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Page 1
On the Core Prescriptions and Their Mechanisms of Traditional Chinese Medicine in Hepatitis B, Liver Cirrhosis, and Liver Cancer Treatment.
Wang Z, Zhang Y, Zhang Q, Ao Q, Luo C, Wang B, Bai C, Ge X, Wang Y, Wang J, Qian Y, Yu H, Gu X. Wang Z, et al. J Oncol. 2022 Sep 23;2022:5300523. doi: 10.1155/2022/5300523. eCollection 2022. J Oncol. 2022. PMID: 36193202 Free PMC article.
This study aims to identify the core TCM herbs in the treatment of hepatitis B, liver cirrhosis, and liver cancer so as to clarify the mechanism of action of the core herb networks. METHODS: There were 1,673 prescriptions for chronic liver diseases col …
This study aims to identify the core TCM herbs in the treatment of hepatitis B, liver cirrhosis, and liver cancer so as …
Triterpenoid saponins from Bupleurum marginatum and their anti-liver fibrotic activities.
Luo K, Dai RJ, Zeng YB, Chang WJ, Deng YL, Lv F. Luo K, et al. J Asian Nat Prod Res. 2024 Jul;26(7):858-864. doi: 10.1080/10286020.2024.2336150. Epub 2024 Apr 4. J Asian Nat Prod Res. 2024. PMID: 38572987
A new triterpenoid saponin (1), along with five known compounds (2-6), was isolated from Bupleurum marginatum Wall. ex DC, of which compounds 2-4 were obtained for the first time from this plant. The structures were confirmed by the analysis of 1D, 2D NMR, and HR-ESIMS dat …
A new triterpenoid saponin (1), along with five known compounds (2-6), was isolated from Bupleurum marginatum Wall. ex DC, of which c …
An optimized herbal combination for the treatment of liver fibrosis: Hub genes, bioactive ingredients, and molecular mechanisms.
Zhao Q, Bai J, Chen Y, Liu X, Zhao S, Ling G, Jia S, Zhai F, Xiang R. Zhao Q, et al. J Ethnopharmacol. 2022 Oct 28;297:115567. doi: 10.1016/j.jep.2022.115567. Epub 2022 Jul 20. J Ethnopharmacol. 2022. PMID: 35870684 Review.
ETHNOPHARMACOLOGICAL RELEVANCE: Liver fibrosis is a chronic liver disease that can lead to cirrhosis, liver failure, and hepatocellular carcinoma, and it is associated with long-term adverse outcomes and mortality. ...Bunge; Astragalus/Huangqi), and Ra …
ETHNOPHARMACOLOGICAL RELEVANCE: Liver fibrosis is a chronic liver disease that can lead to cirrhosis, liver fail …
A comprehensive review of bupleuri radix and its bioactive components: with a major focus on treating chronic liver diseases.
Zhong Y, Li J, Zhu X, Huang N, Liu R, Sun R. Zhong Y, et al. J Ethnopharmacol. 2024 Aug 10;330:118244. doi: 10.1016/j.jep.2024.118244. Epub 2024 Apr 23. J Ethnopharmacol. 2024. PMID: 38663781
Hepatitis, steatohepatitis, cirrhosis, and liver cancer are among the prevalent and impactful liver diseases worldwide. ...RESULTS: BR and its classical prescriptions, such as Xiao Chai Hu decoction, Da Chai Hu decoction, Si Ni San, and Chai Hu Shu Gan San, h …
Hepatitis, steatohepatitis, cirrhosis, and liver cancer are among the prevalent and impactful liver diseases worldwide. …
Protective effect of saikosaponin-d isolated from Bupleurum falcatum L. on CCl4-induced liver injury in the rat.
Abe H, Sakaguchi M, Odashima S, Arichi S. Abe H, et al. Naunyn Schmiedebergs Arch Pharmacol. 1982 Sep;320(3):266-71. doi: 10.1007/BF00510139. Naunyn Schmiedebergs Arch Pharmacol. 1982. PMID: 7133157
The effects of saikosaponin-d extracted from the roots of Bupleurum falcatum L. on carbon tetrachloride-induced hepatic injury were studied in rats. ...A significant inhibition of lipid peroxidation induced by an acute dose of CCl4 in the liver of rats pre-treated w …
The effects of saikosaponin-d extracted from the roots of Bupleurum falcatum L. on carbon tetrachloride-induced hepatic injury were s …
Reparative and toxicity-reducing effects of liposome-encapsulated saikosaponin in mice with liver fibrosis.
Shiu LY, Huang HH, Chen CY, Cheng HY, Chen CI, Kuo SM. Shiu LY, et al. Biosci Rep. 2020 Aug 28;40(8):BSR20201219. doi: 10.1042/BSR20201219. Biosci Rep. 2020. PMID: 32756863 Free PMC article.
Saikosaponin d (SSd), a primary active component of the Chinese herb Bupleurum falcatum, has antitumor and antiliver fibrosis effects. However, the toxicity of SSd at high doses can induce conditions such as metabolic disorders and hemolysis in vivo, thus hampering its cli …
Saikosaponin d (SSd), a primary active component of the Chinese herb Bupleurum falcatum, has antitumor and antiliver fibrosis effects …
Hepatoprotective Effects of Traditional Chinese Medicine on Liver Fibrosis from Ethanol Administration following Partial Hepatectomy.
Wu JP, Ho TJ, Tsai CC, Yeh YL, Lin CC, Lin KH, Hsieh DJ, Chen LM, Pan LF, Huang CY. Wu JP, et al. Chin J Physiol. 2015 Dec 31;58(6):393-403. doi: 10.4077/CJP.2015.BAD339. Chin J Physiol. 2015. PMID: 26717918
CP induced TIMP-1, TIMP-2 and TIMP-3 mRNA increases in fibrotic rats. We detected liver regeneration in fibrotic rats. We also found that the liver regeneration index increased from 6 to 168 h post PHx. ...TCMs play a crucial role in the early mediating process in f …
CP induced TIMP-1, TIMP-2 and TIMP-3 mRNA increases in fibrotic rats. We detected liver regeneration in fibrotic rats. We also found …
Protective effects of kaerophyllin against liver fibrogenesis in rats.
Lee TF, Lin YL, Huang YT. Lee TF, et al. Eur J Clin Invest. 2012 Jun;42(6):607-16. doi: 10.1111/j.1365-2362.2011.02625.x. Epub 2011 Nov 22. Eur J Clin Invest. 2012. PMID: 22103576
This current study evaluated the in vivo role of kaerophyllin in protecting the liver against injury and fibrogenesis caused by thioacetamide (TAA) in rats and further explored the underlying mechanisms. MATERIALS AND METHODS: Liver fibrosis in Sprague-Dawley rats w …
This current study evaluated the in vivo role of kaerophyllin in protecting the liver against injury and fibrogenesis caused by thioa …
Saikosaponin A of Bupleurum chinense (Chaihu) elevates bone morphogenetic protein 4 (BMP-4) during hepatic stellate cell activation.
Wang X, Wang Q, Burczynski FJ, Kong W, Gong Y. Wang X, et al. Phytomedicine. 2013 Nov 15;20(14):1330-5. doi: 10.1016/j.phymed.2013.07.010. Epub 2013 Aug 19. Phytomedicine. 2013. PMID: 23969230
BACKGROUND: Saikosaponin a (SSa) is a compound extracted from a Chinese herb which has been widely used in treating liver diseases such as liver fibrosis. However, the mechanism of SSa in treatment of liver fibrosis still remain unclear. ...Therefore, SSa cou …
BACKGROUND: Saikosaponin a (SSa) is a compound extracted from a Chinese herb which has been widely used in treating liver diseases su …
The hepatoprotective effect of Bupleurum kaoi, an endemic plant to Taiwan, against dimethylnitrosamine-induced hepatic fibrosis in rats.
Yen MH, Weng TC, Liu SY, Chai CY, Lin CC. Yen MH, et al. Biol Pharm Bull. 2005 Mar;28(3):442-8. doi: 10.1248/bpb.28.442. Biol Pharm Bull. 2005. PMID: 15744066 Free article.
In addition, treated with groups of BKW, BKP, BKS markedly raised TP levels in rats serum and liver homogenates. Furthermore, treated with groups of BKW, BKP markedly raised albumin levels in rats serum and liver homogenates. ...Otherwise, treated with groups of BKW …
In addition, treated with groups of BKW, BKP, BKS markedly raised TP levels in rats serum and liver homogenates. Furthermore, treated …
16 results