Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1953 1
1958 2
1963 9
1964 19
1965 14
1969 1
1970 7
1971 10
1972 11
1973 10
1974 24
1975 20
1976 16
1977 17
1978 32
1979 18
1980 15
1981 32
1982 21
1983 29
1984 26
1985 32
1986 24
1987 43
1988 30
1989 31
1990 20
1991 18
1992 21
1993 13
1994 10
1995 16
1996 13
1997 15
1998 24
1999 14
2000 22
2001 20
2002 17
2003 16
2004 17
2005 24
2006 23
2007 33
2008 37
2009 33
2010 35
2011 35
2012 40
2013 27
2014 28
2015 29
2016 22
2017 29
2018 27
2019 31
2020 48
2021 35
2022 31
2023 32
2024 41
2025 37
2026 20

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

1,369 results

Results by year

Filters applied: . Clear all
Page 1
Bromhexine.
Sehgal SK, Mohan M. Sehgal SK, et al. Indian Pediatr. 1990 May;27(5):479-83. Indian Pediatr. 1990. PMID: 2276776 Review. No abstract available.
Beyond the lungs: Exploring diverse applications of bromhexine and ambroxol.
Ahmadi E, Afrooghe A, Soltani ZE, Elahi M, Shayan M, Ohadi MAD, Dehpour AR. Ahmadi E, et al. Life Sci. 2024 Sep 15;353:122909. doi: 10.1016/j.lfs.2024.122909. Epub 2024 Jul 11. Life Sci. 2024. PMID: 38997062 Review.
These assumptions have provided the basis for researchers to investigate the specific characteristics of bromhexine and ambroxol. This has led to the emergence of several repositionings for this compound. ...Accordingly, more clinical studies are needed to determine the ef …
These assumptions have provided the basis for researchers to investigate the specific characteristics of bromhexine and ambroxol. Thi …
Enhancement of lung levels of antibiotics by ambroxol and bromhexine.
Deretic V, Timmins GS. Deretic V, et al. Expert Opin Drug Metab Toxicol. 2019 Mar;15(3):213-218. doi: 10.1080/17425255.2019.1578748. Epub 2019 Feb 7. Expert Opin Drug Metab Toxicol. 2019. PMID: 30721101 Free PMC article. Review.
Areas covered: This review discusses preclinical and clinical studies of the effects of ambroxol (and its prodrug precursor bromhexine) co-treatment upon levels of antibiotics in lung tissue, sputum, and bronchoalveolar lavage fluid. ...
Areas covered: This review discusses preclinical and clinical studies of the effects of ambroxol (and its prodrug precursor bromhexine
Effect of bromhexine in hospitalized patients with COVID-19.
Tolouian R, Mulla ZD, Jamaati H, Babamahmoodi A, Marjani M, Eskandari R, Dastan F. Tolouian R, et al. J Investig Med. 2023 Oct;71(7):691-699. doi: 10.1136/jim-2020-001747. J Investig Med. 2023. PMID: 33722999 Clinical Trial.
BACKGROUND: Bromhexine is a potent inhibitor of transmembrane serine protease 2 and appears to have an antiviral effect in controlling influenza and parainfluenza infection; however, its efficacy in COVID-19 is controversial. ...There were also no differences observed in t …
BACKGROUND: Bromhexine is a potent inhibitor of transmembrane serine protease 2 and appears to have an antiviral effect in controllin …
Mucolytic Drugs Ambroxol and Bromhexine: Transformation under Aqueous Chlorination Conditions.
Sypalov SA, Varsegov IS, Ulyanovskii NV, Lebedev AT, Kosyakov DS. Sypalov SA, et al. Int J Mol Sci. 2024 May 10;25(10):5214. doi: 10.3390/ijms25105214. Int J Mol Sci. 2024. PMID: 38791251 Free PMC article.
Bromhexine and ambroxol are among the mucolytic drugs most widely used to treat acute and chronic respiratory diseases. ...The specific class of bromhexine- and ambroxol-related DBPs are bromine-containing haloanilines. Seven of them, including methoxy derivatives,
Bromhexine and ambroxol are among the mucolytic drugs most widely used to treat acute and chronic respiratory diseases. ...The specif
[Bromhexine].
von Wichert P. von Wichert P. Dtsch Med Wochenschr. 1979 Nov 30;104(48):1696. Dtsch Med Wochenschr. 1979. PMID: 520161 German. No abstract available.
Bromhexine elevates REP2 expression to stimulate secretion from human primary conjunctiva fornix epithelial cells.
Wang L, Yu L, Li N, Wang Y, Yang M, Peng Y, Guo H, Ye L. Wang L, et al. FEBS Lett. 2020 Jan;594(1):153-160. doi: 10.1002/1873-3468.13560. Epub 2019 Aug 9. FEBS Lett. 2020. PMID: 31365127
Bromhexine was reported to relieve the symptoms of Sjogren Syndrome at an early stage. However, the underlying mechanism remains unclear. ...Expression of the metabolism-related gene CHML was also upregulated by bromhexine treatment, and REP2, the protein produced b
Bromhexine was reported to relieve the symptoms of Sjogren Syndrome at an early stage. However, the underlying mechanism remains uncl
Potential new treatment strategies for COVID-19: is there a role for bromhexine as add-on therapy?
Depfenhart M, de Villiers D, Lemperle G, Meyer M, Di Somma S. Depfenhart M, et al. Intern Emerg Med. 2020 Aug;15(5):801-812. doi: 10.1007/s11739-020-02383-3. Epub 2020 May 26. Intern Emerg Med. 2020. PMID: 32458206 Free PMC article. Review.
An effective prophylactic medication to prevent viral entry has to contain, at least, either a protease inhibitor or a competitive virus ACE2-binding inhibitor. Using bromhexine at a dosage that selectively inhibits TMPRSS2 and, in so doing, inhibits TMPRSS2-specific viral …
An effective prophylactic medication to prevent viral entry has to contain, at least, either a protease inhibitor or a competitive virus ACE …
Bromhexine Hydrochloride Tablets for the Treatment of Moderate COVID-19: An Open-Label Randomized Controlled Pilot Study.
Li T, Sun L, Zhang W, Zheng C, Jiang C, Chen M, Chen D, Dai Z, Bao S, Shen X. Li T, et al. Clin Transl Sci. 2020 Nov;13(6):1096-1102. doi: 10.1111/cts.12881. Epub 2020 Oct 10. Clin Transl Sci. 2020. PMID: 32881359 Free PMC article. Clinical Trial.
This open-label randomized controlled pilot study aimed to test the study feasibility of bromhexine hydrochloride (BRH) tablets for the treatment of mild or moderate coronavirus disease 2019 (COVID-19) and to explore its clinical efficacy and safety. ...
This open-label randomized controlled pilot study aimed to test the study feasibility of bromhexine hydrochloride (BRH) tablets for t …
[Bromhexine is a potential drug for COVID-19; From hypothesis to clinical trials].
Bahadoram S, Keikhaei B, Bahadoram M, Mahmoudian-Sani MR, Hassanzadeh S, Saeedi-Boroujeni A, Alikhani K. Bahadoram S, et al. Vopr Virusol. 2022 May 5;67(2):126-132. doi: 10.36233/0507-4088-106. Vopr Virusol. 2022. PMID: 35521985 Russian.
Moreover, several clinical trials are evaluating the efficacy of bromhexine in COVID-19 patients. The findings of these studies have shown that bromhexine is effective in improving the clinical outcomes of COVID-19 and has prophylactic effects by inhibiting TMPRSS2 …
Moreover, several clinical trials are evaluating the efficacy of bromhexine in COVID-19 patients. The findings of these studies have …
1,369 results