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47 results

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Page 1
Development of isothiocyanate-enriched broccoli, and its enhanced ability to induce phase 2 detoxification enzymes in mammalian cells.
Mithen R, Faulkner K, Magrath R, Rose P, Williamson G, Marquez J. Mithen R, et al. Theor Appl Genet. 2003 Feb;106(4):727-34. doi: 10.1007/s00122-002-1123-x. Epub 2002 Oct 24. Theor Appl Genet. 2003. PMID: 12596003
Following tissue disruption, these glucosinolates are hydrolysed to the corresponding isothiocyanates (ITCs), which have been associated with anticarcinogenic activity through a number of physiological mechanisms including the induction of phase II detoxification en …
Following tissue disruption, these glucosinolates are hydrolysed to the corresponding isothiocyanates (ITCs), which have been associated wit …
Exploring the anti-inflammatory activity of sulforaphane.
Treasure K, Harris J, Williamson G. Treasure K, et al. Immunol Cell Biol. 2023 Oct;101(9):805-828. doi: 10.1111/imcb.12686. Epub 2023 Aug 31. Immunol Cell Biol. 2023. PMID: 37650498 Review.
Sulforaphane, a phytochemical derived from plants of the brassica family, is a potent inducer of phase II detoxification enzymes via nuclear factor-erythroid factor 2-related factor 2 (NRF2) signaling. ...
Sulforaphane, a phytochemical derived from plants of the brassica family, is a potent inducer of phase II detoxification …
Sulforaphane as a potential therapeutic agent: a comprehensive analysis of clinical trials and mechanistic insights.
Saito A, Ishikawa S, Yang K, Sawa A, Ishizuka K. Saito A, et al. J Nutr Sci. 2025 Sep 16;14:e65. doi: 10.1017/jns.2025.10033. eCollection 2025. J Nutr Sci. 2025. PMID: 40988712 Free PMC article. Review.
SFN exerts its effects through well-characterised pathways, including the Keap1/Nrf2 axis, which regulates phase II detoxification enzymes, and epigenetic mechanisms such as histone deacetylase inhibition. ...SFN had minimal impact on respiratory diseases but showed …
SFN exerts its effects through well-characterised pathways, including the Keap1/Nrf2 axis, which regulates phase II detoxification …
Induction of phase 2 antioxidant enzymes by broccoli sulforaphane: perspectives in maintaining the antioxidant activity of vitamins a, C, and e.
Boddupalli S, Mein JR, Lakkanna S, James DR. Boddupalli S, et al. Front Genet. 2012 Jan 24;3:7. doi: 10.3389/fgene.2012.00007. eCollection 2012. Front Genet. 2012. PMID: 22303412 Free PMC article.
Members of the cruciferous vegetable family, which includes broccoli, Brussels sprouts, cauliflower, and cabbage, accumulate significant concentrations of glucosinolates, which are metabolized in vivo to biologically active isothiocyanates (ITCs). ...Nrf2/ARE gene products …
Members of the cruciferous vegetable family, which includes broccoli, Brussels sprouts, cauliflower, and cabbage, accumulate signific …
Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers.
Bauman JE, Hsu CH, Centuori S, Guillen-Rodriguez J, Garland LL, Ho E, Padi M, Bageerathan V, Bengtson L, Wojtowicz M, Szabo E, Chow HS. Bauman JE, et al. Cancers (Basel). 2022 Apr 24;14(9):2129. doi: 10.3390/cancers14092129. Cancers (Basel). 2022. PMID: 35565256 Free PMC article.
In residents of Qidong, China, broccoli seed and sprout extracts (BSSE) increased detoxification of air pollutants benzene and acrolein, also found in tobacco smoke. This randomized, crossover trial evaluated detoxification of tobacco carcinogens by the BSSE …
In residents of Qidong, China, broccoli seed and sprout extracts (BSSE) increased detoxification of air pollutants benzene and …
Chemopreventive functions of isothiocyanates.
Keum YS, Jeong WS, Kong AN. Keum YS, et al. Drug News Perspect. 2005 Sep;18(7):445-51. doi: 10.1358/dnp.2005.18.7.939350. Drug News Perspect. 2005. PMID: 16362084 Free article. Review.
Among several possible cellular mechanisms, both the modulation of nuclear factor kappaB (NF-kappaB) and activator protein-1 (AP-1) and the induction of phase II cellular detoxification and antioxidant enzymes (in brief phase II enzymes) have been proposed as …
Among several possible cellular mechanisms, both the modulation of nuclear factor kappaB (NF-kappaB) and activator protein-1 (AP-1) and the …
Dietary histone deacetylase inhibitors: from cells to mice to man.
Dashwood RH, Ho E. Dashwood RH, et al. Semin Cancer Biol. 2007 Oct;17(5):363-9. doi: 10.1016/j.semcancer.2007.04.001. Epub 2007 May 5. Semin Cancer Biol. 2007. PMID: 17555985 Free PMC article. Review.
Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables, such as broccoli and broccoli sprouts. This anticarcinogen was first identified as a potent inducer of Phase 2 detoxification enzymes, but evidence is mounting that SFN als …
Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables, such as broccoli and broccoli sprouts. This anticarci …
The antioxidant properties of organosulfur compounds (sulforaphane).
de Figueiredo SM, Binda NS, Nogueira-Machado JA, Vieira-Filho SA, Caligiorne RB. de Figueiredo SM, et al. Recent Pat Endocr Metab Immune Drug Discov. 2015;9(1):24-39. doi: 10.2174/1872214809666150505164138. Recent Pat Endocr Metab Immune Drug Discov. 2015. PMID: 25944116 Review.
The SFN induces Phase I and II enzymes involved in detoxification processes of chemical carcinogens in order to prevent the start of carcinogenesis. ...This protective effect may be due to its antioxidant status, its recognized capacity to induce the expression and/ …
The SFN induces Phase I and II enzymes involved in detoxification processes of chemical carcinogens in order to prevent the st …
Chemoprotection by sulforaphane: keep one eye beyond Keap1.
Myzak MC, Dashwood RH. Myzak MC, et al. Cancer Lett. 2006 Feb 28;233(2):208-18. doi: 10.1016/j.canlet.2005.02.033. Cancer Lett. 2006. PMID: 16520150 Free PMC article. Review.
Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables, with particularly high levels detected in broccoli and broccoli sprouts. Over a decade ago, this phytochemical was identified as a likely chemopreventive agent based on its ability to induce …
Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables, with particularly high levels detected in broccoli and br …
Molecular basis for chemoprevention by sulforaphane: a comprehensive review.
Juge N, Mithen RF, Traka M. Juge N, et al. Cell Mol Life Sci. 2007 May;64(9):1105-27. doi: 10.1007/s00018-007-6484-5. Cell Mol Life Sci. 2007. PMID: 17396224 Free PMC article. Review.
This protective effect is attributed to isothiocyanates present in these vegetables, and sulforaphane (SF), present in broccoli, is by far the most extensively studied to uncover the mechanisms behind this chemoprotection. The major mechanism by which SF protects cells was …
This protective effect is attributed to isothiocyanates present in these vegetables, and sulforaphane (SF), present in broccoli, is b …
47 results