111/j.1476-5381.1996.tb15235.x. Br J Pharmacol. 1996. PMID: 8646405 Free PMC article.
1. 5-Lipoxygenase (5-LOX) products from endogenous arachidonic acid in ionophore-stimulated peritoneal polymorphonuclear leukocytes (PMNL) and from exogenous substrate (20 microM) in 105,000 g supernatants were measured. 2. The effects of natural pentacyclic …
1. 5-Lipoxygenase (5-LOX) products from endogenous arachidonic acid in ionophore-stimulated peritoneal polymorphonuclea …
Characterization of an acetyl-11-keto-beta-boswellic acid and arachidonate-binding regulatory site of 5-lipoxygenase using photoaffinity labeling.
Sailer ER, Schweizer S, Boden SE, Ammon HP, Safayhi H. Sailer ER, et al. Eur J Biochem. 1998 Sep 1;256(2):364-8. doi: 10.1046/j.1432-1327.1998.2560364.x. Eur J Biochem. 1998. PMID: 9760176 Free article.
AKBA (acetyl-11-keto-beta-boswellic acid), a natural pentacyclic triterpene, is an orally active leukotriene-synthesis inhibitor, which acts by a 5-lipoxygenase-directed, non-redox, non-competitive mechanism. It is the only leukotriene-synthesis …
AKBA (acetyl-11-keto-beta-boswellic acid), a natural pentacyclic triterpene, is an orally active leukotriene-synthesis inhibit …
5-Lipoxygenase inhibition by acetyl-11-keto-beta-boswellic acid (AKBA) by a novel mechanism.
Safayhi H, Sailer ER, Ammon HP. Safayhi H, et al. Phytomedicine. 1996 May;3(1):71-2. doi: 10.1016/S0944-7113(96)80013-4. Phytomedicine. 1996. PMID: 23194864
Acetyl-11-keto-beta-boswellic acid (AKAB) from Boswellia serrata and B. carterii acts directly on purified 5-lipoxygenase of human blood leukocytes at a selective site for pentacyclic triterpenes that is different from the arachidonate substrate …
Acetyl-11-keto-beta-boswellic acid (AKAB) from Boswellia serrata and B. carterii acts directly on purified 5-lipoxyg …
Acetyl-11-keto-beta-boswellic acid prevents testicular torsion/detorsion injury in rats by modulating 5-LOX/LTB4 and p38-MAPK/JNK/Bax/Caspase-3 pathways.
Ahmed MAE, Ahmed AAE, El Morsy EM. Ahmed MAE, et al. Life Sci. 2020 Nov 1;260:118472. doi: 10.1016/j.lfs.2020.118472. Epub 2020 Sep 21. Life Sci. 2020. PMID: 32971106
The use of natural compounds may protect against the associated detrimental oxidative stress and inflammatory responses. Interestingly, acetyl-11-keto-beta-boswellic acid (AKBA), the main active constituent of Boswellia resin, has shown potent inhibitory effect on …
The use of natural compounds may protect against the associated detrimental oxidative stress and inflammatory responses. Interestingly, acet …
Co-administration of acetyl-11-keto-beta-boswellic acid, a specific 5-lipoxygenase inhibitor, potentiates the protective effect of COX-2 inhibitors in kainic acid-induced neurotoxicity in mice.
Bishnoi M, Patil CS, Kumar A, Kulkarni SK. Bishnoi M, et al. Pharmacology. 2007;79(1):34-41. doi: 10.1159/000097627. Epub 2006 Nov 30. Pharmacology. 2007. PMID: 17139192
Kainic acid, a glutamate receptor agonist and responsible for neuronal excitotoxicity and oxidative damage via different mechanisms, is capable of stimulating mRNA of both COX-2 and 5-LOX in the brain. The present study was designed to study the effects of COX inhibitors ( …
Kainic acid, a glutamate receptor agonist and responsible for neuronal excitotoxicity and oxidative damage via different mechanisms, …
Natural pentacyclic triterpenoid as allosteric modulators of human 5-lipoxygenase with potential anti-inflammatory activity.
Mascayano C, Muñoz-Osses M, Navarrete E, Torres P, Torres-González S, Morales P, Huidobro-Toro JP. Mascayano C, et al. J Biomol Struct Dyn. 2024;42(24):13529-13537. doi: 10.1080/07391102.2023.2276875. Epub 2023 Nov 1. J Biomol Struct Dyn. 2024. PMID: 37909479
This study explored new methods to inhibit human 5-lipoxygenase (5-hLOX) by analyzing natural terpenes that share structural similarities with acetoxyboswellic acid (AKBA). ...Our research focused on how certain types of triterpenes can inhibit 5-hLOX alloste …
This study explored new methods to inhibit human 5-lipoxygenase (5-hLOX) by analyzing natural terpenes that share struc …
Boswellic acids in chronic inflammatory diseases.
Ammon HP. Ammon HP. Planta Med. 2006 Oct;72(12):1100-16. doi: 10.1055/s-2006-947227. Planta Med. 2006. PMID: 17024588 Review.
Animal experiments showed anti-inflammatory activity of the extract. The mechanism of this action is due to some boswellic acids. It is different from that of NSAID and is related to components of the immune system. The most evident action is the inhibition of 5- …
Animal experiments showed anti-inflammatory activity of the extract. The mechanism of this action is due to some boswellic acids. It …
Boswellic acids stimulate arachidonic acid release and 12-lipoxygenase activity in human platelets independent of Ca2+ and differentially interact with platelet-type 12-lipoxygenase.
Poeckel D, Tausch L, Kather N, Jauch J, Werz O. Poeckel D, et al. Mol Pharmacol. 2006 Sep;70(3):1071-8. doi: 10.1124/mol.106.024836. Epub 2006 Jun 20. Mol Pharmacol. 2006. PMID: 16788089
Using human platelets, we explored the molecular mechanisms underlying the boswellic acid-induced release of arachidonic acid and the subsequent metabolism by platelet-type 12-li-poxygenase (p12-LO). Both beta-boswellic acid and 3-O-acetyl-11-ke …
Using human platelets, we explored the molecular mechanisms underlying the boswellic acid-induced release of arachidoni …
Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities.
Efferth T, Oesch F. Efferth T, et al. Semin Cancer Biol. 2022 May;80:39-57. doi: 10.1016/j.semcancer.2020.01.015. Epub 2020 Feb 4. Semin Cancer Biol. 2022. PMID: 32027979
We conducted a systematic review on the anti-inflammatory and anti-cancer activities of Boswellia species and their chemical ingredients (e.g. 3-O-acetyl-11-keto-beta boswellic acid, alpha- and beta-boswellic acids, 11-keto-beta-boswellic acid and othe …
We conducted a systematic review on the anti-inflammatory and anti-cancer activities of Boswellia species and their chemical ingredients (e. …
23 results