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287,046 results

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Page 1
The Apoptosis Paradox in Cancer.
Morana O, Wood W, Gregory CD. Morana O, et al. Int J Mol Sci. 2022 Jan 25;23(3):1328. doi: 10.3390/ijms23031328. Int J Mol Sci. 2022. PMID: 35163253 Free PMC article. Review.
Paradoxically, high-grade cancers are generally associated with high constitutive levels of apoptosis. In cancer, cell-autonomous apoptosis constitutes a common tumour suppressor mechanism, a property which is exploited in cancer therapy. ...Not …
Paradoxically, high-grade cancers are generally associated with high constitutive levels of apoptosis. In cancer, cell- …
Apoptosis in cancer: from pathogenesis to treatment.
Wong RS. Wong RS. J Exp Clin Cancer Res. 2011 Sep 26;30(1):87. doi: 10.1186/1756-9966-30-87. J Exp Clin Cancer Res. 2011. PMID: 21943236 Free PMC article. Review.
Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die. ...Despite being the cause of problem, apoptosis plays an important role in the treatment of cancer as it is a popular target of many trea …
Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die. ...Despite b …
Apoptosis in Cancer Biology and Therapy.
Moyer A, Tanaka K, Cheng EH. Moyer A, et al. Annu Rev Pathol. 2025 Jan;20(1):303-328. doi: 10.1146/annurev-pathmechdis-051222-115023. Annu Rev Pathol. 2025. PMID: 39854189 Free article. Review.
Since its inception, the study of apoptosis has been intricately linked to the field of cancer. The term apoptosis was coined more than five decades ago following its identification in both healthy tissues and malignant neoplasms. ...This underscores t …
Since its inception, the study of apoptosis has been intricately linked to the field of cancer. The term apoptosis was …
Intrinsic and extrinsic pathways of apoptosis: Role in cancer development and prognosis.
Kashyap D, Garg VK, Goel N. Kashyap D, et al. Adv Protein Chem Struct Biol. 2021;125:73-120. doi: 10.1016/bs.apcsb.2021.01.003. Epub 2021 Apr 15. Adv Protein Chem Struct Biol. 2021. PMID: 33931145 Review.
Cancer, a genetic disease, is a growing burden on the health and economy of both developing and developed countries. ...Several studies determined the deregulation of different apoptotic components during the cancer development and progression. Apoptosis reli …
Cancer, a genetic disease, is a growing burden on the health and economy of both developing and developed countries. ...Several studi …
Tumor cell metabolism: cancer's Achilles' heel.
Kroemer G, Pouyssegur J. Kroemer G, et al. Cancer Cell. 2008 Jun;13(6):472-82. doi: 10.1016/j.ccr.2008.05.005. Cancer Cell. 2008. PMID: 18538731 Free article. Review.
The essential hallmarks of cancer are intertwined with an altered cancer cell-intrinsic metabolism, either as a consequence or as a cause. As an example, the resistance of cancer mitochondria against apoptosis-associated permeabilization and the altere …
The essential hallmarks of cancer are intertwined with an altered cancer cell-intrinsic metabolism, either as a consequence or …
Ferroptosis in cancer: From molecular mechanisms to therapeutic strategies.
Zhou Q, Meng Y, Li D, Yao L, Le J, Liu Y, Sun Y, Zeng F, Chen X, Deng G. Zhou Q, et al. Signal Transduct Target Ther. 2024 Mar 8;9(1):55. doi: 10.1038/s41392-024-01769-5. Signal Transduct Target Ther. 2024. PMID: 38453898 Free PMC article. Review.
Intriguingly, mesenchymal and dedifferentiated cancer cells, which are usually resistant to apoptosis and traditional therapies, are exquisitely vulnerable to ferroptosis, further underscoring its potential as a treatment approach for cancers, especially for …
Intriguingly, mesenchymal and dedifferentiated cancer cells, which are usually resistant to apoptosis and traditional therapie …
Anti-Cancer Natural Products and Their Bioactive Compounds Inducing ER Stress-Mediated Apoptosis: A Review.
Kim C, Kim B. Kim C, et al. Nutrients. 2018 Aug 4;10(8):1021. doi: 10.3390/nu10081021. Nutrients. 2018. PMID: 30081573 Free PMC article. Review.
Cancer is the second biggest cause of death worldwide. Despite a number of studies being conducted, the effective mechanism for treating cancer has not yet been fully understood. ...Here, we address mechanisms of ER stress-mediated apoptosis and highlight str …
Cancer is the second biggest cause of death worldwide. Despite a number of studies being conducted, the effective mechanism for treat …
ERK: A Double-Edged Sword in Cancer. ERK-Dependent Apoptosis as a Potential Therapeutic Strategy for Cancer.
Sugiura R, Satoh R, Takasaki T. Sugiura R, et al. Cells. 2021 Sep 22;10(10):2509. doi: 10.3390/cells10102509. Cells. 2021. PMID: 34685488 Free PMC article. Review.
Although the repertoire of the compounds which mediate ERK activation and apoptosis is expanding, and various anti-cancer compounds induce ERK activation while exerting their anti-proliferative effects, the mechanisms underlying ERK1/2-mediated cell death are still …
Although the repertoire of the compounds which mediate ERK activation and apoptosis is expanding, and various anti-cancer comp …
Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies.
Pistritto G, Trisciuoglio D, Ceci C, Garufi A, D'Orazi G. Pistritto G, et al. Aging (Albany NY). 2016 Apr;8(4):603-19. doi: 10.18632/aging.100934. Aging (Albany NY). 2016. PMID: 27019364 Free PMC article. Review.
Deregulation in apoptotic cell death machinery is an hallmark of cancer. Apoptosis alteration is responsible not only for tumor development and progression but also for tumor resistance to therapies. ...Therefore, a better understanding of the apoptotic cell death s …
Deregulation in apoptotic cell death machinery is an hallmark of cancer. Apoptosis alteration is responsible not only for tumo …
Apoptosis and apoptotic body: disease message and therapeutic target potentials.
Xu X, Lai Y, Hua ZC. Xu X, et al. Biosci Rep. 2019 Jan 18;39(1):BSR20180992. doi: 10.1042/BSR20180992. Print 2019 Jan 31. Biosci Rep. 2019. PMID: 30530866 Free PMC article. Review.
Small-molecule apoptosis inducers have been clinically used for eliminating morbid cells and therefore treating diseases, such as cancer. ...In this review, current understandings and knowledge of apoptosis were summarized and discussed with a focus on apo …
Small-molecule apoptosis inducers have been clinically used for eliminating morbid cells and therefore treating diseases, such as …
287,046 results
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