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2004 1
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11,437 results

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Page 1
Role of RNA modifications in cancer.
Barbieri I, Kouzarides T. Barbieri I, et al. Nat Rev Cancer. 2020 Jun;20(6):303-322. doi: 10.1038/s41568-020-0253-2. Epub 2020 Apr 16. Nat Rev Cancer. 2020. PMID: 32300195 Review.
Many of the enzymes responsible for regulating protein and DNA modifications are targets of current cancer therapies. RNA epitranscriptomics, the study of RNA modifications, is the new frontier of this arena. ...Increasing evidence suggests that RNA modification pathways a …
Many of the enzymes responsible for regulating protein and DNA modifications are targets of current cancer therapies. RNA epitranscri …
Exploiting the folate receptor α in oncology.
Scaranti M, Cojocaru E, Banerjee S, Banerji U. Scaranti M, et al. Nat Rev Clin Oncol. 2020 Jun;17(6):349-359. doi: 10.1038/s41571-020-0339-5. Epub 2020 Mar 9. Nat Rev Clin Oncol. 2020. PMID: 32152484 Review.
Binding to FRalpha is one of several methods by which folate is taken up by cells; however, this receptor is an attractive anticancer drug target owing to the overexpression of FRalpha in a range of solid tumours, including ovarian, lung and breast cancers. Furthermore, us …
Binding to FRalpha is one of several methods by which folate is taken up by cells; however, this receptor is an attractive anticancer drug t …
Emerging Mechanisms and Disease Relevance of Ferroptosis.
Stockwell BR, Jiang X, Gu W. Stockwell BR, et al. Trends Cell Biol. 2020 Jun;30(6):478-490. doi: 10.1016/j.tcb.2020.02.009. Epub 2020 Mar 21. Trends Cell Biol. 2020. PMID: 32413317 Free PMC article. Review.
Cell death is an essential feature of development in multicellular organisms, a critical driver of degenerative diseases, and can be harnessed for treating some cancers. Understanding the mechanisms governing cell death is critical for addressing its role in disease. ...
Cell death is an essential feature of development in multicellular organisms, a critical driver of degenerative diseases, and can be harness …
Memory CD8(+) T cell responses to cancer.
Han J, Khatwani N, Searles TG, Turk MJ, Angeles CV. Han J, et al. Semin Immunol. 2020 Jun;49:101435. doi: 10.1016/j.smim.2020.101435. Epub 2020 Nov 30. Semin Immunol. 2020. PMID: 33272898 Free PMC article. Review.
Studies over the past two decades have identified four subsets of memory CD8(+) T cells - central, effector, stem-like, and tissue resident memory - that either circulate through blood, lymphoid and peripheral organs, or reside in tissues where cancers develop. In this art …
Studies over the past two decades have identified four subsets of memory CD8(+) T cells - central, effector, stem-like, and tissue resident …
Review of precision cancer medicine: Evolution of the treatment paradigm.
Tsimberidou AM, Fountzilas E, Nikanjam M, Kurzrock R. Tsimberidou AM, et al. Cancer Treat Rev. 2020 Jun;86:102019. doi: 10.1016/j.ctrv.2020.102019. Epub 2020 Mar 31. Cancer Treat Rev. 2020. PMID: 32251926 Free PMC article. Review.
The majority of these trials demonstrated that matched therapy is associated with superior outcomes compared to non-matched therapy across tumor types and in specific cancers. To improve the implementation of precision medicine, this approach should be used early in the co …
The majority of these trials demonstrated that matched therapy is associated with superior outcomes compared to non-matched therapy across t …
Association Between Breastfeeding and Ovarian Cancer Risk.
Babic A, Sasamoto N, Rosner BA, Tworoger SS, Jordan SJ, Risch HA, Harris HR, Rossing MA, Doherty JA, Fortner RT, Chang-Claude J, Goodman MT, Thompson PJ, Moysich KB, Ness RB, Kjaer SK, Jensen A, Schildkraut JM, Titus LJ, Cramer DW, Bandera EV, Qin B, Sieh W, McGuire V, Sutphen R, Pearce CL, Wu AH, Pike M, Webb PM, Modugno F, Terry KL. Babic A, et al. JAMA Oncol. 2020 Jun 1;6(6):e200421. doi: 10.1001/jamaoncol.2020.0421. Epub 2020 Jun 11. JAMA Oncol. 2020. PMID: 32239218 Free PMC article.
DESIGN, SETTING, AND PARTICIPANTS: A pooled analysis of parous women with ovarian cancer and controls from 13 case-control studies participating in the Ovarian Cancer Association Consortium was performed. ...Breastfeeding was associated with a 24% lower risk of inva …
DESIGN, SETTING, AND PARTICIPANTS: A pooled analysis of parous women with ovarian cancer and controls from 13 case-control studies pa …
Generation and Characterization of Patient-Derived Head and Neck, Oral, and Esophageal Cancer Organoids.
Karakasheva TA, Kijima T, Shimonosono M, Maekawa H, Sahu V, Gabre JT, Cruz-Acuña R, Giroux V, Sangwan V, Whelan KA, Natsugoe S, Yoon AJ, Philipone E, Klein-Szanto AJ, Ginsberg GG, Falk GW, Abrams JA, Que J, Basu D, Ferri L, Diehl JA, Bass AJ, Wang TC, Rustgi AK, Nakagawa H. Karakasheva TA, et al. Curr Protoc Stem Cell Biol. 2020 Jun;53(1):e109. doi: 10.1002/cpsc.109. Curr Protoc Stem Cell Biol. 2020. PMID: 32294323 Free PMC article.
Esophageal cancers comprise adenocarcinoma and squamous cell carcinoma, two distinct histologic subtypes. ...We describe protocols to initiate, grow, passage, and characterize patient-derived organoids (PDO) of esophageal cancers, as well as squamous cell carcinomas …
Esophageal cancers comprise adenocarcinoma and squamous cell carcinoma, two distinct histologic subtypes. ...We describe protocols to …
Primary Liver Cancers: Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma.
Mejia JC, Pasko J. Mejia JC, et al. Surg Clin North Am. 2020 Jun;100(3):535-549. doi: 10.1016/j.suc.2020.02.013. Epub 2020 Apr 16. Surg Clin North Am. 2020. PMID: 32402299 Review.
The incidence of liver cancers has continued to increase over the past few decades and mortality related to liver cancer has increased by more than 2% annually since 2007. This article reviews the essential workup and treatment options necessary for general surgeons …
The incidence of liver cancers has continued to increase over the past few decades and mortality related to liver cancer has i …
Cancer Genetics.
Van Cott C. Van Cott C. Surg Clin North Am. 2020 Jun;100(3):483-498. doi: 10.1016/j.suc.2020.02.012. Epub 2020 Apr 16. Surg Clin North Am. 2020. PMID: 32402295 Review.
For most individuals, cancer development is multifactorial; however, up to 10% of all cancers are related to an inherited genetic mutation. As health care shifts to having a greater emphasis on prevention, care providers, including general surgeons, will need to pla …
For most individuals, cancer development is multifactorial; however, up to 10% of all cancers are related to an inherited gene …
Molecular Subtyping of Triple-Negative Breast Cancers by Immunohistochemistry: Molecular Basis and Clinical Relevance.
Zhao S, Ma D, Xiao Y, Li XM, Ma JL, Zhang H, Xu XL, Lv H, Jiang WH, Yang WT, Jiang YZ, Zhang QY, Shao ZM. Zhao S, et al. Oncologist. 2020 Oct;25(10):e1481-e1491. doi: 10.1634/theoncologist.2019-0982. Epub 2020 Jun 1. Oncologist. 2020. PMID: 32406563 Free PMC article.
BACKGROUND: Molecular subtyping of triple-negative breast cancers (TNBCs) via gene expression profiling is essential for understanding the molecular essence of this heterogeneous disease and for guiding individualized treatment. ...MATERIALS AND METHODS: By analyzing the R …
BACKGROUND: Molecular subtyping of triple-negative breast cancers (TNBCs) via gene expression profiling is essential for understandin …
11,437 results
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