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Hyaluronic Acid-Conjugated Nanoparticles for the Targeted Delivery of Cabazitaxel to CD44-Overexpressing Glioblastoma Cells.
Chen C, Fan R, Wang Y, Wang L, Huang C, Zhou L, Xu J, Chen H, Guo G. Chen C, et al. J Biomed Nanotechnol. 2021 Apr 1;17(4):595-605. doi: 10.1166/jbn.2021.3050. J Biomed Nanotechnol. 2021. PMID: 35057886
In decades, the efficiency of glioma therapy is far from satisfaction due to the inability of most therapeutics to accumulate at the glioblastoma (GBM) site. Therefore, it is urgent to develop novel tumor-targeted delivery systems for more optimized and effective glioma tr …
In decades, the efficiency of glioma therapy is far from satisfaction due to the inability of most therapeutics to accumulate at the glio
Therapeutic Effect of Cabazitaxel and Blood-Brain Barrier opening in a Patient-Derived Glioblastoma Model.
Sulheim E, Mørch Y, Snipstad S, Borgos SE, Miletic H, Bjerkvig R, Davies CL, Åslund AKO. Sulheim E, et al. Nanotheranostics. 2019 Feb 7;3(1):103-112. doi: 10.7150/ntno.31479. eCollection 2019. Nanotheranostics. 2019. PMID: 30899638 Free PMC article.
Treatment of glioblastoma and other diseases in the brain is especially challenging due to the blood-brain barrier, which effectively protects the brain parenchyma. In this study we show for the first time that cabazitaxel, a semi-synthetic derivative of docetaxel c …
Treatment of glioblastoma and other diseases in the brain is especially challenging due to the blood-brain barrier, which effectively …
Cabazitaxel inhibits proliferation and potentiates the radiation response of U87MG glioblastoma cells.
Neshasteh-Riz A, Zeinizade E, Safa M, Mousavizadeh K. Neshasteh-Riz A, et al. Cell Biol Int. 2018 Jul;42(7):815-822. doi: 10.1002/cbin.10940. Epub 2018 Feb 14. Cell Biol Int. 2018. PMID: 29369439
Cabazitaxel is a second-generation semisynthetic taxane. The recognized anti-neoplastic effect of Cabazitaxel is cell cycle perturbation by inducing arrest at G2/M. ...Cabazitaxel enhanced the cytotoxicity response of U87MG cells to radiation. ...
Cabazitaxel is a second-generation semisynthetic taxane. The recognized anti-neoplastic effect of Cabazitaxel is cell cycle pe
All-stage targeted therapy for glioblastoma based on lipid membrane coated cabazitaxel nanocrystals.
Wu S, Lu L, Zhou J, Ran D, Wang S, Xu Q, Xu W, Wang J, Liu Y, Xie C, Luo Z, Lu W. Wu S, et al. J Control Release. 2022 May;345:685-695. doi: 10.1016/j.jconrel.2022.03.047. Epub 2022 Mar 26. J Control Release. 2022. PMID: 35346767
Glioblastoma (GBM) is the most aggressive brain tumor with poor prognosis and frequent recurrence. ...Besides, p-hydroxybenzoic acid (pHA) can effectively traverse the BBB. Herein we developed an all-stage glioma-targeted cabazitaxel (CBZ) nanocrystal loaded liposom
Glioblastoma (GBM) is the most aggressive brain tumor with poor prognosis and frequent recurrence. ...Besides, p-hydroxybenzoic acid
Can taxanes provide benefit in patients with CNS tumors and in pediatric patients with tumors? An update on the preclinical development of cabazitaxel.
Sémiond D, Sidhu SS, Bissery MC, Vrignaud P. Sémiond D, et al. Cancer Chemother Pharmacol. 2013 Sep;72(3):515-28. doi: 10.1007/s00280-013-2214-x. Epub 2013 Jul 3. Cancer Chemother Pharmacol. 2013. PMID: 23820961
METHODS: Cabazitaxel brain distribution was assessed in mice, rats and dogs. ...In intracranial human glioblastoma models, cabazitaxel demonstrated superior activity to docetaxel both at early (before BBB disruption) and at advanced stages, consistent with en …
METHODS: Cabazitaxel brain distribution was assessed in mice, rats and dogs. ...In intracranial human glioblastoma models, …
Dendrimer-Functionalized Nanodiamonds as Safe and Efficient Drug Carriers for Cancer Therapy: Nucleus Penetrating Nanoparticles.
Patil S, Mishra VS, Yadav N, Reddy PC, Lochab B. Patil S, et al. ACS Appl Bio Mater. 2022 Jul 18;5(7):3438-3451. doi: 10.1021/acsabm.2c00373. Epub 2022 Jun 27. ACS Appl Bio Mater. 2022. PMID: 35754387
Unlike ND-COOH, the chemically modified nanodiamond platform NP revealed a pH-independent aqueous dispersion stability, enhancing its potential as an effective carrier. Physical encapsulation of poorly water soluble cabazitaxel (CTX) drug on NP formed ND-PAMAM-CTX (NPC) na …
Unlike ND-COOH, the chemically modified nanodiamond platform NP revealed a pH-independent aqueous dispersion stability, enhancing its potent …