breast cancer stem cells - Search Results

Year	Number of Results
1982	2
1983	3
1984	3
1985	3
1986	2
1987	3
1988	2
1989	4
1990	3
1991	3
1992	2
1993	12
1994	9
1995	17
1996	20
1997	16
1998	22
1999	31
2000	28
2001	26
2002	32
2003	24
2004	40
2005	47
2006	45
2007	84
2008	149
2009	171
2010	278
2011	347
2012	387
2013	467
2014	518
2015	591
2016	641
2017	699
2018	629
2019	725
2020	807
2021	820
2022	628
2023	655
2024	562
2025	313
2026	1

1

Roles of oxygen in the tumorigenesis, progression, and treatment of breast cancer.

Darie CC, Hukovic A, Maynard VD, Neagu AN. Darie CC, et al. Med Gas Res. 2026 Mar 1;16(1):41-45. doi: 10.4103/mgr.MEDGASRES-D-25-00023. Epub 2025 Jun 28. Med Gas Res. 2026. PMID: 40580187 Free article. Review.

Breast cancer is the most commonly diagnosed cancer and the second leading cause of cancer death among women worldwide. ...Furthermore, hypoxia is often correlated with resistance to traditional antitumor treatments used alone or in combination, which …

Breast cancer is the most commonly diagnosed cancer and the second leading cause of cancer death among women wor …

2

Modeling breast cancer dynamics through modulable small Vessel Environment Bioreactor (sVEB).

Maiullari F, Ceraolo MG, Presutti D, Fratini N, Galbiati M, Fasciani A, Giżyński K, Bousselmi S, Megiorni F, Marchese C, Kasprzycki P, Karnowski K, Talone A, Varvaro G, Peddis D, Costantini M, Bearzi C, Rizzi R. Maiullari F, et al. Biomaterials. 2025 Dec;323:123441. doi: 10.1016/j.biomaterials.2025.123441. Epub 2025 May 27. Biomaterials. 2025. PMID: 40446711 Free article.

The development of advanced in vitro systems to replicate vascularized tissue environments is critical for studying cancer progression, immune interactions, and therapeutic responses. Traditional models often lack physiological perfusion, scale flexibility, and compatibili …

The development of advanced in vitro systems to replicate vascularized tissue environments is critical for studying cancer progressio …

3

Total flavonoids of litchi seed inhibit breast cancer metastasis by regulating the PI3K/AKT/mTOR and MAPKs signaling pathways.

Yang X, Liu S, Liu Y, Wang Y, Cui D, Lan T, Zhu D, Su Z, Hao E, Qin L, Guo H. Yang X, et al. Pharm Biol. 2025 Dec;63(1):229-249. doi: 10.1080/13880209.2025.2488135. Epub 2025 Apr 15. Pharm Biol. 2025. PMID: 40231974 Free PMC article.

(Sapindaceae) seeds (TFLS) effectively attenuate stem cell-like properties in breast cancer cells. However, their pharmacological effects and mechanisms in suppressing breast cancer metastasis remain unclear. OBJECTIVE: This study aimed t …

(Sapindaceae) seeds (TFLS) effectively attenuate stem cell-like properties in breast cancer cells. However, thei …

4

tRNA modifications: greasing the wheels of translation and beyond.

Zhang M, Lu Z. Zhang M, et al. RNA Biol. 2025 Dec;22(1):1-25. doi: 10.1080/15476286.2024.2442856. Epub 2024 Dec 26. RNA Biol. 2025. PMID: 39723662 Free article. Review.

Transfer RNA (tRNA) is one of the most abundant RNA types in cells, acting as an adaptor to bridge the genetic information in mRNAs with the amino acid sequence in proteins. ...

Transfer RNA (tRNA) is one of the most abundant RNA types in cells, acting as an adaptor to bridge the genetic information in mRNAs w …

5

RNA-binding protein quaking: a multifunctional regulator in tumour progression.

Zhu W, Yang W, Sun G, Huang J. Zhu W, et al. Ann Med. 2025 Dec;57(1):2443046. doi: 10.1080/07853890.2024.2443046. Epub 2024 Dec 23. Ann Med. 2025. PMID: 39711373 Free PMC article. Review.

The dysregulation of QKI is intricately correlated to tumour proliferation, metastasis, angiogenesis, tumor stem cells, the tumour microenvironment, and treatment sensitivity, and represents as a potential biological predictor in tumour diagnosis and prognosis. ...

The dysregulation of QKI is intricately correlated to tumour proliferation, metastasis, angiogenesis, tumor stem cells, the tu …

6

LncRNA MEG3/CTCF-CXCR4 axis functions in the regulation of breast cancer cell migration.

Elhassan G, Bu X, Liu J, Hou S, Yan J, Lei H. Elhassan G, et al. Noncoding RNA Res. 2025 May 28;14:117-128. doi: 10.1016/j.ncrna.2025.05.014. eCollection 2025 Oct. Noncoding RNA Res. 2025. PMID: 40548301 Free PMC article.

Loss or decreased expression of lncRNA MEG3 is a frequent event in the progression of many different malignancies. Overexpression of MEG3 in breast cancer cell lines MCF7 or MDA-MB-231 prevented cell migration, whereas depletion of MEG3 in human mammary epithelial c …

Loss or decreased expression of lncRNA MEG3 is a frequent event in the progression of many different malignancies. Overexpression of MEG3 in …

7

DEK promotes mammary hyperplasia and is associated with H3K27me3 epigenetic modifications.

Johnstone ME, Leck AL, Lange TE, Wilcher KE, Shephard MS, Paranjpe A, Schutte S, Wells SI, Kappes F, Salomonis N, Privette Vinnedge LM. Johnstone ME, et al. Life Sci Alliance. 2025 Jun 25;8(9):e202503230. doi: 10.26508/lsa.202503230. Print 2025 Sep. Life Sci Alliance. 2025. PMID: 40562540 Free PMC article.

The DEK chromatin remodeling protein has oncogenic functions in breast cancers, but its functional role in normal mammary gland epithelium has remained unexplored. ...Analysis of previously published scRNA-sequencing of mouse mammary glands revealed that Dek is most highly …

The DEK chromatin remodeling protein has oncogenic functions in breast cancers, but its functional role in normal mammary gland epith …

8

[Corrigendum] Umbilical cord-derived mesenchymal stem cells promote proliferation and migration in MCF-7 and MDA-MB-231 breast cancer cells through activation of the ERK pathway.

Li T, Zhang C, Ding Y, Zhai W, Liu K, Bu F, Tu T, Sun L, Zhu W, Zhou F, Qi W, Hu J, Chen H, Sun X. Li T, et al. Oncol Rep. 2025 Sep;54(3):100. doi: 10.3892/or.2025.8933. Epub 2025 Jun 20. Oncol Rep. 2025. PMID: 40539432 Free PMC article.

9

Transcriptional repression of SOX2 by p53 in cancer cells regulates cell identity and migration.

Lado-Fernández P, Vilas JM, Fernandes T, Carneiro C, Da Silva-Álvarez S, Estévez-Souto V, Pedrosa P, González-Barcia M, Abatti LE, Mitchell JA, Rivas C, Moreno-Bueno G, Vidal A, Collado M. Lado-Fernández P, et al. Int J Cancer. 2025 Sep 1;157(5):980-992. doi: 10.1002/ijc.35490. Epub 2025 Jun 2. Int J Cancer. 2025. PMID: 40456627 Free PMC article.

SRY-box transcription factor 2 (SOX2) is one of the key pluripotency transcription factors, expressed during embryonic development and active in adult stem cells. In cancer, SOX2 is frequently dysregulated and associated with tumor stemness and poor patient s …

SRY-box transcription factor 2 (SOX2) is one of the key pluripotency transcription factors, expressed during embryonic development and activ …

10

Metabolic reprogramming on breast cancer stem Cells: Proliferation and self-renewal, epithelial-mesenchymal transition (EMT), and drug resistance.

Chen F, Zhao B, Tian Y, Liu Q, Zhang B. Chen F, et al. Biochem Biophys Res Commun. 2025 Aug 8;774:152079. doi: 10.1016/j.bbrc.2025.152079. Epub 2025 May 23. Biochem Biophys Res Commun. 2025. PMID: 40446745 Free article. Review.

Breast cancer currently has the highest incidence among cancers worldwide, and breast cancer stem cells (BCSCs) play a crucial role in the onset, malignant progression, and poor prognosis of breast cancer. ...Additionally, t …

Breast cancer currently has the highest incidence among cancers worldwide, and breast cancer stem cell …

11

Mesenchymal stem cell therapy for breast cancer-related secondary lymphedema (Review).

Han S, Cai J, Zhang Y, Lu F. Han S, et al. Mol Clin Oncol. 2025 Jun 23;23(2):73. doi: 10.3892/mco.2025.2868. eCollection 2025 Aug. Mol Clin Oncol. 2025. PMID: 40599719 Free PMC article. Review.

Secondary lymphedema, affecting ~15-30% of patients who survive breast cancer, is a common consequence following treatment. At present, there is no gold standard for the treatment of breast cancer-related lymphedema (BCRL). ...Mesenchymal stem c …

Secondary lymphedema, affecting ~15-30% of patients who survive breast cancer, is a common consequence following treatment. At …

12

Dual action of pyrimidine derivatives: Targeting tamoxifen resistance in breast cancer.

Yuan J, Wang G, Beeraka NM, Zhang H, Wang Q, Zhang D, Wang M, Ravish A, Chinnathambi A, Alharbi SA, Rangappa KS, Nikolenko VN, Basappa B, Yang L. Yuan J, et al. Transl Oncol. 2025 Aug;58:102418. doi: 10.1016/j.tranon.2025.102418. Epub 2025 Jun 3. Transl Oncol. 2025. PMID: 40466276 Free PMC article.

INTRODUCTION: Approximately 70 % of patients with breast cancer (BC) have estrogen receptor (ER)-positive tumors. Endocrine therapy is the principal treatment for these patients. ...CONCLUSION: Pyrimidine-based TRX-01 and TTP-5 lead structures are promising agents f …

INTRODUCTION: Approximately 70 % of patients with breast cancer (BC) have estrogen receptor (ER)-positive tumors. Endocrine th …

13

Characterization and targeting of chemoresistant triple-negative breast cancer subtypes using amino-pyridine compounds.

Ruiz-Martínez S, Ribas X, Costas M, Landberg G, Puig T. Ruiz-Martínez S, et al. Biochim Biophys Acta Mol Basis Dis. 2025 Aug;1871(6):167899. doi: 10.1016/j.bbadis.2025.167899. Epub 2025 May 9. Biochim Biophys Acta Mol Basis Dis. 2025. PMID: 40350044 Free article.

Triple-negative breast cancer (TNBC) is a highly heterogeneous disease with limited treatment options and high relapse rates due to chemoresistance and the presence of cancer stem cells (CSCs). ...These compounds showed significant cytotoxicity …

Triple-negative breast cancer (TNBC) is a highly heterogeneous disease with limited treatment options and high relapse rates d …

14

A novel CD44-targeting aptamer recognizes chemoresistant mesenchymal stem-like TNBC cells and inhibits tumor growth.

Caliendo A, Camorani S, Ibarra LE, Pinto G, Agnello L, Albanese S, Caianiello A, Illiano A, Festa R, Ambrosio V, Scognamiglio G, Cantile M, Amoresano A, Fedele M, Zannetti A, Cerchia L. Caliendo A, et al. Bioact Mater. 2025 Apr 25;50:443-460. doi: 10.1016/j.bioactmat.2025.04.027. eCollection 2025 Aug. Bioact Mater. 2025. PMID: 40342488 Free PMC article.

Triple-negative breast cancer (TNBC) represents a significant therapeutic challenge owing to the scarcity of targeted medicines and elevated recurrence rates. We previously reported the development of the nuclease-resistant RNA sTN58 aptamer, which selectively targe …

Triple-negative breast cancer (TNBC) represents a significant therapeutic challenge owing to the scarcity of targeted medicine …

15

Generation of two induced pluripotent stem cell lines from breast cancer patients carrying BRCA1 mutations.

Chen YI, Caudal A, Flores-Banuelos AG, Yan CD, Park WG, Viswanathan M, Wu JC. Chen YI, et al. Stem Cell Res. 2025 Aug;86:103716. doi: 10.1016/j.scr.2025.103716. Epub 2025 Apr 18. Stem Cell Res. 2025. PMID: 40286603 Free article.

This study generated and characterized two induced pluripotent stem cell (iPSC) lines derived from breast cancer patients with mutations in the BRCA1 gene (c.676del and c.5096G>A). ...

This study generated and characterized two induced pluripotent stem cell (iPSC) lines derived from breast cancer patien …

16

Expression of the zinc-finger transcription factor Osterix (SP7) in invasive breast cancer and its prognostic significance.

Saidy B, Gull L, Hacker AG, Rakha EA, Green AR, Ellis IO, Martin SG, Storr SJ. Saidy B, et al. Cell Oncol (Dordr). 2025 Aug;48(4):1035-1045. doi: 10.1007/s13402-025-01062-9. Epub 2025 Apr 7. Cell Oncol (Dordr). 2025. PMID: 40192943 Free PMC article.

While initially characterised in bone development, emerging evidence suggests its involvement in cancer, particularly breast cancer metastasis to bone. METHODS: Osterix protein expression was evaluated in 1340 early-stage invasive breast tumours by imm …

While initially characterised in bone development, emerging evidence suggests its involvement in cancer, particularly breast …

17

Exploring resveratrol's inhibitory potential on lung cancer stem cells: a scoping review of mechanistic pathways across cancer models.

Saiful Hakim AR, Chee CF, Wong TW, Abu Kasim NH, Nasruddin NS, Yazid F. Saiful Hakim AR, et al. Med Oncol. 2025 Jul 10;42(8):318. doi: 10.1007/s12032-025-02879-y. Med Oncol. 2025. PMID: 40637827 Free PMC article. Review.

It has shown potential in inhibiting tumorigenesis and tumour progression via targeted therapy, specifically by targeting cancer stem cells (CSCs). CSCs are a small, self-renewing subpopulation within tumours that drive cancer progression and are marke …

It has shown potential in inhibiting tumorigenesis and tumour progression via targeted therapy, specifically by targeting cancer s …

18

Mesenchymal stromal cells highly expressing Sca-1 promote breast cancer lung metastasis through recruiting myeloid cells.

Cao L, Li Y, Ou M, Smirnov A, Liu R, Wang T, Su X, Li P, Mara M, Candi E, Zheng Z, Melino G, Shao C, Shi Y. Cao L, et al. Cell Death Dis. 2025 Jul 9;16(1):507. doi: 10.1038/s41419-025-07845-0. Cell Death Dis. 2025. PMID: 40634316 Free PMC article.

Mesenchymal stem/stromal cells (MSCs) are integral components of the tumor microenvironment and critical for the colonization of disseminated cancer cells; specifically, stem cell antigen (Sca-1) is recognized as a surface marker of MSCs. ...Col …

Mesenchymal stem/stromal cells (MSCs) are integral components of the tumor microenvironment and critical for the colonization …

19

Intraductal Injection of Adenoviruses to Perform Lineage Tracing in the Mammary Gland.

Chen X, Han S, Zhao D, Li Z. Chen X, et al. J Mammary Gland Biol Neoplasia. 2025 Jul 7;30(1):10. doi: 10.1007/s10911-025-09584-6. J Mammary Gland Biol Neoplasia. 2025. PMID: 40622584 Free PMC article. Review.

We discuss applications of Ad-Cre intraductal injection-based lineage tracing in mapping MEC fates, identifying the cellular origins of breast cancer, and modeling tumor progression. Additionally, we highlight its ability to induce genetic marking at a clonal level, …

We discuss applications of Ad-Cre intraductal injection-based lineage tracing in mapping MEC fates, identifying the cellular origins of b …

20

A cohort of mRNAs undergo high-stoichiometry NSUN6-mediated site-specific m⁵C modification.

Zhang YY, Li CT, Zhou YJ, Li H, Li J, Xiong QP, Zhou W, Huang W, Zhang QC, Xiang Y, Wang ED, Xu B, Liu RJ. Zhang YY, et al. Nat Commun. 2025 Jul 4;16(1):6119. doi: 10.1038/s41467-025-60873-4. Nat Commun. 2025. PMID: 40615396 Free PMC article.

By introducing mutations, we further separate its catalytic capabilities toward mRNA and tRNA revealing that NSUN6 promotes breast cancer cell migration depending on mRNA m(5)C modification. Mechanistically, a cohort of mRNAs involved in cell migration carries high …

By introducing mutations, we further separate its catalytic capabilities toward mRNA and tRNA revealing that NSUN6 promotes breast …

21

Distinct follicular T cell subsets regulate lymphoma progression and outcomes.

Abe Y, Zenkoh J, Kanai A, Ikeda D, Kaji D, Sawa A, Matsuoka R, Asayama K, Tabata R, Ishii R, Fujisawa M, Makishima K, Suma S, Suehara Y, Hattori K, Sakamoto T, Nishikii H, Yoshida C, Bando H, Suzuki A, Ota Y, Otsuka Y, Matsubara D, Matsue K, Chiba S, Steidl C, Suzuki Y, Sakata-Yanagimoto M. Abe Y, et al. Cancer Cell. 2025 Jul 1:S1535-6108(25)00263-6. doi: 10.1016/j.ccell.2025.06.013. Online ahead of print. Cancer Cell. 2025. PMID: 40614737 Free article.

However, the heterogeneity and role of follicular T cells beyond T follicular helper (T(FH)) cells remain largely unexplored in FL. Here, we performed multi-omics analyses of follicular T cells in FL leveraging pan-cancer single-cell mapping, spatially …

However, the heterogeneity and role of follicular T cells beyond T follicular helper (T(FH)) cells remain largely unexplored i …

22

Lactate dehydrogenase A: a potential new target for tumor drug resistance intervention.

Wang M, Zhou Q, Cao T, Li F, Li X, Zhang M, Zhou Y. Wang M, et al. J Transl Med. 2025 Jul 1;23(1):713. doi: 10.1186/s12967-025-06773-z. J Transl Med. 2025. PMID: 40598234 Free PMC article. Review.

Tumor drug resistance is a crucial scientific and technological issue that urgently needs to be addressed in cancer treatment. In recent years, research on Lactate dehydrogenase A (LDHA) in the field of tumor drug resistance has progressively deepened, with breakthrough ad …

Tumor drug resistance is a crucial scientific and technological issue that urgently needs to be addressed in cancer treatment. In rec …

23

The novel amino-artemisinin derivative WHN-11 disrupts mitochondria and protein homeostasis, and induces autophagy and apoptosis in cancer cells.

Kajewole D, Wong HN, von Kriegsheim A, Haynes RK, de la Mare JA, Edkins AL. Kajewole D, et al. Sci Rep. 2025 Jul 1;15(1):21604. doi: 10.1038/s41598-025-05284-7. Sci Rep. 2025. PMID: 40594474 Free PMC article.

Semi-synthetic derivatives of artemisinin exhibit anti-cancer activity in vitro and in vivo in addition to anti-malarial activity. Here, we report the anti-cancer and anti-cancer stem cell potential of novel C-10 substituted amino-artemisinin derivativ …

Semi-synthetic derivatives of artemisinin exhibit anti-cancer activity in vitro and in vivo in addition to anti-malarial activity. He …

24

Distinct anticancer properties of exosomes from induced mesenchymal stem cells vs. bone marrow-derived stem cells in MCF7 and A549 models.

Ababneh NA, Aldiqs R, Nashwan S, Ismail MA, Barham R, Al Hadidi S, Alrefae A, Alhallaq FK, Abu-Humaidan AH, Saleh T, Awidi A. Ababneh NA, et al. Biomed Rep. 2025 May 14;23(1):116. doi: 10.3892/br.2025.1994. eCollection 2025 Jul. Biomed Rep. 2025. PMID: 40420975 Free PMC article.

Mesenchymal stem cells (MSCs) have significant potential in regenerative medicine due to their multipotency, however, they face clinical challenges such as limited expansion and heterogeneity. Induced pluripotent stem cell-derived MSCs (iMSCs) are promising a …

Mesenchymal stem cells (MSCs) have significant potential in regenerative medicine due to their multipotency, however, they fac …

25

The CRL7(FBXW8) Complex Controls the Mammary Stem Cell Compartment through Regulation of NUMB Levels.

Sabbioni S, Filippone MG, Amadori L, Confalonieri S, Bonfanti R, Capoano S, Colaluca IN, Freddi S, Bertalot G, Fagà G, Zagarrí E, Varasi M, Gunby RH, Mercurio C, Pece S, Di Fiore PP, Tosoni D. Sabbioni S, et al. Adv Sci (Weinh). 2025 Jul;12(25):e2405812. doi: 10.1002/advs.202405812. Epub 2025 May 24. Adv Sci (Weinh). 2025. PMID: 40411418 Free PMC article.

NUMB is a tumor suppressor gene that functions by inhibiting the action of the NOTCH proto-oncogene and enhancing the levels and activity of the tumor suppressor protein p53. In breast cancer (BC), NUMB loss of function (LOF), mediated by various molecular mechanism …

NUMB is a tumor suppressor gene that functions by inhibiting the action of the NOTCH proto-oncogene and enhancing the levels and activity of …

26

Inhibition of mitochondrial genome-encoded mitomiR-3 contributes to ZEB1 mediated GPX4 downregulation and pro-ferroptotic lipid metabolism to induce ferroptosis in breast cancer cells.

Kandettu A, Ghosal J, Tharayil JS, Kuthethur R, Mallya S, Narasimhamurthy RK, Mumbrekar KD, Subbannayya Y, Kumar NA, Radhakrishnan R, Kabekkodu SP, Chakrabarty S. Kandettu A, et al. Free Radic Biol Med. 2025 Jul;234:151-168. doi: 10.1016/j.freeradbiomed.2025.04.019. Epub 2025 Apr 14. Free Radic Biol Med. 2025. PMID: 40239722 Free article.

We identified 13 novel mitochondrial genome-encoded miRNAs (mitomiRs) that are aberrantly overexpressed in triple-negative breast cancer (TNBC) cell lines and patient tumors. We observed higher levels of mitomiRs in basal-like triple-negative breast cancer …

We identified 13 novel mitochondrial genome-encoded miRNAs (mitomiRs) that are aberrantly overexpressed in triple-negative breast …

27

Salvianic acid A enhances anti-PD-1 therapy by promoting HEV-mediated stem-like CD8 T cells infiltration in TNBC.

Ding X, Liang G, Luo Y, Zhou X, Zhang Q, Luo B. Ding X, et al. Cancer Immunol Immunother. 2025 Jun 30;74(8):256. doi: 10.1007/s00262-025-04116-x. Cancer Immunol Immunother. 2025. PMID: 40586931 Free PMC article.

In vitro experiments were conducted on 4T1, MDA-MB-231, and MDA-MB-453 breast cancer cell lines, as well as CD8 T cells and endothelial cells, to investigate the direct effects of SAA on cell viability, activation, and phenotype maintenance. ...In vitr …

In vitro experiments were conducted on 4T1, MDA-MB-231, and MDA-MB-453 breast cancer cell lines, as well as CD8 T cells …

28

Silibinin Anticancer Effects Through the Modulation of the Tumor Immune Microenvironment in Triple-Negative Breast Cancer.

Mishra SD, Mendonca P, Kaur S, Soliman KFA. Mishra SD, et al. Int J Mol Sci. 2025 Jun 28;26(13):6265. doi: 10.3390/ijms26136265. Int J Mol Sci. 2025. PMID: 40650040 Free article. Review.

Triple-negative breast cancer (TNBC), characterized by the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), remains a therapeutic challenge due to its aggressive nature, limited treatment options, an …

Triple-negative breast cancer (TNBC), characterized by the absence of estrogen receptor (ER), progesterone receptor (PR), and …

29

Impact of neoadjuvant therapy on cancer stem cell gene expression and miRNA profiles in breast cancer patients: Implications for therapy resistance and survival, a cross-sectional observational study.

Kökenek Ünal TD, Kaplan Yilmaz MB, Kandemir O, Yora S, Taheri S. Kökenek Ünal TD, et al. Medicine (Baltimore). 2025 Jun 27;104(26):e43077. doi: 10.1097/MD.0000000000043077. Medicine (Baltimore). 2025. PMID: 40587726 Free PMC article.

The expression levels of cancer stem cell genes CD44, CD24, and related miRNAs miR590-3p, miR599, and miR399-3p were aimed to be investigated before and after neoadjuvant therapy in breast cancer patients in this cross-sectional observational study. .. …

The expression levels of cancer stem cell genes CD44, CD24, and related miRNAs miR590-3p, miR599, and miR399-3p were aimed to …

30

B-cell lymphoma 6 in breast cancer: molecular mechanisms and clinical significance.

Louwen F, Ritter A, Kreis NN, Hoock SC, Solbach C, Yuan J. Louwen F, et al. Crit Rev Biochem Mol Biol. 2025 Jun 27:1-27. doi: 10.1080/10409238.2025.2521319. Online ahead of print. Crit Rev Biochem Mol Biol. 2025. PMID: 40576110 Free article. Review.

Breast cancer is the most frequent malignancy and the most common cause of cancer-related death in women worldwide. ...Moreover, elevated BCL6 is tightly associated with cancerous cellular features, such as increased proliferation and survival, poor different …

Breast cancer is the most frequent malignancy and the most common cause of cancer-related death in women worldwide. ... …

31

In vitro antimicrobial and cytotoxic evaluation of leaf, root, and stem extracts of Solanum dasyphyllum and root and stem extracts of Dovyalis abyssinica.

Belitibo DB, Meressa A, Negassa T, Abebe A, Degu S, Endale M, Assamo FT, Ayana TA, Gurmessa GT, Abdissa N. Belitibo DB, et al. Front Pharmacol. 2025 Jun 26;16:1529854. doi: 10.3389/fphar.2025.1529854. eCollection 2025. Front Pharmacol. 2025. PMID: 40642012 Free PMC article.

The root extract of Dovyalis abyssinica showed the highest cytotoxicity against MCF-7 breast cancer cells (IC(50) = 0.67 mug/mL), outperforming doxorubicin (IC(50) = 3.43 mug/mL). ...Notably, the root extracts of both Solanum dasyphyllum and Dovyalis abyssini …

The root extract of Dovyalis abyssinica showed the highest cytotoxicity against MCF-7 breast cancer cells (IC(50) = 0.6 …

32

C1orf50 Drives Malignant Melanoma Progression Through the Regulation of Stemness.

Otani Y, Maekawa M, Tanaka A, Peña T, Chin VD, Rogachevskaya A, Toyooka S, Roehrl MH, Fujimura A. Otani Y, et al. Cancer Genomics Proteomics. 2025 Jun 26;22(4):510-524. doi: 10.21873/cgp.20518. Cancer Genomics Proteomics. 2025. PMID: 40571314 Free PMC article.

MATERIALS AND METHODS: We performed comprehensive transcriptome data analysis and subsequent functional validation of the human Skin Cutaneous Melanoma project from The Cancer Genome Atlas (TCGA). RESULTS: Elevated expression levels of C1orf50 correlated with worse surviva …

MATERIALS AND METHODS: We performed comprehensive transcriptome data analysis and subsequent functional validation of the human Skin Cutaneo …

33

DDR1 regulates RUNX1-CBFbeta to control breast stem cell differentiation.

Trepicchio C, Rauner G, Traugh N, Wang R, Parrish M, Fein DEC, Mal Y, Gupta PB, Monti S, Kuperwasser C. Trepicchio C, et al. Stem Cell Reports. 2025 Jun 24:102576. doi: 10.1016/j.stemcr.2025.102576. Online ahead of print. Stem Cell Reports. 2025. PMID: 40614729 Free article.

Understanding epithelial stem cell differentiation and morphogenesis during breast tissue development is essential, as disruption in these processes underlie breast cancer formation. ...Together, these findings uncover DDR1-RUNX1 as a central signaling …

Understanding epithelial stem cell differentiation and morphogenesis during breast tissue development is essential, as disrupt …

34

Small modifier, big decision: switching to SUMO mode adds weight to cancer stemness in mammary tumors.

Yevdokimova V, Benoit YD. Yevdokimova V, et al. Mol Oncol. 2025 Jun 23. doi: 10.1002/1878-0261.70082. Online ahead of print. Mol Oncol. 2025. PMID: 40546087 Free article.

Protein SUMOylation is crucial for maintaining the hallmarks of cancer stem cells, including self-renewal and active pluripotency gene networks. While inhibiting key steps of the SUMOylation cascade has been shown to suppress tumorigenesis, the specific mecha …

Protein SUMOylation is crucial for maintaining the hallmarks of cancer stem cells, including self-renewal and active pl …

35

beta-adrenergic signaling modulates breast cancer cell mechanical behaviors through a RhoA-ROCK-myosin II axis.

Kim TH, Tran Le MT, Oh M, Vazquez-Hidalgo E, Chavez B, Lamkin DM, Abdou A, Tan XHM, Christodoulides A, Farris CM, Lee C, Chiou PY, Sloan EK, Katira P, Rowat AC. Kim TH, et al. iScience. 2025 May 15;28(6):112676. doi: 10.1016/j.isci.2025.112676. eCollection 2025 Jun 20. iScience. 2025. PMID: 40520106 Free PMC article.

Here, we investigate how beta-adrenoceptor (betaAR) activation alters the mechanical behaviors of triple-negative breast cancer cells. We find that betaAR activation increases traction forces in metastatic MDA-MB-231(HM) and MDA-MB-468 cells, but not i …

Here, we investigate how beta-adrenoceptor (betaAR) activation alters the mechanical behaviors of triple-negative breast cancer …

36

Claudin-6 mediates an embryonic stem cell-driven antitumor response against breast cancer.

Correia M, Tavares-Marcos C, Pessoa J, Casanova M, Cavadas B, Vitorino R, Tavares E Silva J, Mateus F, Espadas G, Pinheiro M, Alves-Vale C, Sabidó E, Neves B, Nóbrega-Pereira S, Bernardes de Jesus B. Correia M, et al. iScience. 2025 May 16;28(6):112688. doi: 10.1016/j.isci.2025.112688. eCollection 2025 Jun 20. iScience. 2025. PMID: 40520090 Free PMC article.

Stem cells are emerging sources of antigens for cancer immunotherapy. Here, we used TNG-A mouse embryonic stem cells to trigger an anticancer response against tumors derived from E0771 mouse breast cancer cells, possibly med …

Stem cells are emerging sources of antigens for cancer immunotherapy. Here, we used TNG-A mouse embryonic stem …

37

Droplet microfluidics integrated with machine learning reveals how adipose-derived stem cells modulate endocrine response and tumor heterogeneity in ER(+) breast cancer.

Ortega Quesada BA, Chauvin C, Martin E, Melvin A. Ortega Quesada BA, et al. Lab Chip. 2025 Jun 19. doi: 10.1039/d5lc00320b. Online ahead of print. Lab Chip. 2025. PMID: 40534514 Free PMC article.

Approximately 70% of breast cancer (BC) diagnoses are estrogen receptor positive (ER(+)) with 40% of ER(+) BC patients presenting de novo resistance to endocrine therapy (ET). Recent studies identify the tumor microenvironment (TME) as having a key role in endocrine …

Approximately 70% of breast cancer (BC) diagnoses are estrogen receptor positive (ER(+)) with 40% of ER(+) BC patients present …

38

hsa-miR-5688 inhibits FOXC1-OCT4/SOX2 feedforward loop that drives chemoresistance in breast cancer stem cells.

Dutta A, Chakraborty S, Bhattacharya A, Basak U, Pati S, Mukherjee S, Guha D, Banerjee S, Chaudhuri NR, Sarkar D, Jana K, Sa G, Dastidar SG, Das T. Dutta A, et al. Mol Ther Oncol. 2025 Apr 8;33(2):200982. doi: 10.1016/j.omton.2025.200982. eCollection 2025 Jun 18. Mol Ther Oncol. 2025. PMID: 40330903 Free PMC article.

Inherently chemotherapy-resistant breast cancer stem cells (CSCs) are responsible for tumor initiation, metastasis, and relapse. ...Accordingly, we demonstrate a hitherto unknown mechanism underpinning chemotherapy-induced resistance in breast C …

Inherently chemotherapy-resistant breast cancer stem cells (CSCs) are responsible for tumor initiation, metastas …

39

Therapeutic role of caveolin family in stem cell fate and development for management of chronic degenerative diseases: A scientometric study to an in-depth review.

Ma R, Wang S, Cui YL, Zhang H, Chen X, Xie J, Li Y. Ma R, et al. J Adv Res. 2025 Jun 17:S2090-1232(25)00443-6. doi: 10.1016/j.jare.2025.06.034. Online ahead of print. J Adv Res. 2025. PMID: 40554062 Free article. Review.

For instance, CAV1 inhibits neuronal differentiation of neural stem/progenitor cells (NSCs/NPCs) by downregulating VEGF, p44/42MAPK phosphorylation and NeuroD1 signaling pathway following ischemic stroke, while CAV3 interacts with MG53 to enhance the therapeutic eff …

For instance, CAV1 inhibits neuronal differentiation of neural stem/progenitor cells (NSCs/NPCs) by downregulating VEGF, p44/4 …

40

Deciphering Radiotherapy Resistance: A Proteomic Perspective.

Perico D, Mauri P. Perico D, et al. Proteomes. 2025 Jun 16;13(2):25. doi: 10.3390/proteomes13020025. Proteomes. 2025. PMID: 40559998 Free PMC article. Review.

Radiotherapy resistance represents a critical aspect of cancer treatment, and molecular characterization is needed to explore the pathways and mechanisms involved. DNA repair, hypoxia, metabolic reprogramming, apoptosis, tumor microenvironment modulation, and activation of …

Radiotherapy resistance represents a critical aspect of cancer treatment, and molecular characterization is needed to explore the pat …

41

Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation.

Elkholi IE, Robert A, Malouf C, Wu JL, Kuasne H, Drapela S, Macleod G, Hébert S, Pacis A, Calderon V, Kleinman CL, Gomes AP, Alvarez JV, Aguirre-Ghiso JA, Park M, Angers S, Côté JF. Elkholi IE, et al. Cancer Res. 2025 Jun 16;85(12):2179-2198. doi: 10.1158/0008-5472.CAN-23-2654. Cancer Res. 2025. PMID: 40372253 Free PMC article.

Pharmacologic inhibition of PIK3C3 suppressed this phenotype in the 4T1-4T07 models as well as in human breast cancer cell lines and a breast cancer patient-derived xenograft. Furthermore, inhibiting PIK3C3 selectively reduced metastasis burden in the …

Pharmacologic inhibition of PIK3C3 suppressed this phenotype in the 4T1-4T07 models as well as in human breast cancer cell lin …

42

Migration and invasion of cancer stem cells are prevented by low-intensity pulsed ultrasound therapy.

Calero A, Fernández-Marcelo T, Sury P, de Lucas B, Gálvez BG. Calero A, et al. Cancer Cell Int. 2025 Jun 14;25(1):212. doi: 10.1186/s12935-025-03854-3. Cancer Cell Int. 2025. PMID: 40517246 Free PMC article.

We sought to evaluate the effects produced by LIPUS on the properties of human breast cancer stem cells (bCSCs). METHODS: Cells were stimulated using a traditional ultrasound device with the following parameters: 0.05 W/cm(2) with 10% duty cycle …

We sought to evaluate the effects produced by LIPUS on the properties of human breast cancer stem cells (bCSCs). …

43

Cluster-based human-in-the-loop strategy for improving machine learning-based circulating tumor cell detection in liquid biopsy.

Husseini-Wüsthoff H, Riethdorf S, Schneeweiss A, Trumpp A, Pantel K, Wikman H, Nielsen M, Werner R. Husseini-Wüsthoff H, et al. Patterns (N Y). 2025 May 30;6(6):101285. doi: 10.1016/j.patter.2025.101285. eCollection 2025 Jun 13. Patterns (N Y). 2025. PMID: 40575126 Free PMC article.

In liquid biopsy, detecting and differentiating circulating tumor cells (CTCs) and non-CTCs in metastatic cancer patients' blood samples remains challenging. ...By directing human efforts to label a limited set of new training samples from high-uncertainty clusters …

In liquid biopsy, detecting and differentiating circulating tumor cells (CTCs) and non-CTCs in metastatic cancer patients' blo …

44

Dual ENPP1/ATM depletion blunts DNA damage repair boosting radioimmune efficacy to abrogate triple-negative breast cancer.

Ruiz-Fernández de Córdoba B, Valencia K, Welch C, Moreno H, Martínez-Canarias S, Zandueta C, Gómez E, Calvo A, Otegui N, Echepare M, Garzón I, Ajona D, Lara-Astiaso D, Guruceaga E, Guembe L, Pío R, Melero I, Vicent S, Pastor F, Martínez-Monge R, Lecanda F. Ruiz-Fernández de Córdoba B, et al. Signal Transduct Target Ther. 2025 Jun 13;10(1):185. doi: 10.1038/s41392-025-02271-2. Signal Transduct Target Ther. 2025. PMID: 40506449 Free PMC article.

The ATP-hydrolytic ectoenzyme ENPP1 has been implicated in the metastasis and recurrence in triple-negative breast cancer (TNBC), primarily by contributing to tumor cell survival and treatment resistance. ...This impaired DNA damage repair (DDR) sensitized tumor …

The ATP-hydrolytic ectoenzyme ENPP1 has been implicated in the metastasis and recurrence in triple-negative breast cancer (TNB …

45

A Modular Biomimetic Preclinical Platform to Elucidate the Interaction Between Cancer Cells and the Bone Metastatic Niche.

Cocchi C, Dapporto M, Guerrieri AN, Liverani C, Tavoni M, Bellotti C, Spadazzi C, Tampieri A, Gambarotti M, Miserocchi G, Sprio S, Lucarelli E, Iafisco M, Ibrahim T, De Vita A, Mercatali L. Cocchi C, et al. J Funct Biomater. 2025 Jun 12;16(6):220. doi: 10.3390/jfb16060220. J Funct Biomater. 2025. PMID: 40558906 Free PMC article.

Breast cancer (BC) frequently metastasizes to bone, leading to poor patient prognosis. ...We designed strontium-doped calcium phosphate cement to be employed for culturing cancer and bone cells and developed an in vitro bone metastasis model. The platf …

Breast cancer (BC) frequently metastasizes to bone, leading to poor patient prognosis. ...We designed strontium-doped calcium …

46

Sugar-Linked Diethyldithiocarbamate Derivatives: A Novel Class of Anticancer Agents.

Najlah M, McCallum N, Pereira AM, Alves D, Ansari-Fard N, Rehmani S, Kaya A. Najlah M, et al. Int J Mol Sci. 2025 Jun 11;26(12):5589. doi: 10.3390/ijms26125589. Int J Mol Sci. 2025. PMID: 40565053 Free PMC article.

Disulfiram (DSF), a well-known anti-alcoholism drug, exhibits potent anticancer activity via its metabolite, diethyldithiocarbamate (DDC), which forms a cytotoxic copper complex that selectively targets cancer stem cells. However, its clinical utility is limi …

Disulfiram (DSF), a well-known anti-alcoholism drug, exhibits potent anticancer activity via its metabolite, diethyldithiocarbamate (DDC), w …

47

Auranofin, an antirheumatic drug, shows anticancer stem cell potential via suppression of the Stat3 signal.

Ko SY, Kim Y, Chung JS, Kim YB, Kim SL, Lee DS, Chun KH, Choi HS. Ko SY, et al. BMB Rep. 2025 Jun 11:6472. Online ahead of print. BMB Rep. 2025. PMID: 40495487 Free article.

Accumulating data have shown that targeting breast cancer stem cells (CSCs) is an auspicious way for anticancer therapies. This study demonstrated that the antirheumatic drug auranofin is a potent CSC inhibitor with anti-CSC action on breast …

Accumulating data have shown that targeting breast cancer stem cells (CSCs) is an auspicious way for anticancer …

48

Proteomic-based stemness score measures oncogenic dedifferentiation and enables the identification of druggable targets.

Kołodziejczak-Guglas I, Simões RLS, de Souza Santos E, Demicco EG, Lazcano Segura RN, Ma W, Wang P, Geffen Y, Storrs E, Petralia F, Colaprico A, da Veiga Leprevost F, Pugliese P, Ceccarelli M, Noushmehr H, Nesvizhskii AI, Kamińska B, Priebe W, Lubiński J, Zhang B, Lazar AJ, Kurzawa P, Mesri M, Robles AI; Clinical Proteomic Tumor Analysis Consortium; Ding L, Malta TM, Wiznerowicz M. Kołodziejczak-Guglas I, et al. Cell Genom. 2025 Jun 11;5(6):100851. doi: 10.1016/j.xgen.2025.100851. Epub 2025 Apr 17. Cell Genom. 2025. PMID: 40250426 Free PMC article.

Cancer progression and therapeutic resistance are closely linked to a stemness phenotype. ...The findings emphasize PROTsi's efficacy as a valuable tool for selecting predictive protein targets, a crucial step in customizing anti-cancer therapy and advancing the cli …

Cancer progression and therapeutic resistance are closely linked to a stemness phenotype. ...The findings emphasize PROTsi's efficacy …

49

High-Salt Tumor Microenvironment: Not as Bad as It Sounds, Not as Good as It Seems.

Ali U, Tiriveedhi V. Ali U, et al. Cancers (Basel). 2025 Jun 10;17(12):1924. doi: 10.3390/cancers17121924. Cancers (Basel). 2025. PMID: 40563574 Free PMC article. Review.

Importantly, chronic inflammation is recognized as one of the major hallmarks of carcinogenesis. Breast cancer cell culture-based studies demonstrated that high-salt (HS) treatment (delta35-50 mM NaCl) induced cancer cell proliferation. ...This understanding …

Importantly, chronic inflammation is recognized as one of the major hallmarks of carcinogenesis. Breast cancer cell culture-ba …

50

Towards Personalized Medicine: Microdevice-Assisted Evaluation of Cancer Stem Cell Dynamics and Treatment Response.

Agüero EI, Gómez López SM, Peñaherrera-Pazmiño AB, Tellado M, Pérez MS, Lerner B, Belgorosky D, Eiján AM. Agüero EI, et al. Cancers (Basel). 2025 Jun 10;17(12):1922. doi: 10.3390/cancers17121922. Cancers (Basel). 2025. PMID: 40563572 Free PMC article.

Background/Objectives: Cancer stem cells (CSCs) represent a minor yet critical subpopulation within tumors, endowed with self-renewal and differentiation capacities, and are implicated in tumor initiation, progression, metastasis, therapeutic resistance, and …

Background/Objectives: Cancer stem cells (CSCs) represent a minor yet critical subpopulation within tumors, endowed wit …

51

Niclosamide Treatment Suppressed Metastatic, Apoptotic, and Proliferative Characteristics of MDA-MB-231 Cancer Stem Cells.

Altundag-Erdogan Ö, Çelebi-Saltik B. Altundag-Erdogan Ö, et al. ACS Omega. 2025 May 28;10(22):23629-23638. doi: 10.1021/acsomega.5c02545. eCollection 2025 Jun 10. ACS Omega. 2025. PMID: 40521512 Free PMC article.

This study evaluated the efficacy of niclosamide after the invasion of aggressive TNBC breast CSCs into a 3D bone-mimicking model. Initially, the optional dose required for triggering apoptosis was determined for MDA-MB-231 CSCs (CD44+ and CD24-). Our findings revealed tha …

This study evaluated the efficacy of niclosamide after the invasion of aggressive TNBC breast CSCs into a 3D bone-mimicking model. In …

52

Duloxetine's potential dual antitumor and immunomodulatory role in apoptosis and autophagy signaling pathways in cancer: In Vitro and In Vivo evidence.

Nikolic I, Lazovic A, Stanisavljevic I, Andjelkovic M, Popovic S, Pavlovic S, Jurisevic M, Mitrovic M. Nikolic I, et al. Eur J Pharm Sci. 2025 Jun 10;212:107165. doi: 10.1016/j.ejps.2025.107165. Online ahead of print. Eur J Pharm Sci. 2025. PMID: 40505838 Free article.

In HCT116 (colon), HeLa (cervical), and MDA-MB-231 (triple-negative breast cancer) human cancer cells, and 4T1 mouse breast cancer cells, we investigated DUL's cytotoxicity, apoptosis, autophagy, cell cycle arrest, and migration in …

In HCT116 (colon), HeLa (cervical), and MDA-MB-231 (triple-negative breast cancer) human cancer cells, and 4T1 m …

53

Signature-based repurposed drugs resemble the inhibition of TGFbeta-induced NDRG1 as potential therapeutics for triple-negative breast cancer.

López-Tejada A, Blaya-Cánovas JL, Cara FE, Calahorra J, Ramírez-Tortosa C, Blancas I, Delgado-Almenta V, Muñoz-Parra F, Ávalos-Moreno M, Sánchez A, González-González A, Marchal JA, Griñán-Lisón C, Granados-Principal S. López-Tejada A, et al. Int J Biol Sci. 2025 Jun 9;21(9):3949-3967. doi: 10.7150/ijbs.112645. eCollection 2025. Int J Biol Sci. 2025. PMID: 40612674 Free PMC article.

There is an urgent need for new therapeutic strategies against aggressive triple-negative breast cancer (TNBC), and drug repurposing offers a promising, time- and cost-effective solution. ...We determined that the candidate drugs significantly reduced tumor cell pro …

There is an urgent need for new therapeutic strategies against aggressive triple-negative breast cancer (TNBC), and drug repur …

54

New approaches to overcome radioresistance in glioblastoma: mechanisms, targets and role of innovative therapies, new particles and non-photon radiotherapy in 2024. A systematic review.

Debbi K, Loganadane G, To N, Cherif MA, Boukhobza C, Rida H, Grellier N, Mammar H, Belkacemi Y. Debbi K, et al. Rep Pract Oncol Radiother. 2025 Jun 7;30(2):269-281. doi: 10.5603/rpor.105654. eCollection 2025. Rep Pract Oncol Radiother. 2025. PMID: 40635989 Free PMC article. Review.

The main mechanisms of radioresistance that we will discuss are hypoxia, the subpopulation of cancer stem cells in GBM, and the epidermal growth factor receptor (EGFR) expression. We will also focus on the potential role of innovative approaches, such as targ …

The main mechanisms of radioresistance that we will discuss are hypoxia, the subpopulation of cancer stem cells in GBM, …

55

Unraveling the Hippo pathway: YAP/TAZ as central players in cancer metastasis and drug resistance.

Ghaboura N. Ghaboura N. EXCLI J. 2025 Jun 6;24:612-637. doi: 10.17179/excli2025-8351. eCollection 2025. EXCLI J. 2025. PMID: 40630468 Free PMC article. Review.

Potential YAP/TAZ mediated therapy resistance in EGFR TKI-resistant lung cancer and platinum-resistant ovarian cancer and the impact this has on tumor metabolism as a result of YAP/TAZ controlling tumor mesenchymal stem cells in the hypoxic environment …

Potential YAP/TAZ mediated therapy resistance in EGFR TKI-resistant lung cancer and platinum-resistant ovarian cancer and the …

56

Integration of Bulk and Single-Cell Transcriptomics Reveals BCL2L14 as a Novel IGKC+ T Cell-Associated Therapeutic Target in Breast Cancer.

He J, Akhtar A, Li J, Wei Q, Yuan Y, Ran J, Ma Y, Chen D. He J, et al. J Inflamm Res. 2025 Jun 5;18:7215-7234. doi: 10.2147/JIR.S523147. eCollection 2025. J Inflamm Res. 2025. PMID: 40491783 Free PMC article.

Machine learning pinpointed BCL2L14, IGHD, MAPT-AS1, NT5DC4, and TNIP3 as key regulators of breast cancer progression in this subpopulation. The model stratified patients into high- and low-risk groups, with high-risk patients showing worse prognosis and weaker immu …

Machine learning pinpointed BCL2L14, IGHD, MAPT-AS1, NT5DC4, and TNIP3 as key regulators of breast cancer progression in this …

57

Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins.

Chadarevian JP, Davtyan H, Chadarevian AL, Nguyen J, Capocchi JK, Le L, Escobar A, Chadarevian T, Mansour K, Deynega E, Mgerian M, Tu C, Kiani Shabestari S, Carlen-Jones W, Eskandari-Sedighi G, Hasselmann J, Spitale RC, Blurton-Jones M. Chadarevian JP, et al. Cell Stem Cell. 2025 Jun 5;32(6):914-934.e8. doi: 10.1016/j.stem.2025.03.009. Epub 2025 Apr 14. Cell Stem Cell. 2025. PMID: 40233761 Free article.

To determine whether human induced pluripotent stem cell (iPSC)-microglia (iMG) could enable brain-wide and pathology-responsive delivery of therapeutic cargo, we utilized CRISPR gene editing to engineer iMG to express the Abeta-degrading enzyme neprilysin under control of …

To determine whether human induced pluripotent stem cell (iPSC)-microglia (iMG) could enable brain-wide and pathology-responsive deli …

58

Isoform-Specific Gene Regulation by Progesterone Receptors Drives Divergent Phenotypes in Breast Cancer Cells.

Gillis NE, Truong TH, Diep CH, Spartz A, Ostrander JH, Lange CA. Gillis NE, et al. bioRxiv [Preprint]. 2025 Jun 4:2025.05.19.654935. doi: 10.1101/2025.05.19.654935. bioRxiv. 2025. PMID: 40475467 Free PMC article. Preprint.

Exposure to progesterone is a recognized risk factor for breast cancer, and PGR polymorphisms are associated with various malignancies. Two progesterone receptor (PR) isoforms, full length PR-B and truncated PR-A, are expressed from the PGR gene in breast tis …

Exposure to progesterone is a recognized risk factor for breast cancer, and PGR polymorphisms are associated with various mali …

59

Responsive Organoselenium Dendritic Polymers: From Monodisperse Dendrimers to Self-Assembled Micelles for Advanced Therapeutic Applications.

Sanz Del Olmo N, San Jacinto García J, Yin Y, Zhao Y, Hassan M, Malkoch M. Sanz Del Olmo N, et al. J Am Chem Soc. 2025 Jun 4;147(22):18626-18636. doi: 10.1021/jacs.5c00811. Epub 2025 May 23. J Am Chem Soc. 2025. PMID: 40407783 Free PMC article.

Selenium (Se) is a highly biologically active element, and its organic derivatives have attracted growing interest for their promising chemotherapeutic potential, largely due to their redox-modulating activity, which selectively affects cancer cells with high levels …

Selenium (Se) is a highly biologically active element, and its organic derivatives have attracted growing interest for their promising chemo …

60

Intercellular communication between extracellular vesicles from conditioned macrophages and breast cancer cells drives endocrine therapy resistance.

Rodriguez-Baili MC, Palma-Cobo M, Prucca CG, Yáñez-Mó M, Gil GA. Rodriguez-Baili MC, et al. Front Cell Dev Biol. 2025 Jun 3;13:1548724. doi: 10.3389/fcell.2025.1548724. eCollection 2025. Front Cell Dev Biol. 2025. PMID: 40567500 Free PMC article.

INTRODUCTION: Breast cancer is a leading cause of cancer-related mortality among women, with nearly 70% of cases being estrogen receptor-positive (ER+). ...Emerging evidence suggests that endocrine resistance is often driven by the presence and expansion of …

INTRODUCTION: Breast cancer is a leading cause of cancer-related mortality among women, with nearly 70% of cases being …

61

The RNA Binding Protein Bcas2 is Required for Antibody Class Switch in Activated-B Cells.

Chen Y, Sun S, Lu C, Li Y, Fang B, Tang X, Li X, Yu W, Lei Y, Sun L, Zhang M, Sun J, Liu P, Luo Y, Zhao X, Zhan J, Liu L, Liu R, Huang J, Yi Z, Yu Y, Xiao W, Ding Z, Li L, Su D, Ren F, Cao C, Wang R, Shi W, Chen J. Chen Y, et al. Exploration (Beijing). 2025 Feb 16;5(3):270015. doi: 10.1002/EXP.70015. eCollection 2025 Jun. Exploration (Beijing). 2025. PMID: 40585763 Free PMC article.

The antibody diversity is partially determined by the alternative splicing (AS) in the germline, which is mainly regulated by RNA-binding proteins, including Breast cancer amplified sequence 2 (Bcas2). However, the effect of Bcas2 on AS and antibody production in ac …

The antibody diversity is partially determined by the alternative splicing (AS) in the germline, which is mainly regulated by RNA-binding pr …

62

Accurate Transcription Factor Activity Inference to Decipher Cell Identity from Single-Cell Transcriptomic Data with MetaTF.

Hu Y, Zhu Y, Tang G, Shan M, Tan P, Yi Y, Zhang X, Liu M, Li X, Wu L, Chen J, Zheng H, Huang Y, Li Z, Li X, Wang D. Hu Y, et al. Adv Sci (Weinh). 2025 Jun;12(23):e10745. doi: 10.1002/advs.202410745. Epub 2025 May 21. Adv Sci (Weinh). 2025. PMID: 40397381 Free PMC article.

Cellular heterogeneity within cancer tissues determines cancer progression and treatment response. Single-cell RNA sequencing (scRNA-seq) has provided a powerful approach for investigating the cellular heterogeneity of both cancer cells and stroma c …

Cellular heterogeneity within cancer tissues determines cancer progression and treatment response. Single-cell RNA sequencing …

63

The neural stem cell gene PAFAH1B1 controls cell cycle progression, DNA integrity, and paclitaxel sensitivity of triple-negative breast cancer cells.

Majmudar PR, Keri RA. Majmudar PR, et al. J Biol Chem. 2025 Jun;301(6):110235. doi: 10.1016/j.jbc.2025.110235. Epub 2025 May 14. J Biol Chem. 2025. PMID: 40378956 Free PMC article.

Triple-negative breast cancer (TNBC) is a highly aggressive disease with limited approved therapeutic options. ...PAFAH1B1 regulates mitotic spindle orientation, proliferation, and cell migration during neurodevelopment, yet little is known regarding its function in …

Triple-negative breast cancer (TNBC) is a highly aggressive disease with limited approved therapeutic options. ...PAFAH1B1 reg …

64

[Retracted] Notch1 induces epithelial-mesenchymal transition and the cancer stem cell phenotype in breast cancer cells and STAT3 plays a key role.

Zhang X, Zhao X, Shao S, Zuo X, Ning Q, Luo M, Gu S, Zhao X. Zhang X, et al. Int J Oncol. 2025 Jun;66(6):46. doi: 10.3892/ijo.2025.5752. Epub 2025 May 16. Int J Oncol. 2025. PMID: 40376995 Free PMC article.

65

A dataset of chronic nicotine-induced genes in breast cancer cells.

Mugisha S, Labhsetwar S, Dave D, Klemke R, Desgrosellier JS. Mugisha S, et al. Data Brief. 2025 Apr 22;60:111573. doi: 10.1016/j.dib.2025.111573. eCollection 2025 Jun. Data Brief. 2025. PMID: 40371168 Free PMC article.

Since the HCC38 cell line used in these experiments is heterogeneous, including cells with features of stem-like, luminal progenitor-like and more differentiated cells, this dataset allows examination of the conserved as well as disparate gene expression effe …

Since the HCC38 cell line used in these experiments is heterogeneous, including cells with features of stem-like, luminal prog …

66

Targeting transcription factors through an IMiD independent zinc finger domain.

Liu BH, Liu M, Radhakrishnan S, Dai MY, Jaladanki CK, Gao C, Tang JP, Kumari K, Go ML, Vu KAL, Kwon J, Seo HS, Song K, Tian X, Feng L, Tan JL, Melkonian AV, Liu Z, Wulf G, Arthanari H, Qi J, Dhe-Paganon S, Clohessy JG, Choong YK, Sivaraman J, Fan H, Tenen DG, Chai L. Liu BH, et al. EMBO Mol Med. 2025 Jun;17(6):1393-1416. doi: 10.1038/s44321-025-00241-3. Epub 2025 May 14. EMBO Mol Med. 2025. PMID: 40369156 Free PMC article.

Surprisingly, IMiDs do not inhibit the growth of SALL4-expressing cancer cells. To overcome this limit, we focused on a non-IMiD domain, SALL4 zinc finger cluster four (ZFC4). ...In summary, these studies represent a new approach for IMiD independent drug discovery …

Surprisingly, IMiDs do not inhibit the growth of SALL4-expressing cancer cells. To overcome this limit, we focused on a non-IM …

67

CHD8 interacts with BCL11A to induce oncogenic transcription in triple negative breast cancer.

Waterhouse M, Lazarus K, Santolla MF, Pensa S, Williams E, Siu AJQ, Mohammed H, Mohorianu I, Maggiolini M, Carroll J, Itzhaki LS, Rahman T, Khaled WT. Waterhouse M, et al. EMBO J. 2025 Jun;44(12):3448-3467. doi: 10.1038/s44318-025-00447-8. Epub 2025 May 6. EMBO J. 2025. PMID: 40328966 Free PMC article.

The identification of tumour-specific protein-protein interactions remains a challenge for the development of targeted cancer therapies. In this study we describe our approach for the identification of triple negative breast cancer (TNBC)-specific protein-pro …

The identification of tumour-specific protein-protein interactions remains a challenge for the development of targeted cancer therapi …

68

Alpha lipoic acid modulates metabolic reprogramming in breast cancer stem cells enriched 3D spheroids by targeting phosphoinositide 3-kinase: In silico and in vitro insights.

Chakravarti B, Tomar MS, Qais FA, Raza S, Abdullah KM, Sharma G, Tewari A, Yadav A, Gupta P, Chattopadhyay N, Shrivastava A, Sinha RA, Siddiqui JA. Chakravarti B, et al. Biomed Pharmacother. 2025 Jun;187:118121. doi: 10.1016/j.biopha.2025.118121. Epub 2025 May 5. Biomed Pharmacother. 2025. PMID: 40327992 Free article.

Breast cancer stem cells (BCSCs) are a unique subpopulation of tumor cells driving tumor resistance, progression, metastasis, and recurrence. ...LA was found to bind PI3K, disrupting cancer-associated metabolic pathways and significantly …

Breast cancer stem cells (BCSCs) are a unique subpopulation of tumor cells driving tumor resistance, prog …

69

In vivo inhibition of angiogenesis by htsFLT01/MiRGD nano complex.

Khoshandam M, Soheili ZS, Hosseinkhani S, Samiee S, Latifi-Navid H, Ahmadieh H, Soltaninejad H, Jahangiri B. Khoshandam M, et al. Transl Oncol. 2025 Jun;56:102400. doi: 10.1016/j.tranon.2025.102400. Epub 2025 Apr 28. Transl Oncol. 2025. PMID: 40306151 Free article.

The inhibition of angiogenesis is a crucial therapeutic strategy in cancer treatment, as it limits tumor growth and metastasis. In this study, we investigate the anti-angiogenic potential of a novel htsFLT01/MiRGD nanocomplex, designed to target key angiogenesis markers in …

The inhibition of angiogenesis is a crucial therapeutic strategy in cancer treatment, as it limits tumor growth and metastasis. In th …

70

Permeable Lung Vasculature Creates Chemoresistant Endothelial Niche by Producing SERPINE1 at Breast Cancer Metastatic Sites.

Hongu T, Sarenqiqige, Shandan, Kusunoki H, Ishimura A, Suzuki T, Oskarsson T, Gotoh N. Hongu T, et al. Cancer Sci. 2025 Jun;116(6):1604-1615. doi: 10.1111/cas.70050. Epub 2025 Apr 11. Cancer Sci. 2025. PMID: 40217581 Free PMC article.

Chemotherapy resistance remains a major obstacle for eradicating metastatic cancer cells in distant organs. We identified that endothelial cells (ECs) in the lungs, where breast cancer cells often metastasize, form a chemoresistant periva …

Chemotherapy resistance remains a major obstacle for eradicating metastatic cancer cells in distant organs. We identified that …

71

Fibroblast hierarchy dynamics during mammary gland morphogenesis and tumorigenesis.

Pascual R, Cheng J, De Smet AH, Capaldo BD, Tsai M, Kordafshari S, Vaillant F, Song X, Giner G, Milevskiy MJG, Jackling FC, Pal B, Dite T, Yousef J, Dagley LF, Smyth GK, Fu N, Lindeman GJ, Chen Y, Visvader JE. Pascual R, et al. EMBO J. 2025 Jun;44(11):3266-3300. doi: 10.1038/s44318-025-00422-3. Epub 2025 Apr 11. EMBO J. 2025. PMID: 40216939 Free PMC article.

Fibroblasts form a major component of the stroma in normal mammary tissue and breast tumors. Here, we have applied longitudinal single-cell transcriptome profiling of >45,000 fibroblasts in the mouse mammary gland across five different developmental stages and during on …

Fibroblasts form a major component of the stroma in normal mammary tissue and breast tumors. Here, we have applied longitudinal singl …

72

Combinatorial screen with apoptosis pathway targeted agents alrizomadlin, pelcitoclax, and dasminapant in multi-cell type tumor spheroids.

Coussens NP, Dexheimer TS, Silvers T, Sanchez PR, Chen L, Hollingshead MG, Takebe N, Doroshow JH, Teicher BA. Coussens NP, et al. SLAS Discov. 2025 Jun;33:100230. doi: 10.1016/j.slasd.2025.100230. Epub 2025 Apr 9. SLAS Discov. 2025. PMID: 40210129 Free article.

Apoptosis, or programmed cell death, plays a critical role in maintaining tissue homeostasis by eliminating damaged or abnormal cells. Dysregulation of apoptosis pathways is a hallmark of cancer, allowing malignant cells to evade cell death and proliferate un …

Apoptosis, or programmed cell death, plays a critical role in maintaining tissue homeostasis by eliminating damaged or abnormal cells …

73

Utilizing miR-34a-Loaded HER2-Targeting Exosomes to Improve Breast Cancer Treatment: Insights From an Animal Model.

Sun WY, Lee DS, Park JH, Kim OH, Choi HJ, Kim SJ. Sun WY, et al. J Breast Cancer. 2025 Jun;28(3):139-157. doi: 10.4048/jbc.2024.0262. Epub 2025 Mar 14. J Breast Cancer. 2025. PMID: 40133988 Free PMC article.

PURPOSE: Exosomes, nanoscale vesicles with high biocompatibility, were engineered to express human epidermal growth factor receptor 2 (HER2)-binding peptides and carry miR-34a, targeting HER2 and programmed death-ligand 1 (PD-L1)-positive breast cancer cells. …

PURPOSE: Exosomes, nanoscale vesicles with high biocompatibility, were engineered to express human epidermal growth factor receptor 2 (HER2) …

74

Targeted intracellular delivery of molecular cargo to hypoxic human breast cancer stem cells.

Makela AV, Tundo A, Liu H, Schneider D, Hermiston T, Khodakivskyi P, Goun E, Contag CH. Makela AV, et al. Cancer Commun (Lond). 2025 Jun;45(6):714-718. doi: 10.1002/cac2.70018. Epub 2025 Mar 20. Cancer Commun (Lond). 2025. PMID: 40110988 Free PMC article. No abstract available.

75

Biopsy-derived organoids in personalised early breast cancer care: Challenges of tumour purity and normal cell overgrowth cap their practical utility.

Schwerd-Kleine P, Würth R, Cheytan T, Michel L, Thewes V, Gutjahr E, Seker-Cin H, Kazdal D, Neuberth SJ, Thiel V, Schwickert J, Vorberg T, Wischhusen J, Stenzinger A, Zapatka M, Lichter P, Schneeweiss A, Trumpp A, Sprick MR. Schwerd-Kleine P, et al. Int J Cancer. 2025 Jun 1;156(11):2200-2209. doi: 10.1002/ijc.35386. Epub 2025 Feb 28. Int J Cancer. 2025. PMID: 40022208 Free PMC article.

We found that using biopsy material from untreated, early-stage primary breast cancer patients poses significant challenges for consistently culturing tumour cells as organoids. Specifically, we observed frequent outgrowth of genetically normal, non-cancerous …

We found that using biopsy material from untreated, early-stage primary breast cancer patients poses significant challenges fo …

76

Age-dependent differences in breast tumor microenvironment: challenges and opportunities for efficacy studies in preclinical models.

Falvo P, Gruener S, Orecchioni S, Pisati F, Talarico G, Mitola G, Lombardi D, Bravetti G, Winkler J, Barozzi I, Bertolini F. Falvo P, et al. Cell Death Differ. 2025 Jun;32(6):1000-1013. doi: 10.1038/s41418-025-01447-1. Epub 2025 Jan 27. Cell Death Differ. 2025. PMID: 39870804 Free PMC article.

Immunity suffers a function deficit during aging, and the incidence of cancer is increased in the elderly. However, most cancer models employ young mice, which are poorly representative of adult cancer patients. We have previously reported that Triple-Therapy …

Immunity suffers a function deficit during aging, and the incidence of cancer is increased in the elderly. However, most cancer …

77

Exploring the biological impact of bacteria-derived indole compounds on human cell health: Cytotoxicity and cell proliferation across six cell lines.

Janiga-MacNelly A, Vrazel M, Roat AE, Fernandez-Luna MT, Lavado R. Janiga-MacNelly A, et al. Toxicol Rep. 2024 Dec 24;14:101883. doi: 10.1016/j.toxrep.2024.101883. eCollection 2025 Jun. Toxicol Rep. 2024. PMID: 39844884 Free PMC article.

This study examines the cytotoxic effects of five indole derivatives - indole-3-carboxylic acid (I3CA), indole-3-aldehyde (I3A), indole-3-acetic acid (IAA), indole-3-propionic acid (IPA), and 3-methylindole (skatole, 3-MI) - on six human cell lines: adipose-derived mesenchymal …

This study examines the cytotoxic effects of five indole derivatives - indole-3-carboxylic acid (I3CA), indole-3-aldehyde (I3A), indole-3-ac …

78

Author Correction: Paris saponin VII, a Hippo pathway activator, induces autophagy and exhibits therapeutic potential against human breast cancer cells.

Xiang YC, Peng P, Liu XW, Jin X, Shen J, Zhang T, Zhang L, Wan F, Ren YL, Yu QQ, Zhao HZ, Si Y, Liu Y. Xiang YC, et al. Acta Pharmacol Sin. 2025 Jun;46(6):1794. doi: 10.1038/s41401-024-01453-y. Acta Pharmacol Sin. 2025. PMID: 39789372 Free PMC article. No abstract available.

79

The development of growth hormone-releasing hormone analogs: Therapeutic advances in cancer, regenerative medicine, and metabolic disorders.

Schally AV, Cai R, Zhang X, Sha W, Wangpaichitr M. Schally AV, et al. Rev Endocr Metab Disord. 2025 Jun;26(3):385-396. doi: 10.1007/s11154-024-09929-2. Epub 2024 Nov 26. Rev Endocr Metab Disord. 2025. PMID: 39592529 Free PMC article. Review.

Meanwhile, GHRH antagonists, particularly those in the MIA and AVR series, demonstrate potent antitumor activity by inhibiting cancer cell proliferation and downregulating growth factor pathways, while also exhibiting anti-inflammatory properties. Preclinical studies in mo …

Meanwhile, GHRH antagonists, particularly those in the MIA and AVR series, demonstrate potent antitumor activity by inhibiting cancer …

80

Tumor necrosis factor-alpha-treated human adipose-derived stem cells enhance inherent radiation tolerance and alleviate in vivo radiation-induced capsular contracture.

Sutthiwanjampa C, Kang SH, Kim MK, Hwa Choi J, Kim HK, Woo SH, Bae TH, Kim WJ, Kang SH, Park H. Sutthiwanjampa C, et al. J Adv Res. 2025 Jun;72:433-449. doi: 10.1016/j.jare.2024.07.011. Epub 2024 Jul 15. J Adv Res. 2025. PMID: 39019109 Free PMC article.

INTRODUCTION: Post-mastectomy radiotherapy plays a crucial role in breast cancer treatment but can lead to an inflammatory response causing soft tissue damage, particularly radiation-induced capsular contracture (RICC), impacting breast reconstruction outcome …

INTRODUCTION: Post-mastectomy radiotherapy plays a crucial role in breast cancer treatment but can lead to an inflammatory res …

81

Foretelling the Future: Preimplantation Genetic Testing and the Coming of Polygenic Embryo Screening.

Smolarczyk R, Szeliga A, Duszewska AM, Kostrzak A, Rudnicka E, Szczesnowicz A, Kunicki M, Bochynska S, Bala G, Meczekalski B, Adashi EY. Smolarczyk R, et al. J Clin Med. 2025 May 31;14(11):3885. doi: 10.3390/jcm14113885. J Clin Med. 2025. PMID: 40507647 Free PMC article. Review.

It is also used in screening for sex-linked disorders and sourcing stem cells for therapy. The latest PGT direction is polygenic embryo screening (PES, PGT-P), which allows the identification of embryos that are at elevated risk for significant diseases in adulthood …

It is also used in screening for sex-linked disorders and sourcing stem cells for therapy. The latest PGT direction is polygen …

82

Loss of tumor suppressor p53 upregulates stem cell factor SOX9 via Notch signaling.

Sanawar R, Guo W. Sanawar R, et al. bioRxiv [Preprint]. 2025 May 31:2025.05.27.656408. doi: 10.1101/2025.05.27.656408. bioRxiv. 2025. PMID: 40501825 Free PMC article. Preprint.

Basal-like breast cancer (BLBC) consists of the majority of triple-negative breast cancer subtype that has a higher degree of cellular plasticity owing to a greater number of stem-like cancer cells compared to other subtypes(1). .. …

Basal-like breast cancer (BLBC) consists of the majority of triple-negative breast cancer subtype that has a hig …

83

Lovastatin Targets the USP14-Survivin Axis to Suppress Triple-Negative Breast Cancer via Ubiquitin-Mediated Proteasomal Degradation.

Zhou L, Zheng C, Ding S, Wang Z, Yang Y, Wang Y, He G, Fu S, Deng X. Zhou L, et al. Cells. 2025 May 31;14(11):816. doi: 10.3390/cells14110816. Cells. 2025. PMID: 40497992 Free PMC article.

Triple-negative breast cancer (TNBC), characterized by the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor type 2 (HER2) expression, represents a therapeutic challenge due to its aggressive nature and limited …

Triple-negative breast cancer (TNBC), characterized by the absence of estrogen receptor (ER), progesterone receptor (PR), and …

84

The prognostic and immune significance of fibronectin type III domain-containing 1 gene in pan-cancer and its relationship with proliferation and migration of stomach adenocarcinoma.

Deng M, Huang W, Luo R, Wang H, Yu Z, Ma B, Xu L, Zhang X, Su J, Xu C, Hou Y. Deng M, et al. Transl Cancer Res. 2025 May 30;14(5):3069-3095. doi: 10.21037/tcr-2024-2279. Epub 2025 May 20. Transl Cancer Res. 2025. PMID: 40530118 Free PMC article.

BACKGROUND: Fibronectin type III domain containing 1 (FNDC1) exhibits emerging roles in tumorigenesis, yet its pan-cancer implications and mechanistic contributions to stomach adenocarcinoma (STAD) remain underexplored. ...In STAD, FNDC1 shows significant correlations with …

BACKGROUND: Fibronectin type III domain containing 1 (FNDC1) exhibits emerging roles in tumorigenesis, yet its pan-cancer implication …

85

Correction: CD36 enrichment in HER2-positive mesenchymal stem cells drives therapy refractoriness in breast cancer.

Castagnoli L, Franceschini A, Cancila V, Dugo M, Bigliardi M, Chiodoni C, Toneguzzo P, Regondi V, Corsetto PA, Pietrantonio F, Mazzucchelli S, Corsi F, Belfiore A, Vingiani A, Pruneri G, Ligorio F, Colombo MP, Tagliabue E, Tripodo C, Vernieri C, Triulzi T, Pupa SM. Castagnoli L, et al. J Exp Clin Cancer Res. 2025 May 30;44(1):165. doi: 10.1186/s13046-025-03426-3. J Exp Clin Cancer Res. 2025. PMID: 40442724 Free PMC article. No abstract available.

86

Leaf-vein-inspired multi-organ microfluidic chip for modeling breast cancer CTC organotropism.

Liu L, Qu X, Wang Z, Ji C, Ling R, Yan C. Liu L, et al. Front Oncol. 2025 May 29;15:1602225. doi: 10.3389/fonc.2025.1602225. eCollection 2025. Front Oncol. 2025. PMID: 40510151 Free PMC article.

OBJECTIVE: Breast cancer is characterized by a high tendency for organ-specific metastasis. This study aims to develop a multi-organ metastasis model for circulating tumor cells (CTCs) of breast cancer to explore their organotropism in common ta …

OBJECTIVE: Breast cancer is characterized by a high tendency for organ-specific metastasis. This study aims to develop a multi …

87

Current status, hotspots, and trends in cancer prevention, screening, diagnosis, treatment, and rehabilitation: A bibliometric analysis.

Zhang C, Liu Y, Chen Z, Liu YI, Mao Q, Zhang GE, Lin H, Zheng J, Li H. Zhang C, et al. Oncol Res. 2025 May 29;33(6):1437-1458. doi: 10.32604/or.2025.059290. eCollection 2025. Oncol Res. 2025. PMID: 40486880 Free PMC article.

RESULTS: The analysis revealed that major research hotspots include lung and breast cancer. Attention is predominantly concentrated on cancer treatment, subdivided into targeted therapy, immunotherapy, traditional Chinese medicine, and the development of new …

RESULTS: The analysis revealed that major research hotspots include lung and breast cancer. Attention is predominantly concent …

88

Machine learning identifies SRD5A3 as a propionate-related prognostic biomarker in triple-negative breast cancer.

Pan K, Qiu P, Liang H, Wan N, Liu Z, Guo Q. Pan K, et al. Sci Rep. 2025 May 29;15(1):18911. doi: 10.1038/s41598-025-01274-x. Sci Rep. 2025. PMID: 40442220 Free PMC article.

It was found that down-regulation of SRD5A3 inhibited the growth and invasion of tumor cells, thereby affecting the prognosis of TNBC....

It was found that down-regulation of SRD5A3 inhibited the growth and invasion of tumor cells, thereby affecting the prognosis of TNBC …

89

LMO2 regulates epithelial-mesenchymal plasticity of mammary epithelial cells.

Haro-Acosta V, Juarez MA, Fetter IJ, Olander A, Sikandar SS. Haro-Acosta V, et al. bioRxiv [Preprint]. 2025 May 27:2025.05.22.655436. doi: 10.1101/2025.05.22.655436. bioRxiv. 2025. PMID: 40501810 Free PMC article. Preprint.

Cellular plasticity in mammary epithelial cells enables dynamic cell state changes essential for normal development but can be hijacked by breast cancer cells to drive tumor progression. ...Altogether, we show that LMO2 plays a role in maintaining cell …

Cellular plasticity in mammary epithelial cells enables dynamic cell state changes essential for normal development but can be hijack …

90

Fitness and transcriptional plasticity of human breast cancer single-cell-derived clones.

Nguyen LV, Eyal-Lubling Y, Guerrero-Romero D, Kronheim S, Chin SF, Manzano Garcia R, Sammut SJ, Lerda G, Lui AJW, Bardwell HA, Greenwood W, Shin HJ, Masina R, Kania K, Bruna A, Esmaeilishirazifard E, Kolyvas EA, Aparicio S, Rueda OM, Caldas C. Nguyen LV, et al. Cell Rep. 2025 May 27;44(5):115699. doi: 10.1016/j.celrep.2025.115699. Epub 2025 May 12. Cell Rep. 2025. PMID: 40359107 Free PMC article.

This generated a significant resource of growth measurements from over 20,000 single-cell-derived clones in 110 xenografts from 26 patient-derived breast cancer xenograft models. 167,375 single-cell RNA profiles were obtained from 5 models and revealed that rare pro …

This generated a significant resource of growth measurements from over 20,000 single-cell-derived clones in 110 xenografts from 26 patient-d …

91

Targeting of the IL-33/Wnt axis restricts breast cancer stemness and metastasis.

Fan G, Zuo S, Wang Z, Zhang S, Liu L, Luo H, Xie Y, Zhang Y, Li D. Fan G, et al. Sci Rep. 2025 May 25;15(1):18172. doi: 10.1038/s41598-025-03260-9. Sci Rep. 2025. PMID: 40414980 Free PMC article.

Interleukin-33 (IL-33) plays multifaceted roles in tumor progression, but its autocrine regulation of breast cancer stemness and metastasis via the Wnt pathway remains unclear. Here, we investigated the IL-33/ST2 axis in breast cancer using CRISPR/Cas9 …

Interleukin-33 (IL-33) plays multifaceted roles in tumor progression, but its autocrine regulation of breast cancer stemness a …

92

CXCR4⁺ mammary gland macrophageal niche promotes tumor initiating cell activity and immune suppression during tumorigenesis.

Lee E, Hong JJ, Samcam Vargas G, Sauerwald N, Wei Y, Hang X, Theesfeld CL, Volmar JAA, Miller JM, Wang W, Wang S, Laevsky G, DeCoste CJ, Kang Y. Lee E, et al. Nat Commun. 2025 May 25;16(1):4854. doi: 10.1038/s41467-025-59972-z. Nat Commun. 2025. PMID: 40413176 Free PMC article.

Tumor-initiating cells (TICs) share features and regulatory pathways with normal stem cells, yet how the stem cell niche contributes to tumorigenesis remains unclear. ...Furthermore, a CXCR4(+) niche macrophage gene signature correlates with poor progn …

Tumor-initiating cells (TICs) share features and regulatory pathways with normal stem cells, yet how the stem ce …

93

Analysis of drug transporter expression in syncytiotrophoblast derived from human placental stem cells: Expression and function of efflux transporters.

Sawada R, Furugen A, Ueda A, Nishimura A, Umazume T, Narumi K, Kobayashi M. Sawada R, et al. Placenta. 2025 May 23;165:23-32. doi: 10.1016/j.placenta.2025.03.021. Epub 2025 Mar 27. Placenta. 2025. PMID: 40184769 Free article.

The syncytiotrophoblast (ST) is crucial in maintaining the placental barrier. Human trophoblast stem cells (hTSCs) have been recently established; however, their utility in studying placental transport functions has not been fully elucidated. ...Western blotting rev …

The syncytiotrophoblast (ST) is crucial in maintaining the placental barrier. Human trophoblast stem cells (hTSCs) have been r …

94

Targetable BIRC5 dependency in therapy-resistant TP53 mutated acute myeloid leukemia.

Mamdouh AM, Lim FQ, Mi Y, Olesinski EA, Chan CGT, Jasdanwala S, Lin XX, Wang Y, Tan JYM, Bhatia KS, Sapozhnikova V, Wang C, Mahesh AN, Liang DTE, Chitkara N, Mertins P, Hogdal L, Brown BD, Haferlach T, Lobry C, Lindsley C, Puissant A, Ho HK, Das S, Letai A, Kornblau SM, Krönke J, Ayoub E, Itahana K, Andreeff M, Bhatt S. Mamdouh AM, et al. bioRxiv [Preprint]. 2025 May 22:2025.05.17.654633. doi: 10.1101/2025.05.17.654633. bioRxiv. 2025. PMID: 40475516 Free PMC article. Preprint.

Here, we report that TP53 mutated AML, triple negative breast cancer, and colorectal cancer escape therapy-induced apoptosis due to inability to activate caspase-3/7, despite having normal mitochondrial outer membrane permeabilization (MOMP) induction. ...BIR …

Here, we report that TP53 mutated AML, triple negative breast cancer, and colorectal cancer escape therapy-induced apop …

95

EMT induction in normal breast epithelial cells by COX2-expressing fibroblasts.

Kang M, Devarasou S, Sung NJ, Kwon TY, Shin JH. Kang M, et al. Cell Commun Signal. 2025 May 22;23(1):237. doi: 10.1186/s12964-025-02227-7. Cell Commun Signal. 2025. PMID: 40405218 Free PMC article.

Especially, elevated COX2 expressing fibroblasts within the TME, notably in collagen-dense tumors like breast cancer, has been recently emphasized in the literature. However, the specific effect of COX2-expressing CAFs (COX2(+) CAFs) on neighboring cells and …

Especially, elevated COX2 expressing fibroblasts within the TME, notably in collagen-dense tumors like breast cancer, has been …

96

Single Cell RNA Sequencing of Papillary Cancer Mesenchymal Stem/Stromal Cells Reveals a Transcriptional Profile That Supports a Role for These Cells in Cancer Progression.

Jandu D, Latar N, Bajrami A, Queen R, Hasoon M, Teasdale M, Hussain R, Coxhead J, Aspinall S, Meeson A. Jandu D, et al. Int J Mol Sci. 2025 May 21;26(10):4957. doi: 10.3390/ijms26104957. Int J Mol Sci. 2025. PMID: 40430098 Free PMC article.

Papillary thyroid cancer (PTC) contains mesenchymal stem/stromal cells (MSCs), but their contribution to PTC progression is not clear. ...Cluster analysis revealed similarity in expression of both MSC populations for stromal markers, the vascular marker VEGFA …

Papillary thyroid cancer (PTC) contains mesenchymal stem/stromal cells (MSCs), but their contribution to PTC progressio …

97

Genomic-Thermodynamic Phase Synchronization: Maxwell's Demon-like Regulation of Cell Fate Transition.

Tsuchiya M, Yoshikawa K, Giuliani A. Tsuchiya M, et al. Int J Mol Sci. 2025 May 20;26(10):4911. doi: 10.3390/ijms26104911. Int J Mol Sci. 2025. PMID: 40430050 Free PMC article.

In this study, we investigate the distinct behaviors of gene expression dynamics in MCF-7 breast cancer cells under two stimuli: heregulin (HRG), which promotes cell fate transitions, and epidermal growth factor (EGF), which binds to the same receptor but fai …

In this study, we investigate the distinct behaviors of gene expression dynamics in MCF-7 breast cancer cells under two …

98

CD44 Marks Dormant Tumor Cells After HER2 Inhibition in Breast Cancer Cells.

Vargas C, Aguirre-Ducler A, Cereceda K, Quijada S, Escobar-Gómez N, Castillo RL, Escobar-Aguirre M. Vargas C, et al. Int J Mol Sci. 2025 May 20;26(10):4907. doi: 10.3390/ijms26104907. Int J Mol Sci. 2025. PMID: 40430044 Free PMC article.

Therapy resistance remains a major barrier to improving outcomes in HER2-positive breast cancer, with dormant tumor cells (DTCs) and cancer stem cells (CSCs) playing critical roles in recurrence and treatment failure. Herein, we investiga …

Therapy resistance remains a major barrier to improving outcomes in HER2-positive breast cancer, with dormant tumor cells …

99

SDC1 is a critical transmembrane proteoglycan in breast cancer.

Mei Y, Zhao L, Zhou N. Mei Y, et al. World J Surg Oncol. 2025 May 16;23(1):193. doi: 10.1186/s12957-025-03840-z. World J Surg Oncol. 2025. PMID: 40380211 Free PMC article. Review.

There has been an increasing incidence of breast cancer around the world in recent years. As a burgeoning model of diagnosis and treatment, precision medicine has become a new trend in breast cancer management. ...We summarized the recent advances rega …

There has been an increasing incidence of breast cancer around the world in recent years. As a burgeoning model of diagnosis a …

100

Synthesis and evaluation of quinolinvinyl-phenoxy-1,2,3-triazole-acetamide hybrids against breast cancer.

Safavi M, Iraji A, Farid SM, Mahdavi M, Fattaheian-Dehkordi S, Akbarzadeh T, Saeedi M. Safavi M, et al. Sci Rep. 2025 May 16;15(1):17058. doi: 10.1038/s41598-025-01051-w. Sci Rep. 2025. PMID: 40379771 Free PMC article.

This work synthesized and evaluated a new series of quinolinvinyl-phenoxy-1,2,3-triazole-acetamide hybrids 9a-p against breast cancer cell lines, including MCF-7 and MDA-MB-231. Among 16 synthesized compounds, (E)-N-(4-chlorophenyl)-2-(4-((4-(2-(quinolin-2-yl)vinyl) …

This work synthesized and evaluated a new series of quinolinvinyl-phenoxy-1,2,3-triazole-acetamide hybrids 9a-p against breast can …

101

Identification and Validation of Th1-Selective Epitopes Derived from Proteins Overexpressed in Breast Cancer Stem Cells.

Cecil DL, Herendeen D, Slota M, O'Meara MM, Dang Y, Corulli L, Disis ML. Cecil DL, et al. Vaccines (Basel). 2025 May 15;13(5):525. doi: 10.3390/vaccines13050525. Vaccines (Basel). 2025. PMID: 40432134 Free PMC article.

BACKGROUND: Breast cancer stem cells (CSCs), particularly those enriched in triple-negative breast cancer (TNBC), are key contributors to tumor recurrence, metastasis, and resistance to therapy. ...Immunization with these epitopes effecti …

BACKGROUND: Breast cancer stem cells (CSCs), particularly those enriched in triple-negative breast can …

102

Breaking the Chains of Therapeutic Blockade: Pyroptosis-Induced Photothermal-Chemotherapy with Targeted Nanoprobes in Triple-Negative Breast Cancer.

Li Z, Yu K, Cao Y, Yuan H, Wu L, Xiong L, Tang Y, Liang B. Li Z, et al. Biomater Res. 2025 May 15;29:0200. doi: 10.34133/bmr.0200. eCollection 2025. Biomater Res. 2025. PMID: 40376201 Free PMC article.

There is an important clinical need and social significance, especially for young patients, to explore a new breast-conserving strategy that is not dependent on biomarkers for anti-triple-negative breast cancer. ...Benefiting from the involvement of hyaluroni …

There is an important clinical need and social significance, especially for young patients, to explore a new breast-conserving strate …

103

Induction of Apoptosis by Ethanol, Methanol, and Ethyl Acetate Extracts from Cyperus Rotundus' Leaf on In Vitro Human Ovarian, Cervix, and Breast Cancer Cell Lines.

Moradi Kooshkmeydani M, Khoradmehr A, Dehghani Firoozabadi A, Tavassoli A, Mohammad Rezazadeh F, Mohebbi G, A Kaliyev A, Mussin NM, Farjam M, R Zhilisbayeva K, Tamadon A. Moradi Kooshkmeydani M, et al. Int J Fertil Steril. 2025 May 14;19(3):326-336. doi: 10.22074/ijfs.2024.2019125.1602. Int J Fertil Steril. 2025. PMID: 40590293 Free PMC article.

BACKGROUND: Cervical, breast, and ovarian cancers exhibit significant incidence and fatality rates, necessitating diverse approaches for effective cancer cell eradication while preserving normal cells. ...CONCLUSION: Hydroalcoholic extracts from C. rotundus' …

BACKGROUND: Cervical, breast, and ovarian cancers exhibit significant incidence and fatality rates, necessitating diverse approaches …

104

Click chemistry-based quantification of extracellular matrix turnover for drug screening and regenerative medicine.

Porter A, Fan S, Peng Y, Lv M, Zhou Y, Alanazi A, Han L, Wang L, Lu XL. Porter A, et al. bioRxiv [Preprint]. 2025 May 14:2025.05.08.652928. doi: 10.1101/2025.05.08.652928. bioRxiv. 2025. PMID: 40462969 Free PMC article. Preprint.

We validated the method across multiple platforms, including native cartilage explants and monolayer cultures of human mesenchymal stem cells and breast cancer cells. The technique also proved effective for osteoarthritis drug screening by detec …

We validated the method across multiple platforms, including native cartilage explants and monolayer cultures of human mesenchymal stem …

105

RNA-binding protein gene NOP58 exhibits crucial prognostic and therapeutic value in Ewing sarcoma.

Geng Y, Yang L, Shao R, Xu T, Zhang L. Geng Y, et al. Hereditas. 2025 May 14;162(1):76. doi: 10.1186/s41065-025-00440-5. Hereditas. 2025. PMID: 40369667 Free PMC article.

Additionally, the levels of NOP58 were significantly up-regulated in EwS cells compared with human mesenchymal stem cells. Furthermore, knockdown of NOP58 notably inhibited the proliferation and migration of EwS cells. Moreover, NOP58 deficiency remark …

Additionally, the levels of NOP58 were significantly up-regulated in EwS cells compared with human mesenchymal stem cells …

106

Recurring cycles of deprivation of serum and migration in confined spaces augments ganglioside SSEA-4 expression, boosting clonogenicity and cisplatin resistance in TNBC cell line.

Nofal Z, Malakhov P, Pustovalova M, Sakr N, Leonov S. Nofal Z, et al. Sci Rep. 2025 May 14;15(1):16738. doi: 10.1038/s41598-025-99828-6. Sci Rep. 2025. PMID: 40369257 Free PMC article.

This study explores the adaptive responses of breast cancer (BC) cell sublines derived from the highly aggressive, metastatic triple-negative MDA-MB-231 and the non-metastatic MCF7 human BC cell lines, after undergoing three rounds of confined migration (CM) stress. …

This study explores the adaptive responses of breast cancer (BC) cell sublines derived from the highly aggressive, metastatic …

107

Exosomal transfer of pro-pyroptotic miR-216a-5p exacerbates anthracycline cardiotoxicity through breast cancer-heart pathological crosstalk.

Ma Y, Wang Y, Chen R, Wang Y, Fang Y, Qin C, Wang T, Shen X, Zhou T, Tian L, Sun T, Fan L, Wang X, Han D, Cao F. Ma Y, et al. Signal Transduct Target Ther. 2025 May 14;10(1):157. doi: 10.1038/s41392-025-02245-4. Signal Transduct Target Ther. 2025. PMID: 40360476 Free PMC article.

Morphological bubble-like protrusions were observed in both adult murine ventricular cardiomyocytes (AMVCs) and human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) cocultured with breast cancer cells (BCCs), along with elevated expre …

Morphological bubble-like protrusions were observed in both adult murine ventricular cardiomyocytes (AMVCs) and human induced pluripotent …

108

Advancements in Cell Membrane-Derived Biomimetic Nanotherapeutics for Breast Cancer.

Zeng M, Hu C, Chen T, Zhao T, Dai X. Zeng M, et al. Int J Nanomedicine. 2025 May 12;20:6059-6083. doi: 10.2147/IJN.S502144. eCollection 2025. Int J Nanomedicine. 2025. PMID: 40385497 Free PMC article. Review.

Breast cancer remains the leading cause of female mortality worldwide, necessitating innovative and multifaceted approaches to address its various subtypes. ...These membrane-coated drug delivery systems are derived from various cell sources, including blood cell …

Breast cancer remains the leading cause of female mortality worldwide, necessitating innovative and multifaceted approaches to …

109

Localized Cancer Treatment Using Thiol-Ene Hydrogels for Dual Drug Delivery.

Sathi Devi L, Gigliobianco MR, Gabrielli S, Agas D, Sabbieti MG, Morelli MB, Amantini C, Casadidio C, Di Martino P, Censi R. Sathi Devi L, et al. Biomacromolecules. 2025 May 12;26(5):3234-3254. doi: 10.1021/acs.biomac.5c00387. Epub 2025 Apr 8. Biomacromolecules. 2025. PMID: 40198273 Free PMC article.

Combinatorial cancer therapy benefits from injectable hydrogels for localized, controlled drug delivery. ...DOX release accelerated under tumor-mimicking conditions (100% in 46 h vs 58.7% in PBS), while CRV showed an initial burst followed by sustained release. The hydroge …

Combinatorial cancer therapy benefits from injectable hydrogels for localized, controlled drug delivery. ...DOX release accelerated u …

110

Composites of Reduced Graphene Oxide Based on Silver Nanoparticles and Their Effect on Breast Cancer Stem Cells.

Vimalanathan B, Thiyagarajan D, Mary RN, Sachidanandam M, Ignacimuthu S, Gnanasampanthapandian D, Rajasingh J, Palaniyandi K. Vimalanathan B, et al. Bioengineering (Basel). 2025 May 11;12(5):508. doi: 10.3390/bioengineering12050508. Bioengineering (Basel). 2025. PMID: 40428127 Free PMC article.

The GO-rGO-AgNPs exhibited potent anticancer properties as evidenced by cell culture assays, spheroid formation assay, and quantitative RT-PCR analysis. Treatment of breast cancer cells (MCF-7) with GO, rGO, and AgNPs significantly reduced cell proliferation …

The GO-rGO-AgNPs exhibited potent anticancer properties as evidenced by cell culture assays, spheroid formation assay, and quantitative RT-P …

111

Ergosterol Peroxide Disrupts Triple-Negative Breast Cancer Mitochondrial Function and Inhibits Tumor Growth and Metastasis.

Bocachica-Adorno AL, Aponte-Ramos AY, Rivera-Fuentes PS, Espinosa-Ponce NP, Arroyo-Cruz LV, Ling T, Pérez-Ríos N, Rivas-Tumanyan S, Almodóvar-Rivera IA, Barreto-Gamarra C, Domenech-García M, Rivas F, Martínez-Montemayor MM. Bocachica-Adorno AL, et al. Int J Mol Sci. 2025 May 10;26(10):4588. doi: 10.3390/ijms26104588. Int J Mol Sci. 2025. PMID: 40429733 Free PMC article.

Cardiomyocytes derived from human-induced pluripotent stem cells were chosen as a non-cancerous model because of their high mitochondrial content. ...There was also a significant decrease in metastasis to the lung, liver, and cancer stem cells f …

Cardiomyocytes derived from human-induced pluripotent stem cells were chosen as a non-cancerous model because of their high mi …

112

CCNE1 stabilizes ANLN by counteracting FZR1-mediated the ubiquitination modification to promotes triple negative breast cancer cell stemness and progression.

Dai S, Li L, Guo G, Peng Y, Yuan H, Li J. Dai S, et al. Cell Death Discov. 2025 May 9;11(1):228. doi: 10.1038/s41420-025-02518-5. Cell Death Discov. 2025. PMID: 40346052 Free PMC article.

Triple-negative breast cancer (TNBC) is an aggressive subtype lacking targeted therapies. In this study, we aimed to investigate the pivotal role of cyclin E1 (CCNE1) in the onset and progression of TNBC using comprehensive bioinformatic analysis and functional vali …

Triple-negative breast cancer (TNBC) is an aggressive subtype lacking targeted therapies. In this study, we aimed to investiga …

113

Eco-friendly biosynthesis of silver nanoparticles using marine-derived Fusarium exquisite: optimization, characterization, and evaluation of antimicrobial, antioxidant, and cytotoxic activities.

Ali SA, Osman ME, Mohamed ET. Ali SA, et al. World J Microbiol Biotechnol. 2025 May 6;41(5):165. doi: 10.1007/s11274-025-04368-w. World J Microbiol Biotechnol. 2025. PMID: 40325316 Free PMC article.

They also displayed strong antioxidant activity (IC50 = 56.98 g/mL) and cytotoxicity against MCF-7 breast cancer cells (IC50 = 24.38 g/mL). These enhanced effects likely stem from fungal metabolites acting as natural capping agents, minimizing aggregat …

They also displayed strong antioxidant activity (IC50 = 56.98 g/mL) and cytotoxicity against MCF-7 breast cancer cells …

114

Retraction: Response of breast cancer cells and cancer stem cells to metformin and hyperthermia alone or combined.

PLOS One Editors. PLOS One Editors. PLoS One. 2025 May 5;20(5):e0323982. doi: 10.1371/journal.pone.0323982. eCollection 2025. PLoS One. 2025. PMID: 40323830 Free PMC article. No abstract available.

115

Targeting copper homeostasis: Akkermansia-derived OMVs co-deliver Atox1 siRNA and elesclomol for cancer therapy.

Hamza M, Wang S, Wu H, Sun J, Du Y, Zeng C, Liu Y, Li K, Zhu X, Liu H, Chen L, Zhu M. Hamza M, et al. Acta Pharm Sin B. 2025 May;15(5):2640-2654. doi: 10.1016/j.apsb.2025.03.014. Epub 2025 Mar 10. Acta Pharm Sin B. 2025. PMID: 40487636 Free PMC article.

Furthermore, leveraging the immunomodulatory properties of OMVs, siAtox1/ES@OMV promoted T-cell infiltration and the activation of tumor-reactive cytotoxic T cells, enhancing tumor immune responses. The combination of siAtox1/ES-induced cuproptosis and immunogenic cell dea …

Furthermore, leveraging the immunomodulatory properties of OMVs, siAtox1/ES@OMV promoted T-cell infiltration and the activation of tumor-rea …

116

Correction to "LIPH Promotes Metastasis by Enriching Stem-Like Cells in Triple Negative Breast Cancer".

[No authors listed] [No authors listed] J Cell Mol Med. 2025 May;29(10):e70587. doi: 10.1111/jcmm.70587. J Cell Mol Med. 2025. PMID: 40390213 Free PMC article. No abstract available.

117

LINC00908 Inactivates Wnt/beta-Catenin Signaling Pathway to Inhibit Prostate Cancer Cell Stemness via Upregulating GSK3B and FBXW2.

Guan H, Hu Q, Wan L, Wang C, Xue Y, Feng N, Zhao C, Chen M, You Z. Guan H, et al. Cancer Med. 2025 May;14(9):e70887. doi: 10.1002/cam4.70887. Cancer Med. 2025. PMID: 40344383 Free PMC article.

The cancer stem cell-related theoretical model explains the distinct molecular characteristics of cancer, its relapse, metastasis, and drug resistance. ...The long intergenic nonprotein coding RNA 908 (LINC00908) has been reported to restrain cell proliferati …

The cancer stem cell-related theoretical model explains the distinct molecular characteristics of cancer, its relapse, …

118

Targeting Triple-Negative Breast Cancer: Resistance Mechanisms and Therapeutic Advancements.

Raman R, Debata S, Govindarajan T, Kumar P. Raman R, et al. Cancer Med. 2025 May;14(9):e70803. doi: 10.1002/cam4.70803. Cancer Med. 2025. PMID: 40318146 Free PMC article. Review.

BACKGROUND: Triple-negative breast cancer (TNBC) is one of the most heterogeneous and menacing forms of breast cancer, with no sustainable cure available in the current treatment landscape. ...CONCLUSIONS: Shifting the focus of treatment to identify cr …

BACKGROUND: Triple-negative breast cancer (TNBC) is one of the most heterogeneous and menacing forms of breast cance …

119

Malignant germ cells tumor of the ovary.

De Maria F, Amant F, Chiappa V, Paolini B, Bergamini A, Fruscio R, Corso G, Raspagliesi F, Bogani G. De Maria F, et al. J Gynecol Oncol. 2025 May;36(3):e108. doi: 10.3802/jgo.2025.36.e108. Epub 2025 Apr 8. J Gynecol Oncol. 2025. PMID: 40275685 Free PMC article. Review.

Recurrent malignant ovarian germ cell tumors present significant therapeutic challenges. High-dose chemotherapy with stem-cell transplantation offers promise in select cases, while the role of secondary cytoreductive surgery and radiotherapy is limited to specific indicati …

Recurrent malignant ovarian germ cell tumors present significant therapeutic challenges. High-dose chemotherapy with stem-cell transp …

120

Musashi inhibitor Ro 08-2750 attenuates triple-negative breast cancer cell proliferation and migration and acts as a novel chemo- and radiosensitizer.

Brücksken KA, Sicking M, Korsching E, Suárez-Arriaga MC, Espinoza-Sánchez NA, Marzi A, Fuentes-Pananá EM, Kemper B, Götte M, Eich HT, Greve B, Troschel FM. Brücksken KA, et al. Biomed Pharmacother. 2025 May;186:118002. doi: 10.1016/j.biopha.2025.118002. Epub 2025 Mar 21. Biomed Pharmacother. 2025. PMID: 40120555 Free article.

INTRODUCTION: The Musashi RNA-binding proteins contribute to proliferation, stemness, and therapy resistance in triple-negative breast cancer (TNBC) and have been associated with reduced overall survival in patients. ...CONCLUSION: Our results indicate that Musashi …

INTRODUCTION: The Musashi RNA-binding proteins contribute to proliferation, stemness, and therapy resistance in triple-negative breast …

121

Mechanisms of radioresistance and radiosensitization strategies for Triple Negative Breast Cancer.

Wang Y, Liu Z, Lv Y, Long J, Lu Y, Huang P. Wang Y, et al. Transl Oncol. 2025 May;55:102351. doi: 10.1016/j.tranon.2025.102351. Epub 2025 Mar 19. Transl Oncol. 2025. PMID: 40112501 Free PMC article. Review.

Breast cancer is one of the most common malignant tumors in women. Triple-negative breast cancer (TNBC) is a molecular subtype of breast cancer that is characterized by a high risk of recurrence and poor prognosis. ...The above pathways m …

Breast cancer is one of the most common malignant tumors in women. Triple-negative breast cancer (TNBC) is a mol …

122

ALDH1A1 in breast cancer: A prospective target to overcome therapy resistance (Review).

Varisli L, Zoumpourlis P, Spandidos DA, Zoumpourlis V, Vlahopoulos S. Varisli L, et al. Oncol Lett. 2025 Mar 4;29(5):213. doi: 10.3892/ol.2025.14959. eCollection 2025 May. Oncol Lett. 2025. PMID: 40093866 Free PMC article. Review.

The expression of cytosolic aldehyde dehydrogenases (ALDHs), which mediate the last step in the pathway of the synthesis of all-trans retinoic acid, is dysregulated in various types of human cancer, and has been associated with the development of cancer stem …

The expression of cytosolic aldehyde dehydrogenases (ALDHs), which mediate the last step in the pathway of the synthesis of all-trans retino …

123

Adipose-derived stem cells enhance the tumorigenic potential of pre-malignant breast epithelial cells through paracrine activation of PI3K-AKT pathway.

Wu Q, He J, Herrler T, Yu B, Zhou Q, Zheng D, Chen X, Yan Y, Dai C, Liu K, Zou G, Ge S, Qiao Y, Li Q, Wei J. Wu Q, et al. Breast Cancer. 2025 May;32(3):552-565. doi: 10.1007/s12282-025-01686-7. Epub 2025 Feb 28. Breast Cancer. 2025. PMID: 40019720 Free PMC article.

BACKGROUND: Adipose-derived stem cells (ADSCs)-assisted fat grafting has emerged as a widely used procedure for breast reconstruction post mastectomy and for aesthetic augmentation. Given the limited cases of breast cancer following grafting, th …

BACKGROUND: Adipose-derived stem cells (ADSCs)-assisted fat grafting has emerged as a widely used procedure for breast …

124

The tumor suppressor SALL2 opposes chemotherapeutic resistance in breast cancer.

Li Q, Li C, Zhang Y, Zheng Z, Wang Y, Yang Y, Zhu Q, Wang R, Xu W, Zhu C, Tian Q, Wang M, Ye L. Li Q, et al. Mol Cell Biochem. 2025 May;480(5):2971-2983. doi: 10.1007/s11010-024-05155-1. Epub 2024 Nov 22. Mol Cell Biochem. 2025. PMID: 39572504 Free PMC article.

In this research, a significant downregulation of SALL2 expression was observed in chemo-resistant breast cancer, which was attributed to promoter methylation. Decreased SALL2 expression correlated significantly with poorer relapse-free survival in chemotherapy-trea …

In this research, a significant downregulation of SALL2 expression was observed in chemo-resistant breast cancer, which was at …

125

Using a brain-like endothelial cell differentiation to characterize the CS79iBRCA-n2 BRCA1 mutated patient derived stem cell line.

Alexander NG, Buchanan KA, Meyer AE, Mitterway LM, Vanderburgh CO, Rao SS, Kim BJ. Alexander NG, et al. Front Cell Dev Biol. 2025 Apr 30;13:1516669. doi: 10.3389/fcell.2025.1516669. eCollection 2025. Front Cell Dev Biol. 2025. PMID: 40371388 Free PMC article.

Pathogenic germline mutations of BRCA1/2 genes are the most common hereditary cause of breast cancer and ovarian cancer. It has been established that BRCA1 mutations increase the risk of brain metastasis compared to the BRCA1 wildtype, and once metastasis occ …

Pathogenic germline mutations of BRCA1/2 genes are the most common hereditary cause of breast cancer and ovarian cancer …

126

Chemopreventive and therapeutic effects of Hippophae rhamnoides L. fruit peels evaluated in preclinical models of breast carcinoma.

Dvorska D, Sebova D, Kajo K, Kapinova A, Svajdlenka E, Goga M, Frenak R, Treml J, Mersakova S, Strnadel J, Mazurakova A, Baranova I, Halasova E, Brozmanova M, Biringer K, Kassayova M, Dankova Z, Smejkal K, Hornak S, Mojzis J, Sadlonova V, Brany D, Kello M, Kubatka P. Dvorska D, et al. Front Pharmacol. 2025 Apr 30;16:1561436. doi: 10.3389/fphar.2025.1561436. eCollection 2025. Front Pharmacol. 2025. PMID: 40371330 Free PMC article.

BACKGROUND: Cancer remains a major global health challenge, necessitating innovative prevention and treatment approaches. ...Both treatment doses elevated the Bax/Bcl-2 ratio and reduced the expression of cancer stem cell markers CD44, EpCam, and VEGF compare …

BACKGROUND: Cancer remains a major global health challenge, necessitating innovative prevention and treatment approaches. ...Both tre …

127

Detection of circulating tumor cells that predicts the efficacy of neoadjuvant chemotherapy for locally advanced triple-negative breast cancer.

Wang C, Li J, Luo T, Zhu S, Zhao M, Jia Y, Liu Y. Wang C, et al. Front Med (Lausanne). 2025 Apr 30;12:1536971. doi: 10.3389/fmed.2025.1536971. eCollection 2025. Front Med (Lausanne). 2025. PMID: 40370743 Free PMC article.

OBJECTIVE: This study aims to assess the predictive potential of circulating tumor cells (CTCs) and circulating tumor stem cells (CTSCs) in locally advanced triple-negative breast cancer (TNBC) undergoing neoadjuvant chemotherapy (NAC) compared …

OBJECTIVE: This study aims to assess the predictive potential of circulating tumor cells (CTCs) and circulating tumor stem …

128

Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors.

Liang X, Gupta D, Xie J, Van Wonterghem E, Van Hoecke L, Hean J, Niu Z, Ghaeidamini M, Wiklander OPB, Zheng W, Wiklander RJ, He R, Mamand DR, Bost J, Zhou G, Zhou H, Roudi S, Estupiñán HY, Rädler J, Zickler AM, Görgens A, Hou VWQ, Slovak R, Hagey DW, de Jong OG, Uy AG, Zong Y, Mäger I, Perez CM, Roberts TC, Carter D, Vader P, Esbjörner EK, de Fougerolles A, Wood MJA, Vandenbroucke RE, Nordin JZ, El Andaloussi S. Liang X, et al. Nat Commun. 2025 Apr 29;16(1):4028. doi: 10.1038/s41467-025-59377-y. Nat Commun. 2025. PMID: 40301355 Free PMC article.

In vivo, infusion of a single dose Cre loaded EVs into the lateral ventricle in brain of Cre-LoxP R26-LSL-tdTomato reporter mice results in greater than 40% and 30% recombined cells in hippocampus and cortex respectively. In addition, we demonstrate therapeutic potential o …

In vivo, infusion of a single dose Cre loaded EVs into the lateral ventricle in brain of Cre-LoxP R26-LSL-tdTomato reporter mice results in …

129

Dual prophylactic and therapeutic potential of iPSC-based vaccines and neoantigen discovery in colorectal cancer.

Jwo SH, Ng SK, Li CT, Chen SP, Chen LY, Liu PJ, Wang HJ, Lin JS, Ko CJ, Lee CF, Wang CH, Ouyang X, Wang L, Wei TT. Jwo SH, et al. Theranostics. 2025 Apr 28;15(12):5890-5908. doi: 10.7150/thno.111400. eCollection 2025. Theranostics. 2025. PMID: 40365296 Free PMC article.

Rationale: Induced pluripotent stem cells (iPSCs) share transcriptomic similarities with cancer cells and express tumor-specific and tumor-associated antigens, highlighting their potential as cancer vaccines. ...Colorectal cancer (CRC), t …

Rationale: Induced pluripotent stem cells (iPSCs) share transcriptomic similarities with cancer cells and expres …

130

Epigenomic disorder and partial EMT impair luminal progenitor integrity in Brca1-associated breast tumorigenesis.

Landragin C, Saichi M, Laisné M, Durand A, Prompsy P, Leclere R, Mesple J, Borgman K, Trouchet A, Faraldo MM, Chiche A, Vincent-Salomon A, Salmon H, Vallot C. Landragin C, et al. Mol Cancer. 2025 Apr 28;24(1):127. doi: 10.1186/s12943-025-02331-9. Mol Cancer. 2025. PMID: 40289099 Free PMC article.

In breast cancer related to the BRCA1 mutation, luminal progenitor cells are believed to be the cells of origin, yet how these cells transform into invasive cancer cells remain poorly understood. ...In human samples, pre-tumoral ch …

In breast cancer related to the BRCA1 mutation, luminal progenitor cells are believed to be the cells of origin, …

131

Grassystatin G, a new cathepsin D inhibitor from marine cyanobacteria: discovery, synthesis, and biological characterization.

Elsadek LA, Seabra G, Paul VJ, Luesch H. Elsadek LA, et al. RSC Med Chem. 2025 Apr 25. doi: 10.1039/d5md00017c. Online ahead of print. RSC Med Chem. 2025. PMID: 40291136 Free PMC article.

CatD is well-documented to play a role in cancer proliferation and metastasis, particularly in the context of breast cancer. We tested grassystatin G against MDA-MB-231 triple-negative breast cancer cells and demonstrated its cooperative …

CatD is well-documented to play a role in cancer proliferation and metastasis, particularly in the context of breast cancer …

132

CD44 Variant Expression in Follicular Cell-Derived Thyroid Cancers: Implications for Overcoming Multidrug Resistance.

Mosoane B, McCabe M, Jackson BS, Dlamini Z. Mosoane B, et al. Molecules. 2025 Apr 24;30(9):1899. doi: 10.3390/molecules30091899. Molecules. 2025. PMID: 40363706 Free PMC article. Review.

Thyroid cancer (TC) is a significant global health issue that exhibits notable heterogeneity in incidence and outcomes. ...CD44, a transmembrane glycoprotein, and its splice variants (CD44v) mediate cell adhesion, migration, and survival, contributing to cancer s …

Thyroid cancer (TC) is a significant global health issue that exhibits notable heterogeneity in incidence and outcomes. ...CD44, a tr …

133

Continuous collection of human mesenchymal-stromal-cell-derived extracellular vesicles from a stirred tank reactor operated under xenogeneic-free conditions for therapeutic applications.

Ulpiano C, Salvador W, Franchi-Mendes T, Huang MC, Lin YH, Lin HT, Rodrigues CAV, Fernandes-Platzgummer A, Cabral JMS, Monteiro GA, da Silva CL. Ulpiano C, et al. Stem Cell Res Ther. 2025 Apr 24;16(1):210. doi: 10.1186/s13287-025-04341-2. Stem Cell Res Ther. 2025. PMID: 40275409 Free PMC article.

RESULTS: The system sustained the efficient expansion of MSC(WJ), reaching a total of (6.03 0.181) x 10(7) cells after 7 days, which corresponds to a 30.1 0.740-fold expansion. Upon a 3-day continuous CM harvesting, a total of (2.13 0.301) x 10(12) EVs were isolated corres …

RESULTS: The system sustained the efficient expansion of MSC(WJ), reaching a total of (6.03 0.181) x 10(7) cells after 7 days, which …

134

Multi-omics analysis reveals CMTR1 upregulation in cancer and roles in ribosomal protein gene expression and tumor growth.

Campeanu IJ, Jiang Y, Afisllari H, Dzinic S, Polin L, Yang ZQ. Campeanu IJ, et al. Cell Commun Signal. 2025 Apr 24;23(1):197. doi: 10.1186/s12964-025-02147-6. Cell Commun Signal. 2025. PMID: 40275371 Free PMC article.

Functional studies were performed using CRISPR-mediated knockout and siRNA knockdown in human and mouse basal-like breast cancer models. Transcriptomic and pathway enrichment analyses were carried out in CMTR1 knockout/knockdown models to identify CMTR1-regulated ge …

Functional studies were performed using CRISPR-mediated knockout and siRNA knockdown in human and mouse basal-like breast cancer …

135

Expression of the TIGIT axis and the CD39/CD73 purinergic pathway in bone metastasis-derived immune cells.

Brauneck E, Leonhardt LG, Assemissen AM, Wahid Y, Kruppa M, Kruppa N, Krüger J, Menzel S, Koch-Nolte F, Kylies J, Weisel K, Bokemeyer C, Wellbrock J, Fiedler W, Viezens L, Brauneck F. Brauneck E, et al. Cancer Immunol Immunother. 2025 Apr 24;74(6):182. doi: 10.1007/s00262-025-04030-2. Cancer Immunol Immunother. 2025. PMID: 40274631 Free PMC article.

METHOD: Phenotypic and functional analyses were conducted via multiparametric flow cytometry (MFC) on BM-derived aspirates obtained from patients with breast cancer (BC, n = 6), patients with prostate cancer (PC, n = 5), patients with non-small-cell lung c …

METHOD: Phenotypic and functional analyses were conducted via multiparametric flow cytometry (MFC) on BM-derived aspirates obtained from pat …

136

Breast Cancer Stem Cells and Immunogenicity Profile in High-Risk Early Triple-Negative Breast Cancer: A Pilot Study.

Roqué-Lloveras A, Pérez-Bueno F, Pozo-Ariza X, Polonio-Alcalá E, Ausellé-Bosch S, Oliveras G, Viñas G, Puig T. Roqué-Lloveras A, et al. Int J Mol Sci. 2025 Apr 22;26(9):3960. doi: 10.3390/ijms26093960. Int J Mol Sci. 2025. PMID: 40362201 Free PMC article.

Triple-negative breast cancer (TNBC) is an aggressive subtype requiring further knowledge of biomarkers to improve targeted therapy. A major resistance mechanism involves breast cancer stem cells (BCSCs) evading the immune system. Neoadju …

Triple-negative breast cancer (TNBC) is an aggressive subtype requiring further knowledge of biomarkers to improve targeted th …

137

SNORA47 affects stemness and chemotherapy sensitivity via EBF3/RPL11/c-Myc axis in luminal A breast cancer.

Han Q, Zhou Y, Dong Z, Wang W, Wang M, Pang M, Song X, Chen B, Zheng A. Han Q, et al. Mol Med. 2025 Apr 22;31(1):150. doi: 10.1186/s10020-025-01216-3. Mol Med. 2025. PMID: 40264043 Free PMC article.

Chemotherapy sensitivity is an important factor that restricts the prognosis of breast cancer, and breast cancer stem cells (BCSCs) are the root cause of chemotherapy sensitivity. SNORA47, a member of the small nucleolar RNAs, has not bee …

Chemotherapy sensitivity is an important factor that restricts the prognosis of breast cancer, and breast cancer …

138

Force spectroscopy reveals membrane fluctuations and surface adhesion of extracellular nanovesicles impact their elastic behavior.

Stridfeldt F, Pandey V, Kylhammar H, Talebian Gevari M, Metem P, Agrawal V, Görgens A, Mamand DR, Gilbert J, Palmgren L, Holme MN, Gustafsson O, El Andaloussi S, Mitra D, Dev A. Stridfeldt F, et al. Proc Natl Acad Sci U S A. 2025 Apr 22;122(16):e2414174122. doi: 10.1073/pnas.2414174122. Epub 2025 Apr 18. Proc Natl Acad Sci U S A. 2025. PMID: 40249788 Free PMC article.

The method is then applied to EVs derived from human embryonic kidney cells and their genetically engineered classes altering the tetraspanin expression. The data show a large spread; the area modulus is in the range of 4 to 19 mN/m and the bending modulus is in the range …

The method is then applied to EVs derived from human embryonic kidney cells and their genetically engineered classes altering the tet …

139

Unveiling transcriptional mechanisms of B7-H3 in breast cancer stem cells through proteomic approaches.

Seo YR, Kim HB, Jung H, Kim EG, Huh S, Yi EC, Kim KM. Seo YR, et al. iScience. 2025 Mar 14;28(4):112218. doi: 10.1016/j.isci.2025.112218. eCollection 2025 Apr 18. iScience. 2025. PMID: 40230524 Free PMC article.

Despite its critical role in promoting tumorigenesis, metastasis, and immune evasion, the regulatory mechanisms governing B7-H3 expression, particularly in cancer stem cells (CSCs), remain elusive. In this comprehensive study, we focused on breast CSCs …

Despite its critical role in promoting tumorigenesis, metastasis, and immune evasion, the regulatory mechanisms governing B7-H3 expression, …

140

AZIN1-dependent polyamine synthesis accelerates tumor cell cycle progression and impairs effector T-cell function in osteosarcoma.

Yu J, Zhang C, Zhang Q, Lu B, Lu G, Zhang C, Qiu R, Wang X, Zou C, Chu J, Li H, Zhao W. Yu J, et al. Cell Death Dis. 2025 Apr 17;16(1):310. doi: 10.1038/s41419-025-07640-x. Cell Death Dis. 2025. PMID: 40246846 Free PMC article.

We show that osteosarcoma cell proliferation and tumor growth rely on polyamine availability and that disruption of polyamine synthesis significantly boosts the cytotoxic efficacy of TCR-engineered T cells against osteosarcoma cells. Mechanistically, we reveal that …

We show that osteosarcoma cell proliferation and tumor growth rely on polyamine availability and that disruption of polyamine synthesis sign …

141

Streptomycin targets tumor-initiating cells by disrupting oxidative phosphorylation.

Guillorit H, Relier S, Zagiel B, Di Giorgio A, Planque C, Felipe B, Hérault H, Bansard L, Bouclier C, Chabi B, Casas F, Clara O, Bonafos B, Mialhe X, Cazevieille C, Hideg S, Choquet A, Bastide A, Pannequin J, Duca M, Macari F, David A. Guillorit H, et al. Cell Chem Biol. 2025 Apr 17;32(4):570-585.e7. doi: 10.1016/j.chembiol.2025.03.008. Epub 2025 Apr 9. Cell Chem Biol. 2025. PMID: 40209702 Free article.

Tumor initiating cells (TICs) are the roots of current shortcomings in advanced and metastatic cancer treatment. ...Our work identified streptomycin (SM), a potent bactericidal antibiotic, as a molecule capable of specifically targeting non-adherent TIC from colon a …

Tumor initiating cells (TICs) are the roots of current shortcomings in advanced and metastatic cancer treatment. ...Our work i …

142

Breast cancer patient-derived scaffolds enhance the understanding of PD-L1 regulation and T cell cytotoxicity.

Garre E, Rhost S, Gustafsson A, Szeponik L, Araujo TF, Quiding-Järbrink M, Helou K, Ståhlberg A, Landberg G. Garre E, et al. Commun Biol. 2025 Apr 16;8(1):621. doi: 10.1038/s42003-025-08054-3. Commun Biol. 2025. PMID: 40240529 Free PMC article.

When adding T cells to the PDS-based cancer cultures, the killing efficiency of activated T cells vary between the cultures, whereas non-activated T cells modulate the cancer cell PD-L1 expression to treatment-predictive values, matching killing …

When adding T cells to the PDS-based cancer cultures, the killing efficiency of activated T cells vary between the cult …

143

Biocompatible Hyaluronic Acid-Stabilized Copper Nanoparticles for the Selective Oxidation of Morin Dye by H₂O₂.

Yilmaz MD, Altves S, Ozcelik AB, Erbas-Cakmak S. Yilmaz MD, et al. ACS Omega. 2025 Apr 2;10(14):14431-14438. doi: 10.1021/acsomega.5c00769. eCollection 2025 Apr 15. ACS Omega. 2025. PMID: 40256537 Free PMC article.

HA-CuNPs have been characterized by several state-of-the-art analytical techniques, such as FESEM, STEM, UV-Vis, DLS, zeta potential, FTIR and XRD analyses. The average particle size and surface zeta potential of HA-CuNPs were determined to be 35 nm and -28 mV, respectivel …

HA-CuNPs have been characterized by several state-of-the-art analytical techniques, such as FESEM, STEM, UV-Vis, DLS, zeta potential, …

144

Myogenic IGFBP5 levels in rhabdomyosarcoma are nourished by mesenchymal stromal cells and regulate growth arrest and apoptosis.

Zhang Y, Katkhada K, Meng LZ, Zhao B, Tong S, Chaabane W, Kallai A, Tobin NP, Östman A, Mega A, Ehnman M. Zhang Y, et al. Cell Commun Signal. 2025 Apr 15;23(1):184. doi: 10.1186/s12964-025-02171-6. Cell Commun Signal. 2025. PMID: 40234830 Free PMC article.

BACKGROUND: Mesenchymal stromal cells belong to a diverse collection of cells in different states that are poorly characterized in soft-tissue sarcomas. ...RESULTS: The results revealed transiently suppressive paracrine effects of orthotopic stromal cells der …

BACKGROUND: Mesenchymal stromal cells belong to a diverse collection of cells in different states that are poorly characterize …

145

Distinct mammary stem cells orchestrate long-term homeostasis of adult mammary gland.

Lin Z, Guo Y, Bai H, Liu X, Lin M, Zhang Y, Tang R, Hu T, Yu L, Wang C, Cai S. Lin Z, et al. Cell Discov. 2025 Apr 15;11(1):39. doi: 10.1038/s41421-025-00794-0. Cell Discov. 2025. PMID: 40234382 Free PMC article.

The murine mammary gland is sustained by distinct pools of stem cells that are limited in space and time, exhibiting both unipotency and bipotency. ...These findings are crucial for advancing our understanding of breast health and breast cancer …

The murine mammary gland is sustained by distinct pools of stem cells that are limited in space and time, exhibiting both unip …

146

Predicting survival and immune status of breast cancer patients based on prognostic features related to PANoptosis.

Cui J, Wu D, Lv D. Cui J, et al. Discov Oncol. 2025 Apr 15;16(1):527. doi: 10.1007/s12672-025-02209-8. Discov Oncol. 2025. PMID: 40232576 Free PMC article.

BACKGROUND: Breast cancer (BRCA) is a prevalent female malignancy. PANoptosis, integrating diverse cell death traits, is pivotal in BRCA, thus necessitating deeper study. ...Finally, single-cell analysis identified six cell types (including cancer stem …

BACKGROUND: Breast cancer (BRCA) is a prevalent female malignancy. PANoptosis, integrating diverse cell death traits, is pivot …

147

Lineage Tracing and Single-Cell RNA Sequencing Reveal a Common Transcriptional State in Breast Cancer Tumor-Initiating Cells Characterized by IFN/STAT1 Activity.

Souto EP, Gong P, Landua JD, Rajaram Srinivasan R, Ganesan A, Dobrolecki LE, Purdy SC, Pan X, Zeosky M, Chung A, Yi SS, Ford HL, Lewis MT. Souto EP, et al. Cancer Res. 2025 Apr 15;85(8):1390-1409. doi: 10.1158/0008-5472.CAN-23-4022. Cancer Res. 2025. PMID: 40230213 Free PMC article.

A tumor cell subpopulation of tumor-initiating cells (TIC) or "cancer stem cells" is associated with therapeutic resistance, as well as both local and distant recurrences. ...In this study, we developed a STAT-responsive lineage-tracing system and used …

A tumor cell subpopulation of tumor-initiating cells (TIC) or "cancer stem cells" is associated with therapeutic …

148

The R-RAS2 GTPase is a signaling hub in triple-negative breast cancer cell metabolism and metastatic behavior.

Cifuentes C, Horndler L, Grosso P, Oeste CL, Hortal AM, Castillo J, Fernández-Pisonero I, Paradela A, Bustelo X, Alarcón B. Cifuentes C, et al. J Hematol Oncol. 2025 Apr 12;18(1):41. doi: 10.1186/s13045-025-01693-3. J Hematol Oncol. 2025. PMID: 40221767 Free PMC article.

BACKGROUND: Recent research from our group has shown that the overexpression of the wild-type RAS-family GTPase RRAS2 drives the onset of triple-negative breast cancer (TNBC) in mice following one or more pregnancies. This phenomenon mirrors human TNBC, where RRAS2 …

BACKGROUND: Recent research from our group has shown that the overexpression of the wild-type RAS-family GTPase RRAS2 drives the onset of tr …

149

The Modulation of Cell Plasticity by Budesonide: Beyond the Metabolic and Anti-Inflammatory Actions of Glucocorticoids.

Patriarca EJ, D'Aniello C, De Cesare D, Cobellis G, Minchiotti G. Patriarca EJ, et al. Pharmaceutics. 2025 Apr 11;17(4):504. doi: 10.3390/pharmaceutics17040504. Pharmaceutics. 2025. PMID: 40284499 Free PMC article. Review.

Certainly, BUD stabilizes cell-cell adhesions, preventing embryonic stem cell differentiation and inhibiting the development of 3D gastruloids. In addition, BUD inhibits the motile/invasive propensity of different cancer cells, including breast, lung, …

Certainly, BUD stabilizes cell-cell adhesions, preventing embryonic stem cell differentiation and inhibiting the development of 3D ga …

150

The Role of GREMLIN1, a Bone Morphogenetic Protein Antagonist, in Cancer Stem Cell Regulation.

Gao Y, De S, Brazil DP. Gao Y, et al. Cells. 2025 Apr 11;14(8):578. doi: 10.3390/cells14080578. Cells. 2025. PMID: 40277903 Free PMC article. Review.

Bone morphogenetic proteins (BMPs) and their growth differentiation factor (GDF) relatives are crucial regulators of developmental processes such as limb, kidney and lung formation, cell fate determination, cell proliferation, and apoptosis. Cancer stem cells …

Bone morphogenetic proteins (BMPs) and their growth differentiation factor (GDF) relatives are crucial regulators of developmental processes …

151

Potentiating Antibody-Dependent Cellular Cytotoxicity in Triple-Negative Breast Cancer via the Humanized Anti-CD147 Antibody.

Thongheang K, Pamonsupornwichit T, Sornsuwan K, Juntit OA, Chokepaichitkool T, Thongkum W, Yasamut U, Tayapiwatana C. Thongheang K, et al. Antibodies (Basel). 2025 Apr 11;14(2):36. doi: 10.3390/antib14020036. Antibodies (Basel). 2025. PMID: 40265417 Free PMC article.

BACKGROUND: Triple-negative breast cancer (TNBC) is an aggressive subtype with high metastatic potential, poor prognosis, and the absence of estrogen receptors, progesterone receptors, and human epidermal growth factor receptor 2 (HER2). ...Cells were then co …

BACKGROUND: Triple-negative breast cancer (TNBC) is an aggressive subtype with high metastatic potential, poor prognosis, and …

152

Knockdown of BAP31 Suppresses Tumorigenesis and Stemness in Breast Cancer Cells via the Hippo Pathway.

Hao Z, Zhao B, An F, Zhang W, Zhu X, Meng S, Wang B. Hao Z, et al. Int J Mol Sci. 2025 Apr 10;26(8):3576. doi: 10.3390/ijms26083576. Int J Mol Sci. 2025. PMID: 40332113 Free PMC article.

Our findings revealed that BAP31 expression was elevated in breast cancer cells, and its knockdown led to a decrease in both sphere formation and the CD44+CD24- population. Furthermore, the knockdown of BAP31 significantly diminished the expression of core st …

Our findings revealed that BAP31 expression was elevated in breast cancer cells, and its knockdown led to a decrease in …

153

Development of a breast cancer invasion score to predict tumor aggressiveness and prognosis via PI3K/AKT/mTOR pathway analysis.

Li X, Zhang Y, Gong J, Liu W, Zhao H, Xue W, Ren Z, Bao J, Lin Z. Li X, et al. Cell Death Discov. 2025 Apr 9;11(1):157. doi: 10.1038/s41420-025-02422-y. Cell Death Discov. 2025. PMID: 40204712 Free PMC article.

Invasiveness is a key indicator of tumor malignancy and is often linked to poor prognosis in breast cancer (BC). To explore the diverse characteristics of invasive cells, single-cell RNA sequencing (scRNA-seq) data from three ductal carcinoma stages were anal …

Invasiveness is a key indicator of tumor malignancy and is often linked to poor prognosis in breast cancer (BC). To explore th …

154

Associations of circulating insulin-like growth factor-1 and insulin-like growth factor binding protein-3 with the expression of stem cell markers in benign breast tissue.

Yaghjyan L, Heng YJ, Sardella BR, Murthy D, Mahoney MB, Rosner B, Polyak K, Ratcliff M, Tamimi RM. Yaghjyan L, et al. Breast Cancer Res. 2025 Apr 7;27(1):53. doi: 10.1186/s13058-025-02002-z. Breast Cancer Res. 2025. PMID: 40197284 Free PMC article.

BACKGROUND: The insulin-like growth factor (IGF) pathway is implicated in a naturally occurring process of tissue remodeling during which cells acquire stem cell-like characteristics. We examined associations of circulating IGF-1 and IGF binding protein-3 (IGFBP-3) …

BACKGROUND: The insulin-like growth factor (IGF) pathway is implicated in a naturally occurring process of tissue remodeling during which …

155

Anti-Cancer Stem Cell Properties of Square Planar Copper(II) Complexes with Vanillin Schiff Base Ligands.

Wang Y, Singh K, Lu C, Suntharalingam K. Wang Y, et al. Molecules. 2025 Apr 6;30(7):1636. doi: 10.3390/molecules30071636. Molecules. 2025. PMID: 40286223 Free PMC article.

Current breast cancer therapies are unable to positively impact the lives of a significant proportion of diagnosed patients (24% based on 10-year survival rate). Breast cancer relapse and metastasis, the leading cause of breast cancer-ass …

Current breast cancer therapies are unable to positively impact the lives of a significant proportion of diagnosed patients (2 …

156

Multi-omics insights into the roles of CCNB1, PLK1, and HPSE in breast cancer progression: implications for prognosis and immunotherapy.

Su Q, Fang L, Li C, Yue L, Yun Z, Zhang H, Liu Q, Ma R, Zhong P, Liu H, Lou Z, Chen Z, Tan Y, Hao X, Wu C. Su Q, et al. Discov Oncol. 2025 Apr 5;16(1):471. doi: 10.1007/s12672-025-02282-z. Discov Oncol. 2025. PMID: 40186712 Free PMC article.

BACKGROUND: This study examines the roles of Cyclin B1 (CCNB1), Polo-Like Kinase 1 (PLK1), and Heparanase (HPSE) in breast cancer progression using a multi-omics approach. These genes are known for their involvement in various cancer-related processes, but th …

BACKGROUND: This study examines the roles of Cyclin B1 (CCNB1), Polo-Like Kinase 1 (PLK1), and Heparanase (HPSE) in breast cancer …

157

The depth of tumor hierarchy and its impact on hypertumor susceptibility.

Choi J, Kim S, Lee S, Park J. Choi J, et al. Sci Rep. 2025 Apr 3;15(1):11464. doi: 10.1038/s41598-025-94852-y. Sci Rep. 2025. PMID: 40181035 Free PMC article.

Analogous to the apical hierarchy observed in adult stem cells, such versatile cancer cells were termed cancer stem cells. Meanwhile, hypertumors that exploit the cooperation of other cancer cells may disrupt the inte …

Analogous to the apical hierarchy observed in adult stem cells, such versatile cancer cells were termed cance …

158

Functionally enriched epigenetic clocks reveal tissue-specific discordant aging patterns in individuals with cancer.

Herzog CMS, Redl E, Barrett J, Aminzadeh-Gohari S, Weber DD, Tevini J, Lang R, Kofler B, Widschwendter M. Herzog CMS, et al. Commun Med (Lond). 2025 Apr 2;5(1):98. doi: 10.1038/s43856-025-00739-4. Commun Med (Lond). 2025. PMID: 40175686 Free PMC article.

Surprisingly, both mouse and human data reveal accelerated aging in breast cancer tissue but decelerated epigenetic aging in some non-cancer surrogate samples from breast cancer patients, in particular cervical samples. CONCLUSIONS: This work pr …

Surprisingly, both mouse and human data reveal accelerated aging in breast cancer tissue but decelerated epigenetic aging in s …

159

The impact of a high fat diet and platelet activation on pre-metastatic niche formation.

Hergueta-Redondo M, Sánchez-Redondo S, Hurtado B, Santos V, Pérez-Martínez M, Ximénez-Embún P, McDowell SAC, Mazariegos MS, Mata G, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Graña-Castro O, Megias D, Quail D, Quintela-Fandino M, Peinado H. Hergueta-Redondo M, et al. Nat Commun. 2025 Apr 2;16(1):2897. doi: 10.1038/s41467-025-57938-9. Nat Commun. 2025. PMID: 40175356 Free PMC article.

There is active crosstalk between tumor cells and the tumor microenvironment during metastatic progression, a process that is significantly affected by obesity, particularly in breast cancer. ...Moreover, blocking fibronectin reduces the interaction of tumor …

There is active crosstalk between tumor cells and the tumor microenvironment during metastatic progression, a process that is signifi …

160

Ethanol extract from Ziziphus nummularia stem inhibits MCF-7 breast cancer cell proliferation through TP53 regulating kinase (TP53RK)-mediated p53 activation: In silico and genes expression investigations.

Elya B, Rosmalena R, Fajrin AM, Tedjo A, Ramadanti NA, Azizah NN, Hashim NB. Elya B, et al. Narra J. 2025 Apr;5(1):e1382. doi: 10.52225/narra.v5i1.1382. Epub 2025 Feb 10. Narra J. 2025. PMID: 40352177 Free PMC article.

The p53 signaling pathway plays a critical role in regulating the cell cycle, apoptosis, and senescence, making it a key target in cancer research. The aim of this study was to investigate the effects of an ethanol extract from the stem of Ziziphus nummularia on the …

The p53 signaling pathway plays a critical role in regulating the cell cycle, apoptosis, and senescence, making it a key target in cancer …

161

Genomic Differences and Distinct TP53 Mutation Site-Linked Chemosensitivity in Early- and Late-Onset Gastric Cancer.

Kamio T, Kono Y, Hirosuna K, Ozato T, Yamamoto H, Hirasawa A, Ennishi D, Tomida S, Toyooka S, Otsuka M. Kamio T, et al. Cancer Med. 2025 Apr;14(8):e70793. doi: 10.1002/cam4.70793. Cancer Med. 2025. PMID: 40249206 Free PMC article.

BACKGROUND: Gastric cancer (GC) in younger patients often exhibits aggressive behavior and a poorer prognosis than that in older patients. ...The influence of TP53 mutations on the time to treatment failure (TTF) with platinum-based chemotherapy and the sensitivity of c …

BACKGROUND: Gastric cancer (GC) in younger patients often exhibits aggressive behavior and a poorer prognosis than that in older pati …

162

Integrating network pharmacology and experimental validation to uncover the synergistic effects of Huangqi ()-Ezhu () with 5-fluorouracil in colorectal cancer models.

Xiying T, Ruxin GU, Jing T, Yu Z, RuiQian S, Gang Y, Shuo Z, Decai T. Xiying T, et al. J Tradit Chin Med. 2025 Apr;45(2):385-398. doi: 10.19852/j.cnki.jtcm.2025.02.004. J Tradit Chin Med. 2025. PMID: 40151125 Free PMC article.

Then, changes in potential targets were assessed in tumors from tumor-bearing mice and the expression of these targets was also evaluated in colorectal cancer (COAD) patients from the Cancer Genome Atlas Program (TCGA) database. RESULTS: HQEZ significantly enhanced …

Then, changes in potential targets were assessed in tumors from tumor-bearing mice and the expression of these targets was also evaluated in …

163

Mechanistic insights into SENP1 and OCT4 interaction in promoting drug resistance and stem cell features in colon cancer.

Zou J, Chen J, Deng L, Xu B, Yu T, Wang J, He C. Zou J, et al. Am J Physiol Cell Physiol. 2025 Apr 1;328(4):C1260-C1278. doi: 10.1152/ajpcell.00817.2024. Epub 2025 Mar 10. Am J Physiol Cell Physiol. 2025. PMID: 40063360 Free article.

In vitro experiments using enriched HCT116 stem cells revealed that SENP1 and OCT4 expression significantly elevated CD44 and CD133 levels, enhancing stemness. Functional assays showed that SENP1's deSUMOylation of OCT4 intensified Cis resistance, migration, and inv …

In vitro experiments using enriched HCT116 stem cells revealed that SENP1 and OCT4 expression significantly elevated CD44 and …

164

An Intervertebral Disc (IVD) Regeneration Model Using Human Nucleus Pulposus Cells (iHNPCs) and Annulus Fibrosus Cells (iHAFCs).

Zhu Y, Liu Q, Yu C, Zhang H, Zhong J, Wang Y, Mei O, Gerhard E, You W, Shen G, Luo C, Wu X, Li J, Shu Y, Wen Y, Zeb U, Luu HH, Lee MJ, Shi LL, Bi Y, Yang J, Fan J, Reid RR, He TC, Wen L. Zhu Y, et al. Adv Healthc Mater. 2025 Apr;14(10):e2403742. doi: 10.1002/adhm.202403742. Epub 2025 Mar 7. Adv Healthc Mater. 2025. PMID: 40052622 Free PMC article.

While current treatments focus on symptom management or surgical intervention, tissue engineering using IVD-derived cells, biofactors, and scaffolds offers a promising regenerative approach. Here, human NP cells (NPCs) and annulus fibrosus cells (AFCs) are im …

While current treatments focus on symptom management or surgical intervention, tissue engineering using IVD-derived cells, biofactors …

165

Targeting BMP-1 enhances anti-tumoral effects of doxorubicin in metastatic mammary cancer: common and distinct features of TGF-beta inhibition.

Erin N, Tavşan E, Haksever S, Yerlikaya A, Riganti C. Erin N, et al. Breast Cancer Res Treat. 2025 Apr;210(3):563-574. doi: 10.1007/s10549-024-07592-4. Epub 2025 Jan 10. Breast Cancer Res Treat. 2025. PMID: 39792296 Free PMC article.

PURPOSE: Mammary carcinoma is comprised heterogeneous groups of cells with different metastatic potential. 4T1 mammary carcinoma cells metastasized to heart (4THM), liver (4TLM) and brain (4TBM) and demonstrate cancer-stem cell phenotype. Using these …

PURPOSE: Mammary carcinoma is comprised heterogeneous groups of cells with different metastatic potential. 4T1 mammary carcinoma c …

166

LHPP-P38 MAPK/ERK-ETS1 Axis Negative Feedback Signaling Restrains Progression in Breast Cancer.

Liu X, Yu D, Yu Z, Su S, Jiang M, Zhao C. Liu X, et al. Cancer Sci. 2025 Apr;116(4):923-935. doi: 10.1111/cas.16448. Epub 2025 Jan 10. Cancer Sci. 2025. PMID: 39789996 Free PMC article.

Invasion and metastasis are major causes of mortality in breast cancer (BRCA) patients. LHPP, known for its tumor-suppressive effects, has an undefined role in BRCA. ...

Invasion and metastasis are major causes of mortality in breast cancer (BRCA) patients. LHPP, known for its tumor-suppressive …

167

Comparative Analysis of the Therapeutic Potential of Extracellular Vesicles Secreted by Aged and Young Bone Marrow-Derived Mesenchymal Stem Cells in Osteoarthritis Pathogenesis.

Wakale S, Chen Y, Sun AR, Liyanage C, Gunter J, Batra J, Crawford R, Sang H, Prasadam I. Wakale S, et al. Cell Prolif. 2025 Apr;58(4):e13776. doi: 10.1111/cpr.13776. Epub 2024 Dec 20. Cell Prolif. 2025. PMID: 39703140 Free PMC article.

Recent studies show that extracellular vesicles (EVs) from bone marrow-derived mesenchymal stem cells (BMSCs) contribute to joint homeostasis and OA management. However, the impact of donor age on BMSC-derived EV efficacy remains underexplored. ...

Recent studies show that extracellular vesicles (EVs) from bone marrow-derived mesenchymal stem cells (BMSCs) contribute to jo …

168

PRMT5-regulated splicing of DNA repair genes drives chemoresistance in breast cancer stem cells.

Gillespie MS, Chiang K, Regan-Mochrie GL, Choi SY, Ward CM, Sahay D, Garcia P, Arnold R, Davies CC. Gillespie MS, et al. Oncogene. 2025 Apr;44(13):862-876. doi: 10.1038/s41388-024-03264-1. Epub 2024 Dec 18. Oncogene. 2025. PMID: 39695328 Free PMC article.

Breast cancer stem cells (BCSCs) are a rare cell population that is responsible for tumour initiation, metastasis and chemoresistance. ...

Breast cancer stem cells (BCSCs) are a rare cell population that is responsible for tumour initiation, metastasi …

169

The role of the mTOR pathway in breast cancer stem cells (BCSCs): mechanisms and therapeutic potentials.

Zhang C, Xu S, Yin C, Hu S, Liu P. Zhang C, et al. Stem Cell Res Ther. 2025 Mar 29;16(1):156. doi: 10.1186/s13287-025-04218-4. Stem Cell Res Ther. 2025. PMID: 40158191 Free PMC article. Review.

Breast cancer remains the most frequently diagnosed cancer globally, exerting a profound impact on women's health and healthcare systems. Central to its pathogenesis and therapeutic resistance are breast cancer stem cells (BCSCs), …

Breast cancer remains the most frequently diagnosed cancer globally, exerting a profound impact on women's health and h …

170

A novel clinically relevant antagonistic interplay between prolactin and oncogenic YAP-CCN2 pathways as a differentiation therapeutic target in breast cancer.

Liu X, Moamer A, Gomes da Silva R, Shoham-Amizlev A, Hamam D, Shams A, Lebrun JJ, Ali S. Liu X, et al. Cell Death Dis. 2025 Mar 29;16(1):221. doi: 10.1038/s41419-025-07547-7. Cell Death Dis. 2025. PMID: 40157909 Free PMC article.

Importantly, using CRISPR knockout of the PRLR in MCF7, HR+ breast cancer cells, further revealed that the negative relationship between PRL/PRLR pathway and YAP-CCN2 pathway is critical in suppressing luminal-to-basal stem-like lineage plasticity. ... …

Importantly, using CRISPR knockout of the PRLR in MCF7, HR+ breast cancer cells, further revealed that the negative rel …

171

cGAS and STING in Host Myeloid Cells Are Essential for Effective Cyclophosphamide Treatment of Advanced Breast Cancer.

Lai YG, Liao HT, Chen YH, Huang SW, Liou YH, Wu ZQ, Liao NS. Lai YG, et al. Cancers (Basel). 2025 Mar 28;17(7):1130. doi: 10.3390/cancers17071130. Cancers (Basel). 2025. PMID: 40227734 Free PMC article.

Given that CTX induces DNA damage and type I interferon (IFN-I), we investigated the role of host cGAS and STING in the anti-tumor effect of CTX in vivo. METHODS: A metastasized EO771 breast cancer model with chromosomal instability and bone marrow (BM) chimera appr …

Given that CTX induces DNA damage and type I interferon (IFN-I), we investigated the role of host cGAS and STING in the anti-tumor effect of …

172

An in vivo screen identifies NAT10 as a master regulator of brain metastasis.

Chen JF, Xu P, Cai WL, Chen H, Wingrove E, Shi X, Li W, Biancon G, Zhang M, Balabaki A, Krop ED, Asare E, Zhang Y, Yin M, Tebaldi T, Meier JL, Westbrook TF, Halene S, Liu Y, Shen H, Nguyen DX, Yan Q. Chen JF, et al. Sci Adv. 2025 Mar 28;11(13):eads6021. doi: 10.1126/sciadv.ads6021. Epub 2025 Mar 26. Sci Adv. 2025. PMID: 40138393 Free PMC article.

Emerging evidence has shown that epigenetic regulation plays a fundamental role in cancer metastasis, the major cause of cancer-related deaths. Here, we conducted an in vivo screen for vulnerabilities of brain metastasis and identified N-acetyltransferase 10 (NAT10) …

Emerging evidence has shown that epigenetic regulation plays a fundamental role in cancer metastasis, the major cause of cancer …

173

Unveiling Matrix Metalloproteinase 13's Dynamic Role in Breast Cancer: A Link to Physical Changes and Prognostic Modulation.

Sun X, Hu X. Sun X, et al. Int J Mol Sci. 2025 Mar 27;26(7):3083. doi: 10.3390/ijms26073083. Int J Mol Sci. 2025. PMID: 40243781 Free PMC article. Review.

The biomechanical properties of the extracellular matrix (ECM) including its stiffness, viscoelasticity, collagen architecture, and temperature constitute critical biomechanical cues governing breast cancer progression. Matrix metalloproteinase 13 (MMP13) is an impo …

The biomechanical properties of the extracellular matrix (ECM) including its stiffness, viscoelasticity, collagen architecture, and temperat …

174

Connexin46 in the nucleus of cancer cells: a possible role as transcription modulator.

Fernández-Olivares A, Orellana VP, Llanquinao J, Nuñez G, Pérez-Moreno P, Contreras-Riquelme S, Martin AJ, Mammano F, Alfaro IE, Calderón JF, Stehberg J, Sáez MA, Retamal MA. Fernández-Olivares A, et al. Cell Commun Signal. 2025 Mar 27;23(1):153. doi: 10.1186/s12964-025-02151-w. Cell Commun Signal. 2025. PMID: 40148950 Free PMC article.

RESULTS: Cx46 mRNA upregulation was found in a variety of tumors compared to adjacent healthy tissue. In HeLa cells, which do not express Cx46, its transfection promoted proliferation, invasion and self-renewal capacity, cancer stem cell traits and mesenchyma …

RESULTS: Cx46 mRNA upregulation was found in a variety of tumors compared to adjacent healthy tissue. In HeLa cells, which do not exp …

175

beta-Catenin Drives the FOXC2-Mediated Epithelial-Mesenchymal Transition and Acquisition of Stem Cell Properties.

Castaneda M, den Hollander P, Werden S, Ramirez-Peña E, Vasaikar SV, Kuburich NA, Gould C, Soundararajan R, Mani SA. Castaneda M, et al. Cancers (Basel). 2025 Mar 26;17(7):1114. doi: 10.3390/cancers17071114. Cancers (Basel). 2025. PMID: 40227590 Free PMC article.

Background: Aggressive forms of breast cancer, such as triple-negative breast cancer (TNBC), are associated with an increase in cancer cells that exhibit stem cell properties. The activation of the epithelial-mesenchymal transition …

Background: Aggressive forms of breast cancer, such as triple-negative breast cancer (TNBC), are associated with …

176

Organoid models of ovarian cancer: resolving immune mechanisms of metabolic reprogramming and drug resistance.

Zhang L, Zhao J, Su C, Wu J, Jiang L, Chi H, Wang Q. Zhang L, et al. Front Immunol. 2025 Mar 21;16:1573686. doi: 10.3389/fimmu.2025.1573686. eCollection 2025. Front Immunol. 2025. PMID: 40191206 Free PMC article. Review.

Metabolic reprogramming is a hallmark of ovarian cancer, enabling tumor progression, immune evasion and drug resistance. The tumor microenvironment (TME) further shapes metabolic adaptations, enabling cancer cells to withstand hypoxia and nutrient deprivation …

Metabolic reprogramming is a hallmark of ovarian cancer, enabling tumor progression, immune evasion and drug resistance. The tumor mi …

177

The controversial role of CD151 in different solid tumors: promoter or suppressor?

Gao X, Liu S, Cao Y, Shi L, Yin Y. Gao X, et al. Cancer Cell Int. 2025 Mar 21;25(1):110. doi: 10.1186/s12935-025-03751-9. Cancer Cell Int. 2025. PMID: 40119419 Free PMC article. Review.

CD151 is involved in various cellular processes, including cell-cell junction, signal transduction, epithelial-mesenchymal transition (EMT), cancer stem cell maintenance (CSCs), angiogenesis, and exosome regulation. Therefore, CD151 is a potential target for tumor t …

CD151 is involved in various cellular processes, including cell-cell junction, signal transduction, epithelial-mesenchymal transition (EMT), …

178

Targeting the CXCR4/CXCL12 Axis in Cancer Therapy: Analysis of Recent Advances in the Development of Potential Anticancer Agents.

Smaldone G, Di Matteo F, Castelluccio R, Napolitano V, Miranda MR, Manfra M, Campiglia P, Vestuto V. Smaldone G, et al. Molecules. 2025 Mar 20;30(6):1380. doi: 10.3390/molecules30061380. Molecules. 2025. PMID: 40142155 Free PMC article. Review.

Cancer, a leading cause of premature death, arises from genetic and epigenetic mutations that transform normal cells into tumor cells, enabling them to proliferate, evade cell death, and stimulate angiogenesis. ...When it binds to its endogenous ligand, CXCL1 …

Cancer, a leading cause of premature death, arises from genetic and epigenetic mutations that transform normal cells into tumo …

179

The SGK3/GSK3beta/beta-catenin signaling promotes breast cancer stemness and confers resistance to alpelisib therapy.

Kang T, Wang Y, Jiang Y, Chen S, Lin N, Guo M, Zhu H, Tang D, Ding X, He M. Kang T, et al. Int J Biol Sci. 2025 Mar 19;21(6):2462-2475. doi: 10.7150/ijbs.104850. eCollection 2025. Int J Biol Sci. 2025. PMID: 40303291 Free PMC article.

To address this problem, we established an alpelisib-resistant breast cancer cell model and confirmed that the resistant cells exhibited enhanced abilities in colony formation, migration, anti-apoptosis, spheroidization, tumor formation and metastasis. ...Fin …

To address this problem, we established an alpelisib-resistant breast cancer cell model and confirmed that the resistant ce …

180

Cancer stem cell specificity as new targets in breast tumor treatment.

Zhang Z, Li T, Li Y, Wang XI, Liu H, Shen X, Xu A, Xia T, Xu BO. Zhang Z, et al. Oncol Res. 2025 Mar 19;33(4):811-819. doi: 10.32604/or.2024.050505. eCollection 2025. Oncol Res. 2025. PMID: 40191717 Free PMC article. Review.

METHODS: This review synthesizes existing literature on breast cancer stem cells and their applications in breast cancer treatment. PubMed, Web of Science, and other relevant databases were systematically searched using keywords such as " …

METHODS: This review synthesizes existing literature on breast cancer stem cells and their applications in br …

181

Cyperotundone promotes chemosensitivity of breast cancer via SRSF1.

Li C, Wang L, Liu Z, Wang X, Sun L, Song X, Yu Z. Li C, et al. Front Pharmacol. 2025 Mar 19;16:1510161. doi: 10.3389/fphar.2025.1510161. eCollection 2025. Front Pharmacol. 2025. PMID: 40176901 Free PMC article.

Breast cancer is among the most common malignancies and the leading cause of cancer-related deaths in women. ...However, the detailed impact and molecular mechanisms of CYT in breast cancer remain poorly understood. This study aimed to investiga …

Breast cancer is among the most common malignancies and the leading cause of cancer-related deaths in women. ...However …

182

Unraveling the triad of hypoxia, cancer cell stemness, and drug resistance.

Shang T, Jia Z, Li J, Cao H, Xu H, Cong L, Ma D, Wang X, Liu J. Shang T, et al. J Hematol Oncol. 2025 Mar 18;18(1):32. doi: 10.1186/s13045-025-01684-4. J Hematol Oncol. 2025. PMID: 40102937 Free PMC article. Review.

In the domain of addressing cancer resistance, challenges such as limited effectiveness and treatment resistance remain persistent. ...Cancer stem cells (CSCs), a small tumor cell subset with self-renewal and proliferative abilities, are crucial for tu …

In the domain of addressing cancer resistance, challenges such as limited effectiveness and treatment resistance remain persistent. . …

183

Recent studies of the effects of microgravity on cancer cells and the development of 3D multicellular cancer spheroids.

Grimm D, Corydon TJ, Sahana J, González-Torres LF, Kraus A, Marchal S, Wise PM, Simonsen U, Krüger M. Grimm D, et al. Stem Cells Transl Med. 2025 Mar 18;14(3):szaf008. doi: 10.1093/stcltm/szaf008. Stem Cells Transl Med. 2025. PMID: 40099549 Free PMC article. Review.

The still young and developing space age, characterized by lunar and Martian exploration and the vision of extraterrestrial settlements, presents a unique environment to study the impact of microgravity (g) on human physiology and disease development. Cancer research is cu …

The still young and developing space age, characterized by lunar and Martian exploration and the vision of extraterrestrial settlements, pre …

184

A Xanthine Derivative With Novel Heat Shock Protein 90-Alpha Inhibitory and Senolytic Properties.

Atlante S, Cis L, Pirolli D, Gottardi Zamperla M, Barbi V, Mai A, Zwergel C, Marcozzi S, Giuliani ME, Bigossi G, Lai G, Orlando F, Giacconi R, Lattanzio F, Matacchione G, Giordani C, Bracci M, Olivieri F, Boschi F, Tabarelli De Fatis P, Ivaldi GB, Malavolta M, Farsetti A, De Rosa MC, Gaetano C. Atlante S, et al. Aging Cell. 2025 Mar 17:e70047. doi: 10.1111/acel.70047. Online ahead of print. Aging Cell. 2025. PMID: 40098059 Free article.

The accumulation of senescent cells contributes to aging and related diseases; therefore, discovering safe senolytic agents-compounds that selectively eliminate senescent cells-is a critical priority. ...K5 demonstrated senolytic activity across various cellular sen …

The accumulation of senescent cells contributes to aging and related diseases; therefore, discovering safe senolytic agents-compounds …

185

Hyper-responsiveness of cancer stem cells to microenvironmental cues controls metastasis and therapy response through YAP/TAZ/TEAD.

Tang B, Minin J, Gonzalez V, Khan Z, Raviv Y, Yang YA, Carney C, Millman Z, Grun D, Pineda C, Sharma A, Esposito D, Yan H, Huang J, Tran AD, Kruhlak M, Yang H, Lee MP, Wakefield LM. Tang B, et al. bioRxiv [Preprint]. 2025 Mar 15:2025.03.13.643008. doi: 10.1101/2025.03.13.643008. bioRxiv. 2025. PMID: 40568150 Free PMC article. Preprint.

Cancer stem cells (CSCs) are key drivers of metastasis and therapy resistance but have been challenging to visualize and study in situ . ...HIGHLIGHTS: Different population dynamics for breast cancer stem cells (CSCs) and their dif …

Cancer stem cells (CSCs) are key drivers of metastasis and therapy resistance but have been challenging to visualize an …

186

Are monocytes a preferable option to develop myeloid cell-based therapies for solid tumors?

Bhatia D, Dolcetti R, Mazzieri R. Bhatia D, et al. J Exp Clin Cancer Res. 2025 Mar 15;44(1):98. doi: 10.1186/s13046-025-03359-x. J Exp Clin Cancer Res. 2025. PMID: 40089746 Free PMC article. Review.

This is mainly given by the impaired tumor trafficking capability and limited effector activity of these cells within a highly immunosuppressive tumor microenvironment. Myeloid cells spontaneously home to tumors and can thus be reprogrammed and/or engineered to dire …

This is mainly given by the impaired tumor trafficking capability and limited effector activity of these cells within a highly immuno …

187

Targeting stemness pathways modulates macrophage polarization and reprograms the tumor microenvironment.

Butkute A, Baltramonaitis M, Malmige S, Darinskas A, Pasukoniene V, Mlynska A. Butkute A, et al. Front Immunol. 2025 Mar 14;16:1513404. doi: 10.3389/fimmu.2025.1513404. eCollection 2025. Front Immunol. 2025. PMID: 40160820 Free PMC article.

This study aimed to investigate how targeting cancer cell stemness with specific inhibitors could modulate macrophage polarization in CRC in vitro and breast cancer in vivo, potentially shifting the immune balance from pro-tumor M2-like to anti-tumor M1-like …

This study aimed to investigate how targeting cancer cell stemness with specific inhibitors could modulate macrophage polarization in …

188

Insights Into Mammary and Extramammary Paget's Disease: Diagnosis, Management, and Recent Advances.

Ortuz Lessa C, Fernández Varela Gómez F, Garzón Ortega VH, Sandoval García A, López Soto K, Brito Brito NR. Ortuz Lessa C, et al. Cureus. 2025 Mar 13;17(3):e80531. doi: 10.7759/cureus.80531. eCollection 2025 Mar. Cureus. 2025. PMID: 40230781 Free PMC article. Review.

Mammary Paget's disease (MPD) and extramammary Paget's disease (EMPD) are rare cutaneous disorders associated with adenocarcinoma, each presenting unique clinical challenges. MPD typically indicates an underlying breast cancer, manifesting as eczematous changes in t …

Mammary Paget's disease (MPD) and extramammary Paget's disease (EMPD) are rare cutaneous disorders associated with adenocarcinoma, each pres …

189

NCOR2 represses MHC class I molecule expression to drive metastatic progression of breast cancer.

Ticha P, Northey JJ, Kersten K, Velozo HG, Ironside AJ, Zidek M, Drain A, Lakins JN, Chen YY, Tsai KK, Weaver VM. Ticha P, et al. bioRxiv [Preprint]. 2025 Mar 12:2025.03.10.642060. doi: 10.1101/2025.03.10.642060. bioRxiv. 2025. PMID: 40161756 Free PMC article. Preprint.

We identified nuclear corepressor 2 (NCOR2) as a key epigenetic regulator of MHC class I molecule expression on breast tumor cells. Patients with triple negative breast cancers (TNBC) that expressed high levels of NCOR2 also exhibited reduced metastasis free …

We identified nuclear corepressor 2 (NCOR2) as a key epigenetic regulator of MHC class I molecule expression on breast tumor cells …

190

Natural Bioactive Agents: Testable Stem Cell-Targeting Alternatives for Therapy-Resistant Breast Cancer.

Telang NT. Telang NT. Int J Mol Sci. 2025 Mar 12;26(6):2529. doi: 10.3390/ijms26062529. Int J Mol Sci. 2025. PMID: 40141171 Free PMC article. Review.

The clinical limitations, due to the modest therapeutic responses of chemo-resistant cancer-initiating stem cells, emphasize the need for the identification of stem cells targeting testable alternatives for therapy-resistant breast can …

The clinical limitations, due to the modest therapeutic responses of chemo-resistant cancer-initiating stem cells, emph …

191

Pilomatricoma of the breast similar to breast cancer on ultrasound and elastography: a case report.

Zhu S, Xue N. Zhu S, et al. AME Case Rep. 2025 Mar 11;9:46. doi: 10.21037/acr-24-103. eCollection 2025. AME Case Rep. 2025. PMID: 40330933 Free PMC article.

We report a rare case of pilomatricoma located on the breast, which exhibits characteristics are similar to breast cancer. Combining with ultrasound and elastography may provide some references for clinical diagnosis. ...CONCLUSIONS: Pilomatricomas occurring …

We report a rare case of pilomatricoma located on the breast, which exhibits characteristics are similar to breast cancer …

192

Diversity of ER-positive and HER2-negative breast cancer stem cells attained using selective culture techniques.

Sueoka S, Kai A, Kobayashi Y, Ito M, Sasada S, Emi A, Gotoh N, Arihiro K, Nakayama K, Okada M, Kadoya T. Sueoka S, et al. Sci Rep. 2025 Mar 10;15(1):8257. doi: 10.1038/s41598-025-90689-7. Sci Rep. 2025. PMID: 40064935 Free PMC article.

Breast cancer stem cells are a promising therapeutic target in cancer. We explored breast cancer stem cell diversity and establish a methodology for selectively culturing breast cancer stem cells. …

Breast cancer stem cells are a promising therapeutic target in cancer. We explored breast cance …

193

Distinct cellular mechanisms underlie chemotherapies and PD-L1 blockade combinations in triple-negative breast cancer.

Zhang Y, Chen H, Mo H, Zhao N, Sun X, Liu B, Gao R, Xu B, Zhang Z, Liu Z, Ma F. Zhang Y, et al. Cancer Cell. 2025 Mar 10;43(3):446-463.e7. doi: 10.1016/j.ccell.2025.01.007. Epub 2025 Feb 6. Cancer Cell. 2025. PMID: 39919737 Free article.

Combining immune checkpoint blockade (ICB) with chemotherapy shows promise for treating triple-negative breast cancer (TNBC), though the mechanisms remain incompletely understood. Here, we integrate published and new single-cell RNA sequencing (scRNA-seq) data to in …

Combining immune checkpoint blockade (ICB) with chemotherapy shows promise for treating triple-negative breast cancer (TNBC), …

194

GATAD2B O-GlcNAcylation Regulates Breast Cancer Stem-like Potential and Drug Resistance.

Le Minh G, Merzy J, Esquea EM, Ahmed NN, Young RG, Sharp RJ, Dhameliya TT, Agana B, Lee MH, Bethard JR, Comte-Walters S, Ball LE, Reginato MJ. Le Minh G, et al. Cells. 2025 Mar 8;14(6):398. doi: 10.3390/cells14060398. Cells. 2025. PMID: 40136647 Free PMC article.

The growth of breast tumors is driven and controlled by a subpopulation of cancer cells resembling adult stem cells, which are called cancer stem-like cells (CSCs). ...Together, we identify a key role of GATAD2B and ITCH in …

The growth of breast tumors is driven and controlled by a subpopulation of cancer cells resembling adult stem …

195

Small extracellular vesicles and particles (sEVPs) derived from tumor-free pre-metastatic organs promote breast cancer metastasis and support organotropism.

Cheytan T, Schneider M, Würth R, Schwerd-Kleine P, Gutjahr E, Thewes V, Michel LL, Weber R, Vorberg T, Lohr S, Nitschke K, Neßling M, Lichter P, Schneeweiss A, Richter K, Helm D, Sprick M, Trumpp A. Cheytan T, et al. Mol Cancer. 2025 Mar 8;24(1):72. doi: 10.1186/s12943-025-02235-8. Mol Cancer. 2025. PMID: 40057730 Free PMC article.

Metastatic breast cancer remains largely incurable, partly due to our incomplete understanding of its intricate underlying mechanisms. ...Importantly, mice orthotopically injected with breast cancer cells which had been educated with either brai …

Metastatic breast cancer remains largely incurable, partly due to our incomplete understanding of its intricate underlying mec …

196

Society for Immunotherapy of Cancer (SITC) consensus statement on essential biomarkers for immunotherapy clinical protocols.

Cottrell TR, Lotze MT, Ali A, Bifulco CB, Capitini CM, Chow LQM, Cillo AR, Collyar D, Cope L, Deutsch JS, Dubrovsky G, Gnjatic S, Goh D, Halabi S, Kohanbash G, Maecker HT, Maleki Vareki S, Mullin S, Seliger B, Taube J, Vos W, Yeong J, Anderson KG, Bruno TC, Chiuzan C, Diaz-Padilla I, Garrett-Mayer E, Glitza Oliva IC, Grandi P, Hill EG, Hobbs BP, Najjar YG, Pettit Nassi P, Simons VH, Subudhi SK, Sullivan RJ, Takimoto CH. Cottrell TR, et al. J Immunother Cancer. 2025 Mar 7;13(3):e010928. doi: 10.1136/jitc-2024-010928. J Immunother Cancer. 2025. PMID: 40054999 Free PMC article.

Immunotherapy of cancer is now an essential pillar of treatment for patients with many individual tumor types. Novel immune targets and technical advances are driving a rapid exploration of new treatment strategies incorporating immune agents in cancer clinical prac …

Immunotherapy of cancer is now an essential pillar of treatment for patients with many individual tumor types. Novel immune targets a …

197

A New Light-Sensor System Affecting Cancer Cell Fate.

Buonvino S, Arciero I, Moretti S, Iorio E, Melino S. Buonvino S, et al. Biomater Res. 2025 Mar 5;29:0157. doi: 10.34133/bmr.0157. eCollection 2025. Biomater Res. 2025. PMID: 40046560 Free PMC article.

The RPL treatment of nontumoral, mesenchymal stem cells, or cancer cells shows a distinct behavior, depending on the ectopic presence of LYZ. ...A transdifferentiation into osteoblast-like cells of a triple-negative breast cancer c …

The RPL treatment of nontumoral, mesenchymal stem cells, or cancer cells shows a distinct behavior, depending on …

198

Single-cell transcriptomics of clinical grade adipose-derived regenerative cells reveals consistency between donors independent of gender and BMI.

Bjerre FA, Nielsen JV, Burton M, Dhumale P, Jørgensen MG, Hansen ST, Lund L, Thomassen M, Sørensen JA, Andersen DC, Jensen CH. Bjerre FA, et al. Stem Cell Res Ther. 2025 Mar 5;16(1):109. doi: 10.1186/s13287-025-04234-4. Stem Cell Res Ther. 2025. PMID: 40038777 Free PMC article.

Adipose-derived regenerative cells (ADRCs) also referred to as the stromal vascular fraction, provide an ample source of stem cells with widespread regenerative therapeutic use. ...Herein, we provide a comprehensive single-cell RNA sequencing ADRC mapping acr …

Adipose-derived regenerative cells (ADRCs) also referred to as the stromal vascular fraction, provide an ample source of stem …

199

Gut dysbiosis conveys psychological stress to activate LRP5/beta-catenin pathway promoting cancer stemness.

Cui B, Luo H, He B, Liu X, Lv D, Zhang X, Su K, Zheng S, Lu J, Wang C, Yang Y, Zhao Z, Liu X, Wang X, Zhao Y, Nie X, Jiang Y, Zhang Z, Liu C, Chen X, Cai A, Lv Z, Liu Z, An F, Zhang Y, Yan Q, Kelley KW, Xu G, Xu L, Liu Q, Peng F. Cui B, et al. Signal Transduct Target Ther. 2025 Mar 5;10(1):79. doi: 10.1038/s41392-025-02159-1. Signal Transduct Target Ther. 2025. PMID: 40038255 Free PMC article.

Here we showed that psychological stress promotes breast tumor growth and cancer stemness, an outcome that depends on gut microbiota in germ-free and antibiotic-treated mice. ...Clinically, fecal A. muciniphila and serum butyrate were inversely correlated with tumor …

Here we showed that psychological stress promotes breast tumor growth and cancer stemness, an outcome that depends on gut micr …

200

Mechanisms, assessment, and exercise interventions for skeletal muscle dysfunction post-chemotherapy in breast cancer: from inflammation factors to clinical practice.

Zhong P, Li X, Li J. Zhong P, et al. Front Oncol. 2025 Mar 4;15:1551561. doi: 10.3389/fonc.2025.1551561. eCollection 2025. Front Oncol. 2025. PMID: 40104495 Free PMC article. Review.

Chemotherapy remains a central component of breast cancer treatment, significantly improving patient survival rates. However, its toxic side effects, along with cancer-related paraneoplastic syndromes, can lead to the loss of skeletal muscle mass and function …

Chemotherapy remains a central component of breast cancer treatment, significantly improving patient survival rates. However, …

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