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28 results

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Page 1
Short-chain fatty acids: linking diet, the microbiome and immunity.
Mann ER, Lam YK, Uhlig HH. Mann ER, et al. Nat Rev Immunol. 2024 Aug;24(8):577-595. doi: 10.1038/s41577-024-01014-8. Epub 2024 Apr 2. Nat Rev Immunol. 2024. PMID: 38565643 Review.
Indicatively, the anti-inflammatory role of butyrate is mediated through direct effects on the differentiation of intestinal epithelial cells, phagocytes, B cells and plasma cells, and regulatory and effector T cells. Intestinally derived SCFAs also directly …
Indicatively, the anti-inflammatory role of butyrate is mediated through direct effects on the differentiation of intestinal e …
Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis.
Tajik N, Frech M, Schulz O, Schälter F, Lucas S, Azizov V, Dürholz K, Steffen F, Omata Y, Rings A, Bertog M, Rizzo A, Iljazovic A, Basic M, Kleyer A, Culemann S, Krönke G, Luo Y, Überla K, Gaipl US, Frey B, Strowig T, Sarter K, Bischoff SC, Wirtz S, Cañete JD, Ciccia F, Schett G, Zaiss MM. Tajik N, et al. Nat Commun. 2020 Apr 24;11(1):1995. doi: 10.1038/s41467-020-15831-7. Nat Commun. 2020. PMID: 32332732 Free PMC article.
Here, we identify intestinal barrier integrity as an important checkpoint in translating autoimmunity to inflammation. ...Increased serum zonulin levels are accompanied by a leaky intestinal barrier, dysbiosis and inflammation. Restoration of th …
Here, we identify intestinal barrier integrity as an important checkpoint in translating autoimmunity to inflammation. …
High fiber dietary and sodium butyrate attenuate experimental autoimmune hepatitis through regulation of immune regulatory cells and intestinal barrier.
Hu ED, Chen DZ, Wu JL, Lu FB, Chen L, Zheng MH, Li H, Huang Y, Li J, Jin XY, Gong YW, Lin Z, Wang XD, Xu LM, Chen YP. Hu ED, et al. Cell Immunol. 2018 Jun;328:24-32. doi: 10.1016/j.cellimm.2018.03.003. Epub 2018 Mar 22. Cell Immunol. 2018. PMID: 29627063
We investigated the effects of a high fiber diet and sodium butyrate on the Treg/Th17 and intestinal barrier function in an experimental autoimmune hepatitis. ...In conclusion, high fiber diet and sodium butyrate can attenuate development of …
We investigated the effects of a high fiber diet and sodium butyrate on the Treg/Th17 and intestinal barrier function i …
The Potential Role of Butyrate in the Pathogenesis and Treatment of Autoimmune Rheumatic Diseases.
Coccia C, Bonomi F, Lo Cricchio A, Russo E, Peretti S, Bandini G, Lepri G, Bartoli F, Moggi-Pignone A, Guiducci S, Del Galdo F, Furst DE, Matucci Cerinic M, Bellando-Randone S. Coccia C, et al. Biomedicines. 2024 Aug 5;12(8):1760. doi: 10.3390/biomedicines12081760. Biomedicines. 2024. PMID: 39200224 Free PMC article. Review.
Dysbiosis, an imbalance in the composition and function of the gut microbiota, is linked to systemic autoimmune diseases (SAD). Short-chain fatty acids (SCFAs), especially butyrate, produced by the gut microbiota through the fermentation of dietary fibers, play a si …
Dysbiosis, an imbalance in the composition and function of the gut microbiota, is linked to systemic autoimmune diseases (SAD). Short …
Sodium butyrate ameliorates S100/FCA-induced autoimmune hepatitis through regulation of intestinal tight junction and toll-like receptor 4 signaling pathway.
Wu JL, Zou JY, Hu ED, Chen DZ, Chen L, Lu FB, Xu LM, Zheng MH, Li H, Huang Y, Jin XY, Gong YW, Lin Z, Wang XD, Zhao MF, Chen YP. Wu JL, et al. Immunol Lett. 2017 Oct;190:169-176. doi: 10.1016/j.imlet.2017.08.005. Epub 2017 Aug 12. Immunol Lett. 2017. PMID: 28811235
BACKGROUND AND AIM: Recent investigation revealed that dysbiosis in the gut flora and disruption of permeability of intestinal barrier are possible causes for the development of autoimmune hepatitis. Supplementation of sodium butyrate has been suggeste …
BACKGROUND AND AIM: Recent investigation revealed that dysbiosis in the gut flora and disruption of permeability of intestinal bar …
Perspective: Prospects for Nutraceutical Support of Intestinal Barrier Function.
McCarty MF, Lerner A. McCarty MF, et al. Adv Nutr. 2021 Mar 31;12(2):316-324. doi: 10.1093/advances/nmaa139. Adv Nutr. 2021. PMID: 33126251 Free PMC article.
Impairment of intestinal barrier function is linked to certain pathologies and to aging, and can be a cause of bacterial infections, systemic and hepatic inflammation, food allergies, and autoimmune disorders. ...These considerations suggest that rationally d …
Impairment of intestinal barrier function is linked to certain pathologies and to aging, and can be a cause of bacterial infec …
The conspiring role of gut microbiota as primer of autoimmune thyroid diseases: A scoping focus.
Sessa L, Malavolta E, Sodero G, Cipolla C, Rigante D. Sessa L, et al. Autoimmun Rev. 2025 Apr 30;24(5):103780. doi: 10.1016/j.autrev.2025.103780. Epub 2025 Feb 17. Autoimmun Rev. 2025. PMID: 39971108 Free article.
The thyroid gland is the body's largest single organ specialized for endocrine hormone production, and still unraveled mechanisms regulate its interaction between the hypothalamic-pituitary-thyroid axis and composition of the gut microbiota: in particular, a disrupted integrity o …
The thyroid gland is the body's largest single organ specialized for endocrine hormone production, and still unraveled mechanisms regulate i …
Tinosporine alleviates collagen-induced arthritis in rats via modulating the gut microbiota-metabolome-immunity axis.
Liu C, Yi X, Wang P, Wang P, Li Y, Xu H, Li L, Yang W, Tu Y. Liu C, et al. Int Immunopharmacol. 2025 Jun 5;157:114752. doi: 10.1016/j.intimp.2025.114752. Epub 2025 Apr 28. Int Immunopharmacol. 2025. PMID: 40300353
Histopathology showed that TIN protected the intestinal barrier, then use ELISA and flow cytometry to analyze the mechanism of TIN, and qRT-PCR and WB were employed for verification. ...CONCLUSION: TIN inhibited the inflammatory response of CIA rats by regulating th …
Histopathology showed that TIN protected the intestinal barrier, then use ELISA and flow cytometry to analyze the mechanism of …
Immunomodulatory properties of the gut microbiome: diagnostic and therapeutic potential for rheumatoid arthritis.
Abebaw D, Akelew Y, Adugna A, Tegegne BA, Teffera ZH, Belayneh M, Fenta A, Selabat B, Kindie Y, Baylie T, Mekuriaw MG, Jemal M, Atnaf A. Abebaw D, et al. Clin Exp Med. 2025 Jul 1;25(1):226. doi: 10.1007/s10238-025-01777-x. Clin Exp Med. 2025. PMID: 40591032 Free PMC article. Review.
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by persistent joint inflammation, synovial hyperplasia, and progressive joint destruction. ...RA patients exhibit altered metabolite profiles, with reduced levels of short-chain fatty acids (SCFAs), s …
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by persistent joint inflammation, synovial hyperplasia, and …
Jingfang Granules alleviates the lipid peroxidation induced ferroptosis in rheumatoid arthritis rats by regulating gut microbiota and metabolism of short chain fatty acids.
Wang X, Pan L, Niu D, Zhou J, Shen M, Zeng Z, Gong W, Yang E, Tang Y, Cheng G, Sun C. Wang X, et al. J Ethnopharmacol. 2025 Jan 13;339:119160. doi: 10.1016/j.jep.2024.119160. Epub 2024 Nov 26. J Ethnopharmacol. 2025. PMID: 39608616
Serum D-Lactic acid, lipopolysaccharide specific IgA antibody (LPS IgA), diamine oxidase (DAO), and colon Claudin 5 and ZO-1 were used to evaluate the intestinal barrier. RESULTS: The results confirmed that JFG effectively protected rats from RA injury, which was co …
Serum D-Lactic acid, lipopolysaccharide specific IgA antibody (LPS IgA), diamine oxidase (DAO), and colon Claudin 5 and ZO-1 were used to ev …
28 results