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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1962 3
1963 2
1964 3
1968 2
1970 2
1971 1
1972 1
1973 2
1975 2
1978 1
1979 1
1980 2
1986 3
1987 1
2004 1
2008 1
2009 1
2011 1
2012 3
2013 1
2019 1
2022 1
2023 2
2024 1

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36 results

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Page 1
Discovery of 8-Hydroxyquinoline as a Histamine Receptor 2 Blocker Scaffold.
Marquez-Gomez PL, Kruyer NS, Eisen SL, Torp LR, Howie RL, Jones EV, France S, Peralta-Yahya P. Marquez-Gomez PL, et al. ACS Synth Biol. 2022 Aug 19;11(8):2820-2828. doi: 10.1021/acssynbio.2c00205. Epub 2022 Aug 5. ACS Synth Biol. 2022. PMID: 35930594 Free PMC article.
We used the HR(H2)-based sensor to screen a 403-member anti-infection chemical library and identified three HR(H2) blockers, chlorquinaldol, chloroxine, and broxyquinoline, all sharing an 8-hydroxyquinoline scaffold, which is not found among known HR(H2) antagonists. ...Mo …
We used the HR(H2)-based sensor to screen a 403-member anti-infection chemical library and identified three HR(H2) blockers, chlorquinaldol, …
Amaurosis after broxyquinoline.
Strandvik B, Zetterström R. Strandvik B, et al. Lancet. 1968 Apr 27;1(7548):922-3. doi: 10.1016/s0140-6736(68)90280-8. Lancet. 1968. PMID: 4171525 No abstract available.
Broad susceptibility of Candida auris strains to 8-hydroxyquinolines and mechanisms of resistance.
Lohse MB, Laurie MT, Levan S, Ziv N, Ennis CL, Nobile CJ, DeRisi J, Johnson AD. Lohse MB, et al. mBio. 2023 Aug 31;14(4):e0137623. doi: 10.1128/mbio.01376-23. Epub 2023 Jul 26. mBio. 2023. PMID: 37493629 Free PMC article.
These compounds, some of which had been previously identified in independent screens, include three dihalogenated 8-hydroxyquinolines: broxyquinoline, chloroxine, and clioquinol. A subsequent structure-activity study of 32 quinoline derivatives found that 8-hydroxyquinolin …
These compounds, some of which had been previously identified in independent screens, include three dihalogenated 8-hydroxyquinolines: br …
Broad sensitivity of Candida auris strains to quinolones and mechanisms of resistance.
Lohse MB, Laurie MT, Levan S, Ziv N, Ennis CL, Nobile CJ, DeRisi J, Johnson AD. Lohse MB, et al. bioRxiv [Preprint]. 2023 Feb 17:2023.02.16.528905. doi: 10.1101/2023.02.16.528905. bioRxiv. 2023. PMID: 36824717 Free PMC article. Updated. Preprint.
These compounds, some of which had been previously identified in independent screens, include three dihalogenated 8-hydroxyquinolines: broxyquinoline, chloroxine, and clioquinol. A subsequent structure-activity study of 32 quinoline derivatives found that 8-hydroxyquinolin …
These compounds, some of which had been previously identified in independent screens, include three dihalogenated 8-hydroxyquinolines: br …
Use of an ion-selective membrane electrode for the determination of the active components in intestopan.
Ionescu MS, Lazarescu M, Ionescu A, Baiulescu GE. Ionescu MS, et al. Talanta. 1987 Oct;34(10):887-8. doi: 10.1016/0039-9140(87)80120-0. Talanta. 1987. PMID: 18964425
The conditions for the determination of broxyquinoline and brobenzoxaldine, the active components of "Intestopan", by use of ion-selective membrane electrodes are described. Broxyquinoline is determined directly through precipitation with CuSO(4), and brobenzoxaldin …
The conditions for the determination of broxyquinoline and brobenzoxaldine, the active components of "Intestopan", by use of ion-sele …
A study on the neurotoxicity of broxyquinoline and brobenzoxaldine combination in therapeutic doses.
Swain R, Bapna JS, Das AK, Chandrasekar S, Swaminathan RP, Bosco B, Veliath S, Thombre DP. Swain R, et al. Hum Toxicol. 1986 Jan;5(1):35-41. doi: 10.1177/096032718600500107. Hum Toxicol. 1986. PMID: 3081428
The neurotoxicity of a combination of broxyquinoline and brobenzoxaldine (Intestopan Forte, containing 500 mg and 100 mg of the drugs respectively per capsule) was investigated by prospective clinical and electrophysiological studies in patients and volunteer subjects give …
The neurotoxicity of a combination of broxyquinoline and brobenzoxaldine (Intestopan Forte, containing 500 mg and 100 mg of the drugs …
Effects of clioquinol analogues on the hypoxia-inducible factor pathway and intracelullar mobilization of metal ions.
Kim SY, Lee MJ, Kim JW, Na YR, Lee HY, Cho H, Lee KB, Lee YM, Lee C, Park H, Yang EG. Kim SY, et al. Biol Pharm Bull. 2012;35(12):2160-9. doi: 10.1248/bpb.b12-00507. Biol Pharm Bull. 2012. PMID: 23207768 Free article.
Here we report that compounds derived from 8-hydroxyquinoline including CQ, broxyquinoline (BQ), iodoquinol (IQ) and chloroacetoxyquinoline (CAQ) promote neovascularization effectively based on chick chorioallantoic membrane assays. ...
Here we report that compounds derived from 8-hydroxyquinoline including CQ, broxyquinoline (BQ), iodoquinol (IQ) and chloroacetoxyqui …
Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus.
Yuan S, Chan JF, Ye ZW, Wen L, Tsang TG, Cao J, Huang J, Chan CC, Chik KK, Choi GK, Cai JP, Yin F, Chu H, Liang M, Jin DY, Yuen KY. Yuan S, et al. Viruses. 2019 Apr 25;11(4):385. doi: 10.3390/v11040385. Viruses. 2019. PMID: 31027241 Free PMC article.
We identified five drug compounds that inhibited SFTSV replication at low micromolar concentrations, including hexachlorophene, triclosan, regorafenib, eltrombopag, and broxyquinoline. Among them, hexachlorophene was the most potent with an IC(50) of 1.3 0.3 M and a select …
We identified five drug compounds that inhibited SFTSV replication at low micromolar concentrations, including hexachlorophene, triclosan, r …
Supercharged precision killers: Genetically engineered biomimetic drugs of screened metalloantibiotics against Acinetobacter baumanni.
Wei X, Xue B, Ruan S, Guo J, Huang Y, Geng X, Wang D, Zhou C, Zheng J, Yuan Z. Wei X, et al. Sci Adv. 2024 Mar 22;10(12):eadk6331. doi: 10.1126/sciadv.adk6331. Epub 2024 Mar 22. Sci Adv. 2024. PMID: 38517956 Free PMC article.
To eliminate multidrug-resistant bacteria of Acinetobacter baumannii, we screened 1100 Food and Drug Administration-approved small molecule drugs and accessed the broxyquinoline (Bq) efficacy in combination with various metal ions. Antibacterial tests demonstrated that the …
To eliminate multidrug-resistant bacteria of Acinetobacter baumannii, we screened 1100 Food and Drug Administration-approved small molecule …
36 results