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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1969 1
1970 3
1972 3
1973 2
1975 2
1976 1
1978 4
1980 1
1981 5
1982 2
1983 1
1984 3
1985 3
1986 4
1987 11
1988 4
1989 2
1990 2
1991 3
1992 2
1993 2
1994 1
1995 4
1996 2
1997 2
1998 1
1999 1
2000 3
2001 3
2002 2
2003 2
2004 4
2005 3
2006 3
2007 2
2008 2
2009 4
2010 4
2011 1
2012 5
2013 4
2014 9
2015 7
2016 3
2017 2
2018 4
2019 1
2020 1
2021 3
2022 1
2023 5
2024 4
2025 4
2026 2

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157 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Effect of bromhexine in hospitalized patients with COVID-19.
Tolouian R, Mulla ZD, Jamaati H, Babamahmoodi A, Marjani M, Eskandari R, Dastan F. Tolouian R, et al. J Investig Med. 2023 Oct;71(7):691-699. doi: 10.1136/jim-2020-001747. J Investig Med. 2023. PMID: 33722999 Clinical Trial.
BACKGROUND: Bromhexine is a potent inhibitor of transmembrane serine protease 2 and appears to have an antiviral effect in controlling influenza and parainfluenza infection; however, its efficacy in COVID-19 is controversial. ...There were also no differences observed in t …
BACKGROUND: Bromhexine is a potent inhibitor of transmembrane serine protease 2 and appears to have an antiviral effect in controllin …
Bromhexine Hydrochloride Tablets for the Treatment of Moderate COVID-19: An Open-Label Randomized Controlled Pilot Study.
Li T, Sun L, Zhang W, Zheng C, Jiang C, Chen M, Chen D, Dai Z, Bao S, Shen X. Li T, et al. Clin Transl Sci. 2020 Nov;13(6):1096-1102. doi: 10.1111/cts.12881. Epub 2020 Oct 10. Clin Transl Sci. 2020. PMID: 32881359 Free PMC article. Clinical Trial.
This open-label randomized controlled pilot study aimed to test the study feasibility of bromhexine hydrochloride (BRH) tablets for the treatment of mild or moderate coronavirus disease 2019 (COVID-19) and to explore its clinical efficacy and safety. ...
This open-label randomized controlled pilot study aimed to test the study feasibility of bromhexine hydrochloride (BRH) tablets for t …
Efficacy and safety of mucolytics in patients with stable chronic obstructive pulmonary disease: A systematic review and meta-analysis.
Ohnishi H, Tanimoto T, Inaba R, Eitoku M. Ohnishi H, et al. Respir Investig. 2024 Nov;62(6):1168-1175. doi: 10.1016/j.resinv.2024.10.004. Epub 2024 Oct 15. Respir Investig. 2024. PMID: 39413571
METHODS: Reports from randomized controlled trials to evaluate the efficacy and safety of mucolytics, including ambroxol, bromhexine, carbocisteine, erdosteine, fudosteine, l-methylcysteine, and N-acetylcysteine used in patients with stable COPD were searched for in PubMed …
METHODS: Reports from randomized controlled trials to evaluate the efficacy and safety of mucolytics, including ambroxol, bromhexine, …
Mucolytics for bronchiectasis.
Wilkinson M, Sugumar K, Milan SJ, Hart A, Crockett A, Crossingham I. Wilkinson M, et al. Cochrane Database Syst Rev. 2014 May 2;2014(5):CD001289. doi: 10.1002/14651858.CD001289.pub2. Cochrane Database Syst Rev. 2014. PMID: 24789119 Free PMC article.
A reduction in sputum production was noted with bromhexine (MD -21.5%, 95% CI -38.9 to -4.1 at day 16); again the quality of the evidence was rated as low. ...As the number of agents available on the market, such as RhDNase, acetylcysteine and bromhexine, is increas …
A reduction in sputum production was noted with bromhexine (MD -21.5%, 95% CI -38.9 to -4.1 at day 16); again the quality of the evid …
Bromhexine in chronic bronchitis.
Christensen F, Kjer J, Ryskjaer S, Arseth-Hansen P. Christensen F, et al. Br Med J. 1970 Oct 10;4(5727):117. doi: 10.1136/bmj.4.5727.117-a. Br Med J. 1970. PMID: 4919405 Free PMC article. Clinical Trial. No abstract available.
Bromhexine in the treatment of otitis media with effusion.
Stewart IA, Guy AM, Allison RS, Thomson NJ. Stewart IA, et al. Clin Otolaryngol Allied Sci. 1985 Jun;10(3):145-9. doi: 10.1111/j.1365-2273.1985.tb01183.x. Clin Otolaryngol Allied Sci. 1985. PMID: 3896583 Clinical Trial.
There were 198 ears in the placebo group and 182 ears in the bromhexine group. The resolution rate in the placebo treated group was 19% and in the bromhexine treated group 16%. Bromhexine does not appear to be a useful drug for the treatment of OME in childre …
There were 198 ears in the placebo group and 182 ears in the bromhexine group. The resolution rate in the placebo treated group was 1 …
Sjorgren's syndrome treated with bromhexine: a randomised clinical study.
Frost-Larsen K, Isager H, Manthorpe R. Frost-Larsen K, et al. Br Med J. 1978 Jun 17;1(6127):1579-81. doi: 10.1136/bmj.1.6127.1579. Br Med J. 1978. PMID: 350346 Free PMC article. Clinical Trial.
In the first trial bromhexine 24 mg/day was given by mouth; in the second the dose was increased to 48 mg/day. ...It had no effect on salivary gland function. Bromhexine is therefore valuable in the treatment of Sjogren's syndrome....
In the first trial bromhexine 24 mg/day was given by mouth; in the second the dose was increased to 48 mg/day. ...It had no effect on …
Phase IIa randomized placebocontrolled clinical trial to evaluate the efficacy of bromhexine in combination with standard therapy in the early treatment of COVID-19 in primary care patients.
Ramírez D, Rojas R, Fierro H, Nova DA, Renard GM, Ampuero E, Fuentealba J, Martínez A, Gil C, Reyes-Parada M. Ramírez D, et al. Rev Med Chil. 2024 Dec;152(12):1198-1208. doi: 10.4067/s0034-98872024001201198. Rev Med Chil. 2024. PMID: 40178212 Free article. Clinical Trial.
AIM: To evaluate the efficacy of oral bromhexine in patients with mild to moderate symptomatic active SARS-CoV-2 infection. METHODS: A randomized, placebo-controlled clinical trial assessing the effectiveness of oral bromhexine in outpatients with active SARS-CoV-2 …
AIM: To evaluate the efficacy of oral bromhexine in patients with mild to moderate symptomatic active SARS-CoV-2 infection. METHODS: …
Bromhexine treatment of Sjogren's syndrome: effect on lacrimal and salivary secretion, and on proteins in tear fluid and saliva.
Manthorpe R, Frost-Larsen K, Høj L, Isager H, Prause JU. Manthorpe R, et al. Scand J Rheumatol. 1981;10(3):177-80. doi: 10.3109/03009748109095294. Scand J Rheumatol. 1981. PMID: 7027431 Clinical Trial.
Bromhexine stimulated the tear secretion significantly, presumable without changing the protein composition of the tear fluid. In contrast to other proteins in saliva the IgM concentration decreased in patients with high pre-treatment values. Bromhexine may be of va …
Bromhexine stimulated the tear secretion significantly, presumable without changing the protein composition of the tear fluid. In con …
Evaluation of the efficacy of N-acetylcysteine and bromhexine compared with standard care in preventing hospitalization of outpatients with COVID-19: a double blind randomized clinical trial.
Eslami Ghayour A, Nazari S, Keramat F, Shahbazi F, Eslami-Ghayour A. Eslami Ghayour A, et al. Rev Clin Esp (Barc). 2024 Feb;224(2):86-95. doi: 10.1016/j.rceng.2023.12.011. Epub 2024 Jan 11. Rev Clin Esp (Barc). 2024. PMID: 38215974 Clinical Trial.
RESULTS: The study found that both N-acetylcysteine and Bromhexine can effectively reduce hospitalization rates and mortality and shorten the duration of hospitalization. ...CONCLUSION: In conclusion, the results of this study indicate that NAC and bromhexine may be …
RESULTS: The study found that both N-acetylcysteine and Bromhexine can effectively reduce hospitalization rates and mortality and sho …
157 results