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Cabazitaxel inhibits proliferation and potentiates the radiation response of U87MG glioblastoma cells.
Neshasteh-Riz A, Zeinizade E, Safa M, Mousavizadeh K. Neshasteh-Riz A, et al. Cell Biol Int. 2018 Jul;42(7):815-822. doi: 10.1002/cbin.10940. Epub 2018 Feb 14. Cell Biol Int. 2018. PMID: 29369439
Cabazitaxel is a second-generation semisynthetic taxane. The recognized anti-neoplastic effect of Cabazitaxel is cell cycle perturbation by inducing arrest at G2/M. ...Cabazitaxel enhanced the cytotoxicity response of U87MG cells to radiation. ...
Cabazitaxel is a second-generation semisynthetic taxane. The recognized anti-neoplastic effect of Cabazitaxel is cell cycle pe
Therapeutic Effect of Cabazitaxel and Blood-Brain Barrier opening in a Patient-Derived Glioblastoma Model.
Sulheim E, Mørch Y, Snipstad S, Borgos SE, Miletic H, Bjerkvig R, Davies CL, Åslund AKO. Sulheim E, et al. Nanotheranostics. 2019 Feb 7;3(1):103-112. doi: 10.7150/ntno.31479. eCollection 2019. Nanotheranostics. 2019. PMID: 30899638 Free PMC article.
Treatment of glioblastoma and other diseases in the brain is especially challenging due to the blood-brain barrier, which effectively protects the brain parenchyma. In this study we show for the first time that cabazitaxel, a semi-synthetic derivative of docetaxel c …
Treatment of glioblastoma and other diseases in the brain is especially challenging due to the blood-brain barrier, which effectively …
Can taxanes provide benefit in patients with CNS tumors and in pediatric patients with tumors? An update on the preclinical development of cabazitaxel.
Sémiond D, Sidhu SS, Bissery MC, Vrignaud P. Sémiond D, et al. Cancer Chemother Pharmacol. 2013 Sep;72(3):515-28. doi: 10.1007/s00280-013-2214-x. Epub 2013 Jul 3. Cancer Chemother Pharmacol. 2013. PMID: 23820961
METHODS: Cabazitaxel brain distribution was assessed in mice, rats and dogs. ...In intracranial human glioblastoma models, cabazitaxel demonstrated superior activity to docetaxel both at early (before BBB disruption) and at advanced stages, consistent with en …
METHODS: Cabazitaxel brain distribution was assessed in mice, rats and dogs. ...In intracranial human glioblastoma models, …