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53 results

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Page 1
Role of NR3C1 and SLC6A4 methylation in the HPA axis regulation in burnout.
Bakusic J, Ghosh M, Polli A, Bekaert B, Schaufeli W, Claes S, Godderis L. Bakusic J, et al. J Affect Disord. 2021 Dec 1;295:505-512. doi: 10.1016/j.jad.2021.08.081. Epub 2021 Aug 31. J Affect Disord. 2021. PMID: 34509065 Free article.
BACKGROUND: Work-related stress and burnout have become major occupational health concerns. Dysregulation of HPA axis is considered one of the central mechanisms and is potentially moderated through epigenetics. In the present study, we aim to investigate epi …
BACKGROUND: Work-related stress and burnout have become major occupational health concerns. Dysregulation of HPA axis i …
Exposure to the Indian Ocean Tsunami shapes the HPA-axis resulting in HPA "burnout" 14 years later.
Lawton R, Frankenberg E, Seeman T, Crimmins E, Sumantri C, Thomas D. Lawton R, et al. Proc Natl Acad Sci U S A. 2023 Oct 31;120(44):e2306497120. doi: 10.1073/pnas.2306497120. Epub 2023 Oct 16. Proc Natl Acad Sci U S A. 2023. PMID: 37844215 Free PMC article.
Despite significant research on the effects of stress on the hypothalamic-pituitary-adrenal (HPA) axis, questions remain regarding long-term impacts of large-scale stressors. Leveraging data on exposure to an unanticipated major natural disaster, the 2004 Indian Oce …
Despite significant research on the effects of stress on the hypothalamic-pituitary-adrenal (HPA) axis, questions remain regar …
Cortisol Reactivity to Acute Psychosocial Stress in Physician Burnout.
Zuccarella-Hackl C, Princip M, Holzgang SA, Sivakumar S, Kuenburg A, Pazhenkottil AP, Gomez Vieito D, von Känel R. Zuccarella-Hackl C, et al. Biomedicines. 2024 Feb 1;12(2):335. doi: 10.3390/biomedicines12020335. Biomedicines. 2024. PMID: 38397938 Free PMC article.
Salivary cortisol levels were measured before and after a Trier Social Stress Test (TSST). Burnout was assessed with the Maslach Burnout Inventory-Human Services Survey (MBI-HSS). ...This study highlights the necessity for long-term research on cortisol …
Salivary cortisol levels were measured before and after a Trier Social Stress Test (TSST). Burnout was assessed with the Masla …
Chronic stress exposure, diurnal cortisol slope, and implications for mood and fatigue: Moderation by multilocus HPA-Axis genetic variation.
Starr LR, Dienes K, Li YI, Shaw ZA. Starr LR, et al. Psychoneuroendocrinology. 2019 Feb;100:156-163. doi: 10.1016/j.psyneuen.2018.10.003. Epub 2018 Oct 6. Psychoneuroendocrinology. 2019. PMID: 30340064
The nature of the chronic stress-HPA axis dysregulation is unclear and individuals likely vary in the extent to and manner in which indices of HPA axis regulation, such as diurnal cortisol slope, are influenced by chronic stress. ...Participants …
The nature of the chronic stress-HPA axis dysregulation is unclear and individuals likely vary in the extent to and manner in …
The hypothalamo-pituitary-adrenal axis and the autonomic nervous system in burnout.
Sjörs Dahlman A, Jonsdottir IH, Hansson C. Sjörs Dahlman A, et al. Handb Clin Neurol. 2021;182:83-94. doi: 10.1016/B978-0-12-819973-2.00006-X. Handb Clin Neurol. 2021. PMID: 34266613 Review.
It has been hypothesized that the two main stress response systems, the autonomic nervous system (ANS) and the hypothalamus-pituitary-adrenal axis (HPA axis), are involved in the pathogenesis of burnout. A common hypothesis is that in the early stages …
It has been hypothesized that the two main stress response systems, the autonomic nervous system (ANS) and the hypothalamus-pituitary-adrena …
Burnout Is Associated with Reduced Parasympathetic Activity and Reduced HPA Axis Responsiveness, Predominantly in Males.
de Vente W, van Amsterdam JG, Olff M, Kamphuis JH, Emmelkamp PM. de Vente W, et al. Biomed Res Int. 2015;2015:431725. doi: 10.1155/2015/431725. Epub 2015 Oct 18. Biomed Res Int. 2015. PMID: 26557670 Free PMC article.
There is mounting evidence that burnout is a risk factor for cardiovascular disease (CVD). Stress-related dysregulation of the sympathetic and parasympathetic system and the hypothalamic pituitary adrenal (HPA) axis may explain the enhanced risk for CVD. ...T …
There is mounting evidence that burnout is a risk factor for cardiovascular disease (CVD). Stress-related dysregulation of the sympat …
The role of BDNF and HPA axis in the neurobiology of burnout syndrome.
Onen Sertoz O, Tolga Binbay I, Koylu E, Noyan A, Yildirim E, Elbi Mete H. Onen Sertoz O, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Aug 1;32(6):1459-65. doi: 10.1016/j.pnpbp.2008.05.001. Epub 2008 May 8. Prog Neuropsychopharmacol Biol Psychiatry. 2008. PMID: 18541357
Chronic stress is known to affect the HPA axis. The few clinical studies which have been conducted on HPA-axis function in burnout have produced inconsistent results. The etiological relationship between sBDNF and burnout has not yet been …
Chronic stress is known to affect the HPA axis. The few clinical studies which have been conducted on HPA-axis f …
The HPA-axis and immune function in burnout.
Mommersteeg PM, Heijnen CJ, Kavelaars A, van Doornen LJ. Mommersteeg PM, et al. Prog Brain Res. 2008;167:281-5. doi: 10.1016/S0079-6123(07)67024-1. Prog Brain Res. 2008. PMID: 18037026
Burnout results from chronic work stress. Its complaints may be related to HPA-axis disturbances or changes in immune function. In our studies the salivary cortisol awakening response, day-curve, and the suppressed level after dexamethasone intake were …
Burnout results from chronic work stress. Its complaints may be related to HPA-axis disturbances or changes in immune f …
Investigation of cross-sectional and longitudinal associations between work-related burnout and hair cortisol: The Regensburg Burnout Project.
Bärtl C, Kreuzpointner L, Wüst S, Kudielka BM. Bärtl C, et al. Psychoneuroendocrinology. 2023 Mar;149:106026. doi: 10.1016/j.psyneuen.2023.106026. Epub 2023 Jan 13. Psychoneuroendocrinology. 2023. PMID: 36657345
Previous studies on biological correlates of burnout have focused on the hypothalamic-pituitary-adrenal (HPA) axis. However, especially studies on hair cortisol concentrations (HCC) were often based on cross-sectional data and yielded inconsistent resu …
Previous studies on biological correlates of burnout have focused on the hypothalamic-pituitary-adrenal (HPA) axis. How …
The medical perspective on burnout.
Kakiashvili T, Leszek J, Rutkowski K. Kakiashvili T, et al. Int J Occup Med Environ Health. 2013 Jun;26(3):401-12. doi: 10.2478/s13382-013-0093-3. Epub 2013 Sep 10. Int J Occup Med Environ Health. 2013. PMID: 24018996 Free article.
It was also related to reduced fibrinolytic capacity, decreased capacity to cope with stress and hypothalamic-pituitary-adrenal (HPA) axis hypoactivity. Severe burnout symptoms are associated with a lower level or smaller increase of the cortisol awake …
It was also related to reduced fibrinolytic capacity, decreased capacity to cope with stress and hypothalamic-pituitary-adrenal (HPA) …
53 results