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Year Number of Results
1999 1
2001 1
2003 3
2004 3
2005 1
2006 1
2007 3
2008 3
2009 2
2011 1
2012 1
2013 3
2015 7
2016 2
2017 2
2018 2
2019 5
2020 4
2021 4
2022 3
2023 2
2024 2
2025 5
2026 0

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57 results

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Page 1
Auto-inhibition of PRC2 by the broadly expressed long isoform of AEBP2.
Mucha M, Lai Z, McKenzie NJ, Matrà F, Boudes M, Flanigan SF, Alejo-Vinogradova MT, Monger C, Zhang Q, Nimmo D, Healy E, Silva AJ, Angelov D, Reck DM, Holland G, Atmaca ZE, King HE, Hamilton M, Glancy E, Nolan J, Weatheritt RJ, Bell O, Vermeulen M, Davidovich C, Bracken AP. Mucha M, et al. Among authors: bracken ap. EMBO J. 2025 Dec;44(23):6979-7020. doi: 10.1038/s44318-025-00616-9. Epub 2025 Oct 30. EMBO J. 2025. PMID: 41168462 Free PMC article.
Dominant-negative effects of Weaver syndrome-associated EZH2 variants.
Deevy O, Li J, Monger C, Matrà F, Tuck E, Davies M, Badonyi M, Boyce M, Doyle EJ, Hokamp K, Nimmo D, Rodighiero S, Zhang Q, Davidovich C, Marsh JA, Pasini D, Conway E, Bracken AP. Deevy O, et al. Among authors: bracken ap. Genes Dev. 2025 Nov 3;39(21-22):1355-1376. doi: 10.1101/gad.351884.124. Genes Dev. 2025. PMID: 40846643 Free PMC article.
A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma.
Lagan E, Gannon D, Silva AJ, Bibawi P, Doherty AM, Nimmo D, McCole R, Monger C, Genesi GL, Vanderlinden A, Innes JA, Jones CLE, Yang L, Chen B, van Mierlo G, Jansen PWTC, Pednekar C, Von Kriegsheim A, Wynne K, Sánchez-Rivera FJ, Soto-Feliciano YM, Carcaboso AM, Vermeulen M, Oliviero G, Chen CW, Phillips RE, Bracken AP, Brien GL. Lagan E, et al. Among authors: bracken ap. Mol Cell. 2025 Jun 5;85(11):2110-2127.e7. doi: 10.1016/j.molcel.2025.04.026. Epub 2025 May 21. Mol Cell. 2025. PMID: 40403727 Free article.
A conserved switch to less catalytically active Polycomb repressive complexes in non-dividing cells.
McCole R, Nolan J, Reck DM, Monger C, Rustichelli S, Conway E, Brien GL, Wang C, Deevy O, Neikes HK, Bashore FM, Mooney A, Flavin R, Vandenberghe E, Flanigan SF, Pasini D, Davidovich C, Vermeulen M, James LI, Healy E, Bracken AP. McCole R, et al. Among authors: bracken ap. Cell Rep. 2025 Jan 28;44(1):115192. doi: 10.1016/j.celrep.2024.115192. Epub 2025 Jan 11. Cell Rep. 2025. PMID: 39799569 Free PMC article.
PIC-king apart PRC1-mediated repression.
Healy E, Bracken AP. Healy E, et al. Among authors: bracken ap. Trends Genet. 2025 Jan;41(1):4-5. doi: 10.1016/j.tig.2024.10.013. Epub 2024 Nov 20. Trends Genet. 2025. PMID: 39572355 Free article.
Analytical Validation of a Novel 6-Gene Signature for Prediction of Distant Recurrence in Estrogen Receptor-Positive, HER2-Negative, Early-Stage Breast Cancer.
Loughman T, Barron S, Wang CA, Dynoodt P, Fender B, Lopez-Ruiz C, Stapleton S, Fabre A, Quinn C, Nodin B, Jirström K, Razmara F, O'Grady A, Baird AM, Gray SG, Freixo A, Moelans CB, van Diest PJ, Duffy MJ, O'Leary D, Crown J, Bracken AP, Gallagher WM. Loughman T, et al. Among authors: bracken ap. Clin Chem. 2022 Jun 1;68(6):837-847. doi: 10.1093/clinchem/hvac028. Clin Chem. 2022. PMID: 35312747
Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells.
Brien GL, Bressan RB, Monger C, Gannon D, Lagan E, Doherty AM, Healy E, Neikes H, Fitzpatrick DJ, Deevy O, Grant V, Marqués-Torrejón MA, Alfazema N, Pollard SM, Bracken AP. Brien GL, et al. Among authors: bracken ap. Nat Genet. 2021 Aug;53(8):1221-1232. doi: 10.1038/s41588-021-00897-w. Epub 2021 Jul 22. Nat Genet. 2021. PMID: 34294917
Prognostic value of the 6-gene OncoMasTR test in hormone receptor-positive HER2-negative early-stage breast cancer: Comparative analysis with standard clinicopathological factors.
Lynch SM, Russell NM, Barron S, Wang CA, Loughman T, Dynoodt P, Fender B, Lopez-Ruiz C, O'Grady A, Sheehan KM, Fay J, Amberger-Murphy V, Saha A, Klinger R, Gonzalez CA, Al-Attar N, Rahman A, O'Leary D, Lanigan FT, Bracken AP, Crown J, Kelly CM, O'Connor DP, Gallagher WM. Lynch SM, et al. Among authors: bracken ap. Eur J Cancer. 2021 Jul;152:78-89. doi: 10.1016/j.ejca.2021.04.016. Epub 2021 Jun 2. Eur J Cancer. 2021. PMID: 34090143 Free article.
The future of genomics in Ireland - focus on genomics for health.
Seoighe C, Bracken AP, Buckley P, Doran P, Green R, Healy S, Kavanagh D, Kenny E, Lawler M, Lowery M, Morris D, Morrissey D, O'Byrne JJ, Shields D, Smith O, Steward CA, Sweeney B, Kolch W. Seoighe C, et al. Among authors: bracken ap. HRB Open Res. 2020 Dec 4;3:89. doi: 10.12688/hrbopenres.13187.1. eCollection 2020. HRB Open Res. 2020. PMID: 33855271 Free PMC article.
The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages.
Huang Z, Liang N, Goñi S, Damdimopoulos A, Wang C, Ballaire R, Jager J, Niskanen H, Han H, Jakobsson T, Bracken AP, Aouadi M, Venteclef N, Kaikkonen MU, Fan R, Treuter E. Huang Z, et al. Among authors: bracken ap. Mol Cell. 2021 Mar 4;81(5):953-968.e9. doi: 10.1016/j.molcel.2020.12.040. Epub 2021 Jan 26. Mol Cell. 2021. PMID: 33503407 Free article.
Structural basis for PRC2 engagement with chromatin.
Glancy E, Ciferri C, Bracken AP. Glancy E, et al. Among authors: bracken ap. Curr Opin Struct Biol. 2021 Apr;67:135-144. doi: 10.1016/j.sbi.2020.10.017. Epub 2020 Nov 21. Curr Opin Struct Biol. 2021. PMID: 33232890 Free article. Review.
Anticancer innovative therapy: Highlights from the ninth annual meeting.
Volpari T, De Santis F, Bracken AP, Pupa SM, Buschbeck M, Wegner A, Di Cosimo S, Lisanti MP, Dotti G, Massaia M, Pruneri G, Anichini A, Fortunato O, De Braud F, Del Vecchio M, Di Nicola M. Volpari T, et al. Among authors: bracken ap. Cytokine Growth Factor Rev. 2020 Feb;51:1-9. doi: 10.1016/j.cytogfr.2019.12.002. Epub 2019 Dec 13. Cytokine Growth Factor Rev. 2020. PMID: 31862236 Free article. Review.
PRC2.1 and PRC2.2 Synergize to Coordinate H3K27 Trimethylation.
Healy E, Mucha M, Glancy E, Fitzpatrick DJ, Conway E, Neikes HK, Monger C, Van Mierlo G, Baltissen MP, Koseki Y, Vermeulen M, Koseki H, Bracken AP. Healy E, et al. Among authors: bracken ap. Mol Cell. 2019 Nov 7;76(3):437-452.e6. doi: 10.1016/j.molcel.2019.08.012. Epub 2019 Sep 11. Mol Cell. 2019. PMID: 31521505 Free article.
The 3D Genome: EZH2 Comes into the Fold.
Brien GL, Bracken AP. Brien GL, et al. Among authors: bracken ap. Trends Mol Med. 2019 May;25(5):362-365. doi: 10.1016/j.molmed.2019.02.013. Epub 2019 Mar 15. Trends Mol Med. 2019. PMID: 30885427
A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities.
Conway E, Jerman E, Healy E, Ito S, Holoch D, Oliviero G, Deevy O, Glancy E, Fitzpatrick DJ, Mucha M, Watson A, Rice AM, Chammas P, Huang C, Pratt-Kelly I, Koseki Y, Nakayama M, Ishikura T, Streubel G, Wynne K, Hokamp K, McLysaght A, Ciferri C, Di Croce L, Cagney G, Margueron R, Koseki H, Bracken AP. Conway E, et al. Among authors: bracken ap. Mol Cell. 2018 May 3;70(3):408-421.e8. doi: 10.1016/j.molcel.2018.03.005. Epub 2018 Apr 5. Mol Cell. 2018. PMID: 29628311 Free article.
The H3K36me2 Methyltransferase Nsd1 Demarcates PRC2-Mediated H3K27me2 and H3K27me3 Domains in Embryonic Stem Cells.
Streubel G, Watson A, Jammula SG, Scelfo A, Fitzpatrick DJ, Oliviero G, McCole R, Conway E, Glancy E, Negri GL, Dillon E, Wynne K, Pasini D, Krogan NJ, Bracken AP, Cagney G. Streubel G, et al. Among authors: bracken ap. Mol Cell. 2018 Apr 19;70(2):371-379.e5. doi: 10.1016/j.molcel.2018.02.027. Epub 2018 Mar 29. Mol Cell. 2018. PMID: 29606589 Free article.
Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal.
Streubel G, Fitzpatrick DJ, Oliviero G, Scelfo A, Moran B, Das S, Munawar N, Watson A, Wynne K, Negri GL, Dillon ET, Jammula S, Hokamp K, O'Connor DP, Pasini D, Cagney G, Bracken AP. Streubel G, et al. Among authors: bracken ap. EMBO J. 2017 Aug 1;36(15):2216-2232. doi: 10.15252/embj.201696307. Epub 2017 May 29. EMBO J. 2017. PMID: 28554894 Free PMC article.
The PCL1-p53 axis promotes cellular quiescence.
Brien GL, Bracken AP. Brien GL, et al. Among authors: bracken ap. Cell Cycle. 2016;15(3):305-6. doi: 10.1080/15384101.2015.1124701. Epub 2015 Dec 10. Cell Cycle. 2016. PMID: 26652297 Free PMC article. No abstract available.
MED23: a new Mediator of H2B monoubiquitylation.
Streubel G, Bracken AP. Streubel G, et al. Among authors: bracken ap. EMBO J. 2015 Dec 2;34(23):2863-4. doi: 10.15252/embj.201592996. Epub 2015 Oct 5. EMBO J. 2015. PMID: 26438725 Free PMC article.
Delineating transcriptional networks of prognostic gene signatures refines treatment recommendations for lymph node-negative breast cancer patients.
Lanigan F, Brien GL, Fan Y, Madden SF, Jerman E, Maratha A, Aloraifi F, Hokamp K, Dunne EJ, Lohan AJ, Flanagan L, Garbe JC, Stampfer MR, Fridberg M, Jirstrom K, Quinn CM, Loftus B, Gallagher WM, Geraghty J, Bracken AP. Lanigan F, et al. Among authors: bracken ap. FEBS J. 2015 Sep;282(18):3455-73. doi: 10.1111/febs.13354. Epub 2015 Jul 14. FEBS J. 2015. PMID: 26094870 Free article.
Detection of novel germline mutations for breast cancer in non-BRCA1/2 families.
Aloraifi F, McDevitt T, Martiniano R, McGreevy J, McLaughlin R, Egan CM, Cody N, Meany M, Kenny E, Green AJ, Bradley DG, Geraghty JG, Bracken AP. Aloraifi F, et al. Among authors: bracken ap. FEBS J. 2015 Sep;282(17):3424-37. doi: 10.1111/febs.13352. Epub 2015 Jul 14. FEBS J. 2015. PMID: 26094658 Free article.
Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation.
Brien GL, Gambero G, O'Connell DJ, Jerman E, Turner SA, Egan CM, Dunne EJ, Jurgens MC, Wynne K, Piao L, Lohan AJ, Ferguson N, Shi X, Sinha KM, Loftus BJ, Cagney G, Bracken AP. Brien GL, et al. Among authors: bracken ap. Nat Struct Mol Biol. 2012 Dec;19(12):1273-81. doi: 10.1038/nsmb.2449. Epub 2012 Nov 18. Nat Struct Mol Biol. 2012. PMID: 23160351
Transcriptional regulation of cellular senescence.
Lanigan F, Geraghty JG, Bracken AP. Lanigan F, et al. Among authors: bracken ap. Oncogene. 2011 Jun 30;30(26):2901-11. doi: 10.1038/onc.2011.34. Epub 2011 Mar 7. Oncogene. 2011. PMID: 21383691 Review.
H3K79 methylation profiles define murine and human MLL-AF4 leukemias.
Krivtsov AV, Feng Z, Lemieux ME, Faber J, Vempati S, Sinha AU, Xia X, Jesneck J, Bracken AP, Silverman LB, Kutok JL, Kung AL, Armstrong SA. Krivtsov AV, et al. Among authors: bracken ap. Cancer Cell. 2008 Nov 4;14(5):355-68. doi: 10.1016/j.ccr.2008.10.001. Cancer Cell. 2008. PMID: 18977325 Free PMC article.
A model for transmission of the H3K27me3 epigenetic mark.
Hansen KH, Bracken AP, Pasini D, Dietrich N, Gehani SS, Monrad A, Rappsilber J, Lerdrup M, Helin K. Hansen KH, et al. Among authors: bracken ap. Nat Cell Biol. 2008 Nov;10(11):1291-300. doi: 10.1038/ncb1787. Epub 2008 Oct 19. Nat Cell Biol. 2008. PMID: 18931660
E2F target genes: unraveling the biology.
Bracken AP, Ciro M, Cocito A, Helin K. Bracken AP, et al. Trends Biochem Sci. 2004 Aug;29(8):409-17. doi: 10.1016/j.tibs.2004.06.006. Trends Biochem Sci. 2004. PMID: 15362224 Review.
Profiling cancer.
Ciro M, Bracken AP, Helin K. Ciro M, et al. Among authors: bracken ap. Curr Opin Cell Biol. 2003 Apr;15(2):213-20. doi: 10.1016/s0955-0674(03)00007-3. Curr Opin Cell Biol. 2003. PMID: 12648678 Review.