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Page 1
Sulforaphane-Enriched Broccoli Sprouts Pretreated by Pulsed Electric Fields Reduces Neuroinflammation and Ameliorates Scopolamine-Induced Amnesia in Mouse Brain through Its Antioxidant Ability via Nrf2-HO-1 Activation.
Subedi L, Cho K, Park YU, Choi HJ, Kim SY. Subedi L, et al. Oxid Med Cell Longev. 2019 Mar 27;2019:3549274. doi: 10.1155/2019/3549274. eCollection 2019. Oxid Med Cell Longev. 2019. PMID: 31049133 Free PMC article.
Sulforaphane is an active compound produced after conversion of glucoraphanin by the myrosinase enzyme in broccoli (Brassica oleracea var) sprouts. Dietary broccoli extract as well as sulforaphane has previously known to mitigate inflammatory condition …
Sulforaphane is an active compound produced after conversion of glucoraphanin by the myrosinase enzyme in broccoli (Brassica o …
Glucosinolate-rich broccoli sprouts protect against oxidative stress and improve adaptations to intense exercise training.
Flockhart M, Nilsson LC, Tillqvist EN, Vinge F, Millbert F, Lännerström J, Nilsson PH, Samyn D, Apró W, Sundqvist ML, Larsen FJ. Flockhart M, et al. Redox Biol. 2023 Nov;67:102873. doi: 10.1016/j.redox.2023.102873. Epub 2023 Sep 3. Redox Biol. 2023. PMID: 37688976 Free PMC article.
These compounds activate crucial antioxidant defence pathways and support mitochondrial function and protein integrity under oxidative stress, in both Nrf2-dependent and independent manners. We here administered glucosinolate-rich broccoli sprouts (GRS), in a …
These compounds activate crucial antioxidant defence pathways and support mitochondrial function and protein integrity under oxidative stres …
Potential efficacy of broccoli sprouts as a unique supplement for management of type 2 diabetes and its complications.
Bahadoran Z, Mirmiran P, Azizi F. Bahadoran Z, et al. J Med Food. 2013 May;16(5):375-82. doi: 10.1089/jmf.2012.2559. Epub 2013 Apr 30. J Med Food. 2013. PMID: 23631497 Review.
Functional foods and their nutraceutical components are now considered as supplementary treatments in type 2 diabetes and prevention of its long-term complications. Young broccoli sprouts as a functional food contain many bioactive compounds specially sulforaphane. …
Functional foods and their nutraceutical components are now considered as supplementary treatments in type 2 diabetes and prevention of its …
Pharmacokinetics and pharmacodynamics of broccoli sprouts on the suppression of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: implication of induction of Nrf2, HO-1 and apoptosis and the suppression of Akt-dependent kinase pathway.
Keum YS, Khor TO, Lin W, Shen G, Kwon KH, Barve A, Li W, Kong AN. Keum YS, et al. Pharm Res. 2009 Oct;26(10):2324-31. doi: 10.1007/s11095-009-9948-5. Epub 2009 Aug 8. Pharm Res. 2009. PMID: 19669099
PURPOSE: In the present study, we have evaluated the pharmacokinetics and the in vivo prostate chemopreventive activity of broccoli sprouts. METHODS: The in vivo pharmacokinetic profiles of sulforaphane (SFN) and SFN- glutathione (GSH) conjugate in rats after oral a …
PURPOSE: In the present study, we have evaluated the pharmacokinetics and the in vivo prostate chemopreventive activity of broccoli …
Broccoli for the brain: a review of the neuroprotective mechanisms of sulforaphane.
Bessetti RN, Litwa KA. Bessetti RN, et al. Front Cell Neurosci. 2025 Jul 4;19:1601366. doi: 10.3389/fncel.2025.1601366. eCollection 2025. Front Cell Neurosci. 2025. PMID: 40686501 Free PMC article. Review.
Sulforaphane, a phytochemical abundant in the sprouts of cruciferous vegetables, protects plants during a critical period of development. Through sulforaphane's ability to activate the mammalian Nuclear Factor Erythroid 2-related Factor 2 (NRF2) pathway, these benef …
Sulforaphane, a phytochemical abundant in the sprouts of cruciferous vegetables, protects plants during a critical period of developm …
Nutraceuticals/Drugs Promoting Mitophagy and Mitochondrial Biogenesis May Combat the Mitochondrial Dysfunction Driving Progression of Dry Age-Related Macular Degeneration.
Lewis Luján LM, McCarty MF, Di Nicolantonio JJ, Gálvez Ruiz JC, Rosas-Burgos EC, Plascencia-Jatomea M, Iloki Assanga SB. Lewis Luján LM, et al. Nutrients. 2022 May 9;14(9):1985. doi: 10.3390/nu14091985. Nutrients. 2022. PMID: 35565950 Free PMC article. Review.
An analysis of the molecular biology underlying mitophagy/MB and inflammasome activation suggests that nutraceuticals or drugs that can activate Sirt1, AMPK, Nrf2, and PPARalpha may be useful in this regard. These include ferulic acid, melatonin urolithin A and glucosamine …
An analysis of the molecular biology underlying mitophagy/MB and inflammasome activation suggests that nutraceuticals or drugs that can acti …
The neuroprotective mechanisms and effects of sulforaphane.
Klomparens EA, Ding Y. Klomparens EA, et al. Brain Circ. 2019 Apr-Jun;5(2):74-83. doi: 10.4103/bc.bc_7_19. Epub 2019 Jun 27. Brain Circ. 2019. PMID: 31334360 Free PMC article. Review.
SFN is a potent activator of the nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant response element (ARE) genetic pathway. Upregulation of Nrf2-ARE increases the availability of multiple antioxidants. ...
SFN is a potent activator of the nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant response element (ARE) genetic pathwa …
Dietary broccoli sprouts protect against myocardial oxidative damage and cell death during ischemia-reperfusion.
Akhlaghi M, Bandy B. Akhlaghi M, et al. Plant Foods Hum Nutr. 2010 Sep;65(3):193-9. doi: 10.1007/s11130-010-0182-4. Plant Foods Hum Nutr. 2010. PMID: 20706790
In the current study we asked whether dietary broccoli sprouts can protect the heart from ischemia-reperfusion. Rats were fed either control diet (sham and control groups) or a diet mixed with 2% dried broccoli sprouts for 10 days. ...While broccoli …
In the current study we asked whether dietary broccoli sprouts can protect the heart from ischemia-reperfusion. Rats were fed …
Broccoli sprout extract prevents diabetic cardiomyopathy via Nrf2 activation in db/db T2DM mice.
Xu Z, Wang S, Ji H, Zhang Z, Chen J, Tan Y, Wintergerst K, Zheng Y, Sun J, Cai L. Xu Z, et al. Sci Rep. 2016 Jul 26;6:30252. doi: 10.1038/srep30252. Sci Rep. 2016. PMID: 27457280 Free PMC article.
To develop a clinic-relevant protocol for systemic up-regulation of NFE2-related factor 2 (Nrf2) to prevent diabetic cardiomyopathy (DCM), male db/db and age-matched wild-type (WT) mice were given sulforaphane (SFN, an Nrf2 activator) and its natural source, broc …
To develop a clinic-relevant protocol for systemic up-regulation of NFE2-related factor 2 (Nrf2) to prevent diabetic cardiomyopathy ( …
Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans.
Yanaka A, Fahey JW, Fukumoto A, Nakayama M, Inoue S, Zhang S, Tauchi M, Suzuki H, Hyodo I, Yamamoto M. Yanaka A, et al. Cancer Prev Res (Phila). 2009 Apr;2(4):353-60. doi: 10.1158/1940-6207.CAPR-08-0192. Cancer Prev Res (Phila). 2009. PMID: 19349290 Clinical Trial.
Forty-eight H. pylori-infected patients were randomly assigned to feeding of broccoli sprouts (70 g/d; containing 420 micromol of SF precursor) for 8 weeks or to consumption of an equal weight of alfalfa sprouts (not containing SF) as placebo. ...Values recov …
Forty-eight H. pylori-infected patients were randomly assigned to feeding of broccoli sprouts (70 g/d; containing 420 micromol …
76 results