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Page 1
Glutathione and glutathione derivatives in immunotherapy.
Fraternale A, Brundu S, Magnani M. Fraternale A, et al. Biol Chem. 2017 Feb 1;398(2):261-275. doi: 10.1515/hsz-2016-0202. Biol Chem. 2017. PMID: 27514076 Review.
Reduced glutathione (GSH) is the most prevalent non-protein thiol in animal cells. Its de novo and salvage synthesis serves to maintain a reduced cellular environment, which is important for several cellular functions. ...
Reduced glutathione (GSH) is the most prevalent non-protein thiol in animal cells. Its de novo and salvage synthesis serves to mainta …
Dexamethasone improves redox state in ataxia telangiectasia cells by promoting an NRF2-mediated antioxidant response.
Biagiotti S, Menotta M, Orazi S, Spapperi C, Brundu S, Fraternale A, Bianchi M, Rossi L, Chessa L, Magnani M. Biagiotti S, et al. FEBS J. 2016 Nov;283(21):3962-3978. doi: 10.1111/febs.13901. Epub 2016 Oct 12. FEBS J. 2016. PMID: 27636396 Free article.
In the present study, we have demonstrated that dexamethasone treatment of A-T lymphoblastoid cells increases the content of two of the most abundant antioxidants [glutathione (GSH) and NADPH] by up to 30%. Dexamethasone promoted the nuclear accumulation of the transcripti …
In the present study, we have demonstrated that dexamethasone treatment of A-T lymphoblastoid cells increases the content of two of the most …
Glutathione increase by the n-butanoyl glutathione derivative (GSH-C4) inhibits viral replication and induces a predominant Th1 immune profile in old mice infected with influenza virus.
Amatore D, Celestino I, Brundu S, Galluzzi L, Coluccio P, Checconi P, Magnani M, Palamara AT, Fraternale A, Nencioni L. Amatore D, et al. FASEB Bioadv. 2019 Mar 13;1(5):296-305. doi: 10.1096/fba.2018-00066. eCollection 2019 May. FASEB Bioadv. 2019. PMID: 32123833 Free PMC article.
During aging, glutathione (GSH) content declines and the immune system undergoes a deficiency in the induction of Th1 response. ...
During aging, glutathione (GSH) content declines and the immune system undergoes a deficiency in the induction of Th1 response. ...
Glutathione Depletion Is Linked with Th2 Polarization in Mice with a Retrovirus-Induced Immunodeficiency Syndrome, Murine AIDS: Role of Proglutathione Molecules as Immunotherapeutics.
Brundu S, Palma L, Picceri GG, Ligi D, Orlandi C, Galluzzi L, Chiarantini L, Casabianca A, Schiavano GF, Santi M, Mannello F, Green K, Smietana M, Magnani M, Fraternale A. Brundu S, et al. J Virol. 2016 Jul 27;90(16):7118-7130. doi: 10.1128/JVI.00603-16. Print 2016 Aug 15. J Virol. 2016. PMID: 27226373 Free PMC article.
To establish whether the disease is characterized by glutathione imbalance, reduced glutathione (GSH) and cysteine were quantified in different organs. ...
To establish whether the disease is characterized by glutathione imbalance, reduced glutathione (GSH) and cysteine were quanti …
Validation of a Reversed-Phase High Performance Liquid Chromatography Method for the Simultaneous Analysis of Cysteine and Reduced Glutathione in Mouse Organs.
Brundu S, Nencioni L, Celestino I, Coluccio P, Palamara AT, Magnani M, Fraternale A. Brundu S, et al. Oxid Med Cell Longev. 2016;2016:1746985. doi: 10.1155/2016/1746985. Epub 2016 Jan 17. Oxid Med Cell Longev. 2016. PMID: 26885246 Free PMC article.
A depletion of reduced glutathione (GSH) has been observed in pathological conditions and in aging. Measuring GSH in tissues using mouse models is an excellent way to assess GSH depletion and the potential therapeutic efficacy of drugs used to maintain and/or restore cellu …
A depletion of reduced glutathione (GSH) has been observed in pathological conditions and in aging. Measuring GSH in tissues using mo …