Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1977 2
1978 2
1979 3
1980 3
1981 8
1982 8
1983 10
1984 8
1985 6
1986 11
1987 17
1988 13
1989 7
1990 9
1991 7
1992 17
1993 22
1994 22
1995 12
1996 19
1997 21
1998 18
1999 12
2000 13
2001 14
2002 17
2003 22
2004 22
2005 34
2006 32
2007 34
2008 39
2009 28
2010 39
2011 53
2012 66
2013 78
2014 65
2015 68
2016 58
2017 55
2018 51
2019 49
2020 46
2021 56
2022 56
2023 62
2024 54
2025 57
2026 13

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

1,272 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Buprenorphine: clinical pharmacokinetics in the treatment of opioid dependence.
Elkader A, Sproule B. Elkader A, et al. Clin Pharmacokinet. 2005;44(7):661-80. doi: 10.2165/00003088-200544070-00001. Clin Pharmacokinet. 2005. PMID: 15966752 Review.
Most of a dose of buprenorphine is eliminated in the faeces, with approximately 10-30% excreted in urine. Naloxone has been added to a sublingual formulation of buprenorphine to reduce the abuse liability of the product. The presence of naloxone does not appear to i …
Most of a dose of buprenorphine is eliminated in the faeces, with approximately 10-30% excreted in urine. Naloxone has been added to …
Buprenorphine for managing opioid withdrawal.
Gowing L, Ali R, White JM, Mbewe D. Gowing L, et al. Cochrane Database Syst Rev. 2017 Feb 21;2(2):CD002025. doi: 10.1002/14651858.CD002025.pub5. Cochrane Database Syst Rev. 2017. PMID: 28220474 Free PMC article.
The main comparators were clonidine or lofexidine (14 studies). Six studies compared buprenorphine versus methadone, and seven compared different rates of buprenorphine dose reduction. We assessed 12 studies as being at high risk of bias in at least one of seven dom …
The main comparators were clonidine or lofexidine (14 studies). Six studies compared buprenorphine versus methadone, and seven compar …
Buprenorphine-naloxone use in pregnancy: a systematic review and metaanalysis.
Link HM, Jones H, Miller L, Kaltenbach K, Seligman N. Link HM, et al. Am J Obstet Gynecol MFM. 2020 Aug;2(3):100179. doi: 10.1016/j.ajogmf.2020.100179. Epub 2020 Jul 3. Am J Obstet Gynecol MFM. 2020. PMID: 33345863
Of the 1875 mother-baby dyads available for analysis, medications prescribed as part of the medication-assisted treatment included buprenorphine-naloxone, buprenorphine alone, methadone, or long-acting opioids. There were no serious adverse maternal or neonatal outc …
Of the 1875 mother-baby dyads available for analysis, medications prescribed as part of the medication-assisted treatment included bupren …
Buprenorphine for treating cancer pain.
Schmidt-Hansen M, Bromham N, Taubert M, Arnold S, Hilgart JS. Schmidt-Hansen M, et al. Cochrane Database Syst Rev. 2015 Mar 31;2015(3):CD009596. doi: 10.1002/14651858.CD009596.pub4. Cochrane Database Syst Rev. 2015. PMID: 25826743 Free PMC article.
SELECTION CRITERIA: We included randomised controlled trials, with parallel-group or crossover design, comparing buprenorphine (any formulation and any route of administration) with placebo or an active drug (including buprenorphine) for cancer background pain in ad …
SELECTION CRITERIA: We included randomised controlled trials, with parallel-group or crossover design, comparing buprenorphine (any f …
Is Buprenorphine Effective for Chronic Pain? A Systematic Review and Meta-analysis.
Lazaridou A, Paschali M, Edwards RR, Gilligan C. Lazaridou A, et al. Pain Med. 2020 Dec 25;21(12):3691-3699. doi: 10.1093/pm/pnaa089. Pain Med. 2020. PMID: 32330264
OBJECTIVE: The objective was to perform a systematic review and meta-analysis of the literature on the effects of buprenorphine on chronic pain outcomes (i.e., patient-reported pain intensity) in patients with and without opioid use disorder (OUD). ...METHODS: Two separate …
OBJECTIVE: The objective was to perform a systematic review and meta-analysis of the literature on the effects of buprenorphine on ch …
The efficacy and safety of buprenorphine for the treatment of depression: A systematic review and meta-analysis.
Riblet NB, Young-Xu Y, Shiner B, Schnurr PP, Watts BV. Riblet NB, et al. J Psychiatr Res. 2023 May;161:393-401. doi: 10.1016/j.jpsychires.2023.03.037. Epub 2023 Mar 30. J Psychiatr Res. 2023. PMID: 37019069 Free PMC article.
METHODS: A meta-analysis comparing the efficacy, tolerability, and safety of buprenorphine (or combinations such as buprenorphine/samidorphan) versus control in improving symptoms in patients with depression. ...Most studies found buprenorphine was well-toler …
METHODS: A meta-analysis comparing the efficacy, tolerability, and safety of buprenorphine (or combinations such as buprenorphine …
Buprenorphine-naloxone versus buprenorphine for opioid use disorder during pregnancy: A systematic review and meta-analysis.
de Lima FR, Molino GOG, Gallo Ruelas M, Barbosa EC, Silva PHCMD, Guimarães FBM, Petrucci ABC, Silva GHSD, Sbardelotto ÂEE, Lança SB, Garbacka A. de Lima FR, et al. Drug Alcohol Depend. 2025 Jun 1;271:112632. doi: 10.1016/j.drugalcdep.2025.112632. Epub 2025 Feb 28. Drug Alcohol Depend. 2025. PMID: 40073807
This systematic review and meta-analysis aims to compare buprenorphine-naloxone vs buprenorphine alone for OUD during pregnancy, assessing gestational and neonatal outcomes. METHODS: We systematically searched MEDLINE, Embase, and Cochrane Library databases to ident …
This systematic review and meta-analysis aims to compare buprenorphine-naloxone vs buprenorphine alone for OUD during pregnanc …
Buprenorphine for the management of opioid withdrawal.
Gowing L, Ali R, White J. Gowing L, et al. Cochrane Database Syst Rev. 2006 Apr 19;(2):CD002025. doi: 10.1002/14651858.CD002025.pub3. Cochrane Database Syst Rev. 2006. Update in: Cochrane Database Syst Rev. 2009 Jul 08;(3):CD002025. doi: 10.1002/14651858.CD002025.pub4. PMID: 16625553 Updated.
MAIN RESULTS: Eighteen studies (14 randomised controlled trials), involving 1356 participants, were included. Ten studies compared buprenorphine with clonidine; four compared buprenorphine with methadone; one compared buprenorphine with oxazepam; three compar …
MAIN RESULTS: Eighteen studies (14 randomised controlled trials), involving 1356 participants, were included. Ten studies compared bupren …
Buprenorphine for the management of opioid withdrawal.
Gowing L, Ali R, White J. Gowing L, et al. Cochrane Database Syst Rev. 2004 Oct 18;(4):CD002025. doi: 10.1002/14651858.CD002025.pub2. Cochrane Database Syst Rev. 2004. Update in: Cochrane Database Syst Rev. 2006 Apr 19;(2):CD002025. doi: 10.1002/14651858.CD002025.pub3. PMID: 15495026 Updated.
MAIN RESULTS: Thirteen studies (10 RCTs), involving 744 participants, met the criteria for inclusion in the review. Seven studies compared buprenorphine with clonidine; 3 compared buprenorphine with methadone; 1 compared buprenorphine with oxazepam; 2 compare …
MAIN RESULTS: Thirteen studies (10 RCTs), involving 744 participants, met the criteria for inclusion in the review. Seven studies compared …
Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence.
Mattick RP, Breen C, Kimber J, Davoli M. Mattick RP, et al. Cochrane Database Syst Rev. 2014 Feb 6;2014(2):CD002207. doi: 10.1002/14651858.CD002207.pub4. Cochrane Database Syst Rev. 2014. PMID: 24500948 Free PMC article.
SELECTION CRITERIA: Randomised controlled trials of buprenorphine maintenance treatment versus placebo or methadone in management of opioid-dependent persons. ...Methadone is superior to buprenorphine in retaining people in treatment, and methadone equally suppresse …
SELECTION CRITERIA: Randomised controlled trials of buprenorphine maintenance treatment versus placebo or methadone in management of …
1,272 results