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Dual-release 3D-printed porous Ti-6Al-4V implant with drug-eluting photothermal micro-nanotopographies: combating osteosarcoma recurrence, infections, and enhancing osteogenesis.
Ji Z, Wan Y, Zou Y, Wang H, Liang X, Liu P. Ji Z, et al. Biomaterials. 2026 Apr;327:123749. doi: 10.1016/j.biomaterials.2025.123749. Epub 2025 Sep 29. Biomaterials. 2026. PMID: 41066802
Second, a secondary phototherapy platform was created by coating the reservoir with a gelatin/sodium alginate hydrogel containing MgO(2), curcumin, and paclitaxel. Flow acid etching and anodic oxidation removed residuals and formed TiO(2) nanotube arrays, while rare earth …
Second, a secondary phototherapy platform was created by coating the reservoir with a gelatin/sodium alginate hydrogel containing MgO(2), …
Effectiveness and mechanisms of curcumin for colorectal cancer in preclinical models:A systematic review and meta-analysis.
Jia Y, Liu X, Liu C, Wang J, Shen Q, Lu K, Meng X, Li H, Fang X, Xu Z. Jia Y, et al. J Ethnopharmacol. 2026 Jan 10;354:120511. doi: 10.1016/j.jep.2025.120511. Epub 2025 Sep 1. J Ethnopharmacol. 2026. PMID: 40902809
AIM OF THE STUDY: This study aimed to evaluate the efficacy of curcumin in animal models of colorectal cancer and explore its mechanism of action. MATERIALS AND METHODS: Databases including Embase, Web of Science, PubMed, China National Knowledge Infrastructure, and …
AIM OF THE STUDY: This study aimed to evaluate the efficacy of curcumin in animal models of colorectal cancer and explore its …
pH-Responsive gradient hydrophobic multidrug co-delivery microcapsules based on sodium alginate for enhanced tumor accumulation.
Lv D, Li K, Liu K, Li W, Shah SAA, Zhang J, Cheng J, Gao F, Zhang H. Lv D, et al. Int J Biol Macromol. 2026 Jan;335(Pt 2):148786. doi: 10.1016/j.ijbiomac.2025.148786. Epub 2025 Nov 20. Int J Biol Macromol. 2026. PMID: 41274473
The prepared microcapsules (100-200 nm) co-loading paclitaxel (PTX), curcumin (Cur), and doxorubicin (DOX) maintained stable morphology in PBS over 30 days. ...This study proposed a microcapsule design with the potential to overcome tumor heterogeneity and multidrug resist …
The prepared microcapsules (100-200 nm) co-loading paclitaxel (PTX), curcumin (Cur), and doxorubicin (DOX) maintained stable morpholo …
Liposome-chondroitin sulfate/chitosan hybrid system for combinational drug delivery of curcumin and dexamethasone: In vitro anti-cancer activities.
Eldurini S, Tolba E, Abd El-Hady BM, Ibrahim AM, Shafaa MW. Eldurini S, et al. Int J Biol Macromol. 2026 Jan;335(Pt 2):148941. doi: 10.1016/j.ijbiomac.2025.148941. Epub 2025 Nov 9. Int J Biol Macromol. 2026. PMID: 41218671
This study explored a novel drug delivery system for colorectal cancer (CRC) treatment, focusing on cationic liposomes (L(+ve)) and chondroitin sulfate (CHS). The CHS-coated cationic liposome system (CHS@L(+ve)) was used to develop different formulations of dexamethasone ( …
This study explored a novel drug delivery system for colorectal cancer (CRC) treatment, focusing on cationic liposomes (L(+ve)) and c …
A novel GSH depletor for simultaneous ferroptosis and cuproptosis Activation in hepatocellular carcinoma.
Yang H, Chen X, Huang S, Dai H, Xiao Z, Fan J, Zhang H, Du K, Qin Y. Yang H, et al. Biochem Pharmacol. 2026 Jan;243(Pt 1):117488. doi: 10.1016/j.bcp.2025.117488. Epub 2025 Oct 30. Biochem Pharmacol. 2026. PMID: 41173053
Therefore, reducing GSH levels is a key strategy for inducing ferroptosis and cuproptosis. Herein, we successfully developed a curcumin (Cur) derivative, bisdemethylcurcumin (bm-Cur), as a novel GSH depletor that simultaneously induces ferroptosis and cuproptosis in hepato …
Therefore, reducing GSH levels is a key strategy for inducing ferroptosis and cuproptosis. Herein, we successfully developed a curcumin …
TPP-alantolactone conjugates and their nanotherapeutic forms for antitumor application.
Nemtarev AV, Shemakhina ME, Pashirova TN, Voloshina AD, Souto EB, Lyubina AP, Amerkhanova SK, Idrisova LR, Semakov AV, Mironov VF. Nemtarev AV, et al. Colloids Surf B Biointerfaces. 2026 Jan;257:115127. doi: 10.1016/j.colsurfb.2025.115127. Epub 2025 Sep 8. Colloids Surf B Biointerfaces. 2026. PMID: 40945407
Cytotoxicity is increased up to 520-fold when tested TPP-alantolactone-SLN (TPP-AL-SLN) against M-HeLa cancer cell lines. The enhanced cellular uptake and accumulation of curcumin-labeled-TPP-AL-SLN were shown by confocal microscopy. TPP-AL caused a significant depo …
Cytotoxicity is increased up to 520-fold when tested TPP-alantolactone-SLN (TPP-AL-SLN) against M-HeLa cancer cell lines. The enhance …
A hypoxia-responsive nanomedicine for cancer immunotherapy through ligand competition-induced dual-prodrug activation.
Li J, Cao C, Zhang X, Gong X, Wang S. Li J, et al. J Colloid Interface Sci. 2026 Jan;701:138774. doi: 10.1016/j.jcis.2025.138774. Epub 2025 Aug 19. J Colloid Interface Sci. 2026. PMID: 40850105
To simultaneously deliver DTC and Cu with high efficacy, a hypoxia/nitroreductase-responsive DTC prodrug is designed, which is co-assembled with curcumin-Cu(2+) complex (Cur-Cu) and decorated with bovine serum albumin to form a nanodrug. In hypoxic tumor cells, the overexp …
To simultaneously deliver DTC and Cu with high efficacy, a hypoxia/nitroreductase-responsive DTC prodrug is designed, which is co-assembled …
Targeted inhibition of gastric adenocarcinoma by nano-curcumin liposomes: Insights from combined machine learning and experimental analyses into the mechanisms of cuproptosis and metabolic reprogramming.
Cao JF, Hang K, Tan C, Wu Z, Guo Z, Xia Q, Liao D, Xia Z, Men J, Li K. Cao JF, et al. Int J Pharm. 2025 Dec 25;686:126368. doi: 10.1016/j.ijpharm.2025.126368. Epub 2025 Nov 9. Int J Pharm. 2025. PMID: 41218732
Although the anticancer properties of curcumin have been demonstrated, the specific mechanisms by which curcumin inhibites gastric adenocarcinoma through cuproptosis remains unclear. This study investigated how nano-curcumin liposomes mediated the inhibition …
Although the anticancer properties of curcumin have been demonstrated, the specific mechanisms by which curcumin inhibites gas …
RAGE signaling pathway in glioblastoma and cognitive decline: Insights into inflammatory mechanisms and therapeutic implications.
Raj JAT, John G, Ghanekar S, Thiruselvan GK, Shah J, Ande D, Chatterjee A, Goda JS. Raj JAT, et al. Brain Res. 2025 Dec 15;1869:150026. doi: 10.1016/j.brainres.2025.150026. Epub 2025 Nov 6. Brain Res. 2025. PMID: 41205730 Review.
Small-molecule inhibitors such as FPS-ZM1 and Azeliragon, biologics including sRAGE and RAGE antagonistic peptides, and phytochemicals such as curcumin, Tanshinone IIA, and berberine demonstrate the feasibility of modulating this pathway in preclinical models. ...
Small-molecule inhibitors such as FPS-ZM1 and Azeliragon, biologics including sRAGE and RAGE antagonistic peptides, and phytochemicals such …
Assessing the anti-leukemic efficacy of a curcuminoid in cellular and animal models.
Sudarshan V, Shyamjith P, Kumar S, Ravindran F, Teraiya N, Choudhary B, Karki SS. Sudarshan V, et al. Eur J Med Chem. 2025 Dec 15;300:118177. doi: 10.1016/j.ejmech.2025.118177. Epub 2025 Sep 15. Eur J Med Chem. 2025. PMID: 40975006
Leukemia ranks as the tenth most common cause of cancer-related deaths, and significant side effects often limit current treatments. Curcumin, a lipophilic polyphenol, has garnered considerable attention for its therapeutic potential in addressing various conditions …
Leukemia ranks as the tenth most common cause of cancer-related deaths, and significant side effects often limit current treatments. …
Dual role of Curcumin and nano-formulations in radiotherapy: sensitizing cancer cells and protecting normal cells.
Bahreyni Toossi MT, Vaziri F, Gholamhoseinian H, Azimian H, Jaafari MR, Negah SS, Dolat E. Bahreyni Toossi MT, et al. Mol Biol Rep. 2025 Dec 11;53(1):190. doi: 10.1007/s11033-025-11360-y. Mol Biol Rep. 2025. PMID: 41379239
This investigation assesses the effectiveness of two innovative nano-formulations-namely nanomicelles and nanoniosomes-in augmenting curcumin's radiosensitizing and radioprotective properties. METHODS AND RESULTS: Human colorectal carcinoma (HT-29) cells and human f …
This investigation assesses the effectiveness of two innovative nano-formulations-namely nanomicelles and nanoniosomes-in augmenting curc …
Curcumin impacts on cisplatin sensitivity determining apoptotic boost in mesothelioma.
Piccioni M, Caputo E, Cuciniello R, Meo FD, Valentino A, Petillo G, Rinaldi E, Petillo O, Baldi A, Filosa S, Bergamo P, Crispi S. Piccioni M, et al. Biomed Pharmacother. 2025 Dec 10;193:118827. doi: 10.1016/j.biopha.2025.118827. Online ahead of print. Biomed Pharmacother. 2025. PMID: 41380494
To overcome these problems, research interests, aim to develop alternative therapies based on the use of polyphenols, such as curcumin. Polyphenols are effective against different cancers and in combination with standard drugs, display synergism enhancing anticancer …
To overcome these problems, research interests, aim to develop alternative therapies based on the use of polyphenols, such as curcumin …
Predictive topological modeling of the structure-property relationships in naturally occurring anti-cancer chalcones.
Obaid AAR, Hakeem A, Ullah A, Zaman S, Ahmad H, Ali P, Belay MB. Obaid AAR, et al. Sci Rep. 2025 Dec 10. doi: 10.1038/s41598-025-30846-0. Online ahead of print. Sci Rep. 2025. PMID: 41372357 Free article.
The study focuses on eight naturally derived anticancer Chalcones, namely, Isoliquiritigenin, Butein, Cardamonin, Sappanchalcone, Licochalcone A, Millepachine, Xanthohumol, and Curcumin-selected based on their structural diversity and well-documented pharmacological potent …
The study focuses on eight naturally derived anticancer Chalcones, namely, Isoliquiritigenin, Butein, Cardamonin, Sappanchalcone, Licochalco …
Emissive and photothermal poly(N-isopropylacrylamide)-immobilized carbon-nanodots with thermoresponsive drug release properties.
Petralia S, Consoli GML, Maugeri L, Musso N, Lombardo C, Consiglio G, Scuderi M, Scalese S, Forte G. Petralia S, et al. J Mater Chem B. 2025 Dec 10;13(48):15606-15619. doi: 10.1039/d5tb01844g. J Mater Chem B. 2025. PMID: 41283795
UV-Vis spectroscopy demonstrated effective loading of curcumin and its temperature-dependent release, with drug release triggered above the LCST threshold. ...In summary, the synthesized nanocomposite exhibits enhanced thermal responsiveness, robust photothermal properties …
UV-Vis spectroscopy demonstrated effective loading of curcumin and its temperature-dependent release, with drug release triggered abo …
A ratiometric theranostic nanoplatform with acid-triggered drug release and glutathione-activated fluorescence turn-on.
Flores-Cruz RD, Figueroa-DePaz Y, Lobita MC, Hernández-Ayala LF, López-Pacheco AP, Dijkstra E, Ruiz-Azuara L, Santos HA. Flores-Cruz RD, et al. J Control Release. 2025 Dec 10;388(Pt 1):114309. doi: 10.1016/j.jconrel.2025.114309. Epub 2025 Oct 10. J Control Release. 2025. PMID: 41076139 Free article.
Here, we report a novel nanoformulation that integrates acid-sensitive drug release with a glutathione (GSH)-activated fluorescence turn-on mechanism for targeted cancer therapy and real-time tracking. Our system is based on folic acid-functionalized zinc oxide quantum dot …
Here, we report a novel nanoformulation that integrates acid-sensitive drug release with a glutathione (GSH)-activated fluorescence turn-on …
Multi-pathway therapeutics in colorectal cancer: Targeting EMT, CSCs, and non-apoptotic cell death for drug resistance reversal.
Hu J, Tang Z, M Beeraka N, Xu R, Liu J, Zhao X, Li L, Wang R, Gayathri T, Reddy Y P, Reddy Kandula D, Vikram P R H, Jayadevappa B, Pradeepkumar B, He Z. Hu J, et al. J Drug Target. 2025 Dec 9:1-43. doi: 10.1080/1061186X.2025.2600679. Online ahead of print. J Drug Target. 2025. PMID: 41367286 Review.
Colorectal cancer (CRC) is a leading global malignancy, with therapeutic outcomes hampered by chemoresistance from epithelial-mesenchymal transition (EMT), colorectal cancer stem cells (CR-CSCs), and apoptosis evasion. ...Natural compounds (neferine, ajoene, baicale …
Colorectal cancer (CRC) is a leading global malignancy, with therapeutic outcomes hampered by chemoresistance from epithelial-mesench …
Dual-Functional Nanotherapy-Reinforced Hydrogel for Synergistic Antimicrobial and Immunomodulatory Oral Tissue Repair.
Li Z, Zhang H, Ye Y, Xu J, Li X, Chu H, Zhang J, Luo Q, Li X. Li Z, et al. ACS Nano. 2025 Dec 9. doi: 10.1021/acsnano.5c13401. Online ahead of print. ACS Nano. 2025. PMID: 41366845
To address these limitations, we propose a nanotherapy-reinforced multifunctional hydrogel strategy. Curcumin (CUR)/polyaminopropyl biguanide (PAPB) nanoparticles (CP NPs) are first prepared by electrostatic interaction-mediated self-assembly of the anti-inflammatory/antio …
To address these limitations, we propose a nanotherapy-reinforced multifunctional hydrogel strategy. Curcumin (CUR)/polyaminopropyl b …
Precision Nanoscale Engineering of Chitosan Nanoparticles via Ionic Gelation, Eco-friendly Synthesis, and Ligand Functionalization for Improved Targeted Drug Delivery in Colon Cancer Treatment.
Shimpi AN, Sonawane YD, Bhattacharya S. Shimpi AN, et al. Nanotechnology. 2025 Dec 9. doi: 10.1088/1361-6528/ae2a3d. Online ahead of print. Nanotechnology. 2025. PMID: 41364931
Colon cancer is one of the leading cancers worldwide, with standard treatments hindered by inadequate targeting and toxicities that limit dosage. ...Functionalization of surfaces with ligands (such as folate or hyaluronic acid) promotes receptor-mediated endocytosis …
Colon cancer is one of the leading cancers worldwide, with standard treatments hindered by inadequate targeting and toxicities …
On-Chip Prediction of Combination Drug Efficacy Using a Magnetofluidic Platform with Integrated Capacitive Sensors.
Yadav VK, Ganguly P, Das S, Mishra P, Mallick D. Yadav VK, et al. ACS Appl Mater Interfaces. 2025 Dec 9. doi: 10.1021/acsami.5c11809. Online ahead of print. ACS Appl Mater Interfaces. 2025. PMID: 41364833
Such unique concentration variation is attributed to the localized magnetic field-induced deflection of the magnetically tagged drugs in the predefined microchannel regions of the device, controlled by tuning the flow rate in the range of 0.9-2 muL min(-1). Human breast cancer …
Such unique concentration variation is attributed to the localized magnetic field-induced deflection of the magnetically tagged drugs in the …
Curcumin-based biocompatible nanocarriers: a contemporary perspective in functional foods and biomedical applications.
Alshammari EM. Alshammari EM. Discov Nano. 2025 Dec 8;20(1):226. doi: 10.1186/s11671-025-04379-4. Discov Nano. 2025. PMID: 41359133 Free PMC article. Review.
Recent advances in nanotechnology have opened new pathways for enhancing curcumin's therapeutic potential through the development of biocompatible nanocarrier systems. ...In therapeutic applications, curcumin-loaded nanocarriers demonstrate superior efficacy …
Recent advances in nanotechnology have opened new pathways for enhancing curcumin's therapeutic potential through the developm …
3-Carboxyphenylboronic acid functionalized polydopamine-coated cellulose nanocrystals as a pH-responsive nanocarrier for targeted curcumin delivery.
Li Z, Wang Y, Chen W, Zheng L, Wan W, Wang X. Li Z, et al. Int J Biol Macromol. 2025 Dec 5;337(Pt 2):149515. doi: 10.1016/j.ijbiomac.2025.149515. Online ahead of print. Int J Biol Macromol. 2025. PMID: 41352493
Targeted and stimuli-responsive drug delivery systems (DDS) hold significant potential for improving therapeutic efficacy and mitigating adverse effects in cancer treatment. Here, we developed a pH-responsive nanocarrier through a surface modification strategy, which enabl …
Targeted and stimuli-responsive drug delivery systems (DDS) hold significant potential for improving therapeutic efficacy and mitigating adv …
Nano-curcumin enhances the sensitivity of tamoxifen-resistant breast cancer cells via the Cyclin D1-DILA1 axis and the PI3K/AKT/mTOR pathway downregulation.
Givi T, Mohajerani F, Tehrankhah ZM, Karimi Taheri M, Amirahmadi M, Babashah S, Sadeghizadeh M. Givi T, et al. PLoS One. 2025 Dec 5;20(12):e0335165. doi: 10.1371/journal.pone.0335165. eCollection 2025. PLoS One. 2025. PMID: 41348684 Free PMC article.
This research investigates the effects of nano-curcumin on the expression of Cyclin D1 and DILA1 genes, as well as on the PI3K/AKT/mTOR pathway, in tamoxifen-sensitive and resistant MCF-7 breast cancer cell lines. ...Additionally, nano-curcumin induces apopto …
This research investigates the effects of nano-curcumin on the expression of Cyclin D1 and DILA1 genes, as well as on the PI3K/AKT/mT …
Natural compound-nanoparticle therapies for breast cancer: A review from 2018-2025.
Zhang X, Fei G, Xiujia S, Ganesan K, Chen J. Zhang X, et al. Phytomedicine. 2025 Dec 3;150:157652. doi: 10.1016/j.phymed.2025.157652. Online ahead of print. Phytomedicine. 2025. PMID: 41380417
BACKGROUND: Breast cancer (BC) poses significant global challenges due to drug resistance, toxicity, and subtype heterogeneity. ...Clinically, liposomal paclitaxel has reached Phase III trials, and nano-curcumin has shown promise in Phase II studies. CONCLUSION: Thi …
BACKGROUND: Breast cancer (BC) poses significant global challenges due to drug resistance, toxicity, and subtype heterogeneity. ...Cl …
Novel cyclic C5-curcuminoids possess anticancer activities against HeLa cervix carcinoma, HEC-1A adenocarcinoma, and T24 bladder carcinoma cells.
Pandur E, Schenk P, Kulcsár G, Gulyás-Fekete G, Sipos K, Huber I. Pandur E, et al. Cancer Cell Int. 2025 Dec 3;25(1):431. doi: 10.1186/s12935-025-04077-2. Cancer Cell Int. 2025. PMID: 41339896 Free PMC article.
BACKGROUND: Umin was discovered in Curcuma longa L. and/or Curcuma domestica L. C(5)-curcumin and its derivatives, like synthetic cyclic C(5)-curcuminoids, are promising anticancer compounds with exceptional pharmacokinetic profiles compared to curcumin. ...These re …
BACKGROUND: Umin was discovered in Curcuma longa L. and/or Curcuma domestica L. C(5)-curcumin and its derivatives, like synthetic cyc …
CCA-1.1 Destabilizes MYC proteins to induce irreversible anti-proliferative effects in hepatocellular carcinoma.
Utomo RY, Hapsari NP, Nugraheni N, Lestari B, Hanifa M, Linda Laksmiani NP, Zulfin UM, Muto D, Ikawati M, Suenaga Y, Hippo Y, Meiyanto E, Jenie RI. Utomo RY, et al. Med Oncol. 2025 Dec 3;43(1):34. doi: 10.1007/s12032-025-03135-z. Med Oncol. 2025. PMID: 41331192
CCA-1.1 exhibits enhanced biological and physicochemical properties over its parent compound, curcumin, and demonstrates potent anti-cancer activity in various cancer types. We aim to investigate the anti-proliferative activity of CCA-1.1 through modulation o …
CCA-1.1 exhibits enhanced biological and physicochemical properties over its parent compound, curcumin, and demonstrates potent anti- …
Multi-responsive hydrogels with dual-dynamic covalent and hydrogen-bonded networks: Aldehyde-functionalised silica reinforced beta-cyclodextrin/hyaluronic acid frameworks for enhanced breast cancer therapy and inflammation suppression.
Zhang F, Huang Q, Li X, Yang S, Li D, Lu W, Zhao S, Gao Y, Yang J. Zhang F, et al. J Colloid Interface Sci. 2025 Dec 2;706:139497. doi: 10.1016/j.jcis.2025.139497. Online ahead of print. J Colloid Interface Sci. 2025. PMID: 41380426
By means of dual-dynamic covalent and hydrogen-bonded networks, we designed a multi-responsive hydrogel (HDPCC) which was constructed by oxidised hyaluronic acid (HA-Cys), oxidised beta-cyclodextrin including curcumin (OXbeta-CD/CUR) and aldehyde functionalized silica load …
By means of dual-dynamic covalent and hydrogen-bonded networks, we designed a multi-responsive hydrogel (HDPCC) which was constructed by oxi …
The Role of Natural Products in Liver Cancer: Focus on Angiogenesis, Inflammation, Oxidative Stress, and Apoptosis.
Üremiş N, Mehdi Üremiş M. Üremiş N, et al. Mol Nutr Food Res. 2025 Dec 2:e70332. doi: 10.1002/mnfr.70332. Online ahead of print. Mol Nutr Food Res. 2025. PMID: 41331992 Review.
Compounds such as silymarin, silibinin, resveratrol, curcumin, quercetin, genistein, naringenin, cucurbitacin, lycopene, crocin, aronia, Nigella sativa, epigallocatechin-3-gallate, and ginger (Zingiber officinale) demonstrate promise in HCC treatment, primarily through mec …
Compounds such as silymarin, silibinin, resveratrol, curcumin, quercetin, genistein, naringenin, cucurbitacin, lycopene, crocin, aron …
Magnetic Resonance Imaging, Fluorescence, and Drug Release Properties of Curcumin-Loaded PEGylated Magnetite@Graphene Quantum Dots Nanocomposite.
Divband B, Al-Yasiri AY, Saeed NM, Khezerloo D, Gharehaghaji N. Divband B, et al. J Biomed Phys Eng. 2025 Dec 1;15(6):505-514. doi: 10.31661/jbpe.v0i0.2509-1994. eCollection 2025 Dec. J Biomed Phys Eng. 2025. PMID: 41377132 Free PMC article.
BACKGROUND: Multifunctional nanosystems, containing medical imaging components and cancer therapeutic drugs, can provide early cancer diagnosis and treatment. OBJECTIVE: The aim of this study was to investigate Magnetic Resonance Imaging (MRI), anticancer drug deliv …
BACKGROUND: Multifunctional nanosystems, containing medical imaging components and cancer therapeutic drugs, can provide early can …
Hierarchically assembled curcumin-vitamin E-zinc thermo-gel for multi-synergistic prevention and treatment of radiation-induced oral mucositis.
Duan J, Chen M, Wang M, He R, Li K, Shi L. Duan J, et al. Mater Today Bio. 2025 Nov 14;35:102525. doi: 10.1016/j.mtbio.2025.102525. eCollection 2025 Dec. Mater Today Bio. 2025. PMID: 41362456 Free PMC article.
This study developed a curcumin-based intelligent-responsive integrated therapeutic platform (Cur-VE-Zn@gel) via a hierarchical assembly strategy. Specifically, curcumin was covalently bound to vitamin E to form the active center, while its coordination with Zn(2+) …
This study developed a curcumin-based intelligent-responsive integrated therapeutic platform (Cur-VE-Zn@gel) via a hierarchical assem …
Curcumin's Therapeutic Potential in Ovarian Cancer: Current Insights and Future Perspectives.
Elena S, Anjana S, Cat Tuong DT, Chin S, Moniruzzaman M, Huy Doanh B, Karthikeyan A, Min T. Elena S, et al. Food Sci Nutr. 2025 Nov 28;13(12):e71099. doi: 10.1002/fsn3.71099. eCollection 2025 Dec. Food Sci Nutr. 2025. PMID: 41323836 Free PMC article. Review.
This review summarizes recent advances in understanding curcumin's role in ovarian cancer therapy. Preclinical studies underscore curcumin's potential as an adjunctive agent, particularly in combination with standard therapies. ...Future researc …
This review summarizes recent advances in understanding curcumin's role in ovarian cancer therapy. Preclinical studies …
Dual-targeted hyaluronic acid conjugates on lipid nanoparticles improve delivery and efficacy against glioblastoma: The linkage leads the fate.
Mendes M, Sereno J, Ramos ML, Fortuna A, Oliveira R, Simões S, Ferreira L, Falcão A, Castelo-Branco M, Abrunhosa AJ, Sousa J, Pais A, Vitorino C. Mendes M, et al. Int J Biol Macromol. 2025 Dec;332(Pt 1):148404. doi: 10.1016/j.ijbiomac.2025.148404. Epub 2025 Oct 25. Int J Biol Macromol. 2025. PMID: 41284504 Free article.
This study explores modifying ultra-small nanostructured lipid carriers (usNLCs) co-loading atorvastatin (ATO) and curcumin (CUR), functionalized with hyaluronic acid (HA)-based conjugates to enhance targeted delivery to GB. ...
This study explores modifying ultra-small nanostructured lipid carriers (usNLCs) co-loading atorvastatin (ATO) and curcumin (CUR), fu …
A Decade of Mitochondria-Targeting Drugs in Cancer Treatment: Case Review on Mitochondria-Targeting Curcumin or Mitocurcumin.
Shah R, Varghese R, Anchan H, Pai S, Zagade T, Oswal M, Agarwal S, Sood P, Digholkar G, Deshpande A, Peri RV, Tiwary P, Oswal K, Sharma R. Shah R, et al. Drug Dev Res. 2025 Dec;86(8):e70188. doi: 10.1002/ddr.70188. Drug Dev Res. 2025. PMID: 41268808 Review.
Mitochondrial targeting is of particular interest to researchers, as it presents as a personalized medicine approach in cancer cell metabolism and survival. By specifically targeting mitochondria, targeted therapies can disrupt energy production, induce apoptosis, and over …
Mitochondrial targeting is of particular interest to researchers, as it presents as a personalized medicine approach in cancer cell m …
Enhanced skin cancer therapy using green synthesized titanium dioxide-polycaprolactone-chitosan nanostructure loaded with curcumin.
Nazari Moghaddam S, Labbaf S, Karbasi M, Mohammadzadeh M. Nazari Moghaddam S, et al. Int J Biol Macromol. 2025 Dec;334(Pt 2):149095. doi: 10.1016/j.ijbiomac.2025.149095. Epub 2025 Nov 18. Int J Biol Macromol. 2025. PMID: 41260423
Skin cancer remains a global health concern that demands innovative approaches for effective treatment. ...The curcumin release rate in the final scaffold was found to be 36.7 %. The findings of this study demonstrate the successful green synthesis of TiO2 nanoparti …
Skin cancer remains a global health concern that demands innovative approaches for effective treatment. ...The curcumin releas …
Revolutionary hyaluronic acid-modified edge-activated spanlastics as a novel approach to boost Hepatoprotective activity of Curcumin: Optimization, biochemical analysis and in-vivo assessment.
Ahmed S, Saher O, ElBishbishy RM, Ibrahim MM. Ahmed S, et al. Int J Pharm X. 2025 Oct 31;10:100430. doi: 10.1016/j.ijpx.2025.100430. eCollection 2025 Dec. Int J Pharm X. 2025. PMID: 41245514 Free PMC article.
Drug-induced liver injury (DILI) represents a critical clinical problem that often necessitates lowering the therapeutic dose or even complete drug withdrawal, ultimately resulting in treatment failure. Curcumin (Cur), a natural polyphenolic compound, demonstrates strong h …
Drug-induced liver injury (DILI) represents a critical clinical problem that often necessitates lowering the therapeutic dose or even comple …
Chemoresistance mitigation of dual drug-loaded nanoparticles with doxorubicin and curcumin.
Wang B, Li W, Hong W, Wang J, Tao L, Shen S. Wang B, et al. Cytotechnology. 2025 Dec;77(6):196. doi: 10.1007/s10616-025-00855-y. Epub 2025 Nov 11. Cytotechnology. 2025. PMID: 41234481
This study investigates the characterization and biological effects of Dual Drug-Loaded Nanoparticles on HepG2/doxorubicin (DOX) cells, focusing on the anti-cancer ability of Doxorubicin/Curcumin-Polyethylene Glycol-Polycaprolactone Nanoparticles (DOX/Cur-PEG-PCL-NP …
This study investigates the characterization and biological effects of Dual Drug-Loaded Nanoparticles on HepG2/doxorubicin (DOX) cells, focu …
Design and development of a hyaluronic acid-targeted nanosystem featuring dual imaging capabilities for diagnosing and treating breast cancer: An in vitro investigation.
Beiranvand M, Dehghan G, Soleymani J, Amini M. Beiranvand M, et al. Int J Biol Macromol. 2025 Dec;334(Pt 1):148702. doi: 10.1016/j.ijbiomac.2025.148702. Epub 2025 Nov 11. Int J Biol Macromol. 2025. PMID: 41232871
The World Health Organization (WHO) states that nearly 20 million people are impacted by cancer, with breast cancer being the second most common type, accounting for a large number of deaths annually. ...These findings suggest that Fe(3)O(4)/CQDs@HA-Cur holds promis …
The World Health Organization (WHO) states that nearly 20 million people are impacted by cancer, with breast cancer being the …
Nutraceuticals in breast cancer therapy: Mechanistic insights and therapeutic potential.
Ganjipete S, Dinesh BGH, Bandral SK, Ramar M, Ammunje DN, Pavadai P. Ganjipete S, et al. Int J Biol Macromol. 2025 Dec;333(Pt 2):148811. doi: 10.1016/j.ijbiomac.2025.148811. Epub 2025 Nov 9. Int J Biol Macromol. 2025. PMID: 41218669 Review.
Breast cancer (BC) remains a major global health burden, ranking as the most diagnosed cancer and a leading cause of cancer-related deaths among women. ...This review examines the mechanistic functions and therapeutic potential of various natural compounds fr …
Breast cancer (BC) remains a major global health burden, ranking as the most diagnosed cancer and a leading cause of cancer …
Advancing cancer radiotherapy: Harnessing radiosensitizers and nanotechnology for enhanced tumor control.
Shiridokht F, Kehtari P, Eskandani M, Farajollahi A, Vandghanooni S. Shiridokht F, et al. Int J Pharm X. 2025 Oct 15;10:100419. doi: 10.1016/j.ijpx.2025.100419. eCollection 2025 Dec. Int J Pharm X. 2025. PMID: 41189671 Free PMC article. Review.
Cancer affects millions of individuals annually, with radiotherapy playing a crucial role in the treatment of over 70% of cases. ...This review evaluates diverse radiosensitizers, including natural compounds (curcumin, resveratrol), chemotherapeutics (cisplatin, dox …
Cancer affects millions of individuals annually, with radiotherapy playing a crucial role in the treatment of over 70% of cases. ...T …
Carbon Nanodots Loaded with Natural Bioactive Compounds for P-gp Inhibition, Antimetastatic Activity, and Biosensing in 2D and 3D Breast Cancer Cells.
Ganguly P, Mishra P. Ganguly P, et al. Mol Pharm. 2025 Dec 1;22(12):7570-7589. doi: 10.1021/acs.molpharmaceut.5c01186. Epub 2025 Oct 31. Mol Pharm. 2025. PMID: 41171305
Breast cancer is one of the most common cancers in women and has a major impact on cancer-related deaths worldwide. ...The enhancement occurs because the coloaded carbon nanodots block multidrug resistance and the metastasis of cancer cells by downregu …
Breast cancer is one of the most common cancers in women and has a major impact on cancer-related deaths worldwide. ... …
Mechanistic insights into plant-derived natural compounds for the treatment of skin cancer: Targeting molecular signaling for therapeutic intervention.
Pathak A, Surendra G, Sridhar SB, Jahnavi P, Gupta JK, Balaji P, Juniorsundresh N, Reddy KTK, Billah AAM, Krishnan K. Pathak A, et al. Pathol Res Pract. 2025 Dec;276:156277. doi: 10.1016/j.prp.2025.156277. Epub 2025 Oct 22. Pathol Res Pract. 2025. PMID: 41151198 Review.
Skin cancer, a prevalent global cancer, is primarily caused by chronic environmental exposures and cellular signaling pathway deregulation. ...This review explores the potential of natural compounds in treating skin cancer by modifying key molecular signaling …
Skin cancer, a prevalent global cancer, is primarily caused by chronic environmental exposures and cellular signaling pathway …
Development of a reverse-phase HPLC method for the simultaneous determination of curcumin and dexamethasone in polymeric micelles.
Haj-Ali D, Azzam H, Aiedeh K, Alshaer W. Haj-Ali D, et al. Future Sci OA. 2025 Dec;11(1):2577618. doi: 10.1080/20565623.2025.2577618. Epub 2025 Oct 26. Future Sci OA. 2025. PMID: 41139882 Free PMC article.
RESULTS: The limits of detection (LOD) were 0.0035 mg/mL for curcumin and 0.0029 mg/mL for dexamethasone, while limits of quantification (LOQ) were 0.0106 mg/mL for curcumin and 0.0088 mg/mL for dexamethasone, respectively. ...EE% values were 78.84 0.05% for curc …
RESULTS: The limits of detection (LOD) were 0.0035 mg/mL for curcumin and 0.0029 mg/mL for dexamethasone, while limits of quantificat …
A novel folate receptor-targeted curcumin nano-delivery system: A dual therapeutic strategy for precise inhibition of MRCKbeta to suppress ovarian cancer proliferation and immune escape.
Shi M, Chen L, Yu Y, Wang H, Zhang MJ. Shi M, et al. Mater Today Bio. 2025 Sep 14;35:102307. doi: 10.1016/j.mtbio.2025.102307. eCollection 2025 Dec. Mater Today Bio. 2025. PMID: 41080722 Free PMC article.
Experimental results demonstrate that this material not only substantially increases curcumin's absorption rate and bioavailability but also enhances its antitumor activity via targeted delivery mechanisms. ...These findings not only elucidate the mechanism of a nov …
Experimental results demonstrate that this material not only substantially increases curcumin's absorption rate and bioavailab …
Curcumin reverses irinotecan-acquired resistance in DLD1 colorectal cancer cells: Insights from whole transcriptomic data.
Gavrilas L, Sava O, Balacescu L, Miron S, Miere D, Balacescu O, Cruceriu D. Gavrilas L, et al. Biochem Pharmacol. 2025 Dec;242(Pt 3):117386. doi: 10.1016/j.bcp.2025.117386. Epub 2025 Oct 3. Biochem Pharmacol. 2025. PMID: 41047042 Free article.
Acquired resistance to chemotherapy, including irinotecan, remains a major challenge in treating metastatic colorectal cancer (CRC). Natural compounds such as curcumin have demonstrated potential in resensitizing chemoresistant cancer cells to existing therap …
Acquired resistance to chemotherapy, including irinotecan, remains a major challenge in treating metastatic colorectal cancer (CRC). …
Polyphenolic phytosomes for targeted drug delivery.
Khabarov IA, Sergazy SD, Amanzhan A, Maikenova AS, Zhabayeva AN, Adekenov SM. Khabarov IA, et al. Fitoterapia. 2025 Dec;187:106920. doi: 10.1016/j.fitote.2025.106920. Epub 2025 Oct 3. Fitoterapia. 2025. PMID: 41046876 Review.
Polyphenolic compounds, such as silybin, curcumin, quercetin, epigallocatechin gallate (EGCG), and grape seed proanthocyanidins, have been successfully formulated into phytosomes, resulting in a significant enhancement of oral bioavailability and therapeutic efficacy in bo …
Polyphenolic compounds, such as silybin, curcumin, quercetin, epigallocatechin gallate (EGCG), and grape seed proanthocyanidins, have …
A prophylactic study of curcumin nanoparticle-induced bacterial ghosts against Helicobacter pylori in a C57BL/6 mouse model.
Das S, Halder P, Banerjee S, Sultana S, Mukherjee A, Nandy P, Debnath A, Mukhopadhyay AK, Dutta S, Koley H. Das S, et al. Microb Pathog. 2025 Dec;209:108084. doi: 10.1016/j.micpath.2025.108084. Epub 2025 Oct 4. Microb Pathog. 2025. PMID: 41045975
Formulation of curcumin nanoparticles alters its biophysical properties without affecting its chemical integrity, allowing the preparation of a suspension with a heterogeneous particle population. In vitro, curcumin nanoparticle-induced bacterial ghost cells (CurBGs …
Formulation of curcumin nanoparticles alters its biophysical properties without affecting its chemical integrity, allowing the prepar …
Curcumin exerts therapeutic effects on colorectal cancer by inducing pyroptosis through caspase-1 activation.
Zhu J, Yang L, Fang Z, Chen J, Wu Y, Liu H, Liu S, Fei B. Zhu J, et al. Mol Med Rep. 2025 Dec;32(6):327. doi: 10.3892/mmr.2025.13692. Epub 2025 Sep 26. Mol Med Rep. 2025. PMID: 40999987 Free PMC article.
Colorectal cancer (CRC) is a substantial global health challenge, with current treatments often leading to relapse and metastasis. Curcumin, a natural compound derived from turmeric, has shown promise in cancer therapy; however, its mechanisms in CRC are not …
Colorectal cancer (CRC) is a substantial global health challenge, with current treatments often leading to relapse and metastasis. …
Smart-responsive dual cross-linked chitooligosaccharide nanoparticles with high stability and ROS-triggered self-accelerating drug release for enhanced breast cancer therapy.
Sun Y, He J, Sun Y, Wang L, Li H, Miao Y, Shi P, Zhang J, Luo K, Zhao Y. Sun Y, et al. Carbohydr Res. 2025 Dec;558:109671. doi: 10.1016/j.carres.2025.109671. Epub 2025 Sep 13. Carbohydr Res. 2025. PMID: 40967161
In vitro studies have shown that the curcumin release behavior of CTCG NPs depends on the GOx encapsulated inside the nanoparticles. ...This nanodrug delivery system shows promising potential for breast cancer therapy....
In vitro studies have shown that the curcumin release behavior of CTCG NPs depends on the GOx encapsulated inside the nanoparticles. …
Design, synthesis and molecular modelling studies of bile acid-curcumin conjugates as potential antiproliferative agents for breast cancer.
Rathod NV, Dalai P, Agrawal-Rajput R, Mishra S. Rathod NV, et al. Bioorg Med Chem. 2025 Dec 1;130:118387. doi: 10.1016/j.bmc.2025.118387. Epub 2025 Sep 10. Bioorg Med Chem. 2025. PMID: 40944993
The cytotoxic potential of these conjugates was evaluated against two triple negative breast cancer cell lines (TNBC), 4T1, and MDA-MB-231. Conjugate 3 displayed exceptional cytotoxic activity, with IC50 values of 3.3 0.06 muM for 4 T1 and 0.7 0.01 muM for MDA-MB-231, sign …
The cytotoxic potential of these conjugates was evaluated against two triple negative breast cancer cell lines (TNBC), 4T1, and MDA-M …
Comparative analysis of curcuminoid content, antioxidant capacity, and target-specific molecular docking of turmeric extracts sourced from Thailand.
Anukanon S, Saeng-Ngoen K, Ngamnon Y, Rapan N, Seelarat W, Takolpuckdee P, Pakvilai N, Chatree Y. Anukanon S, et al. Food Chem (Oxf). 2025 Aug 25;11:100291. doi: 10.1016/j.fochms.2025.100291. eCollection 2025 Dec. Food Chem (Oxf). 2025. PMID: 40933390 Free PMC article.
Curcuminoids are the active compounds richest in turmeric rhizomes (Curcuma longa L.), comprising curcumin I, demethoxycurcumin (curcumin II), and bisdemethoxycurcumin (curcumin III). This study hypothesized that particular curcumin derivatives could m …
Curcuminoids are the active compounds richest in turmeric rhizomes (Curcuma longa L.), comprising curcumin I, demethoxycurcumin (c …
Curcumin derivatives as ferroptosis inducers: design, synthesis and anti breast cancer activity evaluation.
Wu N, Zhang Y, Yin X, Du P, Piao Y, Zhao J, Zhu J, Quan Z, Wu CZ, Jin L, Zhang C. Wu N, et al. Bioorg Med Chem. 2025 Dec 1;130:118374. doi: 10.1016/j.bmc.2025.118374. Epub 2025 Aug 29. Bioorg Med Chem. 2025. PMID: 40907221
Curcumin (CUR) is a natural product isolated from Curcuma longa L., which has become a research hotspot due to its significant anti-tumor activity by inducing tumor cell apoptosis and inhibiting proliferation. ...It can induce apoptosis of cells by regulating multiple targ …
Curcumin (CUR) is a natural product isolated from Curcuma longa L., which has become a research hotspot due to its significant anti-t …
Hybrid molecules of ibuprofen and piperidone: a rational approach toward anti-cancer drug development.
Panda SS, Fayad W, Soliman AAF, Chagas PS, Emami Naeini S, Morsy MA, Ferguson FA, Gupta KB, Verbeck GF, Baban B, Thangaraju M, Lokeshwar BL, Girgis AS. Panda SS, et al. Bioorg Med Chem. 2025 Dec 1;130:118370. doi: 10.1016/j.bmc.2025.118370. Epub 2025 Aug 25. Bioorg Med Chem. 2025. PMID: 40885018 Free article.
The persistent challenge of cancer treatment, exacerbated by multidrug resistance and the limited effectiveness of monotherapies, underscores the need for innovative therapeutic strategies. ...These findings underscore the therapeutic potential of curcumin-inspired …
The persistent challenge of cancer treatment, exacerbated by multidrug resistance and the limited effectiveness of monotherapies, und …
Complexes of star-shaped block copolymers of poly(2-alkyl-2-oxazine)s and curcumin can affect lipid bilayers mimicking biomembranes.
Efimova SS, Martynyuk VA, Kozina ND, Kirila TY, Filippov AP, Ostroumova OS. Efimova SS, et al. Biochim Biophys Acta Biomembr. 2025 Dec;1867(8):184443. doi: 10.1016/j.bbamem.2025.184443. Epub 2025 Aug 22. Biochim Biophys Acta Biomembr. 2025. PMID: 40850466
Here, we investigated the effects of hexaaza[2(6)]cyclophane (CPh6), poly(2-methyl-2-oxazine) (PMedOz), a block copolymer of poly(2-ethyl-2-oxazine) (PEtOz) and poly(2-isopropyl-2-oxazine) (PiPrOz), star-shaped block copolymers with six PAlOz arms and a CPh6 branching center (CPh …
Here, we investigated the effects of hexaaza[2(6)]cyclophane (CPh6), poly(2-methyl-2-oxazine) (PMedOz), a block copolymer of poly(2-ethyl-2- …
Safety evaluation of a novel effervescent curcumin-ascorbic acid-polysaccharide-beta-cyclodextrin inclusion complex: Acute oral toxicity - fixed dose procedure (OECD TG 420) in mice.
Wanta A, Aluksanasuwan S, Charoensup R, Jaidee W, Pramvichai C, Saengnoy K, Pongpakit D, Jindarak S, Khamchan A, Ariyawan W, Praserthsee W, Morchang A, Rongjumnong A, Somsuan K. Wanta A, et al. Toxicol Rep. 2025 Aug 6;15:102107. doi: 10.1016/j.toxrep.2025.102107. eCollection 2025 Dec. Toxicol Rep. 2025. PMID: 40821709 Free PMC article.
Curcumin, the principal bioactive compound in turmeric, is known for its antioxidant, anti-inflammatory, and anti-cancer activities. ...These results suggest that the CUR-A-Poly-beta-CD complex is well tolerated at the evaluated doses, supporting its potential for f …
Curcumin, the principal bioactive compound in turmeric, is known for its antioxidant, anti-inflammatory, and anti-cancer activ …
Ginger-derived vesicle-like nanoparticles loaded with curcumin to alleviate ionizing radiation-induced intestinal damage via gut microbiota regulation.
Zhang X, Cui Q, Yin L, Zhu J, Mao Y, Yin R, Shao H, Wang W, Sun X, Zhang Z, Gu C, Zhang M, Zhang R, Lu H, Cai Z, Li H, Yang Z. Zhang X, et al. Gut Microbes. 2025 Dec;17(1):2531210. doi: 10.1080/19490976.2025.2531210. Epub 2025 Jul 17. Gut Microbes. 2025. PMID: 40671673 Free PMC article.
Herein, an available strategy has been explored to shape gut microbiota for radioprotection by loading curcumin (Cur) into ginger-derived vesicle-like nanoparticles (GDNs). Engineered biomimetic nanovesicles (GDN-Cur) exhibited superb stability in the gastrointestinal trac …
Herein, an available strategy has been explored to shape gut microbiota for radioprotection by loading curcumin (Cur) into ginger-der …
Dual drug delivery of Paclitaxel and Curcumin via hyaluronic acid functionalized nanoparticles for improved breast cancer therapy.
Praveena J, Rallapalli Y, Kizhakkanoodan KS, Paladugulu DV, Acharya S, Guru BR. Praveena J, et al. J Biomater Sci Polym Ed. 2025 Dec;36(17):2677-2700. doi: 10.1080/09205063.2025.2525668. Epub 2025 Jul 9. J Biomater Sci Polym Ed. 2025. PMID: 40632643 Free article.
Nuclear factor kappa B (NFKB) a transcription factor will be up regulated with frequent use of paclitaxel, and this increases drug resistance in cancer cells. Usage of curcumin will down regulate the NFKB and using both the drugs in combination with different mechan …
Nuclear factor kappa B (NFKB) a transcription factor will be up regulated with frequent use of paclitaxel, and this increases drug resistanc …
Diagnosis of ulcerative colitis of colon-targeting NIR probe via monitoring peroxynitrite.
Zeng M, Wu Y, Yi Q, Quan H, Wang Y, Huang Z, Wang M, Wang J. Zeng M, et al. Talanta. 2025 Dec 1;295:128381. doi: 10.1016/j.talanta.2025.128381. Epub 2025 May 24. Talanta. 2025. PMID: 40435756
DGO could effectively distinguish human colon cancer cells (HCT116) from hepatocellular cells (HepG2) and aggregate in HCT116 cells under the mediation of glucose groups, demonstrating significant colon-targeting potential. The mice experiment further confirmed that DGO en …
DGO could effectively distinguish human colon cancer cells (HCT116) from hepatocellular cells (HepG2) and aggregate in HCT116 cells u …
Cyclodextrin-grafted thermo/redox dual-responsive polymer mediated by disulfide bridges for regulated drug delivery.
Yan Z, Xu X, Xu J. Yan Z, et al. J Biomater Sci Polym Ed. 2025 Dec;36(18):2701-2719. doi: 10.1080/09205063.2025.2506207. Epub 2025 May 21. J Biomater Sci Polym Ed. 2025. PMID: 40397613
Cytotoxicity assays and hemolysis tests respectively demonstrated over 95% cell viability and no significant hemolytic activity, indicating its superior biocompatibility. Curcumin was used as a model to evaluate drug loading and in vitro release behavior of the thermo/redo …
Cytotoxicity assays and hemolysis tests respectively demonstrated over 95% cell viability and no significant hemolytic activity, indicating …
An overview of potential of natural compounds to regulate epigenetic modifications in colorectal cancer: a recent update.
Roy S, Deka D, Kondaveeti SB, Ayyadurai P, Siripragada S, Philip N, Pathak S, Duttaroy AK, Banerjee A. Roy S, et al. Epigenetics. 2025 Dec;20(1):2491316. doi: 10.1080/15592294.2025.2491316. Epub 2025 Apr 16. Epigenetics. 2025. PMID: 40239010 Free PMC article. Review.
Colorectal cancer (CRC) remains an alarming global health concern despite advancements in treatment modalities over recent decades. ...Publications from the previous five years were searched and retrieved using well-known search engines and databases like PubMed, Google Sc …
Colorectal cancer (CRC) remains an alarming global health concern despite advancements in treatment modalities over recent decades. . …
Curcumin induces ferroptosis in hepatocellular carcinoma by regulating PERK/Nrf2/HO-1 signaling pathway.
Yuan C, Liu R, Xu X, Sun J, Zhu Y, Lu R, Liu Y, Chen J. Yuan C, et al. Transl Cancer Res. 2025 Nov 30;14(11):7641-7653. doi: 10.21037/tcr-2025-1208. Epub 2025 Nov 19. Transl Cancer Res. 2025. PMID: 41378035 Free PMC article.
The present study aims to further elucidate curcumin's anti-HCC mechanisms, thereby offering a promising therapeutic candidate for HCC patients. ...Additionally, using PERK inhibitor, HO-1 inhibitor, and endoplasmic reticulum (ER) stress inhibitor could partially re …
The present study aims to further elucidate curcumin's anti-HCC mechanisms, thereby offering a promising therapeutic candidate …
Promising Anticancer Activity of Novel Hydroxyethyloxy and Bromo derivatives of Curcumin and Its Complexes with BF(2).
Potapskyi E, Lazewski D, Myszkiewicz J, Korzańska G, Kuzminska J, Popenda Ł, Korzański A, Zgoła-Grześkowiak A, Gielara-Korzańska A, Chmaj-Wierzchowska K, Finiuk N, Kozak Y, Ivasechko I, Stoika R, Lesyk R, Wierzchowski M. Potapskyi E, et al. Molecules. 2025 Nov 30;30(23):4609. doi: 10.3390/molecules30234609. Molecules. 2025. PMID: 41375205 Free PMC article.
Curcumin has long been used for health purposes and is currently attracting significant research interest. ...The cytotoxic activity of the compounds obtained was tested against BA/F3 wt, BA/F3 del52, BA/F3 ins5, K562, Jurkat, HCT-116, and MDA-MB-231 cell lines and non- …
Curcumin has long been used for health purposes and is currently attracting significant research interest. ...The cytotoxic activity …
From Interaction to Intervention: Intentional CYP Inhibition as a Scalable Strategy to Expand Access to High-Cost Therapies.
De la Garza Salazar F. De la Garza Salazar F. Eur J Drug Metab Pharmacokinet. 2025 Nov 29. doi: 10.1007/s13318-025-00976-x. Online ahead of print. Eur J Drug Metab Pharmacokinet. 2025. PMID: 41318718
Synthetic (e.g. ketoconazole, itraconazole) and natural inhibitors (e.g. grapefruit juice, curcumin) provide feasible pharmacologic options adaptable to varied healthcare infrastructures. ...Recent studies in Latin America and Europe show that combining strong CYP inhibito …
Synthetic (e.g. ketoconazole, itraconazole) and natural inhibitors (e.g. grapefruit juice, curcumin) provide feasible pharmacologic o …
Curcumin induces ferroptosis in hepatocellular carcinoma by regulating the P62-KEAP1-NRF2-signaling pathway.
Deng J, Wu Z, Ning S, Chang X, Liu J, Yu Y, Zhang M, Zhang L. Deng J, et al. BMC Cancer. 2025 Nov 29. doi: 10.1186/s12885-025-15307-1. Online ahead of print. BMC Cancer. 2025. PMID: 41316098 Free article.
OBJECTIVE: To assess whether curcumin induces ferroptosis in HCC cells through modulation of the P62-KEAP1-NRF2-signaling pathway. ...Moreover, P62 overexpression significantly attenuated the ability of curcumin to regulate the P62-KEAP1-NRF2-signaling pathway and i …
OBJECTIVE: To assess whether curcumin induces ferroptosis in HCC cells through modulation of the P62-KEAP1-NRF2-signaling pathway. .. …
Targeting Ferroptosis in Nasopharyngeal Carcinoma: Mechanisms, Resistance, and Precision Therapeutic Opportunities.
Lee J, Roh JL. Lee J, et al. Int J Mol Sci. 2025 Nov 26;26(23):11439. doi: 10.3390/ijms262311439. Int J Mol Sci. 2025. PMID: 41373599 Free PMC article. Review.
Natural compounds including solasodine, berberine, cucurbitacin B, and celastrol-curcumin combinations, as well as pharmacologic modulators such as HO-1 inhibitors and GPX4 antagonists, have shown ferroptosis-inducing effects in preclinical models, although their translati …
Natural compounds including solasodine, berberine, cucurbitacin B, and celastrol-curcumin combinations, as well as pharmacologic modu …
Fucoidan-based pharmaceutical formulations for the delivery of phytochemicals: A review.
Bora S, Medicherla K, Kulhari H, Pooja D. Bora S, et al. Int J Biol Macromol. 2025 Nov 26:149279. doi: 10.1016/j.ijbiomac.2025.149279. Online ahead of print. Int J Biol Macromol. 2025. PMID: 41314576 Review.
Recent fabrication approaches, including ionic gelation, antisolvent precipitation, and self-assembly, have optimized their physicochemical and stimuli-responsive properties for cancer and inflammatory disease management. Preclinical studies with fucoidan-based nanocarrier …
Recent fabrication approaches, including ionic gelation, antisolvent precipitation, and self-assembly, have optimized their physicochemical …
Nature's gold against skin cancer: A comprehensive narrative review of the anticancer potential of curcumin.
Esmaeli M, Dehabadi MD. Esmaeli M, et al. Crit Rev Oncol Hematol. 2025 Nov 26;217:105056. doi: 10.1016/j.critrevonc.2025.105056. Online ahead of print. Crit Rev Oncol Hematol. 2025. PMID: 41314482 Review.
Because increasing evidence shows the anticancer potential of curcumin, a polyphenolic compound of Curcuma longa, this narrative review seeks to elucidate the preclinical evidence of curcumin for skin cancer, specifically melanoma and non-melanoma skin can …
Because increasing evidence shows the anticancer potential of curcumin, a polyphenolic compound of Curcuma longa, this narrative revi …
Mechanism of Curcumin in Inhibiting Proliferation of Head and Neck Squamous Cell Carcinoma: A Network Pharmacology and Cellular Experimental Study.
He Y, Liao Y, Fang S, Zhu L, Zhao Z, Chen T, Zhang Z. He Y, et al. Biomed Res Int. 2025 Nov 26;2025:4318115. doi: 10.1155/bmri/4318115. eCollection 2025. Biomed Res Int. 2025. PMID: 41312415 Free PMC article.
Despite advances in cancer therapy, head and neck squamous cell carcinoma (HNSCC) remains a challenging malignancy with limited treatment options, prompting this investigation into curcumin's antitumor mechanisms through integrated network pharmacology, molec …
Despite advances in cancer therapy, head and neck squamous cell carcinoma (HNSCC) remains a challenging malignancy with limited treat …
In Vitro Analysis of Microneedle Patches for Transdermal Drug Delivery: A Minimally Invasive Route to Systemic Circulation.
Wagner HL, McCarty TY, Prachyathipsakul T, de Jesus MR, Thayumanavan S, Kearney CJ. Wagner HL, et al. ACS Biomater Sci Eng. 2025 Nov 26. doi: 10.1021/acsbiomaterials.5c01411. Online ahead of print. ACS Biomater Sci Eng. 2025. PMID: 41295082
We demonstrate that therapeutics encapsulated in these MNPs effectively release from the polymer matrix, and that released therapeutics retain their bioactivity and can be taken up by cells of interest. Here, curcumin released from alginate MNPs retained its antimicrobial …
We demonstrate that therapeutics encapsulated in these MNPs effectively release from the polymer matrix, and that released therapeutics reta …
Exploratory Covalent Docking of Michael-Acceptor Natural Products at Reactive Cysteines in Cancer Tyrosine Kinases.
Lobo F, Pérez de la Lastra JM, Curieses CM, Bustamante-Munguira E, Juan CA, Pérez-Lebeña E. Lobo F, et al. Int J Mol Sci. 2025 Nov 25;26(23):11390. doi: 10.3390/ijms262311390. Int J Mol Sci. 2025. PMID: 41373548 Free PMC article.
NP-like electrophiles (parthenolide, withaferin A, celastrol, and curcumin as a low-reactivity geometry probe) displayed pocket-compatible orientations in several targets, particularly EGFR and BTK, suggesting feasible pre-reaction alignment toward the reactive cysteine. . …
NP-like electrophiles (parthenolide, withaferin A, celastrol, and curcumin as a low-reactivity geometry probe) displayed pocket-compa …
Unveiling the influence of polyphenols on histone modifications in human diseases.
Wu Q, Xiao C, Ouyang B, Farag MA, Yuan Y, Simal-Gandara J, Cao H, Xiao J. Wu Q, et al. Phytomedicine. 2025 Nov 25;148:157495. doi: 10.1016/j.phymed.2025.157495. Epub 2025 Oct 30. Phytomedicine. 2025. PMID: 41202379 Review.
Aberrant histone modification patterns are increasingly recognized as key contributors to the pathogenesis of cancer, neurodegenerative disorders, and cardiovascular diseases. PURPOSE: This review aims to provide a comprehensive overview of current evidence on the regulato …
Aberrant histone modification patterns are increasingly recognized as key contributors to the pathogenesis of cancer, neurodegenerati …
Functional Characterization of VS-186B, a Novel HDAC Inhibitor with Anticancer Activity.
Sanchez-Michael LA, Sudarshan V, Elias A, Gutierrez DA, Lopez-Saenz JA, Pena-Zacarias J, Torres GC, Varela-Ramirez A, Kumar S, Karki SS, Aguilera RJ. Sanchez-Michael LA, et al. Int J Mol Sci. 2025 Nov 24;26(23):11354. doi: 10.3390/ijms262311354. Int J Mol Sci. 2025. PMID: 41373513 Free PMC article.
This study aimed to identify novel compounds that selectively target cancer cells while minimizing toxicity to non-cancerous cell lines. A series of novel HDAC inhibitors was evaluated using the Differential Nuclear Staining (DNS) assay, flow cytometry, and HDAC inh …
This study aimed to identify novel compounds that selectively target cancer cells while minimizing toxicity to non-cancerous c …
The role of Chinese medicines in targeting non-coding RNAs to overcome cancer drug resistance: Mechanisms and clinical translation challenges.
Chen G, He Q, Xiao Q, Ai J, Qin Z, Zhong Z, Zou J, Chen B, Zhang C, Feng Y. Chen G, et al. Pharmacol Res. 2025 Nov 24;222:108049. doi: 10.1016/j.phrs.2025.108049. Online ahead of print. Pharmacol Res. 2025. PMID: 41297571 Free article. Review.
As a major obstacle in cancer treatment, drug resistance is increasingly recognized that non-coding RNA (ncRNA) plays an important role in regulating cell plasticity. ...Preclinical evidence suggests that certain CMs and their bioactive compounds have been shown to inhibit …
As a major obstacle in cancer treatment, drug resistance is increasingly recognized that non-coding RNA (ncRNA) plays an important ro …
The golden touch: a comprehensive network pharmacology-guided review of synergy between curcumin and PARP inhibitors.
Khanehzar E, Shams F, Jafari A. Khanehzar E, et al. Med Oncol. 2025 Nov 24;43(1):20. doi: 10.1007/s12032-025-03140-2. Med Oncol. 2025. PMID: 41284132 Review.
Cancer remains the second leading cause of death globally. Poly (ADP-ribose) polymerase inhibitors (PARPi) are effective targeted therapies, but their use is largely limited to BRCA-deficient cancers and is often hampered by resistance. ...This synergy offers a prom …
Cancer remains the second leading cause of death globally. Poly (ADP-ribose) polymerase inhibitors (PARPi) are effective targeted the …
Curcumin-Loaded Polysaccharide Nanoparticles Enhance Aqueous Dispersibility and In Vitro Cytotoxicity in Breast Cancer Cell Lines.
Tsai YC, Miyajima H, Chou MY, Fujita S. Tsai YC, et al. Nanomaterials (Basel). 2025 Nov 20;15(22):1747. doi: 10.3390/nano15221747. Nanomaterials (Basel). 2025. PMID: 41295652 Free PMC article.
Curcumin (CUR) is a natural compound with anticancer potential; however, its poor water solubility, instability, and rapid degradation limit its therapeutic use. ...
Curcumin (CUR) is a natural compound with anticancer potential; however, its poor water solubility, instability, and rapid degradatio …
Formulation and evaluation of taste-masked curcumin nanoparticles for improved antioxidant and anticancer efficacy.
Alfatama M, Rashid ZM, Harasstani OA, Alkhatib H, Nawaz A, Choukaife H. Alfatama M, et al. Sci Rep. 2025 Nov 20;15(1):41055. doi: 10.1038/s41598-025-25022-3. Sci Rep. 2025. PMID: 41266757 Free PMC article.
Curcumin, a natural polyphenolic compound derived from turmeric, is well-documented for its therapeutic properties, including anti-inflammatory, antioxidant, antimicrobial, and anticancer activities. ...FTIR analysis confirmed the compatibility and successful encapsulation …
Curcumin, a natural polyphenolic compound derived from turmeric, is well-documented for its therapeutic properties, including anti-in …
The Ubiquitin-Proteasome System in Brain Disorders: Pathogenic Pathways, Post-Translational Tweaks, and Therapeutic Frontiers.
Gupta R, Begum MY, Kumar R, Gupta J, Nagraik R, Panda SP, Abomughaid MM, Lakhanpal S, D A, Osmani RAM, Jha NK. Gupta R, et al. J Neuroimmune Pharmacol. 2025 Nov 20;20(1):105. doi: 10.1007/s11481-025-10258-7. J Neuroimmune Pharmacol. 2025. PMID: 41264052 Review.
However, dysregulation of ubiquitination due to aberrant enzyme function is implicated in various disorders, including cancer, diabetes, stroke, and neurodegenerative diseases (NDDs). Additionally, the ubiquitin-proteasome system (UPS) not only mediates protein degradation …
However, dysregulation of ubiquitination due to aberrant enzyme function is implicated in various disorders, including cancer, diabet …
Curcumin Analogues Trigger HMOX1-Mediated Ferroptosis to Halt Endometrial Cancer Growth.
Wu X, Padilla JL, Smith LE, Goodla L, Leslie KK, Xue X. Wu X, et al. bioRxiv [Preprint]. 2025 Nov 19:2025.11.18.689080. doi: 10.1101/2025.11.18.689080. bioRxiv. 2025. PMID: 41332788 Free PMC article. Preprint.
Ferroptosis, an iron-dependent form of cell death, offers a potential strategy for overcoming resistance. Curcumin analogues with improved bioavailability, such as HO-3867 and AKT-100, exhibit potent anti-cancer activity, but their mechanisms remain under-explored. …
Ferroptosis, an iron-dependent form of cell death, offers a potential strategy for overcoming resistance. Curcumin analogues with imp …
Engineered Cancer Cell Membrane-Functionalized Metal-Organic Frameworks for Irinotecan/Curcumin Codelivery in Colorectal Cancer: Enhanced Efficacy and Mitigated Toxicity.
Jin S, Zhou A, Zhang Q, Zhao D, Dong X, Meng HM, Yu Z, Li Z. Jin S, et al. Int J Nanomedicine. 2025 Nov 19;20:13857-13869. doi: 10.2147/IJN.S558675. eCollection 2025. Int J Nanomedicine. 2025. PMID: 41287765 Free PMC article.
METHODS: In this study, we developed a cancer cell membrane-functionalized metal-organic frameworks for irinotecan/curcumin (named MZCC) for colorectal cancer treatment. In this study, by combining irinotecan, curcumin, MOFs and functionalized cance …
METHODS: In this study, we developed a cancer cell membrane-functionalized metal-organic frameworks for irinotecan/curcumin (n …
Curcumin Nanoparticle Induces Apoptosis in Colon Cancer Cells via ROS-Mediated AMPK/mTOR/ULK1 Autophagy Pathway.
Liang B, Shi F, Jin C, Chen M, Niu Y, Li A, Xu W, Ning Z, Xue F, Li X, Yan Y. Liang B, et al. Phytother Res. 2025 Nov 18. doi: 10.1002/ptr.70122. Online ahead of print. Phytother Res. 2025. PMID: 41252742
It has been reported that excessive autophagy is considered to be the main mechanism of death of various cancer cells. The aim of this study is to investigate whether the Curcumin-loaded Pluronic F-127 nanoparticles exert anti-colon cancer effects by modulati …
It has been reported that excessive autophagy is considered to be the main mechanism of death of various cancer cells. The aim of thi …
Resveratrol-Curcumin Hybrid Selectively Induces Chromosomal Abnormalities and Apoptosis in Colon Adenocarcinoma Cells.
Baptistella MM, Siqueira AP, Magalhães DLS, Zavan B, de Oliveira CS, de Freitas Silva M, Falleiros Lima ET, Viegas C Jr, Dala-Paula BM, Caixeta ES, Ionta M, de Oliveira PF. Baptistella MM, et al. Antioxidants (Basel). 2025 Nov 17;14(11):1367. doi: 10.3390/antiox14111367. Antioxidants (Basel). 2025. PMID: 41300524 Free PMC article.
Colorectal cancer (CRC) therapy frequently relies on chemotherapeutic agents with high cytotoxicity, low selectivity, and suboptimal efficacy. ...Taken together, our data indicate that PQM-162 is a promising antitumor agent due to its disruption of the redox balance in …
Colorectal cancer (CRC) therapy frequently relies on chemotherapeutic agents with high cytotoxicity, low selectivity, and suboptimal …
Ferroptosis in Anaplastic Thyroid Cancer: Molecular Mechanisms, Preclinical Evidence, and Therapeutic Prospects.
Lee J, Roh JL. Lee J, et al. Cells. 2025 Nov 17;14(22):1800. doi: 10.3390/cells14221800. Cells. 2025. PMID: 41294853 Free PMC article. Review.
Anaplastic thyroid cancer (ATC) is among the most lethal human malignancies, characterized by rapid progression, therapeutic resistance, and a median survival of less than one year. ...Preclinical studies show that pharmacological inducers, including vitamin C, tenacissosi …
Anaplastic thyroid cancer (ATC) is among the most lethal human malignancies, characterized by rapid progression, therapeutic resistan …
Phytochemicals as Radioprotective and Radiosensitizing Agents in Cancer Radiotherapy: Advances, Challenges, and Future Perspectives.
Dweh TJ, Taye M, Deka D, Samanta SK, Talukdar NC. Dweh TJ, et al. Planta Med. 2025 Nov 17. doi: 10.1055/a-2654-6072. Online ahead of print. Planta Med. 2025. PMID: 41086865 Free article.
Radiation therapy (RT) remains a fundament of cancer treatment, yet its effectiveness is often hindered by normal tissue toxicity and radiation-induced fibrosis. ...The findings stated that the phytochemicals such as curcumin, resveratrol, quercetin, genistein, and …
Radiation therapy (RT) remains a fundament of cancer treatment, yet its effectiveness is often hindered by normal tissue toxicity and …
Gellan gum/chitosan-based bilayer scaffold for the targeted delivery of curcumin and green tea, designed to enhance breast cancer treatment paradigms.
Yu X, Yu H, Yang C, Wu C, Cui Y, Xu N. Yu X, et al. Carbohydr Polym. 2025 Nov 15;368(Pt 2):124159. doi: 10.1016/j.carbpol.2025.124159. Epub 2025 Jul 31. Carbohydr Polym. 2025. PMID: 40947192
The surge in breast cancer cases in breast cancer cases emphasizes the need for advanced materials that can provide effective therapeutic results while reducing side effects. In light of this pressing need, we generated a bilayer green formulation, consisting of a p …
The surge in breast cancer cases in breast cancer cases emphasizes the need for advanced materials that can provide effective …
Targeting the HGF/MET axis in cancer: therapeutic promise for natural compounds.
Goleij P, Heidari MM, Motevalli H, Abolfazli S, Khazeei Tabari MA, Rezaee A, S Larsen D, Daglia M, Aschner M, Khan H. Goleij P, et al. Eur J Med Chem. 2025 Nov 15;298:118027. doi: 10.1016/j.ejmech.2025.118027. Epub 2025 Jul 30. Eur J Med Chem. 2025. PMID: 40752339 Review.
Dysregulation of this pathway-through mutations, amplifications, or overexpression-contributes to tumorigenesis, drug resistance, and poor prognosis in various cancers, including lung, breast, gastric, and hepatocellular carcinomas. This review explores the molecular mecha …
Dysregulation of this pathway-through mutations, amplifications, or overexpression-contributes to tumorigenesis, drug resistance, and poor p …
Photothermal-responsive curcumin-loaded copper-based nanocomposites for targeted drug release and combined immunotherapy.
Ji A, Yang P, Ma B, Li J, Yu Y, Zhang X, Chen P, Yao H, Shi L, Hu H, Gao S, Cheng H. Ji A, et al. J Colloid Interface Sci. 2025 Nov 15;698:138042. doi: 10.1016/j.jcis.2025.138042. Epub 2025 Jun 3. J Colloid Interface Sci. 2025. PMID: 40505466
The integration of photothermal therapy (PTT) with chemotherapy and immunotherapy holds great promise for improving cancer treatment efficacy, yet achieving precise control over drug release and synergistic modulation of the immunosuppressive tumor microenvironment (TME) r …
The integration of photothermal therapy (PTT) with chemotherapy and immunotherapy holds great promise for improving cancer treatment …
A Self-healable Hydrogel for Co-delivery of Hot-Melt Extruded System With Curcumin and Hesperetin Intended for Topical Application.
Szymczak J, Wdowiak K, Różańska S, Różański J, Plech T, Cielecka-Piontek J. Szymczak J, et al. AAPS PharmSciTech. 2025 Nov 14;27(1):35. doi: 10.1208/s12249-025-03290-6. AAPS PharmSciTech. 2025. PMID: 41239144
Therefore, our research aimed to develop a hydrogel carrier with distinct features for a hot-melt extruded system containing curcumin and hesperetin, both having anti-cancer activity against skin cancer. We used a double cross-linking method with tannic acid …
Therefore, our research aimed to develop a hydrogel carrier with distinct features for a hot-melt extruded system containing curcumin …
Curcumin: biochemistry, pharmacology, advanced drug delivery systems, and its epigenetic role in combating cancer.
Smail SW, Bergsten P, Taha KO, Yashooa RK, Hawezy DJ, Abbas MA, Shekha MS. Smail SW, et al. Front Pharmacol. 2025 Nov 13;16:1695200. doi: 10.3389/fphar.2025.1695200. eCollection 2025. Front Pharmacol. 2025. PMID: 41322307 Free PMC article. Review.
Despite its broad therapeutic potential, curcumin's clinical application is limited by poor solubility, rapid metabolism, and low systemic bioavailability. ...Collectively, these molecular and epigenetic effects reinforce curcumin's potential as a prom …
Despite its broad therapeutic potential, curcumin's clinical application is limited by poor solubility, rapid metabolism, and …
Unraveling the structure-activity relationships of organometallic ferrocene-pyrazole and ferrocene-pyrimidine curcumin analogues in amyloid-beta aggregation and glioblastoma treatment.
Kovač V, Huntosova V, Fedorova V, Georgiou N, Lai JZ, Chien FC, Chen SJ, Dolenec F, Siposova K. Kovač V, et al. Sci Rep. 2025 Nov 13;15(1):39867. doi: 10.1038/s41598-025-23467-0. Sci Rep. 2025. PMID: 41233403 Free PMC article.
We hypothesized that ferrocene-containing curcumin derivatives could exert dual-functional effects by simultaneously modulating amyloid-beta (Abeta) aggregation and inhibiting glioblastoma cell proliferation. This study explores organometallic ferrocene compounds linked to …
We hypothesized that ferrocene-containing curcumin derivatives could exert dual-functional effects by simultaneously modulating amylo …
Calcium ion nanomodulators induce pyroptosis for tumor immunotherapy.
Qi F, Guo Y, Xu Y, Liu Y, Hu P, Shi J. Qi F, et al. Nanoscale. 2025 Nov 13;17(44):25516-25525. doi: 10.1039/d5nr01897h. Nanoscale. 2025. PMID: 41159427
Here, we developed a pH-responsive calcium nanomodulator by loading curcumin onto ultrathin Ca/Al layered double hydroxide nanosheets (LDH-CUR). LDH-CUR induces pyroptosis via mitochondrial calcium overload. ...LDH-CUR demonstrates a novel approach to combining pyroptosis …
Here, we developed a pH-responsive calcium nanomodulator by loading curcumin onto ultrathin Ca/Al layered double hydroxide nanosheets …
[Therapeutic potential of curcumin in colorectal cancer - A systematic review].
Gamboa-Flores PDC, Castillo-Cálix N, Quiroz-Gómez S, Guzmán-Priego CG, Celorio-Méndez KDS. Gamboa-Flores PDC, et al. Nutr Hosp. 2025 Nov 12. doi: 10.20960/nh.05920. Online ahead of print. Nutr Hosp. 2025. PMID: 41313334 Free article. Spanish.
This systematic review, based on the PRISMA methodology, analyzed studies on the effects of curcumin in colorectal cancer. Curcumin was found to promote apoptosis through the generation of reactive oxygen species and the activation of P53. ...It is concluded …
This systematic review, based on the PRISMA methodology, analyzed studies on the effects of curcumin in colorectal cancer. …
Based on multi-pathway induction of tumor immunogenic death and three-mode highly integrated strategy: a nanocomposite system loaded with irinotecan for colorectal cancer therapy.
Lei X, Wang Y, Zhang X, Du S, She J. Lei X, et al. J Mater Chem B. 2025 Nov 12;13(44):14338-14353. doi: 10.1039/d5tb01381j. J Mater Chem B. 2025. PMID: 41117014
Irinotecan (CPT-11), a first-line chemotherapeutic agent for colorectal cancer, faces challenges like tumor drug resistance and severe toxicities such as neutropenia and diarrhea. ...In this study, we developed a novel nanosystem (ICP@PDA-PP@HA NPs) by first coordinating C …
Irinotecan (CPT-11), a first-line chemotherapeutic agent for colorectal cancer, faces challenges like tumor drug resistance and sever …
Ayurvedic Phytochemicals in Oncology: ADP-Ribosylation as a Molecular Nexus.
Reddy GSVSR, Nandy SK, Cherukuri P, Samanta K, Kar P. Reddy GSVSR, et al. Cells. 2025 Nov 10;14(22):1753. doi: 10.3390/cells14221753. Cells. 2025. PMID: 41294806 Free PMC article. Review.
Cancer remains one of the most pressing health challenges of the 21st century, with rising global incidence underscoring the need for innovative therapeutic strategies. ...Overall, the synthesis of Ayurvedic pharmacology with molecular oncology reveals mechanistic insights …
Cancer remains one of the most pressing health challenges of the 21st century, with rising global incidence underscoring the need for …
Cancer-specific cytotoxicity of curcumin through regulation of integrin beta1 expression in colon cancer.
Kim HK, Lee RA, Hong KS, Noh GT, Oh BY. Kim HK, et al. Sci Rep. 2025 Nov 10;15(1):39218. doi: 10.1038/s41598-025-21627-w. Sci Rep. 2025. PMID: 41214031 Free PMC article.
Curcumin has attracted attention for its nontoxic chemopreventive effects; however, the pathways underlying these effects in colon cancer remain unclear. We investigated the potential interplay between curcumin and integrin beta1 in colon cancer. Human …
Curcumin has attracted attention for its nontoxic chemopreventive effects; however, the pathways underlying these effects in colon …
Contrasting Impacts of Targeted Disruption of the Cancer Stem Cell Marker CD133 and Its Epigenetic Regulator TRIM28 in Colorectal Cancer Cells.
Kholodenko IV, Saidova AA, Potashnikova DM, Arzumanian VA, Romashin DD, Tvorogova AV, Poverennaya EV, Yarygin KN, Kim YS. Kholodenko IV, et al. Int J Mol Sci. 2025 Nov 9;26(22):10862. doi: 10.3390/ijms262210862. Int J Mol Sci. 2025. PMID: 41303350 Free PMC article.
Cancer stem cells (CSCs) play a crucial role in colorectal cancer by sustaining intratumoral heterogeneity, therapeutic resistance, and metastatic potential. ...In this study, we performed a detailed molecular and functional analysis of Caco2 colorectal cancer …
Cancer stem cells (CSCs) play a crucial role in colorectal cancer by sustaining intratumoral heterogeneity, therapeutic resist …
A dual-strategy nanocomposite hydrogel platform of nanosuspensions and deformable liposomes for enhanced curcumin delivery against skin cancer cells.
Aye KC, Pengnam S, Pamornpathomkul B, Charoenying T, Patrojanasophon P, Opanasopit P, Pornpitchanarong C. Aye KC, et al. Eur J Pharm Sci. 2025 Nov 8;216:107373. doi: 10.1016/j.ejps.2025.107373. Online ahead of print. Eur J Pharm Sci. 2025. PMID: 41213304 Free article.
This study aimed to develop dual-strategy nanocomposite hydrogel platforms for enhanced, localized delivery of curcumin against skin cancer cells. Two distinct nanocarriers, curcumin nanosuspensions (CUR-Ns) and curcumin liposomes (CUR-Lip), were engin …
This study aimed to develop dual-strategy nanocomposite hydrogel platforms for enhanced, localized delivery of curcumin against skin …
iRGD-modified co-loaded curcumin piperine liposomes inhibit angiogenesis in non-small cell lung cancer through the VEGFR2/P38/MK2 signaling axis.
Huang X, Chen Y, Chen J, Lin J, Zhuang Y, Huang M, Yu H, Wang M, Wang Y, Wang Y. Huang X, et al. Discov Oncol. 2025 Nov 7;16(1):2056. doi: 10.1007/s12672-025-03922-0. Discov Oncol. 2025. PMID: 41201753 Free PMC article.
BACKGROUND: In our previous study, we provided evidence that iRGD-modified co-loaded curcumin piperine liposomes (iRGD-LP-CUR-PIP) have in vitro and in vivo anti-non-small cell lung cancer (NSCLC) activity. ...
BACKGROUND: In our previous study, we provided evidence that iRGD-modified co-loaded curcumin piperine liposomes (iRGD-LP-CUR-PIP) ha …
Telomeres, Telomerase, and Curcumin: A New Frontier in Cancer Therapy: A Narrative Review.
Albadrani HM, Zakariyah AF. Albadrani HM, et al. Biomedicines. 2025 Nov 6;13(11):2721. doi: 10.3390/biomedicines13112721. Biomedicines. 2025. PMID: 41301813 Free PMC article. Review.
Curcumin modulates telomere dynamics and inhibits telomerase activity, leading to cancer cell senescence and telomere shortening. Curcumin downregulates human telomerase reverse transcriptase expression and reduces telomerase activity in various cancer …
Curcumin modulates telomere dynamics and inhibits telomerase activity, leading to cancer cell senescence and telomere shorteni …
Structure based in-silico study for the design of novel Curcumin analogs against Farnesoid-X-receptor (FXR) receptor as hepatoprotective agents.
Joshi A, Vyas VK, Seshadri S. Joshi A, et al. In Silico Pharmacol. 2025 Nov 6;13(3):175. doi: 10.1007/s40203-025-00456-9. eCollection 2025. In Silico Pharmacol. 2025. PMID: 41211466
As the expression of FXR is downregulated during the development of liver cancer, there may be a loss of function, and hence, designing a novel therapeutic can help overcome this issue. Curcumin, a polyphenol extracted from the rhizome of Curcuma longa L., has multi …
As the expression of FXR is downregulated during the development of liver cancer, there may be a loss of function, and hence, designi …
A curcumin-enabled ZIF8 nanosystem enables ovarian cancer treatment by inducing mitochondrial disruption.
Zhang Z, Luo G, Tang X, Ma X, Huang W, Wang B, Meng X, He C, Cai X, Zhang P, Luo S. Zhang Z, et al. Discov Nano. 2025 Nov 6;20(1):200. doi: 10.1186/s11671-025-04380-x. Discov Nano. 2025. PMID: 41196493 Free PMC article.
Ovarian cancer is a common malignancy affecting the female reproductive system. Curcumin (Cur) demonstrates potential as a treatment for ovarian cancer, but creating an effective curcumin-based drug delivery system remains challenging. ...In this study …
Ovarian cancer is a common malignancy affecting the female reproductive system. Curcumin (Cur) demonstrates potential as a tre …
Curcumin Analogs Containing Pyrazole-Pyridine Hybrids as Novel Anticancer Agents: Synthesis, Cytotoxicity, Apoptosis Induction, and Molecular Modeling.
Doan NQH, Nguyen HTT, Huynh HT, Truong TN. Doan NQH, et al. ChemMedChem. 2025 Nov 6;20(21):e202500577. doi: 10.1002/cmdc.202500577. Epub 2025 Sep 14. ChemMedChem. 2025. PMID: 40946228
In recent years, curcumin analogs have not only demonstrated potent anticancer activities but have also addressed several limitations of curcumin itself, thereby remaining a promising focus of research within the scientific community. ...Among them, curcumin …
In recent years, curcumin analogs have not only demonstrated potent anticancer activities but have also addressed several limitations …
Mitochondria-Targeted Dual-Ion Perturbator Amplifies Cuproptosis for Enhanced Melanoma Immunotherapy and Accelerated Postoperative Wound Healing.
Du H, Li Z, Fu ST, Yang CJ, Yin YZ, Chen Z, Zhao CQ, Qiao H, Ji DK. Du H, et al. ACS Nano. 2025 Nov 4;19(43):37544-37560. doi: 10.1021/acsnano.5c05965. Epub 2025 Oct 25. ACS Nano. 2025. PMID: 41137798
However, a significant challenge remains in overcoming the adaptive defenses of cancer cells and sensitizing them to cuproptosis. Herein, we explore a mitochondrial-targeted Ca/Cu dual-ion chaos inducer (Mito-chaos) by integrating a mitochondria-targeted curcumin de …
However, a significant challenge remains in overcoming the adaptive defenses of cancer cells and sensitizing them to cuproptosis. Her …
RNA sequencing reveals novel lncRNA modulators in gemini nanocurcumin-treated colorectal cancer cells.
Zibaei Z, Azeez HJ, Babaei E. Zibaei Z, et al. Sci Rep. 2025 Nov 3;15(1):38444. doi: 10.1038/s41598-025-24202-5. Sci Rep. 2025. PMID: 41184476 Free PMC article.
Due to a high rate of recurrence coupled with resistance towards modern therapies, colorectal cancer (CRC) is considered as the third cause of cancer-related death worldwide. Gemini curcumin (Gemini-Cur) is one of the last nanoformulation of curcumin w …
Due to a high rate of recurrence coupled with resistance towards modern therapies, colorectal cancer (CRC) is considered as the third …
Synergistic Chemopreventive Effects of Curcumin, Gingerol, and Shogaol on HeLa Cervical Cancer Cells.
Abdull Rahim U, Mohd Yusof YA, Mustapa M, Nurdin A, Che Roos NA, Mohamad Taridi N, Mad Nordin MF, Mohamed Shakrin NNS. Abdull Rahim U, et al. Asian Pac J Cancer Prev. 2025 Nov 1;26(11):4087-4096. doi: 10.31557/APJCP.2025.26.11.4087. Asian Pac J Cancer Prev. 2025. PMID: 41312935 Free article.
OBJECTIVE: Bioactive compounds including curcumin, gingerols, and shogaols possess strong anti-inflammatory and anti-tumour properties. ...This study aimed to investigate the chemopreventive potential of individual and combined treatments of 6-/10-gingerols (6-/10-G), 6-/1 …
OBJECTIVE: Bioactive compounds including curcumin, gingerols, and shogaols possess strong anti-inflammatory and anti-tumour propertie …
Natural Products and LncRNAs in Non-Small Cell Lung Cancer: Emerging Therapeutic Approaches.
Doghish AS, Abd-Elmawla MA, Ghaiad HR, Aborehab NM, Radwan AF, Nassar K, Mohammed OA, Elimam H. Doghish AS, et al. J Gene Med. 2025 Nov;27(11):e70054. doi: 10.1002/jgm.70054. J Gene Med. 2025. PMID: 41261514 Review.
Non-small cell lung cancer (NSCLC) is considered a major contributor to cancer-related death rates worldwide, chiefly owing to late diagnosis, occurrence of metastasis, and treatment resistance. ...Compounds like curcumin, resveratrol, and epigallocatechin ga …
Non-small cell lung cancer (NSCLC) is considered a major contributor to cancer-related death rates worldwide, chiefly owing to …
Integrative nanoformulation of paclitaxel, ruthenium (II), and curcumin for enhanced oral cancer cell suppression.
Senthil R, Angamuthu D, Geetha Sravanthy P, Pradeep Kumar R. Senthil R, et al. J Oral Biol Craniofac Res. 2025 Nov-Dec;15(6):1824-1830. doi: 10.1016/j.jobcr.2025.10.024. Epub 2025 Nov 1. J Oral Biol Craniofac Res. 2025. PMID: 41230045 Free PMC article.
This study aimed to enhance the efficacy of paclitaxel (PTX) by co-encapsulating it with a ruthenium (II) complex (Ru-II) and curcumin nanoparticles (C-NP). METHODS: C-NPs were prepared via wet milling, and Ru-II was synthesized through ligand coordination and reduction. . …
This study aimed to enhance the efficacy of paclitaxel (PTX) by co-encapsulating it with a ruthenium (II) complex (Ru-II) and curcumin …
Phytochemicals in overcoming venetoclax resistance in acute myeloid leukemia: mechanistic insights and therapeutic potential.
Prajapati S, Patel M, Jyotishi C, Gupta R. Prajapati S, et al. Ann Hematol. 2025 Nov;104(11):5573-5591. doi: 10.1007/s00277-025-06710-6. Epub 2025 Nov 7. Ann Hematol. 2025. PMID: 41201585 Free PMC article. Review.
Emerging evidence suggests that resistance to venetoclax arises through multiple pathways, including the overexpression of anti-apoptotic proteins, such as MCL1 and BCL2L1, mitochondrial adaptations, metabolic rewiring, and genetic mutations in key regulators, such as TP53 and KM …
Emerging evidence suggests that resistance to venetoclax arises through multiple pathways, including the overexpression of anti-apoptotic pr …
Curcumin Mediated Ferroptosis: An Auspicious Therapeutic Avenue in Cancer Treatment.
Karati D, Sen D, Mahanti B, Roy S, Mukherjee S. Karati D, et al. J Biochem Mol Toxicol. 2025 Nov;39(11):e70594. doi: 10.1002/jbt.70594. J Biochem Mol Toxicol. 2025. PMID: 41196637 Review.
According to recent studies, curcumin and its derivatives can induce ferroptosis in cancerous cells, offering a novel means of halting tumor growth and overcoming drug resistance. ...This study intends to demonstrate curcumin and its derivatives as strong ind …
According to recent studies, curcumin and its derivatives can induce ferroptosis in cancerous cells, offering a novel means of …
Co-encapsulation of an AKT Inhibitor Enhances the Tumor-cell Selectivity of STING Agonists in Co-delivery Liposomes.
Ge Z, Zhang Q, Wang Y, Miao L, Wang X, Fan N, Duan L, Li Y, Qi XJ. Ge Z, et al. Pharm Res. 2025 Nov;42(11):2029-2050. doi: 10.1007/s11095-025-03951-y. Epub 2025 Nov 4. Pharm Res. 2025. PMID: 41184546
OBJECTIVE: The therapeutic potential of STING agonists in cancer immunotherapy is hindered by poor tumor selectivity, resulting in systemic inflammation. ...By leveraging intracellular biomarkers rather than surface antigens, the co-delivery liposomal system achieves poten …
OBJECTIVE: The therapeutic potential of STING agonists in cancer immunotherapy is hindered by poor tumor selectivity, resulting in sy …
Elucidating the Anticancer Mechanisms of Tetrahydroxycurcumin: A Comprehensive Review of Preclinical Studies.
Shahbaz M, Momal U, Mohamed HM, Perween A, Naeem H, Imran M, Hussain M, Mohamed GA, Ibrahim SRM, Yehuala TF, Alsagaby SA, Al Abdulmonem W, Abdelgawad MA, Mostafa EM, Selim S. Shahbaz M, et al. Food Sci Nutr. 2025 Oct 29;13(11):e71125. doi: 10.1002/fsn3.71125. eCollection 2025 Nov. Food Sci Nutr. 2025. PMID: 41179371 Free PMC article. Review.
One significant reductive metabolite of curcumin, tetrahydroxycurcumin (THC), is a promising oncology candidate because of its multifunctional bioactivities. ...Experimental research has also shown the effectiveness of THC in various cancers such as breast cancer …
One significant reductive metabolite of curcumin, tetrahydroxycurcumin (THC), is a promising oncology candidate because of its multif …
A comprehensive review of alkaloids in cancer therapy: focusing on molecular mechanisms and synergistic potential of piperine in colorectal cancer.
Chidananda C, Thakur G, Datta D, Popat K. Chidananda C, et al. 3 Biotech. 2025 Nov;15(11):403. doi: 10.1007/s13205-025-04535-8. Epub 2025 Oct 27. 3 Biotech. 2025. PMID: 41164768 Free PMC article. Review.
Combination studies revealed synergistic effects with chemotherapeutics (celecoxib, apatinib), radiotherapy, and nutraceuticals (curcumin, resveratrol, and cannabinoids), significantly enhancing therapeutic efficacy and overcoming drug resistance. ...Nonetheless, standardi …
Combination studies revealed synergistic effects with chemotherapeutics (celecoxib, apatinib), radiotherapy, and nutraceuticals (curcumin …
Chitosan based hydrogels as temporary implants for breast cancer postsurgical treatment and site-infections prophylaxis.
Ailincai D, Bercea M, Rosca I, Sandu IA, Marin L. Ailincai D, et al. Int J Biol Macromol. 2025 Nov;331(Pt 2):148453. doi: 10.1016/j.ijbiomac.2025.148453. Epub 2025 Oct 23. Int J Biol Macromol. 2025. PMID: 41138871
Mastectomy is a primary treatment for breast cancer, which can cause both psychological distress and physical complications, such as post-surgical infections. ...In vitro assays (MTS and live/dead assay) confirmed potent anticancer activity, highlightening the dual therape …
Mastectomy is a primary treatment for breast cancer, which can cause both psychological distress and physical complications, such as …
Boosting curcumin derivatives' cytotoxicity in cancer cells with light: An in vitro study.
Greco G, Turrini E, Ferrini F, Maffei F, Neggiani G, Calvaresi M, Di Sante M, Di Giosia M, Belluti F, Sestili P, Fimognari C. Greco G, et al. Biomed Pharmacother. 2025 Nov;192:118643. doi: 10.1016/j.biopha.2025.118643. Epub 2025 Oct 9. Biomed Pharmacother. 2025. PMID: 41072353 Free article.
Due to its ability to absorb visible light, curcumin has also been investigated as a natural photosensitizer (PS) for photodynamic therapy (PDT), a therapeutic approach that utilizes light-activated compounds to kills cancer cells by ROS generation. This study inves …
Due to its ability to absorb visible light, curcumin has also been investigated as a natural photosensitizer (PS) for photodynamic th …
Optimizing the antimicrobial photodynamic efficacy of curcumin liposomes to treat pulmonary infections caused by gram-positive bacteria.
Schöne L, Klein SC, Schorr D, Preis E, Engelhardt K, Diemer S, Munir R, Schlüter S, Schäfer J, Bakowsky U. Schöne L, et al. Eur J Pharm Sci. 2025 Nov 1;214:107311. doi: 10.1016/j.ejps.2025.107311. Epub 2025 Oct 5. Eur J Pharm Sci. 2025. PMID: 41057050 Free article.
To overcome AMR, novel therapy options are required, such as antimicrobial photodynamic therapy (aPDT), initially developed for cancer treatment. In this study, positively charged curcumin (Cur)-loaded 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and 1,2-diole …
To overcome AMR, novel therapy options are required, such as antimicrobial photodynamic therapy (aPDT), initially developed for cancer …
Curcumin: multifaceted biological actions and therapeutic implications-a narrative review.
Ghorbani-Nejad B, Baghani M, Amiri S, Delche NA, Darijani MH, Soltani M, Nezami A, Rahimzadegan M. Ghorbani-Nejad B, et al. Inflammopharmacology. 2025 Nov;33(11):6309-6327. doi: 10.1007/s10787-025-01932-6. Epub 2025 Oct 4. Inflammopharmacology. 2025. PMID: 41045344 Review.
Curcumin, a bioactive polyphenol extracted from the rhizome of Curcuma longa, has garnered considerable attention for its wide-ranging pharmacological properties and potential therapeutic applications. This narrative review critically synthesizes current evidence on cur …
Curcumin, a bioactive polyphenol extracted from the rhizome of Curcuma longa, has garnered considerable attention for its wide-rangin …
Smart nanoconjugates of functionalized cashew gum for targeted co-delivery of curcumin and paclitaxel.
Gomes RF, Vasconcelos ÁV, Carneiro MJM, Ribeiro IS, de Aguiar ACV, Araújo Júnior RF, Torres EJB, Sousa JS, Feitosa JPA, de Paula RCM. Gomes RF, et al. Int J Biol Macromol. 2025 Nov;330(Pt 2):147813. doi: 10.1016/j.ijbiomac.2025.147813. Epub 2025 Sep 21. Int J Biol Macromol. 2025. PMID: 40987361
Carboxymethylated cashew gum (CMCG) was successfully conjugated with curcumin (CUR) forming an acid-sensitive prodrug. Paclitaxel (PTX) was then encapsulated in CMCG-CUR nanoparticles (CMCG-CUR/PTX) via hydrophobic interaction with CUR. ...
Carboxymethylated cashew gum (CMCG) was successfully conjugated with curcumin (CUR) forming an acid-sensitive prodrug. Paclitaxel (PT …
A Systematic Review of Food-Derived DNA Methyltransferase Modulators: Mechanistic Insights and Perspectives for Healthy Aging.
Campisi M, Cannella L, Visioli F, Pavanello S. Campisi M, et al. Adv Nutr. 2025 Nov;16(11):100521. doi: 10.1016/j.advnut.2025.100521. Epub 2025 Sep 18. Adv Nutr. 2025. PMID: 40975498 Free PMC article.
Dysregulation of DNA methyltransferases (DNMTs)-the enzymes catalyzing this process-has been implicated in a wide spectrum of chronic conditions, including cancer, cardiovascular and metabolic disorders, and neurodegenerative diseases. Emerging evidence suggests that food- …
Dysregulation of DNA methyltransferases (DNMTs)-the enzymes catalyzing this process-has been implicated in a wide spectrum of chronic condit …
Curcumin suppresses colorectal cancer by inhibiting TRIM2 and mTOR signaling.
Yu H, Wu H, Zhao Q, Zhao R, Liu J, Yang Z, Song W, Li Y. Yu H, et al. Transl Oncol. 2025 Nov;61:102517. doi: 10.1016/j.tranon.2025.102517. Epub 2025 Sep 13. Transl Oncol. 2025. PMID: 40946588 Free PMC article.
Curcumin, a natural polyphenol, exhibits potent anti-cancer activities, but its underlying molecular mechanisms in colorectal cancer (CRC) are not fully elucidated. ...We initially performed a whole-genome expression profile chip to examine gene alterations f …
Curcumin, a natural polyphenol, exhibits potent anti-cancer activities, but its underlying molecular mechanisms in colorectal …
Investigating the Potential of Curcumin in the Treatment of Nonsmall Cell Lung Cancer: A Systematic Review With Meta-Analysis, Network Pharmacology, and Mendelian Randomization.
Guo Y, Xu H, Shen P, Cai R. Guo Y, et al. Phytother Res. 2025 Nov;39(11):5062-5084. doi: 10.1002/ptr.70073. Epub 2025 Sep 9. Phytother Res. 2025. PMID: 40925573 Free PMC article.
Meta-analysis results showed that curcumin significantly reduced tumor volume of mice (p < 0.001) in the NSCLC group compared to the control group. ...Our study provides a scientific basis for clinical applications of curcumin in NSCLC....

Meta-analysis results showed that curcumin significantly reduced tumor volume of mice (p < 0.001) in the NSCLC group compared to t

…
Chitosan/dialdehyde starch coating onto l-tyrosine and curcumin intercalated layered double hydroxide for improved the therapeutic effects of breast cancer.
Karimi S, Namazi H. Karimi S, et al. Int J Biol Macromol. 2025 Nov;329(Pt 1):147274. doi: 10.1016/j.ijbiomac.2025.147274. Epub 2025 Sep 5. Int J Biol Macromol. 2025. PMID: 40915447
Furthermore, based on the cell viability assessment, LDH exhibited minimal cytotoxicity towards both normal MCF-10A cells (>97 %) and MCF-7 breast cancer cells (>90 %), confirming its good biocompatibility. In contrast, the DAS-CS@Tyr-CUR@LDH bio-hydrogel showed high …
Furthermore, based on the cell viability assessment, LDH exhibited minimal cytotoxicity towards both normal MCF-10A cells (>97 %) and MCF …
Efficacy and Safety of Curcumin as an Adjuvant to Standard Chemotherapy in Advanced and Metastatic Breast Cancer Patients: A Randomized Controlled Study.
Goyal S, Beniwal SK, Agarwal P, Brar RK, Jain P, Kumar HS, Das BC. Goyal S, et al. Phytother Res. 2025 Nov;39(11):5006-5024. doi: 10.1002/ptr.70086. Epub 2025 Sep 3. Phytother Res. 2025. PMID: 40898993 Clinical Trial.
The potential of the phytoconstituent, curcumin, as an adjuvant to chemoradiotherapy has been investigated because of its ameliorating effects, including the sensitization of cancer and cancer stem cells. ...The study suggests that curcumin can be used …
The potential of the phytoconstituent, curcumin, as an adjuvant to chemoradiotherapy has been investigated because of its amelioratin …
Pentagamavunone-1 targets excessive MYCN/NCYM expression mediated by mitotic arrest to suppress hepatocellular carcinoma proliferation.
Novitasari D, Nakamae I, Yoneda-Kato N, Meiyanto E, Kato JY. Novitasari D, et al. Cancer Gene Ther. 2025 Nov;32(11):1233-1244. doi: 10.1038/s41417-025-00956-y. Epub 2025 Sep 1. Cancer Gene Ther. 2025. PMID: 40890311
This study investigated the effects of Pentagamavunone-1 (PGV-1), a curcumin analog with strong antiproliferative properties, on HCC cells expressing MYCN/NCYM. PGV-1 was more effective than curcumin and sorafenib in inhibiting HCC cell proliferation by inducing mit …
This study investigated the effects of Pentagamavunone-1 (PGV-1), a curcumin analog with strong antiproliferative properties, on HCC …
Evaluation of curcumin (CUR) loaded BSA nanoparticles for in-vitro photodynamic therapy on MCF-7 cell line.
Ranjbaran H, Maboudi SA, Moshtaghioun SM, Shojaosadati SA. Ranjbaran H, et al. Drug Dev Ind Pharm. 2025 Nov;51(11):1542-1554. doi: 10.1080/03639045.2025.2542474. Epub 2025 Aug 5. Drug Dev Ind Pharm. 2025. PMID: 40748047
OBJECTIVE: Curcumin (CUR) is a natural phenolic compound with potent anticancer properties and potential as a photosensitizer (PS) for photodynamic therapy (PDT). ...To address these challenges, this study introduces curcumin-loaded bovine serum albumin nanoparticle …
OBJECTIVE: Curcumin (CUR) is a natural phenolic compound with potent anticancer properties and potential as a photosensitizer (PS) fo …
Drug loaded hydrogel nanoparticles with long retention in tumor and multi drug co delivery for melanoma treatment.
Bai J, Liu Y, Chen X, Wang L, Shi J, Liu H, Peng W, Zhao Y, Weng J, Zhi W, Wang J. Bai J, et al. Colloids Surf B Biointerfaces. 2025 Nov;255:114962. doi: 10.1016/j.colsurfb.2025.114962. Epub 2025 Jul 17. Colloids Surf B Biointerfaces. 2025. PMID: 40690894
This study adopted a dual drug loading strategy of curcumin and dexamethasone and designed a drug-loaded nano-system based on polyglutamic acid and caffeic acid. ...
This study adopted a dual drug loading strategy of curcumin and dexamethasone and designed a drug-loaded nano-system based on polyglu …
Nano-curcumin attenuates tamoxifen resistance and malignant progression in ER-positive breast cancer cells by inhibiting the PI3K/AKT/mTOR signaling pathway.
Zhang C, Wang H, Lei H, Ou J. Zhang C, et al. J Steroid Biochem Mol Biol. 2025 Nov;254:106825. doi: 10.1016/j.jsbmb.2025.106825. Epub 2025 Jul 3. J Steroid Biochem Mol Biol. 2025. PMID: 40617262
Breast cancer (BC) is one of the most prevalent malignant tumors among women, with estrogen receptor (ER)-positive patients constituting approximately 70 % of all cases. Endocrine therapy is currently a treatment option for patients with ER-positive BC; however, the develo …
Breast cancer (BC) is one of the most prevalent malignant tumors among women, with estrogen receptor (ER)-positive patients constitut …
pH-responsive chitosan-sodium alginate nanocarriers for curcumin delivery against brain cancer.
Shabestari SM, Pourmadadi M, Abdouss H, Ghanbari T, Abdouss M, Rahdar A, Cambón A, Taboada P. Shabestari SM, et al. Colloids Surf B Biointerfaces. 2025 Nov;255:114875. doi: 10.1016/j.colsurfb.2025.114875. Epub 2025 Jun 9. Colloids Surf B Biointerfaces. 2025. PMID: 40554193 Free article.
Curcumin (CUR) exhibits potent anticancer properties and has been widely investigated for the treatment of various malignancies. ...Collectively, these findings underscore the potential of the developed CS/SA/CeO2@CUR nanoplatform as an effective and biocompatible strategy …
Curcumin (CUR) exhibits potent anticancer properties and has been widely investigated for the treatment of various malignancies. ...C …
Alginate coated mesoporous silica nanoparticles as oral delivery carrier of curcumin and quercetin to colon cancer: preparation, optimization, characterization, and anticancer activity.
Alallam B, Abdkadir E, Hayati A, Keong YY, Lim V. Alallam B, et al. Drug Deliv Transl Res. 2025 Nov;15(11):3793-3834. doi: 10.1007/s13346-024-01777-6. Epub 2025 Jan 12. Drug Deliv Transl Res. 2025. PMID: 39800814
The synergistic bioactive effect of polyphenols can enhance the development of functional foods to prevent chronic diseases such as cancer. Curcumin and quercetin have been shown to possess anticancer properties. The combination of curcumin and quercetin has …
The synergistic bioactive effect of polyphenols can enhance the development of functional foods to prevent chronic diseases such as cance …
Novel Taxol-Derivative, STO-1, Induces Selective Anti-Tumor Immunity and Sustained Remission of Glioblastoma Without Triggering Autoimmune Reactions.
Mohapatra S, Guerrero A, Rahman N, Zaman KT, Wu J, Onyeagba C, Hu C, Pellegrini M, Vankudoth J, Kitamura S, O'Donnell L, Wadghiri YZ, Banerjee P. Mohapatra S, et al. Cells. 2025 Oct 30;14(21):1703. doi: 10.3390/cells14211703. Cells. 2025. PMID: 41227348 Free PMC article.
Reprogramming of macrophages into the inflammatory state (also known as M1) is currently considered as an effective way of eliminating cancer cells, but systemic deployment of this strategy is likely to induce dangerous autoimmune reactions. Consequently, converting immuno …
Reprogramming of macrophages into the inflammatory state (also known as M1) is currently considered as an effective way of eliminating ca …
On the intrinsic stability of curcumin.
Gibbard JA. Gibbard JA. Phys Chem Chem Phys. 2025 Oct 29;27(42):22698-22709. doi: 10.1039/d5cp02049b. Phys Chem Chem Phys. 2025. PMID: 41085585
Curcumin is the primary polyphenol and active ingredient in turmeric, which has demonstrated anti-cancer, anti-microbial, anti-inflammatory and anti-oxidant properties, leading to a significant effort to produce therapeutic variants, with, for example, improved solu …
Curcumin is the primary polyphenol and active ingredient in turmeric, which has demonstrated anti-cancer, anti-microbial, anti …
A multifunctional curcumin-Fe(3)O(4)@ZIF-8 nanoformulation as a T(2) MRI contrast agent and pH-responsive theranostic platform for targeted ROS generation, radiosensitization, and triple-negative breast cancer treatment.
Rahmani A, Maleki A, Jafari R, Rezaeejam H, Nadri S. Rahmani A, et al. J Mater Chem B. 2025 Oct 29;13(42):13805-13829. doi: 10.1039/d5tb00789e. J Mater Chem B. 2025. PMID: 41054909
Triple-negative breast cancer (TNBC) is one of the most aggressive and treatment-resistant malignancies, necessitating the development of innovative therapeutic approaches. ...The ZIF-8 shell enabled tumor-specific curcumin release, with 75% drug release at pH 5.5 ( …
Triple-negative breast cancer (TNBC) is one of the most aggressive and treatment-resistant malignancies, necessitating the developmen …
Deciphering the Anti-Cancer Efficacy of the Combination of Small-Molecule Inhibitor KAN0438757 and Curcumin in Lung Cancer Cell Lines.
Özdemir D, Ağca CA. Özdemir D, et al. Curr Issues Mol Biol. 2025 Oct 28;47(11):892. doi: 10.3390/cimb47110892. Curr Issues Mol Biol. 2025. PMID: 41296396 Free PMC article.
Lung cancer is among the most aggressive malignancies, with the highest incidence and mortality rates worldwide. ...This study aimed to evaluate the anticancer effects of KAN0438757 in combination with curcumin in lung cancer cells. Evaluation of cell viabili …
Lung cancer is among the most aggressive malignancies, with the highest incidence and mortality rates worldwide. ...This study aimed …
Antitumor and Immunoregulatory Effects of Curcumin Analog, (Z)-3-Hydroxy-1-(2-hydroxyphenyl)-3-phenyl prop-2-ene-1-one (DK1), on CT26-Tumor-Bearing BALB/c Mi.
Hussin Y, Che Rahim NF, Aziz MNM, Izham MNM, Yeap SK, Mohamad NE, Nik Abdul Rahman NMA, Osman MA, Akhtar MN, Alitheen NB. Hussin Y, et al. Curr Med Chem. 2025 Oct 24. doi: 10.2174/0109298673396217251003070048. Online ahead of print. Curr Med Chem. 2025. PMID: 41140209
Even though it has many strong biological properties, curcumin lacks solubility, which affects its clinical efficacy. DK1 is a curcumin analogue that has been found to possess selective cytotoxicity on breast cancer cells compared to normal breast cells; howe …
Even though it has many strong biological properties, curcumin lacks solubility, which affects its clinical efficacy. DK1 is a cur …
Curcumin alleviates ferroptosis in CCl4-induced acute liver injury in vitro: involvement of TXNIP/NLRP3 inhibition and SLC7A11/GSH/GPX4 activation.
Zhang W, Liu Z, Dong C, Yang H, Zhang Y, Li S, Qiu Y, Xu L. Zhang W, et al. Naunyn Schmiedebergs Arch Pharmacol. 2025 Oct 24. doi: 10.1007/s00210-025-04748-x. Online ahead of print. Naunyn Schmiedebergs Arch Pharmacol. 2025. PMID: 41136720
Acute liver injury (ALI) is a global health issue associated with high mortality rates and has garnered significant clinical attention. Curcumin (CUR), a natural compound derived from turmeric rhizomes, possesses diverse therapeutic benefits. ...
Acute liver injury (ALI) is a global health issue associated with high mortality rates and has garnered significant clinical attention. C …
Curcumin attenuates LPS-induced inflammation in RAW 264.7 cells: A multifaceted study integrating network pharmacology, molecular docking, molecular dynamics simulation, and experimental validation.
Gong X, Xue D, Meng H, Xie B, Zhao L, Zang C, Kong J. Gong X, et al. PLoS One. 2025 Oct 23;20(10):e0335139. doi: 10.1371/journal.pone.0335139. eCollection 2025. PLoS One. 2025. PMID: 41129534 Free PMC article.
Despite extensive research, the comprehensive molecular mechanisms underlying curcumin's anti-inflammatory effects, particularly its multi-target regulatory network, remain incompletely understood. ...CONCLUSION: Our study provides a comprehensive understanding of …
Despite extensive research, the comprehensive molecular mechanisms underlying curcumin's anti-inflammatory effects, particular …
Insights into Hepatic, Neuronal, and hERG Channel Safety of Plant-Derived Active Compounds.
Kasemnitichok Y, Lee S, Kwon OB, Plengsuriyakarn T, Na-Bangchang K. Kasemnitichok Y, et al. J Xenobiot. 2025 Oct 22;15(6):175. doi: 10.3390/jox15060175. J Xenobiot. 2025. PMID: 41283413 Free PMC article.
Curcumin (CUR), atractylodin (ATD), alpha-mangostin (alphaMG), ethyl-p-methoxycinnamate (EPMC), ligustilide (LIG), and beta-eudesmol (BEU) are commonly used in Thai traditional medicine formulations. This study evaluated the cytotoxic effects of these compounds in HepG2 li …
Curcumin (CUR), atractylodin (ATD), alpha-mangostin (alphaMG), ethyl-p-methoxycinnamate (EPMC), ligustilide (LIG), and beta-eudesmol …
Integrated molecular and ADME-toxicity profiling identifies PGV-5 and HGV-5 as potential agents to counteract multidrug-resistant (MDR) cancer.
Ritmaleni, Anargya RDP, Alivia N, Marbun P, Murwanti R, Habibie RK. Ritmaleni, et al. Sci Rep. 2025 Oct 21;15(1):36515. doi: 10.1038/s41598-025-02858-3. Sci Rep. 2025. PMID: 41120301 Free PMC article.
Curcumin, a pharmacological agent found in turmeric's rhizome, has been studied for its various therapeutic properties. ...Their ADME profile indicates they serve as effective P-glycoprotein (P-gp) inhibitors, making them potential candidates for development as anti-multid …
Curcumin, a pharmacological agent found in turmeric's rhizome, has been studied for its various therapeutic properties. ...Their ADME …
AN02, a Naovel Curcumin Derivative, Orchestrates APC-SMAD4-Mediated CTLA-4 Degradation for Ovarian Cancer Therapy.
Jin H, Zhang M, Shi M, Miao P, Zhang MJ. Jin H, et al. Mol Carcinog. 2025 Oct 21. doi: 10.1002/mc.70048. Online ahead of print. Mol Carcinog. 2025. PMID: 41118559
Experimental results demonstrated that AN02 significantly inhibited ovarian cancer cell proliferation at very low concentrations, with its half-maximal inhibitory concentration (IC(50)) significantly lower than that of curcumin. ...As a novel curcumin derivat …
Experimental results demonstrated that AN02 significantly inhibited ovarian cancer cell proliferation at very low concentrations, wit …
Synergistic anticancer efficacy of optimized curcumin-piperine loaded magnetic nanoparticles for the treatment of colorectal cancer.
Puri R, Arora V. Puri R, et al. Explor Target Antitumor Ther. 2025 Oct 20;6:1002340. doi: 10.37349/etat.2025.1002340. eCollection 2025. Explor Target Antitumor Ther. 2025. PMID: 41140878 Free PMC article.
AIM: The current study uses the depicted approach to synthesize curcumin-piperine loaded Poloxamer F-68 coated magnetic nanoparticles (CUR-PIP-F68-Fe(3)O(4) NPs) to achieve a synergistic anti-cancer impact on an in vitro HCT-116 colon cancer cell. ...CONCLUSI …
AIM: The current study uses the depicted approach to synthesize curcumin-piperine loaded Poloxamer F-68 coated magnetic nanoparticles …
Chitosan-embedded beta-cyclodextrin-magnetic graphene oxide nanoparticles for curcumin loading: evaluating cytotoxicity and apoptosis induction in esophageal cancer.
Sajjadi SS, Einafshar E, Javid H, Assaran Darban R, Jafari N, Hashemy SI. Sajjadi SS, et al. Naunyn Schmiedebergs Arch Pharmacol. 2025 Oct 20. doi: 10.1007/s00210-025-04737-0. Online ahead of print. Naunyn Schmiedebergs Arch Pharmacol. 2025. PMID: 41111130
The high mortality rate associated with esophageal cancer highlights the critical need for innovative therapeutic approaches. This study aimed to evaluate the cytotoxic effects of Curcumin@beta-CD-MGO/CS nanoparticles on YM1 and KYSE-30 esophageal cancer cell …
The high mortality rate associated with esophageal cancer highlights the critical need for innovative therapeutic approaches. This st …
Stimuli-Responsive Upconversion Nanoparticles-Embedded Mesoporous SiO2 Nanospheres for Delivery of Hydrophilic and Hydrophobic Anticancer Drugs and Cellular Imaging.
Dubey N, Gupta S, Shelar SB, Dutta B, Barick KC, Chandra S. Dubey N, et al. ACS Appl Bio Mater. 2025 Oct 20;8(10):8815-8828. doi: 10.1021/acsabm.5c00966. Epub 2025 Oct 3. ACS Appl Bio Mater. 2025. PMID: 41042529
Furthermore, the porous nature of the silica matrix allows efficient encapsulation of anticancer drugs, doxorubicin hydrochloride (DOX) and curcumin (CUR), and demonstrates their sustained and controlled pH-responsive release with higher release in a mildly acidic environm …
Furthermore, the porous nature of the silica matrix allows efficient encapsulation of anticancer drugs, doxorubicin hydrochloride (DOX) and …
Molecular Insights into Paclitaxel and Curcumin-Loaded Carbon Dots: Computational and Experimental Evidence of NRF2 and Autophagy Modulation in Ovarian Cancer.
Alibolandi Z, Seyed Hosseini E, Mirsafi A, Pourhanifeh MH, Jafari SM, Yasamian A, Nikzad H, Masoum S. Alibolandi Z, et al. ACS Appl Bio Mater. 2025 Oct 20;8(10):8673-8686. doi: 10.1021/acsabm.5c00701. Epub 2025 Sep 16. ACS Appl Bio Mater. 2025. PMID: 40956010
Results demonstrated that NBCDs exhibit excellent biocompatibility and enhance curcumin's cellular uptake. CUR-NBCDs effectively induced autophagy, evidenced by acridine orange staining and modulation of autophagy markers. ...Molecular docking and dynamics simulatio …
Results demonstrated that NBCDs exhibit excellent biocompatibility and enhance curcumin's cellular uptake. CUR-NBCDs effective …
Curcumin in prostate cancer: a systematic review of molecular mechanisms and nanoformulated therapeutic strategies.
Esmaeli M, Dehghanpour Dehabadi M. Esmaeli M, et al. BMC Cancer. 2025 Oct 18;25(1):1609. doi: 10.1186/s12885-025-15152-2. BMC Cancer. 2025. PMID: 41109942 Free PMC article.
Curcumin, a polyphenol from Curcuma longa, has emerged as a potent anti-cancer agent by modulating several molecular pathways. OBJECTIVE: This systematic review seeks to synthesize current preclinical evidence on the molecular mechanisms underlying curcumin' …
Curcumin, a polyphenol from Curcuma longa, has emerged as a potent anti-cancer agent by modulating several molecular pathways. …
Development of Iron-Chelating/Antioxidant Nutraceuticals and Natural Products as Pharmaceuticals for Clinical Use in Diseases with Free Radical Pathologies.
Kontoghiorghes GJ. Kontoghiorghes GJ. Nutrients. 2025 Oct 17;17(20):3270. doi: 10.3390/nu17203270. Nutrients. 2025. PMID: 41156522 Free PMC article. Review.
Millions of people choose to use nutraceutical and natural product antioxidants as therapeutics and also for chemoprevention against cancer and other diseases. New academic efforts and strategies are required for the development of antioxidant drugs in clinical practice in …
Millions of people choose to use nutraceutical and natural product antioxidants as therapeutics and also for chemoprevention against canc …
Curcumin-Loaded Nanomaterials as Carriers for Photodynamic Therapy Against Cancers.
Xu C, Law SK, Leung AWN, Feng M. Xu C, et al. Gels. 2025 Oct 17;11(10):833. doi: 10.3390/gels11100833. Gels. 2025. PMID: 41149437 Free PMC article. Review.
Cancer is a prevalent disease worldwide. Photodynamic therapy (PDT) is a non-invasive and highly targeted treatment for certain types of cancer. ...Growing evidence has shown that curcumin-loaded nanogels have their specific functions, such as drug delivery a …
Cancer is a prevalent disease worldwide. Photodynamic therapy (PDT) is a non-invasive and highly targeted treatment for certain types …
Integrated bioinformatics and molecular docking ıdentify CCNB1, CDK1, and CYP1A2 as therapeutic targets of phytochemicals in hepatocellular carcinoma.
Isıyel M, Ceylan H, Demir Y. Isıyel M, et al. Naunyn Schmiedebergs Arch Pharmacol. 2025 Oct 16. doi: 10.1007/s00210-025-04729-0. Online ahead of print. Naunyn Schmiedebergs Arch Pharmacol. 2025. PMID: 41099846
Hepatocellular carcinoma (HCC) is a globally prevalent malignancy and a leading cause of cancer-related mortality; robust prognostic biomarkers and actionable therapeutic strategies are urgently needed. ...To explore pharmacological relevance, hub genes were cross-referenc …
Hepatocellular carcinoma (HCC) is a globally prevalent malignancy and a leading cause of cancer-related mortality; robust prognostic …
Development and Application of a CAFLUX HepG2 Reporter Cell Line for Real-Time Monitoring of AhR-Mediated CYP1A1 Gene Expression in Response to Environmental Toxicants and Bioactive Modulators.
La HT, Hoang HH, Le PMT, Nguyen LT, Nguyen DT, Nguyen VH, Ha TMT, Nguyen LH, Nguyen DT. La HT, et al. Int J Mol Sci. 2025 Oct 15;26(20):10029. doi: 10.3390/ijms262010029. Int J Mol Sci. 2025. PMID: 41155323 Free PMC article.
This reporter activity correlated with endogenous CYP1A1 mRNA expression as determined by quantitative polymerase chain reaction (qPCR), confirming that GFP signals reflected native transcriptional responses. In functional assays, curcumin suppressed GFP expression in a co …
This reporter activity correlated with endogenous CYP1A1 mRNA expression as determined by quantitative polymerase chain reaction (qPCR), con …
Nano-curcumin potentiates antitumor immunity in prostate cancer via co-culture with adipose-derived mesenchymal stem cells.
Zeynali F, Tehran MH, Faraji F, Mahmoudi M, Tabasi NS, Ghoreyshi S, Arab FL. Zeynali F, et al. BMC Complement Med Ther. 2025 Oct 15;25(1):373. doi: 10.1186/s12906-025-05129-w. BMC Complement Med Ther. 2025. PMID: 41094465 Free PMC article.
BACKGROUND: Curcumin is a polyphenolic compound from Curcuma longa that exhibits immunoregulatory and anti-cancer properties. ...This study investigates the combined effects of nano-curcumin and adipose-derived mesenchymal stem cells (ASCs) on peripheral bloo …
BACKGROUND: Curcumin is a polyphenolic compound from Curcuma longa that exhibits immunoregulatory and anti-cancer properties. …
Targeting Key Molecular Mechanisms in Triple-Negative Breast Cancer Therapies with Natural Compounds.
Faysal M, Zehravi M, Al Amin M, Sweilam SH, Panigrahy UP, Khan AS, Kar NR, Dash SK, Padhan A, Rab SO, Uddin MZ, Cherrada N, Bin Emran T. Faysal M, et al. Curr Pharm Des. 2025 Oct 14. doi: 10.2174/0113816128411154250918060514. Online ahead of print. Curr Pharm Des. 2025. PMID: 41102953
BACKGROUND: Triple-negative breast cancer (TNBC) is characterized by the absence of HER2 expression, progesterone receptor (PR), and estrogen receptor (ER). ...RESULTS: Natural bioactive compounds like curcumin, resveratrol, quercetin, EGCG, berberine, and thymoquin …
BACKGROUND: Triple-negative breast cancer (TNBC) is characterized by the absence of HER2 expression, progesterone receptor (PR), and …
Dual redox effects of 2,6-bis-(4-hydroxyl-3-methoxybenzylidene) cyclohexanone (BHMC) on human liver cancer cells, HepG2 via ROS, glutathione and Nrf2/Keap1 pathway.
Mohd Shafiee MA, Syed Alwi SS, Othman Z, Nurdin A, Md Razip NN. Mohd Shafiee MA, et al. Sci Rep. 2025 Oct 13;15(1):35731. doi: 10.1038/s41598-025-19874-y. Sci Rep. 2025. PMID: 41083693 Free PMC article.
INTRODUCTION: Curcumin has demonstrated significant potential as a chemoprotective agent by inducing death in malignant cells while exhibiting selective cytotoxicity toward normal cells. ...However, at a higher concentration of 20 M, BHMC induces oxidative stress like c …
INTRODUCTION: Curcumin has demonstrated significant potential as a chemoprotective agent by inducing death in malignant cells while e …
Curcumin triggers reactive oxygen species-mediated apoptosis and suppresses tumor growth in metastatic oral squamous cell carcinoma.
Ramos TCF, Dias RB, Santos LS, Valverde LF, Nogueira RLR, Bastos IN, Coletta RD, Soares MBP, Souza BSF, Dos Santos JN, Dos Reis MG, Bezerra DP, Gurgel CA. Ramos TCF, et al. Front Oncol. 2025 Oct 10;15:1668271. doi: 10.3389/fonc.2025.1668271. eCollection 2025. Front Oncol. 2025. PMID: 41142603 Free PMC article.
In this context, several natural compounds (NC), such as curcumin, have shown promising effects in OSCC. However, there is still limited evidence about curcumin's effects on cell death in metastatic OSCC cells and its cytotoxicity in preclinical models. ...ME …
In this context, several natural compounds (NC), such as curcumin, have shown promising effects in OSCC. However, there is still limi …
Polymerized Apoferritin: A promising carrier for efficient compartmentalized and deep-layer delivery of calcium donors in tumor Ca overload therapy.
Sun P, Wang S, Wang H, Li Y, Wang S, Chen X, Wu Z, Qi X. Sun P, et al. J Control Release. 2025 Oct 10;386:114096. doi: 10.1016/j.jconrel.2025.114096. Epub 2025 Aug 4. J Control Release. 2025. PMID: 40752861
This carrier is further compartmentalized with calcium phosphate and the calcium ion extrusion inhibitor curcumin. We have confirmed that during in vivo circulation, polymerized apoferritin can effectively reduce the interception and interference of the nanocage by masking …
This carrier is further compartmentalized with calcium phosphate and the calcium ion extrusion inhibitor curcumin. We have confirmed …
The novel curcumin analogue AKT-100 targets mutant p53 in gynecologic cancer cells.
Williams GL, Smith LE, Padilla JL, Goss AS, Belmares-Ortega D, Wu X, Daw JN, Mitra S, Jagtap P, Choe JY, Leslie KK. Williams GL, et al. bioRxiv [Preprint]. 2025 Oct 9:2025.10.06.680794. doi: 10.1101/2025.10.06.680794. bioRxiv. 2025. PMID: 41279406 Free PMC article. Preprint.
We hypothesize that directly targeting missense mutant p53 instead of downstream pathways has substantial advantages. Analogues of curcumin have been reported to bind mutant p53 to accomplish this goal. In this report, we developed a series of novel molecules derived from …
We hypothesize that directly targeting missense mutant p53 instead of downstream pathways has substantial advantages. Analogues of curcum …
Size-variable self-feedback nanomotors for glioblastoma therapy via mitochondrial mineralization.
Chen T, Duan Y, Wang Y, Liang T, Liu S, Xia X, Mao C, Wan M. Chen T, et al. Nat Commun. 2025 Oct 9;16(1):8990. doi: 10.1038/s41467-025-64020-x. Nat Commun. 2025. PMID: 41068089 Free PMC article.
It comprises three components: a self-feedback degradable lipid shell (containing nitric oxide-releasing lipid and nitric oxide-responsive degradable lipid), a motion nanomotor core (containing L-arginine derivatives and carboxyl-rich zwitterionic monomers for Ca(2+) recruitment) …
It comprises three components: a self-feedback degradable lipid shell (containing nitric oxide-releasing lipid and nitric oxide-responsive d …
Nano-phytochemical-based formulations as promising opportunities for prostate cancer therapy and management: a comprehensive narrative review.
Bakhshan MA, Sheikhzadeh S, Ramezanimoladehi M, Pourkamalzadeh M, Sheikhzadeh S. Bakhshan MA, et al. Med Oncol. 2025 Oct 8;42(11):510. doi: 10.1007/s12032-025-03059-8. Med Oncol. 2025. PMID: 41062899 Review.
By enhancing their pharmacokinetics, nanotechnology allows for targeted delivery to prostate cancer cells, increasing therapeutic effectiveness. This innovation has redefined phytochemical-based cancer treatment, providing a solution to their previous limitations. E …
By enhancing their pharmacokinetics, nanotechnology allows for targeted delivery to prostate cancer cells, increasing therapeutic eff …
Novel curcumin nanocarrier for targeting drug delivery of mitochondria proves efficacy in in vivo experiments on hepatocellular carcinoma mice models.
Kianamiri S, Shokri E, Maleki P, Soudi S, Soltaninejad H, Sadeghizadeh M. Kianamiri S, et al. Sci Rep. 2025 Oct 8;15(1):35114. doi: 10.1038/s41598-025-19147-8. Sci Rep. 2025. PMID: 41062714 Free PMC article.
This design enables mitochondrial targeting, leveraging the elevated membrane potential of cancer cells to enhance curcumin's anticancer activity. According to the results, the TDC influences the secreted levels of INF-gamma and IL-4 on tumor lysis-stimulated …
This design enables mitochondrial targeting, leveraging the elevated membrane potential of cancer cells to enhance curcumin' …
Bioinspired synthesis of ultra-small copper-aspartate BioMOF nanodots using sodium caseinate for targeted curcumin delivery.
Rezaee R, Tohidi M, Rastegari B, Zeinali S. Rezaee R, et al. Sci Rep. 2025 Oct 8;15(1):35086. doi: 10.1038/s41598-025-18880-4. Sci Rep. 2025. PMID: 41062636 Free PMC article.
Ultra-small nanodots of biocompatible Cu-Asp was synthesized as a carrier for curcumin (CCM) in the presence of sodium caseinate (CAS) in an aqueous medium at room temperature. ...The potential cytotoxicity was evaluated using the MTT assay in Normal skin fibroblast and He …
Ultra-small nanodots of biocompatible Cu-Asp was synthesized as a carrier for curcumin (CCM) in the presence of sodium caseinate (CAS …
Curcumin and Acute Myeloid Leukemia: Synergistic Effects with Targeted Therapy.
Badagliacca R, Fazio M, Stagno F, Mirabile G, Gerace D, Allegra A. Badagliacca R, et al. Int J Mol Sci. 2025 Oct 5;26(19):9700. doi: 10.3390/ijms26199700. Int J Mol Sci. 2025. PMID: 41096965 Free PMC article. Review.
The aim of this review is to demonstrate the possible anti-leukemic effect of curcumin, thus its ability to induce apoptosis, inhibit cell proliferation, and modulate angiogenesis. Nowadays, although multiple synergistic effects have been observed and curcumin's …
The aim of this review is to demonstrate the possible anti-leukemic effect of curcumin, thus its ability to induce apoptosis, inhibit …
Curcumin for the treatment of pituitary adenomas: the potential of a single agent for multifaceted therapeutic effects.
Yan Z, Liang C, Nian F, Peng G, Li Y, Guan J, Pan R, Song G. Yan Z, et al. Front Endocrinol (Lausanne). 2025 Oct 3;16:1648521. doi: 10.3389/fendo.2025.1648521. eCollection 2025. Front Endocrinol (Lausanne). 2025. PMID: 41113703 Free PMC article. Review.
While current treatments (surgery, pharmacotherapy, radiation) face challenges such as drug resistance, recurrence, and metabolic complications, curcumin emerges as a promising multi-target agent for PA management. This review synthesizes evidence on curcumin's …
While current treatments (surgery, pharmacotherapy, radiation) face challenges such as drug resistance, recurrence, and metabolic complicati …
Molecular targets and therapeutic implications of curcumin in hepatocellular carcinoma: a comprehensive literature review.
Esmaeli M, Dehabadi MD, Ghanbari A. Esmaeli M, et al. Cancer Cell Int. 2025 Oct 3;25(1):335. doi: 10.1186/s12935-025-03988-4. Cancer Cell Int. 2025. PMID: 41044771 Free PMC article. Review.
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, with Limited treatment options and poor outcomes in advanced stages. Curcumin, a bioactive compound derived from Curcuma longa, has drawn significant attention for its anti …
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, with Limited treatment options and poor …
Curcumin's dual effect on pyroptosis and autophagy in metabolic- associated fatty liver disease: a potential therapeutic strategy.
Eldken ZH, Youssef OM, Khalil RM, Kassab AAM, Ramadan A, Sakr NH. Eldken ZH, et al. Sci Rep. 2025 Oct 2;15(1):34309. doi: 10.1038/s41598-025-11135-2. Sci Rep. 2025. PMID: 41038833 Free PMC article.
Gasdermin D (GSDMD), a key executor of pyroptosis, plays a central role in this process by mediating inflammatory cell death and has emerged as a potential marker of liver injury severity. This study evaluates curcumin's effects on liver fat accumulation, inflammato …
Gasdermin D (GSDMD), a key executor of pyroptosis, plays a central role in this process by mediating inflammatory cell death and has emerged …
Chemopreventive Effects of Resveratrol and Curcumin on Melanoma Growth in C57BL/6 Mice.
Ul Islam S, Al Saidi A, Akbar S, Akhlaq A, Shehzad A, Ul-Islam M. Ul Islam S, et al. Asian Pac J Cancer Prev. 2025 Oct 1;26(10):3671-3677. doi: 10.31557/APJCP.2025.26.10.3671. Asian Pac J Cancer Prev. 2025. PMID: 41148606 Free article.
This study investigates the chemopreventive potential of two phytochemicals, resveratrol (RV) and curcumin (CUR), in a C57BL/6 mouse model of melanoma. Utilizing a xenograft approach, we implanted B16F10 cells subcutaneously into mice and treated them with RV and CUR at a …
This study investigates the chemopreventive potential of two phytochemicals, resveratrol (RV) and curcumin (CUR), in a C57BL/6 mouse …
In vitro Evaluation of the Combined Effects of a Static Magnetic Field and Curcumin on MCF7 and HeLa Cell Lines.
Shojapour M, Mosayebi G, Fathi Y, Soleimani H. Shojapour M, et al. Asian Pac J Cancer Prev. 2025 Oct 1;26(10):3653-3662. doi: 10.31557/APJCP.2025.26.10.3653. Asian Pac J Cancer Prev. 2025. PMID: 41148604 Free article.
OBJECTIVE: This study examined how varying levels of curcumin and static magnetic fields (SMF) affected three cell types, with outcomes influenced by field strength and curcumin concentration in normal and cancerous cells. ...CONCLUSION: This study demonstrat …
OBJECTIVE: This study examined how varying levels of curcumin and static magnetic fields (SMF) affected three cell types, with outcom …
Synthesis of First Copper Metal Complex of C=C Extended Curcuminoid Analogue: Structure, β-Cyclodextrin Association, and Biological Properties.
Tavera-Hernández R, Sánchez-Obregón R, Obregón-Mendoza MA, Nieto-Camacho A, Ramírez-Apan MT, Pérez-González LL, Enríquez RG. Tavera-Hernández R, et al. Molecules. 2025 Oct 1;30(19):3943. doi: 10.3390/molecules30193943. Molecules. 2025. PMID: 41097363 Free PMC article.
The search for bioactive compounds against chronic diseases such as cancer and diabetes includes curcuminoids as promising scaffolds. Here, we report the synthesis of a family of curcuminoid analogue compounds with an extended unsaturated central chain, as follows: difluor …
The search for bioactive compounds against chronic diseases such as cancer and diabetes includes curcuminoids as promising scaffolds. …
One Pot Synthesis of the C-3 Complex (Curcumin, Demethoxycurcumin, and Bis-Demethoxycurcumin): Their Joint and Independent Biological Actions.
Obregón-Mendoza MA, Sánchez-Obregón R, Tavera-Hernández R, Pérez-González LL, Nieto-Camacho A, Rodríguez-Sotres R, Escobedo-Martínez C, Romero I, Enríquez RG. Obregón-Mendoza MA, et al. Int J Mol Sci. 2025 Oct 1;26(19):9599. doi: 10.3390/ijms26199599. Int J Mol Sci. 2025. PMID: 41096864 Free PMC article.
Curcumin (CUR) is the primary metabolite isolated from the Curcuma longa L. rhizome. Most synthetic and biological studies have focused mainly on the curcumin molecule due to its essential biological activity as an antioxidant, anti-cancer, and anti-Alzheimer …
Curcumin (CUR) is the primary metabolite isolated from the Curcuma longa L. rhizome. Most synthetic and biological studies have focus …
Mechanistic Insights into the Therapeutic Role of Curcumin in Leukemia: Molecular Targets and Clinical Implications.
Logesh R, Alam W, Alsharif KF, Filosa R, Theyab A, Xu B, Orhan IE, Khan H. Logesh R, et al. Curr Pharm Biotechnol. 2025 Oct 1. doi: 10.2174/0113892010367533250923105438. Online ahead of print. Curr Pharm Biotechnol. 2025. PMID: 41036753
This review investigates the therapeutic potential of curcumin (CUR), a naturally derived polyphenol, in leukemia management, with a focus on its molecular mechanisms and regulatory effects on various signaling pathways. ...CUR exhibits strong potential as a therapeutic ag …
This review investigates the therapeutic potential of curcumin (CUR), a naturally derived polyphenol, in leukemia management, with a …
Chitosan-Based Systems for Curcumin Delivery: Evidence for Therapeutic Applications.
Monteiro MM, Bastos Silveira B, Di Carvalho Melo L, Tolentino S, Amorim Dos Santos J, Ferreira EB, Reis PEDD, Gelfuso GM, Guerra ENS. Monteiro MM, et al. J Biochem Mol Toxicol. 2025 Oct;39(10):e70515. doi: 10.1002/jbt.70515. J Biochem Mol Toxicol. 2025. PMID: 40995635 Review.
Despite its therapeutic promise, curcumin's clinical use is limited by poor water solubility and low bioavailability. Chitosan-based delivery systems, especially polymeric nanoparticles, have been a strategy to improve curcumin's solubility, stability, …
Despite its therapeutic promise, curcumin's clinical use is limited by poor water solubility and low bioavailability. Chitosan …
Redox-triggered hyaluronic acid polymersomes for co-delivery of methotrexate and curcumin to breast cancer cells.
Ahrar S, Bagheri F, Ganji F. Ahrar S, et al. Int J Biol Macromol. 2025 Oct;327(Pt 2):147232. doi: 10.1016/j.ijbiomac.2025.147232. Epub 2025 Aug 31. Int J Biol Macromol. 2025. PMID: 40897276
In this study, an amphiphilic, redox-sensitive hyaluronic acid-polycaprolactone block copolymer was synthesized for targeted drug delivery to CD44-overexpressing breast cancer MDA-MB-231 cells. Nanopolymersomes were formed via nanoprecipitation and co-loaded with curcum …
In this study, an amphiphilic, redox-sensitive hyaluronic acid-polycaprolactone block copolymer was synthesized for targeted drug delivery t …
Tailoring curcumin-loaded PLGA electrospun nanofibers for anti-cancer treatment via different delivery routes and for potential post-tumor removal implantation.
Ajalloueian F, Malakpour-Permlid A, Yeganegi M, Azizi S, Vasos A, Soufi G, Boisen A. Ajalloueian F, et al. Biomed Pharmacother. 2025 Oct;191:118444. doi: 10.1016/j.biopha.2025.118444. Epub 2025 Aug 16. Biomed Pharmacother. 2025. PMID: 40819540 Free article.
In this study, we addressed the challenge of enhancing the efficacy of curcumin (Cur) delivery for cancer treatment by developing Cur-loaded electrospun sheets (ES) fabricated from PLGA (poly(lactic-co-glycolic acid)) with a focus on tailoring both the dosage and th …
In this study, we addressed the challenge of enhancing the efficacy of curcumin (Cur) delivery for cancer treatment by develop …
Controlled release of curcumin and gemcitabine from mucoadhesive chitosan-gelatin polymeric ovules: Cytotoxic effects on cervical cancer cells.
Alvarez-Quezada OA, Espino-Núñez YE, Valencia-Gómez LE, Martel-Estrada SA, Arellano-Rodríguez NC, Zapata-Benavides P, Vargas-Requena CL. Alvarez-Quezada OA, et al. Eur J Pharm Biopharm. 2025 Oct;215:114834. doi: 10.1016/j.ejpb.2025.114834. Epub 2025 Aug 5. Eur J Pharm Biopharm. 2025. PMID: 40754206
Cervical cancer (CxCa) is the fourth most common type of neoplasm affecting the global female population. ...After 8 h of incubation at 37 C, ovules containing 10 % gelatin released more curcumin, while those with 10 % and 20 % released more gemcitabine. Curcumin …
Cervical cancer (CxCa) is the fourth most common type of neoplasm affecting the global female population. ...After 8 h of incubation …
Anti-Inflammatory and Antibacterial Properties of Curcuma longa Extract Against Helicobacter pylori.
Kim J, Kim KW, Jang JK, Kim MJ, Cooray A, Lee YS, Lee KP, Lee DY. Kim J, et al. Mol Nutr Food Res. 2025 Oct;69(20):e70161. doi: 10.1002/mnfr.70161. Epub 2025 Jun 29. Mol Nutr Food Res. 2025. PMID: 40583343 Free PMC article.
Helicobacter pylori is a Gram-negative, microaerophilic bacterium that colonizes the human stomach, causing gastritis, gastric ulcers, and gastric cancer. This study investigated the anti-Helicobacter and anti-inflammatory effects of Curcuma longa extract (CLE) as a potent …
Helicobacter pylori is a Gram-negative, microaerophilic bacterium that colonizes the human stomach, causing gastritis, gastric ulcers, and g …
Corrigendum to "Hyaluronic acid coating on the surface of curcumin-loaded ZIF-8 nanoparticles for improved breast cancer therapy: An in vitro and in vivo study" [Colloid. Surf. B Biointerfaces 203 (2021) 111759 /COLSUB-D-20-01957].
Yu S, Wang S, Xie Z, Yu S, Li L, Xiao H, Song Y. Yu S, et al. Colloids Surf B Biointerfaces. 2025 Oct;254:114894. doi: 10.1016/j.colsurfb.2025.114894. Epub 2025 Jun 28. Colloids Surf B Biointerfaces. 2025. PMID: 40582936 No abstract available.
An old spice with new tricks: Curcumin targets adenoma and colorectal cancer stem-like cells associated with poor survival outcomes.
Khan S, Karmokar A, Howells L, Britton RG, Parrott E, Palacios-Gallego R, Tufarelli C, Cai H, Higgins J, Sylvius N, West K, McGregor A, Moore D, Burgess SG, Richards MW, Winter A, Sidat Z, Foreman N, Hoorn ST, Vermeulen L, Singh B, Hemingway D, Norwood M, Miller A, Boyle K, Ho C, Aslam MI, Bayliss R, Nateri AS, Rufini A, Gescher A, Thomas AL, Steward WP, Brown K. Khan S, et al. Cancer Lett. 2025 Oct 1;629:217885. doi: 10.1016/j.canlet.2025.217885. Epub 2025 Jun 19. Cancer Lett. 2025. PMID: 40543657 Free article.
Development of curcumin, from the spice turmeric, as a preventive therapy for colorectal cancer (CRC) is hindered by poor understanding of its mechanism of action. Using patient derived xenografts and ex-vivo 3D-models exposed to clinically achievable curcumin …
Development of curcumin, from the spice turmeric, as a preventive therapy for colorectal cancer (CRC) is hindered by poor unde …
Folic Acid Targeted Selenium-Curcumin Nanoparticles to Enhance Apoptosis in Breast Cancer Cells.
Davarani Asl F, Mohammadi Arvejeh P, Rezaee M, Saffari-Chaleshtori J, Deris F, Satari A, Asgharzadeh S, Khosravian P. Davarani Asl F, et al. Chem Biodivers. 2025 Oct;22(10):e00183. doi: 10.1002/cbdv.202500183. Epub 2025 Jun 16. Chem Biodivers. 2025. PMID: 40522777
Selenium (Se) and curcumin (Cur) exhibit antioxidant and anticancer properties, but their efficient application in cancer therapy is complex. This study developed a targeted drug delivery system for 4T1 breast cancer cells using selenium nanoparticles (SeNPs) …
Selenium (Se) and curcumin (Cur) exhibit antioxidant and anticancer properties, but their efficient application in cancer ther …
Therapeutic Effects of Curcuminoids and Silymarin, Individually and in Combination, in Patients With Hepatic Impairment.
Elgendy EM, El Sherbiny WA, Sedki AG, Gaber HH. Elgendy EM, et al. Chem Biodivers. 2025 Oct;22(10):e03340. doi: 10.1002/cbdv.202403340. Epub 2025 Jun 13. Chem Biodivers. 2025. PMID: 40513108
Results indicated considerable antioxidant properties, antimicrobial effectiveness against pathogens like Staphylococcus aureus and Escherichia coli, and anticancer potential against liver and colorectal cancers. Significant improvements in liver enzyme indicators and seru …
Results indicated considerable antioxidant properties, antimicrobial effectiveness against pathogens like Staphylococcus aureus and Escheric …
Herbal Medicine for Colorectal Cancer Treatment: Molecular Mechanisms and Clinical Applications.
Su Z, Li Y, Zhou Z, Feng B, Chen H, Zheng G. Su Z, et al. Cell Prolif. 2025 Oct;58(10):e70065. doi: 10.1111/cpr.70065. Epub 2025 Jun 9. Cell Prolif. 2025. PMID: 40488304 Free PMC article. Review.
Colorectal cancer (CRC) is one of the most common malignant tumours and is the second leading cause of cancer-related mortality worldwide. ...Furthermore, numerous studies have reported the anti-cancer and anti-metastatic effects of various phytomedicines, in …
Colorectal cancer (CRC) is one of the most common malignant tumours and is the second leading cause of cancer-related mortalit …
Endoplasmic Reticulum Stress and Liver Cancer: Regulation Through Natural Products.
Sharma N, Gupta M, Guleria M, Anand M, Malhan A, Chitme HR, Singh S, Sarwat M. Sharma N, et al. Chem Biodivers. 2025 Oct;22(10):e00592. doi: 10.1002/cbdv.202500592. Epub 2025 Jun 5. Chem Biodivers. 2025. PMID: 40472069 Review.
Cancer is the prime cause of mortality and morbidity globally that demands a proactive strategy for the cure. ...The natural products are rich in potent bioactive compounds with coordinated, multi-level, and multi-targeted effects that can be utilized in management of vari …
Cancer is the prime cause of mortality and morbidity globally that demands a proactive strategy for the cure. ...The natural products …
A facile dual-drug delivery system using cellulose-based microgel/hydrogel for enhanced gastric cancer therapy.
Zhou J, Zhang Z, Zhang Z, Wu T, Li H, Hao X, Liu X, Gong T, Liu D, Wei S. Zhou J, et al. Colloids Surf B Biointerfaces. 2025 Oct;254:114813. doi: 10.1016/j.colsurfb.2025.114813. Epub 2025 May 21. Colloids Surf B Biointerfaces. 2025. PMID: 40412286
Gastric cancer remains a significant clinical challenge due to its high incidence, elevated mortality, frequent recurrence, and increasing chemotherapy resistance. ...In summary, this innovative CMC-SH-based microgel system provides a promising, minimally invasive platform …
Gastric cancer remains a significant clinical challenge due to its high incidence, elevated mortality, frequent recurrence, and incre …
Potential mechanism of inhibitory effect of "medicine food homology" curcumin and its analogue EF24 on oral squamous cell carcinoma.
Fu R, Li Z, Liu J, Xu B, Wen X, Zhang L. Fu R, et al. Clin Transl Oncol. 2025 Oct;27(10):3965-3980. doi: 10.1007/s12094-025-03871-8. Epub 2025 May 2. Clin Transl Oncol. 2025. PMID: 40314923
PPI networks were created using Cytoscape software. RESULTS: Both curcumin and EF24 inhibit the viability, migration, and invasion, and induce apoptosis of OSCC cells and the IC(50) of EF24 was much lower than that of curcumin. ...Curcumin and EF24 were found …
PPI networks were created using Cytoscape software. RESULTS: Both curcumin and EF24 inhibit the viability, migration, and invasion, a …
Synergistic effects of curcumin and piperine in cocrystal form: a breakthrough in bladder cancer therapy.
Polati D, Neerati P. Polati D, et al. J Biomater Sci Polym Ed. 2025 Oct;36(15):2109-2136. doi: 10.1080/09205063.2025.2491606. Epub 2025 Apr 24. J Biomater Sci Polym Ed. 2025. PMID: 40270345
Curcumin (CUR) is a promising anticancer agent for urinary bladder cancer (UBC) but is hindered by poor oral bioavailability. ...This study underscores the potential of cocrystallization as a novel approach to enhance bioavailability and therapeutic effectiveness in …
Curcumin (CUR) is a promising anticancer agent for urinary bladder cancer (UBC) but is hindered by poor oral bioavailability. …
Transformative potential of plant-based nanoparticles in cancer diagnosis and treatment: bridging traditional medicine and modern therapy.
M A, S KB, Liyana EP, Jasmine JS. M A, et al. Naunyn Schmiedebergs Arch Pharmacol. 2025 Oct;398(10):12869-12890. doi: 10.1007/s00210-025-04113-y. Epub 2025 Apr 16. Naunyn Schmiedebergs Arch Pharmacol. 2025. PMID: 40237799 Review.
Cancer is a primary global health concern, with an estimated 35.3 million cancer cases expected worldwide, representing a 76.6% increase in 2022, and 20 million by 2050, resulting from genetic mutation and environmental factors that cause uncontrolled cell growth. . …
Cancer is a primary global health concern, with an estimated 35.3 million cancer cases expected worldwide, representing a 76.6 …
Enhanced Intracellular Delivery of Curcumin Using Polymeric Nanocarriers: A Natural Photosensitizing Agent for Anti-Cancer Photodynamic Therapy.
Zahid A, Khurshid A, Rehman SU, Hassan SMU, Akhtar R. Zahid A, et al. J Fluoresc. 2025 Oct;35(10):9147-9159. doi: 10.1007/s10895-025-04179-0. Epub 2025 Mar 8. J Fluoresc. 2025. PMID: 40056323
The In-vitro investigation was conducted using BT-474 human breast cancer cells to evaluate the dark and phototoxic effect of both variants of curcumin (free CUR and CUR NPs). ...During the phototoxic study, CUR NPs exhibit improved efficacy in the presence of light …
The In-vitro investigation was conducted using BT-474 human breast cancer cells to evaluate the dark and phototoxic effect of both va …
"The protective effect of nano curcumin supplementation on doxorubicin induced cardiotoxicity in breast cancer patients; a randomized, double-blind clinical trial".
Tohidi M, Allahyari A, Ataei Azimi S, Alimi H, Elyasi S, Qoorchi Moheb Seraj F, Mehrad-Majd H. Tohidi M, et al. J Oncol Pharm Pract. 2025 Oct;31(7):1076-1085. doi: 10.1177/10781552241277958. Epub 2024 Sep 2. J Oncol Pharm Pract. 2025. PMID: 39223927 Clinical Trial.
BackgroundAnthracycline drugs play a fundamental role in breast cancer treatment; however, the cardiotoxicity side effects obscure the advantages of treatment. ...In this randomized clinical trial, a week before starting the doxorubicin regimen for breast cancer pat …
BackgroundAnthracycline drugs play a fundamental role in breast cancer treatment; however, the cardiotoxicity side effects obscure th …
In Silico Design and Computational Elucidation of Hypothetical Resveratrol-Curcumin Hybrids as Potential Cancer Pathway Modulators.
Sazlı N, Karataş D. Sazlı N, et al. Pharmaceuticals (Basel). 2025 Sep 30;18(10):1473. doi: 10.3390/ph18101473. Pharmaceuticals (Basel). 2025. PMID: 41155587 Free PMC article.
Background/Objectives: Cancer progression is characterized by the suppression of apoptosis, activation of metastatic processes, and dysregulation of cell proliferation. ...The binding energies of the hybrid molecules, curcumin, resveratrol, their analogs, and the re …
Background/Objectives: Cancer progression is characterized by the suppression of apoptosis, activation of metastatic processes, and d …
Curcumin in colorectal cancer: mechanistic insights, pharmacological limitations, and translational perspectives.
Li SQ, Zhu XR, Qin BC, Chen MB. Li SQ, et al. Front Pharmacol. 2025 Sep 29;16:1667731. doi: 10.3389/fphar.2025.1667731. eCollection 2025. Front Pharmacol. 2025. PMID: 41089849 Free PMC article. Review.
Curcumin, a natural polyphenolic compound from Curcuma longa, has been extensively investigated for its potential role in colorectal cancer (CRC) prevention and therapy. ...Curcumin is also recognized as a pan-assay interfering compound (PAINS), which may acc …
Curcumin, a natural polyphenolic compound from Curcuma longa, has been extensively investigated for its potential role in colorectal …
PhytoCAT: A Comprehensive Data Repository of PhytoChemicals for Affordable Breast Cancer Therapeutics.
Fatima F, Ansari AH, Seth S, Parveen S, Dawer Y, Singh M, Chaudhary K, Ramachandran S. Fatima F, et al. Curr Pharm Biotechnol. 2025 Sep 29. doi: 10.2174/0113892010399400250903074949. Online ahead of print. Curr Pharm Biotechnol. 2025. PMID: 41029012
INTRODUCTION: Breast cancer is a global health challenge with a high mortality rate of 30% of total cases in a year. ...DISCUSSION: Phytochemicals have gained significant attention in recent years because of their potential health benefits, particularly in the prevention a …
INTRODUCTION: Breast cancer is a global health challenge with a high mortality rate of 30% of total cases in a year. ...DISCUSSION: P …
Unveiling the anticancer potential of medicinal plants: metabolomics and analytical tools in phytomedicine.
Bansal N, Alaseem AM, Babu AM, Alasiri G, Singh TG, Tyagi Y, Sharma G. Bansal N, et al. Mol Divers. 2025 Sep 27. doi: 10.1007/s11030-025-11362-9. Online ahead of print. Mol Divers. 2025. PMID: 41015609 Review.
Metabolomics accounts for the metabolic alterations and identification of novel biomarkers in the war to combat cancer. This review explores advancements in metabolomics, emphasizing its application in understanding cancer-associated metabolic pathways and phytochem …
Metabolomics accounts for the metabolic alterations and identification of novel biomarkers in the war to combat cancer. This review e …
miR-22-Mediated Regulation of Wnt/beta-Catenin Signaling by Curcumin in Retinoblastoma.
Li P, Zheng L, Yang Q, Huang W, Yan X. Li P, et al. J Vis Exp. 2025 Sep 26;(223). doi: 10.3791/69300. J Vis Exp. 2025. PMID: 41082408
Curcumin treatment resulted in decreased proliferation and invasiveness in RB cells, while enhancing apoptosis and elevating miR-22 expression. Inhibition of miR-22 diminished curcumin's effects on the Wnt/beta-catenin signaling pathway. In xenograft studies, …
Curcumin treatment resulted in decreased proliferation and invasiveness in RB cells, while enhancing apoptosis and elevating miR-22 e …
Tannic Acid/Fe(III)-Coated Curcumin Self-Assembled Nanoparticles for Combination Therapy to Treat Triple-Negative Breast Cancer.
Li J, Han N, Ruan M, Wei H, Dong Y, Zhang H, Guo Z, Du S, Li P. Li J, et al. Pharmaceutics. 2025 Sep 25;17(10):1257. doi: 10.3390/pharmaceutics17101257. Pharmaceutics. 2025. PMID: 41155893 Free PMC article.
Background/Objectives: Triple-negative breast cancer (TNBC) exhibits pronounced biological heterogeneity, aggressive behavior, and a high risk of recurrence and metastasis. ...Results: CUR@TA-Fe(III) NPs had high drug loading efficiency (LE) of 27.99%, good dispersion stab …
Background/Objectives: Triple-negative breast cancer (TNBC) exhibits pronounced biological heterogeneity, aggressive behavior, and a …
Active Targeting Strategies for Improving the Bioavailability of Curcumin: A Systematic Review.
Wei YS, Liu KL, Feng K, Wang Y. Wei YS, et al. Foods. 2025 Sep 25;14(19):3331. doi: 10.3390/foods14193331. Foods. 2025. PMID: 41097499 Free PMC article. Review.
Curcumin (CUR) is a bioactive compound with well-documented therapeutic potential in diverse pathological conditions, encompassing intestinal disorders-most notably colonic cancer-as well as extra-intestinal malignancies such as hepatic, breast, and renal tumors. .. …
Curcumin (CUR) is a bioactive compound with well-documented therapeutic potential in diverse pathological conditions, encompassing in …
Effectiveness of curcumin for anticancer activity by surface functionalized nickel and manganese ferrites.
Hanif H, Hussain S, Ahmed MN, Waseem M. Hanif H, et al. Nat Prod Res. 2025 Sep 24:1-6. doi: 10.1080/14786419.2025.2565709. Online ahead of print. Nat Prod Res. 2025. PMID: 40991748
These nanoparticles (NPs) were loaded with curcumin drug after surface functionalization with polyethylene glycol (PEG) and silica. ...MTT (3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay was used to test anticancer activity on the 4 T-1 cancer …
These nanoparticles (NPs) were loaded with curcumin drug after surface functionalization with polyethylene glycol (PEG) and silica. . …
Role of Ferroptosis on Lung Epithelial Cells in Disease Progression and Treatment: A Review.
Yin X, Hou X, Feng J. Yin X, et al. Med Sci Monit. 2025 Sep 24;31:e948226. doi: 10.12659/MSM.948226. Med Sci Monit. 2025. PMID: 40988320 Free PMC article. Review.
In pulmonary fibrosis, ferroptosis of alveolar epithelial cells contributes to tissue remodeling through oxidative stress and epithelial-mesenchymal transition. In lung cancer, ferroptosis affects carcinogenesis, therapy resistance, and response to radiotherapy. Emerging t …
In pulmonary fibrosis, ferroptosis of alveolar epithelial cells contributes to tissue remodeling through oxidative stress and epithelial-mes …
Engineered dual-functional gold nanoparticles enhance radiosensitization in prostate cancer cells: synergistic action of curcumin and gold.
Aborig M, Alsefaou M, Osei E, Wettig S. Aborig M, et al. Nanoscale Adv. 2025 Jul 10;7(19):5964-5977. doi: 10.1039/d5na00376h. eCollection 2025 Sep 24. Nanoscale Adv. 2025. PMID: 40666606 Free PMC article.
Prostate cancer remains a leading cause of cancer-related mortality in men, with the three main treatment modalities being surgery, chemotherapy, radiotherapy, or a combination depending on the stage. ...To address this challenge, we developed curcumin-coated …
Prostate cancer remains a leading cause of cancer-related mortality in men, with the three main treatment modalities being sur …
Anti-Helicobacter pylori Activity and Gastroprotective Effects of Diacetylcurcumin and Four Metal Derivatives.
Agabo-Martínez A, Gomez-Chang E, Hernández-Hipólito E, Estrada-Muñiz E, Escobedo-Martínez C, Obregón-Mendoza MA, Enríquez RG, Vega L, Romero I. Agabo-Martínez A, et al. Molecules. 2025 Sep 23;30(19):3849. doi: 10.3390/molecules30193849. Molecules. 2025. PMID: 41097273 Free PMC article.
Helicobacter pylori is the main etiological factor of gastritis, peptic ulcers, and gastric cancer. This bacterium's antibiotic resistance has led to a lower eradication rate; therefore, new drugs with anti-H. pylori activity are needed. Curcumin exhibits multiple b …
Helicobacter pylori is the main etiological factor of gastritis, peptic ulcers, and gastric cancer. This bacterium's antibiotic resis …
Interaction between Notch signaling pathway and bioactive compounds and its intervention on cancer.
Nie RZ, Wang H, Wang SS, Luo HM, Chen C, Jing ZH, Li PF. Nie RZ, et al. Front Nutr. 2025 Sep 23;12:1647661. doi: 10.3389/fnut.2025.1647661. eCollection 2025. Front Nutr. 2025. PMID: 41064286 Free PMC article. Review.
The Notch signaling pathway is pivotal in cancer regulation, with its effects varying based on activation degree, tissue origin, and microenvironment. ...Bioactive compounds, such as flavonoids, non-flavonoids polyphenols, and terpenoids, show potential in modulating Notch …
The Notch signaling pathway is pivotal in cancer regulation, with its effects varying based on activation degree, tissue origin, and …
Genomic discovery of EF-24 targets unveils antitumorigenic mechanisms in leukemia cells.
Singh AP, Wax N, Duncan J, Fernandes AS, Jacobs JL. Singh AP, et al. PLoS One. 2025 Sep 23;20(9):e0330906. doi: 10.1371/journal.pone.0330906. eCollection 2025. PLoS One. 2025. PMID: 40986633 Free PMC article.
Curcumin, a polyphenolic compound derived from the plant Curcuma longa L., has demonstrated a wide range of therapeutic properties, including potential anticancer effects. However, its clinical efficacy is limited due to poor bioavailability and stability. To overcome thes …
Curcumin, a polyphenolic compound derived from the plant Curcuma longa L., has demonstrated a wide range of therapeutic properties, i …
New Alkaloid and Sesquiterpenoid From the Leaves of Cinnamomum bejolghota.
Le TP, Nguyen TL, Truong BN, Litaudon M, Doan TMH, Pham VC. Le TP, et al. Chem Biodivers. 2025 Sep 23:e02118. doi: 10.1002/cbdv.202502118. Online ahead of print. Chem Biodivers. 2025. PMID: 40986331
.- Ham. ex Nees) Sweet, one new alkaloid, 3,6-dimethoxy-9H-pyrido[3,4-b]indole (1) and one new aromadendrane sesquiterpenoid, 4alpha,10alpha-dihydroxyaromadendrane-13-oic acid (2) along with seven known compounds, 4beta,10alpha-dihydroxyaromadendrane (3), litseachromolaevane A (4 …
.- Ham. ex Nees) Sweet, one new alkaloid, 3,6-dimethoxy-9H-pyrido[3,4-b]indole (1) and one new aromadendrane sesquiterpenoid, 4alpha,10alpha …
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