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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1969 1
1970 3
1972 3
1973 2
1975 2
1976 1
1978 4
1980 1
1981 5
1982 2
1983 1
1984 3
1985 3
1986 4
1987 11
1988 4
1989 2
1990 2
1991 3
1992 2
1993 2
1994 1
1995 4
1996 2
1997 2
1998 1
1999 1
2000 3
2001 3
2002 2
2003 2
2004 4
2005 3
2006 3
2007 2
2008 2
2009 4
2010 4
2011 1
2012 5
2013 4
2014 9
2015 7
2016 3
2017 2
2018 4
2019 2
2020 1
2021 3
2022 1
2023 5
2024 2

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150 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Effect of bromhexine in hospitalized patients with COVID-19.
Tolouian R, Mulla ZD, Jamaati H, Babamahmoodi A, Marjani M, Eskandari R, Dastan F. Tolouian R, et al. J Investig Med. 2023 Oct;71(7):691-699. doi: 10.1136/jim-2020-001747. J Investig Med. 2023. PMID: 33722999 Clinical Trial.
BACKGROUND: Bromhexine is a potent inhibitor of transmembrane serine protease 2 and appears to have an antiviral effect in controlling influenza and parainfluenza infection; however, its efficacy in COVID-19 is controversial. ...The potential prevention benefits of brom
BACKGROUND: Bromhexine is a potent inhibitor of transmembrane serine protease 2 and appears to have an antiviral effect in controllin …
Bromhexine in chronic bronchitis.
Christensen F, Kjer J, Ryskjaer S, Arseth-Hansen P. Christensen F, et al. Br Med J. 1970 Oct 10;4(5727):117. doi: 10.1136/bmj.4.5727.117-a. Br Med J. 1970. PMID: 4919405 Free PMC article. Clinical Trial. No abstract available.
Bromhexine Hydrochloride Tablets for the Treatment of Moderate COVID-19: An Open-Label Randomized Controlled Pilot Study.
Li T, Sun L, Zhang W, Zheng C, Jiang C, Chen M, Chen D, Dai Z, Bao S, Shen X. Li T, et al. Clin Transl Sci. 2020 Nov;13(6):1096-1102. doi: 10.1111/cts.12881. Epub 2020 Oct 10. Clin Transl Sci. 2020. PMID: 32881359 Free PMC article. Clinical Trial.
This open-label randomized controlled pilot study aimed to test the study feasibility of bromhexine hydrochloride (BRH) tablets for the treatment of mild or moderate coronavirus disease 2019 (COVID-19) and to explore its clinical efficacy and safety. ...
This open-label randomized controlled pilot study aimed to test the study feasibility of bromhexine hydrochloride (BRH) tablets for t …
Bromhexine in the treatment of otitis media with effusion.
Stewart IA, Guy AM, Allison RS, Thomson NJ. Stewart IA, et al. Clin Otolaryngol Allied Sci. 1985 Jun;10(3):145-9. doi: 10.1111/j.1365-2273.1985.tb01183.x. Clin Otolaryngol Allied Sci. 1985. PMID: 3896583 Clinical Trial.
There were 198 ears in the placebo group and 182 ears in the bromhexine group. The resolution rate in the placebo treated group was 19% and in the bromhexine treated group 16%. Bromhexine does not appear to be a useful drug for the treatment of OME in childre …
There were 198 ears in the placebo group and 182 ears in the bromhexine group. The resolution rate in the placebo treated group was 1 …
[Evaluation of the efficacy and safety of a combination drug containing ambroxol, guaifenesin, and levosalbutamol versus a fixed-dose combination of bromhexine/guaifenesin/salbutamol in the treatment of productive cough in adult patients with acute bronchitis].
Zaitsev AA, Leshchenko IV, Esaulova NA, Viktorova IA. Zaitsev AA, et al. Ter Arkh. 2023 Apr 26;95(3):236-242. doi: 10.26442/00403660.2023.03.202099. Ter Arkh. 2023. PMID: 37167145 Clinical Trial. Russian.
AIM: To evaluate the efficacy and safety of a combination drug containing ambroxol, guaifenesin, and levosalbutamol, oral solution, versus Ascoril Expectorant, syrup (combination of bromhexine, guaifenesin, and salbutamol) in the treatment of productive cough in adult pati …
AIM: To evaluate the efficacy and safety of a combination drug containing ambroxol, guaifenesin, and levosalbutamol, oral solution, versus A …
Ambroxol as a novel disease-modifying treatment for Parkinson's disease dementia: protocol for a single-centre, randomized, double-blind, placebo-controlled trial.
Silveira CRA, MacKinley J, Coleman K, Li Z, Finger E, Bartha R, Morrow SA, Wells J, Borrie M, Tirona RG, Rupar CA, Zou G, Hegele RA, Mahuran D, MacDonald P, Jenkins ME, Jog M, Pasternak SH. Silveira CRA, et al. BMC Neurol. 2019 Feb 9;19(1):20. doi: 10.1186/s12883-019-1252-3. BMC Neurol. 2019. PMID: 30738426 Free PMC article. Clinical Trial.
Bromhexine in severe asthma.
Rudolf M, Riordan JF, Grant BJ, Maberly DJ, Saunders KB. Rudolf M, et al. Br J Dis Chest. 1978 Oct;72(4):307-12. Br J Dis Chest. 1978. PMID: 365213 Clinical Trial.
Fourteen patients with acute severe asthma necessitating hospital admission were all treated with a standard therapeutic regimen, and in addition received either bromhexine or placebo (initially intravenously and subsequently orally) double-blind. We were unable to show an …
Fourteen patients with acute severe asthma necessitating hospital admission were all treated with a standard therapeutic regimen, and in add …
Mucolytics for bronchiectasis.
Wilkinson M, Sugumar K, Milan SJ, Hart A, Crockett A, Crossingham I. Wilkinson M, et al. Cochrane Database Syst Rev. 2014 May 2;2014(5):CD001289. doi: 10.1002/14651858.CD001289.pub2. Cochrane Database Syst Rev. 2014. PMID: 24789119 Free PMC article. Review.
A reduction in sputum production was noted with bromhexine (MD -21.5%, 95% CI -38.9 to -4.1 at day 16); again the quality of the evidence was rated as low. ...As the number of agents available on the market, such as RhDNase, acetylcysteine and bromhexine, is increas …
A reduction in sputum production was noted with bromhexine (MD -21.5%, 95% CI -38.9 to -4.1 at day 16); again the quality of the evid …
Bioavailability of bromhexine tablets and preliminary pharmacokinetics in humans.
Bechgaard E, Nielsen A. Bechgaard E, et al. Biopharm Drug Dispos. 1982 Oct-Dec;3(4):337-44. doi: 10.1002/bdd.2510030407. Biopharm Drug Dispos. 1982. PMID: 6897618 Clinical Trial.
The absorption of bromhexine from Bromhexin tablets 8 mg, DAK has been compared with that from Bisolvon tablets 8 mg, Boehringer Ingelheim, in a two-way complete crossover study. Four tablets of each of the two bromhexine products, corresponding to a single d …
The absorption of bromhexine from Bromhexin tablets 8 mg, DAK has been compared with that from Bisolvon tablets 8 mg, Boehring …
Bromhexine treatment of Sjogren's syndrome: effect on lacrimal and salivary secretion, and on proteins in tear fluid and saliva.
Manthorpe R, Frost-Larsen K, Høj L, Isager H, Prause JU. Manthorpe R, et al. Scand J Rheumatol. 1981;10(3):177-80. doi: 10.3109/03009748109095294. Scand J Rheumatol. 1981. PMID: 7027431 Clinical Trial.
Bromhexine stimulated the tear secretion significantly, presumable without changing the protein composition of the tear fluid. In contrast to other proteins in saliva the IgM concentration decreased in patients with high pre-treatment values. Bromhexine may be of va
Bromhexine stimulated the tear secretion significantly, presumable without changing the protein composition of the tear fluid. In con
150 results