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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1851 1
1860 1
1861 1
1868 1
1873 1
1881 1
1885 3
1886 1
1888 1
1889 1
1890 1
1891 1
1894 2
1895 1
1907 1
1910 2
1911 1
1912 2
1913 1
1917 1
1918 1
1920 1
1923 1
1924 1
1925 2
1926 1
1928 1
1930 1
1931 1
1939 1
1941 1
1943 1
1944 1
1945 13
1946 20
1947 13
1948 13
1949 17
1950 22
1951 35
1952 39
1953 66
1954 64
1955 45
1956 52
1957 57
1958 38
1959 48
1960 42
1961 41
1962 74
1963 123
1964 177
1965 125
1966 122
1967 169
1968 211
1969 238
1970 279
1971 269
1972 301
1973 310
1974 329
1975 339
1976 341
1977 292
1978 296
1979 312
1980 321
1981 335
1982 370
1983 391
1984 486
1985 495
1986 527
1987 500
1988 523
1989 616
1990 623
1991 643
1992 645
1993 608
1994 681
1995 665
1996 679
1997 677
1998 657
1999 711
2000 762
2001 752
2002 760
2003 736
2004 784
2005 824
2006 907
2007 875
2008 884
2009 869
2010 974
2011 992
2012 1080
2013 1142
2014 1217
2015 1220
2016 1293
2017 1262
2018 1402
2019 1400
2020 1452
2021 1536
2022 1538
2023 1488
2024 1579
2025 1654
2026 535

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42,315 results

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Page 1
Caffeine: cognitive and physical performance enhancer or psychoactive drug?
Cappelletti S, Piacentino D, Sani G, Aromatario M. Cappelletti S, et al. Curr Neuropharmacol. 2015 Jan;13(1):71-88. doi: 10.2174/1570159X13666141210215655. Curr Neuropharmacol. 2015. PMID: 26074744 Free PMC article. Review.
The present review summarizes the main findings concerning caffeine's mechanisms of action (focusing on adenosine antagonism, intracellular calcium mobilization, and phosphodiesterases inhibition), use, abuse, dependence, intoxication, and lethal effects. It also su …
The present review summarizes the main findings concerning caffeine's mechanisms of action (focusing on adenosine antagonism, …
Common questions and misconceptions about caffeine supplementation: what does the scientific evidence really show?
Antonio J, Newmire DE, Stout JR, Antonio B, Gibbons M, Lowery LM, Harper J, Willoughby D, Evans C, Anderson D, Goldstein E, Rojas J, Monsalves-Álvarez M, Forbes SC, Gomez Lopez J, Ziegenfuss T, Moulding BD, Candow D, Sagner M, Arent SM. Antonio J, et al. J Int Soc Sports Nutr. 2024 Dec;21(1):2323919. doi: 10.1080/15502783.2024.2323919. Epub 2024 Mar 11. J Int Soc Sports Nutr. 2024. PMID: 38466174 Free PMC article. Review.
7. Can too much caffeine kill you? 8. Are there sex differences regarding caffeine's effects? 9. Does caffeine work for everyone? 10. Does caffeine cause heart problems? 11. Does caffeine promote the loss of bone mineral? 12. Should pregn …
7. Can too much caffeine kill you? 8. Are there sex differences regarding caffeine's effects? 9. Does caffeine w …
A review of caffeine's effects on cognitive, physical and occupational performance.
McLellan TM, Caldwell JA, Lieberman HR. McLellan TM, et al. Neurosci Biobehav Rev. 2016 Dec;71:294-312. doi: 10.1016/j.neubiorev.2016.09.001. Epub 2016 Sep 6. Neurosci Biobehav Rev. 2016. PMID: 27612937 Free article. Review.
Caffeine is consumed by over 80% of U.S. adults. This review examines the effects caffeine has on cognitive and physical function, since most real-world activities require complex decision making, motor processing and movement. Caffeine exerts its effects by …
Caffeine is consumed by over 80% of U.S. adults. This review examines the effects caffeine has on cognitive and physical funct …
Caffeine, coffee, and appetite control: a review.
Schubert MM, Irwin C, Seay RF, Clarke HE, Allegro D, Desbrow B. Schubert MM, et al. Int J Food Sci Nutr. 2017 Dec;68(8):901-912. doi: 10.1080/09637486.2017.1320537. Epub 2017 Apr 27. Int J Food Sci Nutr. 2017. PMID: 28446037 Review.
The purpose of this review was to examine the evidence regarding coffee and caffeine's influence on energy intake and appetite control. The literature was examined for studies that assessed the effects of caffeine and coffee on energy intake, gastric emptying …
The purpose of this review was to examine the evidence regarding coffee and caffeine's influence on energy intake and appetite …
Caffeine's mechanisms of action and its cosmetic use.
Herman A, Herman AP. Herman A, et al. Skin Pharmacol Physiol. 2013;26(1):8-14. doi: 10.1159/000343174. Epub 2012 Oct 11. Skin Pharmacol Physiol. 2013. PMID: 23075568 Review.
Caffeine is being increasingly used in cosmetics due to its high biological activity and ability to penetrate the skin barrier. ...The commercially available topical formulations of caffeine normally contain 3% caffeine. As for a cosmetic purpose, caffeine …
Caffeine is being increasingly used in cosmetics due to its high biological activity and ability to penetrate the skin barrier. ...Th …
Caffeine and Exercise: What Next?
Pickering C, Grgic J. Pickering C, et al. Sports Med. 2019 Jul;49(7):1007-1030. doi: 10.1007/s40279-019-01101-0. Sports Med. 2019. PMID: 30977054 Free PMC article. Review.
In recent years, a number of meta-analyses have demonstrated that caffeine's ergogenic effects on exercise performance are well-established and well-replicated, appearing consistent across a broad range of exercise modalities. ...We propose that future research shou …
In recent years, a number of meta-analyses have demonstrated that caffeine's ergogenic effects on exercise performance are wel …
Coffee and mental disorders: How caffeine affects anxiety and depression.
Meamar M, Raise-Abdullahi P, Rashidy-Pour A, Raeis-Abdollahi E. Meamar M, et al. Prog Brain Res. 2024;288:115-132. doi: 10.1016/bs.pbr.2024.06.015. Epub 2024 Jul 8. Prog Brain Res. 2024. PMID: 39168554 Review.
Individual variations in caffeine metabolism, sensitivity, and genetic factors considerably impact responses to caffeine. The chapter also explores the therapeutic potential of caffeine as an adjunct treatment and outlines challenges and future research direc …
Individual variations in caffeine metabolism, sensitivity, and genetic factors considerably impact responses to caffeine. The …
Impacts of Caffeine during Pregnancy.
Qian J, Chen Q, Ward SM, Duan E, Zhang Y. Qian J, et al. Trends Endocrinol Metab. 2020 Mar;31(3):218-227. doi: 10.1016/j.tem.2019.11.004. Epub 2019 Dec 6. Trends Endocrinol Metab. 2020. PMID: 31818639 Free PMC article. Review.
Epidemiological studies have revealed that caffeine consumption during pregnancy is associated with adverse gestational outcomes, yet the underlying mechanisms remain obscure. ...Interestingly, caffeine's effects are highly variable between individual animals …
Epidemiological studies have revealed that caffeine consumption during pregnancy is associated with adverse gestational outcomes, yet …
Caffeine and Vision: Effects on the Eye.
Yan A, La Rosa A, Chhablani PP, Chhablani J. Yan A, et al. Turk J Ophthalmol. 2024 Oct 25;54(5):291-300. doi: 10.4274/tjo.galenos.2024.43895. Turk J Ophthalmol. 2024. PMID: 39463170 Free PMC article. Review.
Moreover, caffeine can potentially cause tremors and might hinder surgical performance, especially in less experienced surgeons. ...For delicate procedures like microsurgery, where tremors can be detrimental, caution should be exercised with caffeine. This review un …
Moreover, caffeine can potentially cause tremors and might hinder surgical performance, especially in less experienced surgeons. ...F …
Effects of Caffeine on Resistance Exercise: A Review of Recent Research.
Grgic J. Grgic J. Sports Med. 2021 Nov;51(11):2281-2298. doi: 10.1007/s40279-021-01521-x. Epub 2021 Jul 22. Sports Med. 2021. PMID: 34291426 Review.
This review evaluates and summarizes the most recent findings. Given that toxic doses of caffeine are needed to increase skeletal muscle contractility, the binding of caffeine to adenosine receptors is likely the primary mechanism for caffeine's ergoge …
This review evaluates and summarizes the most recent findings. Given that toxic doses of caffeine are needed to increase skeletal mus …
42,315 results
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