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Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model.
Mansoori S, Blom K, Andersson C, Fryknäs M, Larsson R, Nygren P. Mansoori S, et al. Oncol Rep. 2026 Jan;55(1):9. doi: 10.3892/or.2025.9014. Epub 2025 Nov 7. Oncol Rep. 2026. PMID: 41201043 Free PMC article.
Mebendazole (Mbz), a well-known anthelminthic drug, has demonstrated anticancer properties in tumor models and patients, and is thus under consideration for repositioning into an anticancer drug. ...In the present study, the anticancer effects of Mbz, alone and in combinat …
Mebendazole (Mbz), a well-known anthelminthic drug, has demonstrated anticancer properties in tumor models and patients, and is thus …
Mebendazole induces ZBP-1 mediated PANoptosis of acute myeloid leukemia cells by targeting TUBA1A and exerts antileukemia effect.
Yang W, Xu Y, Liu S, Gao L, Li S, Xie X, Zhang Q, Habib O, Chen R, Sun X, Li Z. Yang W, et al. J Adv Res. 2025 Dec;78:487-496. doi: 10.1016/j.jare.2025.02.013. Epub 2025 Feb 12. J Adv Res. 2025. PMID: 39952321 Free PMC article.
Cell viability, cell morphological analysis, western blotting, and RNA-seq were used to determine the pathway of Mebendazole (MBD)-induced AML cell death. Cell cycle analysis, protein expression profiling, molecular docking, western blotting and lentivirus overexpression w …
Cell viability, cell morphological analysis, western blotting, and RNA-seq were used to determine the pathway of Mebendazole (MBD)-in …
Preliminary assessment of repurposed mebendazole nano-systems for passive targeting and potential treatment of bone metastasis.
Atia NM, Abdallah OY, Hazzah HA, Aly RG, Abdelkader H, Fatease AA, Alany RG, Barakat HS. Atia NM, et al. Pharm Dev Technol. 2025 Nov;30(9):1285-1305. doi: 10.1080/10837450.2025.2574082. Epub 2025 Oct 16. Pharm Dev Technol. 2025. PMID: 41082306
Bone metastasis is commonly observed in cancer patients, necessitating high-dose chemotherapy for effective treatment. Repurposing mebendazole (Meb) has shown promise in inhibiting cancer progression. ...
Bone metastasis is commonly observed in cancer patients, necessitating high-dose chemotherapy for effective treatment. Repurposing …
Effects of nanoflubendazole and purinergic signaling modulation in overcoming neuroblastoma chemoresistance.
de Mello RS, Bento CA, de Oliveira Faria R, Arnaud-Sampaio VF, Ulrich H, Miyagi MYS, de Araujo GLB, Lameu C. de Mello RS, et al. Purinergic Signal. 2025 Oct;21(5):1155-1169. doi: 10.1007/s11302-025-10078-7. Epub 2025 Mar 13. Purinergic Signal. 2025. PMID: 40075009 Free PMC article.
Neuroblastoma is a pediatric tumor accounting for approximately 8% of childhood cancers and is associated with high mortality rates among children aged 1 to 5 years. Standard treatments often fall short, leading to recurrence and metastasis due to the development of chemor …
Neuroblastoma is a pediatric tumor accounting for approximately 8% of childhood cancers and is associated with high mortality rates a …
Evaluating the Efficacy of Mebendazole Repurposing for Ovarian Cancer Therapy Using Optical Coherence Tomography.
Rai R, Zhang Q, Mutembei BM, Yan F, Pandit K, Zhang K, Wang C, Liu R, Liu J, Mercyshalinie ERS, Cui Y, Peek HA, Dai LJ, Ling Y, Dockery LE, Tang Q. Rai R, et al. J Biophotonics. 2025 Sep 9:e202500369. doi: 10.1002/jbio.202500369. Online ahead of print. J Biophotonics. 2025. PMID: 40922675
Ovarian cancer (OvCa) remains the leading cause of gynecological cancer mortality, with most patients developing chemoresistance. ...This study demonstrates SD-OCT's utility for noninvasive therapy monitoring in 3D cancer models....
Ovarian cancer (OvCa) remains the leading cause of gynecological cancer mortality, with most patients developing chemoresistan …
Preparation and pharmacokinetic study of mebendazole complex with HP-beta-cyclodextrin.
Ding C, Ding Y, Xu Z, Wang P, Xu S. Ding C, et al. Front Vet Sci. 2025 Aug 7;12:1611154. doi: 10.3389/fvets.2025.1611154. eCollection 2025. Front Vet Sci. 2025. PMID: 40852433 Free PMC article.
Mebendazole, approved by the Food and Drug Administration (FDA) in 1974 to expel intestinal parasite infections, was found to exhibit multiple anti-cancer activities. ...The C (max) of mebendazole was increased from 8.96 0.15 mug/mL to 17.34 2.02 mug/mL. T (m …
Mebendazole, approved by the Food and Drug Administration (FDA) in 1974 to expel intestinal parasite infections, was found to exhibit …
Critical dysregulated signaling pathways in drug resistance: highlighting the repositioning of mebendazole for cancer therapy.
Aliabadi A, Moradi SZ, Abdian S, Fakhri S, Echeverría J. Aliabadi A, et al. Front Pharmacol. 2025 Jul 25;16:1631419. doi: 10.3389/fphar.2025.1631419. eCollection 2025. Front Pharmacol. 2025. PMID: 40786044 Free PMC article. Review.
BACKGROUND: Cancer drug resistance significantly reduces the effectiveness of current anticancer treatments. ...PURPOSE: Therefore, MBZ demonstrated potential in suppressing the growth of various cancer cells, both in vitro and in vivo. Consequently, we thoroughly r …
BACKGROUND: Cancer drug resistance significantly reduces the effectiveness of current anticancer treatments. ...PURPOSE: Therefore, M …
The therapeutic potential of repurposed mebendazole, alone and in synergistic combination with ONC201, in the treatment of diffuse midline glioma.
Gentile S, Toma F, Lucchetti D, Lisi L, Navarra P, Sgambato A, Servidei T, Ruggiero A. Gentile S, et al. Am J Cancer Res. 2025 Jun 15;15(6):2701-2718. doi: 10.62347/MXZH5646. eCollection 2025. Am J Cancer Res. 2025. PMID: 40667566 Free PMC article.
H3K27-altered diffuse midline glioma (DMG) is a universally fatal disease with no available therapeutic strategies apart from palliative radiotherapy. Repurposing marketed non-cancer drugs in oncology is emerging as a fast-tracking approach to speed up the development of n …
H3K27-altered diffuse midline glioma (DMG) is a universally fatal disease with no available therapeutic strategies apart from palliative rad …
Evaluation of the cytotoxicity and anthelmintic activity of Olea europaea (stem and leaves) methanolic extract: in vitro investigation.
Al-Shaebi EM, Abdel-Gaber R, Al-Hoshani N, Al-Quraishy S. Al-Shaebi EM, et al. Helminthologia. 2025 May 24;62(1):8-18. doi: 10.2478/helm-2025-0002. eCollection 2025 Mar. Helminthologia. 2025. PMID: 40443494 Free PMC article.
Several diseases, including cancer and parasites, may be treated with medicinal plants. The purpose of this study was to examine in vitro the phytochemical profile, cytotoxic, and anthelmintic properties of Olea europaea stem and leaves methanolic extracts (OESME and OELME …
Several diseases, including cancer and parasites, may be treated with medicinal plants. The purpose of this study was to examine in v …
Synergistic inhibition of proliferation and induction of apoptosis in oral tongue squamous cell carcinoma by mebendazole and paclitaxel via PI3K/AKT pathway mitigation.
Zhang J, Cui Y. Zhang J, et al. Naunyn Schmiedebergs Arch Pharmacol. 2025 May;398(5):5881-5893. doi: 10.1007/s00210-024-03670-y. Epub 2024 Nov 30. Naunyn Schmiedebergs Arch Pharmacol. 2025. PMID: 39614899
Serve as one of common cancer in the mouth, oral tongue squamous cell carcinoma (OTSCC) is a serious problem affecting human oral health. The aim of this study was to evaluate the effects of mebendazole (MBZ) alone and combined with paclitaxel on the proliferation a …
Serve as one of common cancer in the mouth, oral tongue squamous cell carcinoma (OTSCC) is a serious problem affecting human oral hea …
Stearyl amine tailored spanlastics embedded within tetronic() nanogel for boosting the repurposed anticancer potential of mebendazole: formulation, in vitro profiling, cytotoxicity assessment, and in vivo permeation analysis.
El Halawany M, Sharaky M, Aziz D. El Halawany M, et al. Daru. 2025 Mar 29;33(1):17. doi: 10.1007/s40199-025-00560-3. Daru. 2025. PMID: 40156679
BACKGROUND: Mebendazole (MBZ) is an anthelmintic drug that was repurposed as an anti-cancer agent. OBJECTIVES: This study aimed at formulating MBZ into stearylamine tailored spanlastics dispersed in nanogel for enhancing MBZ anti-tumor efficacy against skin cance …
BACKGROUND: Mebendazole (MBZ) is an anthelmintic drug that was repurposed as an anti-cancer agent. OBJECTIVES: This study aime …
Repositioning anthelmintics for the treatment of inflammatory-based pathological conditions.
Rodrigues DCDN, Porto JCS, Dos Santos IL, Filho JIAB, Ferreira PMP. Rodrigues DCDN, et al. Inflammopharmacology. 2025 Feb;33(2):551-571. doi: 10.1007/s10787-024-01605-w. Epub 2024 Nov 26. Inflammopharmacology. 2025. PMID: 39589670 Review.
Despite low bioavailability, many benzimidazoles (albendazole and mebendazole), salicylanilides (niclosamide), macrocyclic lactones (avermectins), pyrazinoisoquinolones (praziquantel), thiazolides (nitazoxanide), piperazine derivatives, and imidazothiazoles (levamisole) in …
Despite low bioavailability, many benzimidazoles (albendazole and mebendazole), salicylanilides (niclosamide), macrocyclic lactones ( …
Mebendazole Exerts Anticancer Activity in Ovarian Cancer Cell Lines via Novel Girdin-Mediated AKT/IKKalpha/beta/NF-kappaB Signaling Axis.
Gupta R, Roy D, Ghosh A, Begum Y, Ghosh D, Swarnakar S. Gupta R, et al. Cells. 2025 Jan 14;14(2):113. doi: 10.3390/cells14020113. Cells. 2025. PMID: 39851541 Free PMC article.
Mebendazole (MBZ), a benzimidazole anthelmintic and cytoskeleton-disrupting compound, exhibits antitumor properties; however, its action on ovarian cancer (OC) is not clearly understood. ...Thus, by targeting Girdin, MBZ presents a promising repurposed therapeutic s …
Mebendazole (MBZ), a benzimidazole anthelmintic and cytoskeleton-disrupting compound, exhibits antitumor properties; however, its act …
USP5 Binds and Stabilizes EphA2 to Increase Nasopharyngeal Carcinoma Radioresistance.
Tang JY, Peng YX, Zhu W, Qiu JY, Huang W, Yi H, Lu SS, Feng J, Yu ZZ, Wu D, Wen Q, Yuan L, Peng J, Xiao ZQ. Tang JY, et al. Int J Biol Sci. 2025 Jan 6;21(3):893-909. doi: 10.7150/ijbs.102461. eCollection 2025. Int J Biol Sci. 2025. PMID: 39897046 Free PMC article.
Overexpression of USP5 and EphA2 has been linked to various cancers, and both the proteins have attracted considerable attention for the development of new anti-cancer drugs. ...These findings suggest that USP5 binds and stabilizes EphA2 by ubiquitin proteasome path …
Overexpression of USP5 and EphA2 has been linked to various cancers, and both the proteins have attracted considerable attention for …
Transcriptome analysis displays new molecular insights into the mechanisms of action of Mebendazole in gastric cancer cells.
da Silva EL, Mesquita FP, Pinto LC, Gomes BPS, de Oliveira EHC, Burbano RMR, Moraes MEA, de Souza PFN, Montenegro RC. da Silva EL, et al. Comput Biol Med. 2025 Jan;184:109415. doi: 10.1016/j.compbiomed.2024.109415. Epub 2024 Nov 19. Comput Biol Med. 2025. PMID: 39566281
Gastric cancer (GC) is a common cancer worldwide. Therefore, searching for effective treatments is essential, and drug repositioning can be a promising strategy to find new potential drugs for GC therapy. For the first time, we sought to identify molecular alteratio …
Gastric cancer (GC) is a common cancer worldwide. Therefore, searching for effective treatments is essential, and drug reposit …
Mebendazole effectively overcomes imatinib resistance by dual-targeting BCR/ABL oncoprotein and beta-tubulin in chronic myeloid leukemia cells.
Yang L, Du Z, Peng Y, Zhang W, Feng W, Yuan Y. Yang L, et al. Korean J Physiol Pharmacol. 2025 Jan 1;29(1):67-81. doi: 10.4196/kjpp.24.176. Epub 2024 Nov 14. Korean J Physiol Pharmacol. 2025. PMID: 39539176 Free PMC article.
In recent years, drug repositioning provided alternative and promising perspectives apart from the classical cancer therapies, and promoted anthelmintic mebendazole (MBZ) as an effective anti-cancer drug in various cancers. ...
In recent years, drug repositioning provided alternative and promising perspectives apart from the classical cancer therapies, and pr …
Mebendazole.
Thakur RK, Patel SP. Thakur RK, et al. 2023 Jul 15. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. 2023 Jul 15. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 32491637 Free Books & Documents.
Mebendazole is a medication used in the treatment of parasitic infection. This activity reviews the indications, contraindications, activity, adverse events, and other key elements of mebendazole therapy in the clinical setting related to the essential points needed …
Mebendazole is a medication used in the treatment of parasitic infection. This activity reviews the indications, contraindications, a …
Albumin and Polysorbate-80 Coated Sterile Nanosuspensions of Mebendazole for Glioblastoma Therapy.
Patel H, Patel A, Vats M, Patel K. Patel H, et al. AAPS PharmSciTech. 2024 Nov 26;25(8):271. doi: 10.1208/s12249-024-02978-5. AAPS PharmSciTech. 2024. PMID: 39586850
The scarcity of existing and novel therapies for brain cancer has significantly affected the survival rate of glioblastoma patients. Mebendazole (MBZ), an antiparasitic agent demonstrated promising activity against brain cancer. ...Albumin-PS 80 coated NS is …
The scarcity of existing and novel therapies for brain cancer has significantly affected the survival rate of glioblastoma patients. …
In vitro evaluation of lipidic nanocarriers for mebendazole delivery to improve anticancer activity.
Tamma MA, Nsairat H, El-Tanani M, Madi R. Tamma MA, et al. Drug Dev Ind Pharm. 2024 Nov;50(11):917-926. doi: 10.1080/03639045.2024.2428405. Epub 2024 Nov 13. Drug Dev Ind Pharm. 2024. PMID: 39527027
OBJECTIVE: To enhance the anticancer activity of the repurposed drug mebendazole (MBZ) against A549 cell lines by developing nanostructured lipid carriers (NLCs). ...These promising results suggest that MBZ-NLCs could be a potent therapeutic approach for lung cancer …
OBJECTIVE: To enhance the anticancer activity of the repurposed drug mebendazole (MBZ) against A549 cell lines by developing nanostru …
From Deworming to Cancer Therapy: Benzimidazoles in Hematological Malignancies.
Golla U, Patel S, Shah N, Talamo S, Bhalodia R, Claxton D, Dovat S, Sharma A. Golla U, et al. Cancers (Basel). 2024 Oct 12;16(20):3454. doi: 10.3390/cancers16203454. Cancers (Basel). 2024. PMID: 39456548 Free PMC article. Review.
Among these, anthelmintic benzimidazoles (such as albendazole, mebendazole, and flubendazole) have garnered interest due to their effects on microtubules and oncogenic signaling pathways. Blood cancers, which frequently develop resistance and have high mortality rat …
Among these, anthelmintic benzimidazoles (such as albendazole, mebendazole, and flubendazole) have garnered interest due to their eff …
PLGA-PEG-COOH nanoparticles are efficient systems for delivery of mefloquine to Echinococcus multilocularis metacestodes.
Autier B, Verger A, Plaisse C, Manuel C, Chollet-Krugler M, Preza M, Lundstroem-Stadelmann B, Amela-Cortes M, Aninat C, Samson M, Brandhonneur N, Dion S. Autier B, et al. Exp Parasitol. 2024 Oct;265:108811. doi: 10.1016/j.exppara.2024.108811. Epub 2024 Aug 5. Exp Parasitol. 2024. PMID: 39111383 Free article.
As there is no actual curative drug therapy, recommendations to manage AE patients are based on radical surgery and prophylactic administration of albendazole or mebendazole during 2 years to prevent relapses. There is an urgent need for new therapeutic strategies for the …
As there is no actual curative drug therapy, recommendations to manage AE patients are based on radical surgery and prophylactic administrat …
Oral Fenbendazole for Cancer Therapy in Humans and Animals.
Nguyen J, Nguyen TQ, Han BO, Hoang BX. Nguyen J, et al. Anticancer Res. 2024 Sep;44(9):3725-3735. doi: 10.21873/anticanres.17197. Anticancer Res. 2024. PMID: 39197912 Review.
In humans, other benzimidazoles, such as mebendazole and albendazole, are used as antiparasitic agents. Since fenbendazole is not currently approved by the FDA or EMA, its pharmacokinetics and safety in humans have yet to be well-documented in medical literature. ...Given …
In humans, other benzimidazoles, such as mebendazole and albendazole, are used as antiparasitic agents. Since fenbendazole is not cur …
Case report: Precision guided reactive cancer management: molecular complete response in heavily pretreated metastatic CRC by dual immunotherapy and sorafenib.
Aydın E, Tokat ÜM, Adibi A, Özgü E, Bilgiç ŞN, Demiray M. Aydın E, et al. Front Oncol. 2024 Jul 1;14:1405170. doi: 10.3389/fonc.2024.1405170. eCollection 2024. Front Oncol. 2024. PMID: 39011472 Free PMC article.
With a tumor mutational burden of 10 muts/mb and TPS, CPS scores of 0, immunotherapy was considered, employing dual immune checkpoint inhibitors alongside mebendazole and Lenvatinib targeting the WNT and VEGF/angiogenesis pathways. MRD testing revealed early treatment fail …
With a tumor mutational burden of 10 muts/mb and TPS, CPS scores of 0, immunotherapy was considered, employing dual immune checkpoint inhibi …
Chiral Hydroxy Metabolite of Mebendazole: Analytical and Semi-Preparative High-Performance Liquid Chromatography Resolution and Chiroptical Properties.
Guglielmi P, Pulitelli G, Arrighi F, Secci D, Pierini M, Cirilli R. Guglielmi P, et al. Pharmaceuticals (Basel). 2024 May 28;17(6):696. doi: 10.3390/ph17060696. Pharmaceuticals (Basel). 2024. PMID: 38931363 Free PMC article.
Mebendazole (MBZ) is a benzimidazole carbamate anthelmintic used worldwide for the treatment and prevention of parasitic disorders in animals and humans. A large number of in vivo and in vitro studies have demonstrated that MBZ also has anticancer activity in multiple type …
Mebendazole (MBZ) is a benzimidazole carbamate anthelmintic used worldwide for the treatment and prevention of parasitic disorders in …
Repurposing mebendazole against triple-negative breast cancer CNS metastasis.
Rodrigues AJ, Chernikova SB, Wang Y, Trinh TTH, Solow-Cordero DE, Alexandrova L, Casey KM, Alli E, Aggarwal A, Quill T, Koegel AK, Feldman BJ, Ford JM, Hayden-Gephart M. Rodrigues AJ, et al. J Neurooncol. 2024 May;168(1):125-138. doi: 10.1007/s11060-024-04654-x. Epub 2024 Apr 2. J Neurooncol. 2024. PMID: 38563850 Free PMC article.
PURPOSE: Triple-negative breast cancer (TNBC) often metastasizes to the central nervous system (CNS) and has the highest propensity among breast cancer subtypes to develop leptomeningeal disease (LMD). LMD is a spread of cancer into leptomeningeal space that …
PURPOSE: Triple-negative breast cancer (TNBC) often metastasizes to the central nervous system (CNS) and has the highest propensity a …
Mebendazole preferentially inhibits cilia formation and exerts anticancer activity by synergistically augmenting DNA damage.
Hong J, Kwon KY, Jang DG, Kwon T, Yoon H, Park TJ. Hong J, et al. Biomed Pharmacother. 2024 May;174:116434. doi: 10.1016/j.biopha.2024.116434. Epub 2024 Mar 20. Biomed Pharmacother. 2024. PMID: 38513592 Free article.
However, it remains unclear whether and how primary cilia contribute to cancer development. Mebendazole (MBZ) is an anthelmintic drug with anticancer properties in some cancer cells. ...Our findings shed light on the specific influence of MBZ on cilia, rather …
However, it remains unclear whether and how primary cilia contribute to cancer development. Mebendazole (MBZ) is an anthelmint …
Concomitant ectopic Enterobius vermicularis infection in uterine cervical cancer.
Takač I, Kavalar R, Lovrec MR, Lovrec VG. Takač I, et al. BMC Womens Health. 2024 Apr 27;24(1):265. doi: 10.1186/s12905-024-03073-4. BMC Womens Health. 2024. PMID: 38678281 Free PMC article.
Diagnosis is made by identifying ova in the sample collected from the perineal skin using a transparent adhesive tape or microscopic examination of resected tissue. Mebendazole is the first-line medication and should also be administered to all household members. CASE PRES …
Diagnosis is made by identifying ova in the sample collected from the perineal skin using a transparent adhesive tape or microscopic examina …
A phase 1 study of mebendazole with bevacizumab and irinotecan in high-grade gliomas.
Krystal J, Hanson D, Donnelly D, Atlas M. Krystal J, et al. Pediatr Blood Cancer. 2024 Apr;71(4):e30874. doi: 10.1002/pbc.30874. Epub 2024 Jan 17. Pediatr Blood Cancer. 2024. PMID: 38234020 Clinical Trial.
BACKGROUND: High-grade gliomas (HGG) have a dismal prognosis despite multimodal therapy. Mebendazole is an anti-helminthic benzimidazole that has demonstrated efficacy in numerous in vitro cancer models, and is able to cross the blood-brain barrier. ...RESULTS: Betw …
BACKGROUND: High-grade gliomas (HGG) have a dismal prognosis despite multimodal therapy. Mebendazole is an anti-helminthic benzimidaz …
In vitro and in vivo anticancer activity of mebendazole in colon cancer: a promising drug repositioning.
Aliabadi A, Haghshenas MR, Kiani R, Koohi-Hosseinabadi O, Purkhosrow A, Pirsalami F, Panjehshahin MR, Erfani N. Aliabadi A, et al. Naunyn Schmiedebergs Arch Pharmacol. 2024 Apr;397(4):2379-2388. doi: 10.1007/s00210-023-02722-z. Epub 2023 Oct 14. Naunyn Schmiedebergs Arch Pharmacol. 2024. PMID: 37837472
Colon cancer is one of the most common cancers and one of the main causes of death worldwide. Therefore, new treatment methods with better efficiency and fewer risks are very necessary. Mebendazole (MBZ), a drug commonly used for helminthic infections, has re …
Colon cancer is one of the most common cancers and one of the main causes of death worldwide. Therefore, new treatment methods …
Flubendazole suppresses VEGF-induced angiogenesis in HUVECs and exerts antitumor effects in PC-3 cells.
Zhang B, Zhao J, Kang D, Wang Z, Xu L, Zheng R, Liu A. Zhang B, et al. Chem Biol Drug Des. 2024 Mar;103(3):e14503. doi: 10.1111/cbdd.14503. Chem Biol Drug Des. 2024. PMID: 38480495
Flubendazole, an FDA-approved anthelmintic, has been predicted to show strong VEGFR2 inhibitory activity in silico screening combined with in vitro experimental validation, and it has shown anti-cancer effects on some human cancer cell lines, but little is known abo …
Flubendazole, an FDA-approved anthelmintic, has been predicted to show strong VEGFR2 inhibitory activity in silico screening combined with i …
Mebendazole induces apoptosis and inhibits migration via the reactive oxygen species-mediated STAT3 signaling downregulation in non-small cell lung cancer.
Liang Z, Chen Q, Pan L, She X, Chen T. Liang Z, et al. J Thorac Dis. 2024 Feb 29;16(2):1412-1423. doi: 10.21037/jtd-23-1978. Epub 2024 Feb 27. J Thorac Dis. 2024. PMID: 38505087 Free PMC article.
BACKGROUND: The incidence and mortality of non-small cell lung cancer (NSCLC) are extremely high. Previous research has confirmed that the signal transducer and activator of the transcription 3 (STAT3) protein critically participate in the tumorigenesis of NSCLC. Mebend …
BACKGROUND: The incidence and mortality of non-small cell lung cancer (NSCLC) are extremely high. Previous research has confirmed tha …
Repurposing mebendazole against triple-negative breast cancer leptomeningeal disease.
Rodrigues A, Chernikova SB, Wang Y, Trinh TTH, Solow-Cordero DE, Alexandrova L, Casey KM, Alli E, Aggarwal A, Quill T, Koegel A, Feldman BJ, Ford JM, Hayden-Gephart M. Rodrigues A, et al. Res Sq [Preprint]. 2024 Feb 5:rs.3.rs-3915392. doi: 10.21203/rs.3.rs-3915392/v1. Res Sq. 2024. Update in: J Neurooncol. 2024 May;168(1):125-138. doi: 10.1007/s11060-024-04654-x. PMID: 38405839 Free PMC article. Updated. Preprint.
PURPOSE: Triple-negative breast cancer (TNBC) is an aggressive subtype that often metastasizes to the brain. Leptomeningeal disease (LMD), a devastating brain metastasis common in TNBC, has limited treatment options. We sought to test whether the common anti-helminthic dru …
PURPOSE: Triple-negative breast cancer (TNBC) is an aggressive subtype that often metastasizes to the brain. Leptomeningeal disease ( …
Efficacy of novel agents against cellular models of familial platelet disorder with myeloid malignancy (FPD-MM).
Mill CP, Fiskus WC, DiNardo CD, Reville P, Davis JA, Birdwell CE, Das K, Hou H, Takahashi K, Flores L, Ruan X, Su X, Loghavi S, Khoury JD, Bhalla KN. Mill CP, et al. Blood Cancer J. 2024 Feb 5;14(1):25. doi: 10.1038/s41408-024-00981-4. Blood Cancer J. 2024. PMID: 38316746 Free PMC article.
GMR-AML1 and PD FPD-MM cells were sensitive to homoharringtonine (HHT or omacetaxine) or mebendazole-induced lethality, associated with repression of c-Myc, EVI1, PLK1, CDK6 and MCL1. ...
GMR-AML1 and PD FPD-MM cells were sensitive to homoharringtonine (HHT or omacetaxine) or mebendazole-induced lethality, associated wi …
In vivo evaluation of mebendazole and Ran GTPase inhibition in breast cancer model system.
Abu-Hdaib B, Nsairat H, El-Tanani M, Al-Deeb I, Hasasna N. Abu-Hdaib B, et al. Nanomedicine (Lond). 2024;19(12):1087-1101. doi: 10.2217/nnm-2023-0351. Epub 2024 Apr 25. Nanomedicine (Lond). 2024. PMID: 38661720 Free PMC article.
Aim: To investigate the therapeutic potential of mebendazole (MBZ)-loaded nanostructured lipid carriers (NLCs). Methodology: NLC-MBZ was prepared and characterized to evaluate the in vitro and in vivo anticancer effects and the inhibitory effect on RanGTP and its potential …
Aim: To investigate the therapeutic potential of mebendazole (MBZ)-loaded nanostructured lipid carriers (NLCs). Methodology: NLC-MBZ …
Network pharmacology and molecular docking study-based approach to explore mechanism of benzimidazole-based anthelmintics for the treatment of lung cancer.
Garg A, Karhana S, Bano A, Khan IA, Reeta, Nidhi, Khan MA. Garg A, et al. J Biomol Struct Dyn. 2024;42(20):10739-10760. doi: 10.1080/07391102.2023.2258419. Epub 2023 Sep 23. J Biomol Struct Dyn. 2024. PMID: 37740654
The BBA were prioritized according to their S scores, with ricobendazole ranking highest followed by flubendazole, fenbendazole, mebendazole, triclabendazole, albendazole, oxibendazole, parbendazole, thiabendazole and oxfendazole. ...BBA can be further explored as a therap …
The BBA were prioritized according to their S scores, with ricobendazole ranking highest followed by flubendazole, fenbendazole, mebendaz …
Structure-Based Optimization of Carbendazim-Derived Tubulin Polymerization Inhibitors through Alchemical Free Energy Calculations.
Cano-González L, Espinosa-Mendoza JD, Matadamas-Martínez F, Romero-Velásquez A, Flores-Ramos M, Colorado-Pablo LF, Cerbón-Cervantes MA, Castillo R, González-Sánchez I, Yépez-Mulia L, Hernández-Campos A, Aguayo-Ortiz R. Cano-González L, et al. J Chem Inf Model. 2023 Nov 27;63(22):7228-7238. doi: 10.1021/acs.jcim.3c01379. Epub 2023 Nov 10. J Chem Inf Model. 2023. PMID: 37947759
Carbendazim derivatives, commonly used as antiparasitic drugs, have shown potential as anticancer agents due to their ability to induce cell cycle arrest and apoptosis in human cancer cells by inhibiting tubulin polymerization. Crystallographic structures of alpha/beta-tub …
Carbendazim derivatives, commonly used as antiparasitic drugs, have shown potential as anticancer agents due to their ability to induce cell …
Mebendazole targets essential proteins in glucose metabolism leading gastric cancer cells to death.
da Silva EL, Mesquita FP, Aragão DR, de Sousa Portilho AJ, Marinho AD, de Oliveira LLB, Lima LB, de Moraes MEA, Souza PFN, Montenegro RC. da Silva EL, et al. Toxicol Appl Pharmacol. 2023 Sep 15;475:116630. doi: 10.1016/j.taap.2023.116630. Epub 2023 Jul 18. Toxicol Appl Pharmacol. 2023. PMID: 37473966
Gastric cancer (GC) is among the most-diagnosed and deadly malignancies worldwide. Deregulation in cellular bioenergetics is a hallmark of cancer. ...Mebendazole (MBZ), an antihelminthic approved by FDA, has shown antitumoral activity against cancer ce …
Gastric cancer (GC) is among the most-diagnosed and deadly malignancies worldwide. Deregulation in cellular bioenergetics is a hallma …
Not all benzimidazole derivatives are microtubule destabilizing agents.
Song IH, Park SJ, Yeom GS, Song KS, Kim T, Nimse SB. Song IH, et al. Biomed Pharmacother. 2023 Aug;164:114977. doi: 10.1016/j.biopha.2023.114977. Epub 2023 Jun 2. Biomed Pharmacother. 2023. PMID: 37271075 Free article.
FDA-approved drugs containing a benzimidazole ring (nocodazole, albendazole, mebendazole, etc.) are well-known microtubule-destabilizing agents. Thus, most recent research on benzimidazole scaffold-based MTAs focuses on developing microtubule-destabilizing agents. ...Thus, …
FDA-approved drugs containing a benzimidazole ring (nocodazole, albendazole, mebendazole, etc.) are well-known microtubule-destabiliz …
Repurposing Drugs in Controlling Recurrent Platinum-Resistant Clear-Cell Ovarian Cancer.
Sinsuwan W, Norchai P. Sinsuwan W, et al. Case Rep Oncol Med. 2023 Jun 7;2023:2079654. doi: 10.1155/2023/2079654. eCollection 2023. Case Rep Oncol Med. 2023. PMID: 37323625 Free PMC article.
Repurposed conventional drugs have recently been found to offer the ability to control cancer with few side effects and at a reasonable cost to healthcare organizations. Case Presentation. ...This work introduces a novel strategy for the management of recurrent platinum-re …
Repurposed conventional drugs have recently been found to offer the ability to control cancer with few side effects and at a reasonab …
Drug Repurposing in Oncology: A Systematic Review of Randomized Controlled Clinical Trials.
Ioakeim-Skoufa I, Tobajas-Ramos N, Menditto E, Aza-Pascual-Salcedo M, Gimeno-Miguel A, Orlando V, González-Rubio F, Fanlo-Villacampa A, Lasala-Aza C, Ostasz E, Vicente-Romero J. Ioakeim-Skoufa I, et al. Cancers (Basel). 2023 May 30;15(11):2972. doi: 10.3390/cancers15112972. Cancers (Basel). 2023. PMID: 37296934 Free PMC article. Review.
Quality pharmacological treatment can improve survival in many types of cancer. Drug repurposing offers advantages in comparison with traditional drug development procedures, reducing time and risk. ...Metformin has been studied for potential use in various types of can …
Quality pharmacological treatment can improve survival in many types of cancer. Drug repurposing offers advantages in comparison with …
Phase II, Double-Blinded, Randomized, Placebo-Controlled Clinical Trial Investigating the Efficacy of Mebendazole in the Management of Symptomatic COVID-19 Patients.
El-Tanani M, Ahmed KA, Shakya AK, Ammari WG, Al-Shudifat AE. El-Tanani M, et al. Pharmaceuticals (Basel). 2023 May 29;16(6):799. doi: 10.3390/ph16060799. Pharmaceuticals (Basel). 2023. PMID: 37375747 Free PMC article.
The current double-blind, randomized, placebo-controlled, phase II clinical trial sought to evaluate the clinical efficacy and safety of mebendazole as an adjuvant therapy for outpatients with COVID-19. The patients were recruited and divided into two groups: a Mebendaz …
The current double-blind, randomized, placebo-controlled, phase II clinical trial sought to evaluate the clinical efficacy and safety of …
TUBB4B is a novel therapeutic target in non-alcoholic fatty liver disease-associated hepatocellular carcinoma.
Yang Z, Gao S, Wong CC, Liu W, Chen H, Shang H, Wu ZY, Xu L, Zhang X, Wong N, Kuang M, Yu J. Yang Z, et al. J Pathol. 2023 May;260(1):71-83. doi: 10.1002/path.6065. Epub 2023 Mar 14. J Pathol. 2023. PMID: 36787097
RNA-sequencing and functional assays revealed that TUBB4B knockout in NAFLD-HCC promoted cell apoptosis, cell cycle arrest, and cellular senescence, leading to suppressed NAFLD-HCC growth in vitro and in vivo. We identified that TUBB4B inhibitor mebendazole (MBZ), an FDA-a …
RNA-sequencing and functional assays revealed that TUBB4B knockout in NAFLD-HCC promoted cell apoptosis, cell cycle arrest, and cellular sen …
Drug Repurposing in Pediatric Brain Tumors: Posterior Fossa Ependymoma and Diffuse Midline Glioma under the Looking Glass.
Servidei T, Sgambato A, Lucchetti D, Navarra P, Ruggiero A. Servidei T, et al. Front Biosci (Landmark Ed). 2023 Apr 24;28(4):77. doi: 10.31083/j.fbl2804077. Front Biosci (Landmark Ed). 2023. PMID: 37114548 Free article. Review.
Tumors of the Central Nervous System (CNS) represent the leading cause of cancer-related deaths in children. Current treatment options are not curative for most malignant histologies, and intense preclinical and clinical research is needed to develop more effective therape …
Tumors of the Central Nervous System (CNS) represent the leading cause of cancer-related deaths in children. Current treatment option …
Mebendazole Treatment Disrupts the Transcriptional Activity of Hypoxia-Inducible Factors 1 and 2 in Breast Cancer Cells.
Joe NS, Wang Y, Oza HH, Godet I, Milki N, Riggins GJ, Gilkes DM. Joe NS, et al. Cancers (Basel). 2023 Feb 20;15(4):1330. doi: 10.3390/cancers15041330. Cancers (Basel). 2023. PMID: 36831670 Free PMC article.
Breast cancer is the most diagnosed cancer in women in the world. Mebendazole (MBZ) has been demonstrated to have preclinical efficacy across multiple cancers, including glioblastoma multiforme, medulloblastoma, colon, breast, pancreatic, and thyroid …
Breast cancer is the most diagnosed cancer in women in the world. Mebendazole (MBZ) has been demonstrated to have precl …
Harnessing the MYB-dependent TAL1 5'super-enhancer for targeted therapy in T-ALL.
Smith C, Touzart A, Simonin M, Tran-Quang C, Hypolite G, Latiri M, Andrieu GP, Balducci E, Dourthe MÉ, Goyal A, Huguet F, Petit A, Ifrah N, Baruchel A, Dombret H, Macintyre E, Plass C, Ghysdael J, Boissel N, Asnafi V. Smith C, et al. Mol Cancer. 2023 Jan 18;22(1):12. doi: 10.1186/s12943-022-01701-x. Mol Cancer. 2023. PMID: 36650499 Free PMC article.
The acquisition of genetic abnormalities engendering oncogene dysregulation underpins cancer development. Certain proto-oncogenes possess several dysregulation mechanisms, yet how each mechanism impacts clinical outcome is unclear. ...Remarkably, the MYB dependent oncogeni …
The acquisition of genetic abnormalities engendering oncogene dysregulation underpins cancer development. Certain proto-oncogenes pos …
Emerging Perspectives on the Antiparasitic Mebendazole as a Repurposed Drug for the Treatment of Brain Cancers.
Meco D, Attinà G, Mastrangelo S, Navarra P, Ruggiero A. Meco D, et al. Int J Mol Sci. 2023 Jan 10;24(2):1334. doi: 10.3390/ijms24021334. Int J Mol Sci. 2023. PMID: 36674870 Free PMC article. Review.
Moreover, several preclinical models and ongoing clinical trials explore the efficacy of Mebendazole in multiple cancers, including acute myeloid leukemia, brain cancer, oropharyngeal squamous cell carcinoma, breast cancer, gastrointestinal cancer …
Moreover, several preclinical models and ongoing clinical trials explore the efficacy of Mebendazole in multiple cancers, incl …
Inhibition of Wnt Signaling in Colon Cancer Cells via an Oral Drug that Facilitates TNIK Degradation.
Zhou K, Cheong JE, Krishnaji ST, Ghalali A, Fu H, Sui L, Alix-Panabières C, Cayrefourcq L, Bielenberg D, Sun L, Zetter B. Zhou K, et al. Mol Cancer Ther. 2023 Jan 3;22(1):25-36. doi: 10.1158/1535-7163.MCT-21-0801. Mol Cancer Ther. 2023. PMID: 36302395
We have synthesized an oxetane derivative of the benzimidazole compound mebendazole (OBD9) with enhanced solubility and strong anticancer activity in multiple types of cancer cells, especially colorectal cancer. In this report, we provide evidence that OBD9 s …
We have synthesized an oxetane derivative of the benzimidazole compound mebendazole (OBD9) with enhanced solubility and strong antica …
Mebendazole prevents distant organ metastases in part by decreasing ITGbeta4 expression and cancer stemness.
Joe NS, Godet I, Milki N, Ain NUI, Oza HH, Riggins GJ, Gilkes DM. Joe NS, et al. Breast Cancer Res. 2022 Dec 28;24(1):98. doi: 10.1186/s13058-022-01591-3. Breast Cancer Res. 2022. PMID: 36578038 Free PMC article.
Breast cancer is the most diagnosed cancer among women. Approximately 15-20% of all breast cancers are highly invasive triple-negative breast cancer (TNBC) and lack estrogen, progesterone, and ERBB2 receptors. ...To advance current therapeutics, we rep …
Breast cancer is the most diagnosed cancer among women. Approximately 15-20% of all breast cancers are highly invasive …
Mebendazole Increases Anticancer Activity of Radiotherapy in Radiotherapy-Resistant Triple-Negative Breast Cancer Cells by Enhancing Natural Killer Cell-Mediated Cytotoxicity.
Choi HS, Ko YS, Jin H, Kang KM, Ha IB, Jeong H, Lee JH, Jeong BK, Kim HJ. Choi HS, et al. Int J Mol Sci. 2022 Dec 7;23(24):15493. doi: 10.3390/ijms232415493. Int J Mol Sci. 2022. PMID: 36555137 Free PMC article.
Breast cancer is the most commonly diagnosed cancer worldwide and ranks first in terms of both prevalence and cancer-related mortality in women. In this study, we aimed to evaluate the anticancer effect of mebendazole (MBZ) and radiotherapy (RT) concom …
Breast cancer is the most commonly diagnosed cancer worldwide and ranks first in terms of both prevalence and cancer-re …
Pulmonary Hydatid Cyst in Children and Adults: Diagnosis and Management.
Aydin Y, Ulas AB, Ahmed AG, Eroglu A. Aydin Y, et al. Eurasian J Med. 2022 Dec;54(Suppl1):133-140. doi: 10.5152/eurasianjmed.2022.22289. Eurasian J Med. 2022. PMID: 36655457 Free PMC article.
When the hydatid cyst ruptures and becomes complicated, it is clinically and radiologically confused with many diseases, especially lung cancer. Surgery is accepted as primary treatment of lung hydatid cysts all over the world. ...Pulmonary resection should be avoided as m …
When the hydatid cyst ruptures and becomes complicated, it is clinically and radiologically confused with many diseases, especially lung …
The Novel IGF-1R Inhibitor PB-020 Acts Synergistically with Anti-PD-1 and Mebendazole against Colorectal Cancer.
Kang B, Zhang X, Wang W, She S, Chen W, Chen C, Wang Y, Pan X, Xu O, Wang Y. Kang B, et al. Cancers (Basel). 2022 Nov 23;14(23):5747. doi: 10.3390/cancers14235747. Cancers (Basel). 2022. PMID: 36497233 Free PMC article.
CRC is one of the leading causes of cancer mortality worldwide. Chemotherapy is widely used for the treatment of CRC, but its efficacy remains unsatisfactory, mainly due to drug resistance. ...In this study, we revealed that the novel IGF-1R inhibitor PB-020 can act synerg …
CRC is one of the leading causes of cancer mortality worldwide. Chemotherapy is widely used for the treatment of CRC, but its efficac …
Mebendazole Impedes the Proliferation and Migration of Pancreatic Cancer Cells through SK1 Inhibition Dependent Pathway.
Limbu KR, Chhetri RB, Oh YS, Baek DJ, Park EY. Limbu KR, et al. Molecules. 2022 Nov 22;27(23):8127. doi: 10.3390/molecules27238127. Molecules. 2022. PMID: 36500220 Free PMC article.
Sphingosine 1-phosphate (S1P), produced by sphingosine kinase (SK), plays a vital role in cancer growth, metastasis, chemotherapy, and drug resistance. Focusing on the structural characteristics of mebendazole (MBZ), we studied whether MBZ would affect metastasis, i …
Sphingosine 1-phosphate (S1P), produced by sphingosine kinase (SK), plays a vital role in cancer growth, metastasis, chemotherapy, an …
Insights into the Role of Compendial/Biorelevant Media on the Supersaturation Behaviour of Drug Combination (Drug-Drug Interaction) and Precipitation Inhibition by Polymers.
Joshi P, Sangamwar AT. Joshi P, et al. AAPS PharmSciTech. 2022 Nov 15;23(8):300. doi: 10.1208/s12249-022-02448-w. AAPS PharmSciTech. 2022. PMID: 36380100
Combination drug therapy (CDT) plays an immense role in the treatment of various diseases such as malaria, hypertension, cancer, HIV-AIDS, helminthiasis, and many more. However, in vitro drug-drug interaction (DDI) is not well reported for better efficacy of CDT. ...Herein …
Combination drug therapy (CDT) plays an immense role in the treatment of various diseases such as malaria, hypertension, cancer, HIV- …
Modulation of Autophagy is a Potential Strategy for Enhancing the Anti-Tumor Effect of Mebendazole in Glioblastoma Cells.
Jo SB, Sung SJ, Choi HS, Park JS, Hong YK, Joe YA. Jo SB, et al. Biomol Ther (Seoul). 2022 Nov 1;30(6):616-624. doi: 10.4062/biomolther.2022.122. Biomol Ther (Seoul). 2022. PMID: 36305295 Free PMC article.
Mebendazole (MBZ), a microtubule depolymerizing drug commonly used for the treatment of helminthic infections, has been suggested as a repositioning candidate for the treatment of brain tumors. ...
Mebendazole (MBZ), a microtubule depolymerizing drug commonly used for the treatment of helminthic infections, has been suggested as …
A novel network pharmacology approach for leukaemia differentiation therapy using Mogrify®.
Lee LM, Christodoulou EG, Shyamsunder P, Chen BJ, Lee KL, Fung TK, So CWE, Wong GC, Petretto E, Rackham OJL, Tiong Ong S. Lee LM, et al. Oncogene. 2022 Nov;41(48):5160-5175. doi: 10.1038/s41388-022-02505-5. Epub 2022 Oct 21. Oncogene. 2022. PMID: 36271030
Acute myeloid leukaemia (AML) is a rapidly fatal blood cancer that is characterised by the accumulation of immature myeloid cells in the blood and bone marrow as a result of blocked differentiation. ...Thus, these results suggest that Mogrify() could be used for drug disco …
Acute myeloid leukaemia (AML) is a rapidly fatal blood cancer that is characterised by the accumulation of immature myeloid cells in …
Behavior of Mebendazole during NF/RO Adsorption and Photolysis.
Babić B, Andrić D, Farkaš A, Vuk D, Ašperger D, Dolar D. Babić B, et al. Membranes (Basel). 2022 Sep 15;12(9):888. doi: 10.3390/membranes12090888. Membranes (Basel). 2022. PMID: 36135907 Free PMC article.
However, their use as antiparasitics and in cancer treatment will increase their already recorded occurrence in the aquatic environment. ...Mebendazole is a photosensitive drug whose photodegradation follows first-order kinetics and depends on the drug concentration …
However, their use as antiparasitics and in cancer treatment will increase their already recorded occurrence in the aquatic environme …
Antidiabetics, Anthelmintics, Statins, and Beta-Blockers as Co-Adjuvant Drugs in Cancer Therapy.
Gales L, Forsea L, Mitrea D, Stefanica I, Stanculescu I, Mitrica R, Georgescu M, Trifanescu O, Anghel R, Serbanescu L. Gales L, et al. Medicina (Kaunas). 2022 Sep 7;58(9):1239. doi: 10.3390/medicina58091239. Medicina (Kaunas). 2022. PMID: 36143915 Free PMC article. Review.
Despite the abundance of results from in vitro and in vivo studies, the only solid data from randomized clinical trials confirm metformin-related oncological benefits for only a small subset of nondiabetic patients with HER2-positive breast cancer and early-stage colorecta …
Despite the abundance of results from in vitro and in vivo studies, the only solid data from randomized clinical trials confirm metformin-re …
Targeting the Unwindosome by Mebendazole Is a Vulnerability of Chemoresistant Hepatoblastoma.
Li Q, Demir S, Del Río-Álvarez Á, Maxwell R, Wagner A, Carrillo-Reixach J, Armengol C, Vokuhl C, Häberle B, von Schweinitz D, Schmid I, Cairo S, Kappler R. Li Q, et al. Cancers (Basel). 2022 Aug 30;14(17):4196. doi: 10.3390/cancers14174196. Cancers (Basel). 2022. PMID: 36077733 Free PMC article.
Viability assays clearly indicated a potent reduction of tumor cell growth upon mebendazole treatment in a dose-dependent manner. The combination of mebendazole and cisplatin revealed a strong synergistic effect, which was comparable to the one seen with cisplatin a …
Viability assays clearly indicated a potent reduction of tumor cell growth upon mebendazole treatment in a dose-dependent manner. The …
Mebendazole's Conformational Space and Its Predicted Binding to Human Heat-Shock Protein 90.
Fiedler W, Freisleben F, Wellbrock J, Kirschner KN. Fiedler W, et al. J Chem Inf Model. 2022 Aug 8;62(15):3604-3617. doi: 10.1021/acs.jcim.2c00290. Epub 2022 Jul 22. J Chem Inf Model. 2022. PMID: 35867562
Recent experimental evidence suggests that mebendazole, a popular antiparasitic drug, binds to heat shock protein 90 (Hsp90) and inhibits acute myeloid leukemia cell growth. ...All simulations support the hypothesis that mebendazole is able to bind to the ATP bindin …
Recent experimental evidence suggests that mebendazole, a popular antiparasitic drug, binds to heat shock protein 90 (Hsp90) and inhi …
Mebendazole plus lomustine or temozolomide in patients with recurrent glioblastoma: A randomised open-label phase II trial.
Patil VM, Menon N, Chatterjee A, Tonse R, Choudhari A, Mahajan A, Puranik AD, Epari S, Jadhav M, Pathak S, Peelay Z, Walavalkar R, Muthuluri HK, Ravi Krishna M, Chandrasekharan A, Pande N, Gupta T, Banavali S, Jalali R. Patil VM, et al. EClinicalMedicine. 2022 May 27;49:101449. doi: 10.1016/j.eclinm.2022.101449. eCollection 2022 Jul. EClinicalMedicine. 2022. PMID: 35747192 Free PMC article.
BACKGROUND: Recurrent glioblastoma (GBM) has dismal outcomes and limited treatment options. Mebendazole (MBZ) has activity in glioma both in-vivo and in-vitro, and is well tolerated in combination with lomustine (CCNU) and temozolomide (TMZ). ...FUNDING: Brain Tumor Founda …
BACKGROUND: Recurrent glioblastoma (GBM) has dismal outcomes and limited treatment options. Mebendazole (MBZ) has activity in glioma …
Mebendazole; from an anti-parasitic drug to a promising candidate for drug repurposing in colorectal cancer.
Hegazy SK, El-Azab GA, Zakaria F, Mostafa MF, El-Ghoneimy RA. Hegazy SK, et al. Life Sci. 2022 Jun 15;299:120536. doi: 10.1016/j.lfs.2022.120536. Epub 2022 Apr 3. Life Sci. 2022. PMID: 35385794 Clinical Trial.
AIMS: Metastatic colorectal cancer (mCRC) predominantly contributes to cancer-related mortalities secondary to distant metastasis. This study aimed at investigating anti-tumor activity and safety of mebendazole in patients with mCRC. MATERIALS AND METHODS: Th …
AIMS: Metastatic colorectal cancer (mCRC) predominantly contributes to cancer-related mortalities secondary to distant metasta …
HPMA Copolymer Mebendazole Conjugate Allows Systemic Administration and Possesses Antitumour Activity In Vivo.
Studenovský M, Rumlerová A, Kovářová J, Dvořáková B, Sivák L, Kostka L, Berdár D, Etrych T, Kovář M. Studenovský M, et al. Pharmaceutics. 2022 Jun 4;14(6):1201. doi: 10.3390/pharmaceutics14061201. Pharmaceutics. 2022. PMID: 35745774 Free PMC article.
Mebendazole and other benzimidazole antihelmintics, such as albendazole, fenbendazole, or flubendazole, have been shown to possess antitumour activity, primarily due to their microtubule-disrupting activity. However, the extremely poor water-solubility of mebendazole …
Mebendazole and other benzimidazole antihelmintics, such as albendazole, fenbendazole, or flubendazole, have been shown to possess an …
Identification of a c-MYB-directed therapeutic for acute myeloid leukemia.
Clesham K, Walf-Vorderwülbecke V, Gasparoli L, Virely C, Cantilena S, Tsakaneli A, Inglott S, Adams S, Samarasinghe S, Bartram J, Williams G, de Boer J, Williams O. Clesham K, et al. Leukemia. 2022 Jun;36(6):1541-1549. doi: 10.1038/s41375-022-01554-9. Epub 2022 Apr 2. Leukemia. 2022. PMID: 35368048 Free PMC article.
We have previously screened the Connectivity Map database to identify mebendazole as an anti-AML therapeutic targeting c-MYB. In the present study we demonstrate that another hit from this screen, the steroidal lactone withaferin A (WFA), induces rapid ablation of c-MYB pr …
We have previously screened the Connectivity Map database to identify mebendazole as an anti-AML therapeutic targeting c-MYB. In the …
Nutraceuticals and Phytotherapy in Men's Health: Antioxidants, Pro-oxidants, and a Novel Opportunity for Lifestyle Changes.
Moyad MA. Moyad MA. Urol Clin North Am. 2022 May;49(2):239-248. doi: 10.1016/j.ucl.2021.12.006. Epub 2022 Mar 22. Urol Clin North Am. 2022. PMID: 35428430 Review.
"Less is more" should be the current mantra in the prostate cancer milieu, and potentially in some men with male infertility based on the FAZST trial because it is plausible some antioxidants are exhibiting prooxidant activity in some settings. Some prescription anthelmint …
"Less is more" should be the current mantra in the prostate cancer milieu, and potentially in some men with male infertility based on …
Flubendazole induces mitochondrial dysfunction and DRP1-mediated mitophagy by targeting EVA1A in breast cancer.
Zhen Y, Yuan Z, Zhang J, Chen Y, Fu Y, Liu Y, Fu L, Zhang L, Zhou XL. Zhen Y, et al. Cell Death Dis. 2022 Apr 19;13(4):375. doi: 10.1038/s41419-022-04823-8. Cell Death Dis. 2022. PMID: 35440104 Free PMC article.
Breast cancer is still one of the most common malignancies worldwide and remains a major clinical challenge. ...The resultant excessive mitophagy contributed to mitochondrial damage and dysfunction induced by flubendazole, thus inhibiting breast cancer cells prolife …
Breast cancer is still one of the most common malignancies worldwide and remains a major clinical challenge. ...The resultant excessi …
Biodegradable and biocompatible subcutaneous implants consisted of pH-sensitive mebendazole-loaded/folic acid-targeted chitosan nanoparticles for murine triple-negative breast cancer treatment.
Kefayat A, Hosseini M, Ghahremani F, Jolfaie NA, Rafienia M. Kefayat A, et al. J Nanobiotechnology. 2022 Mar 31;20(1):169. doi: 10.1186/s12951-022-01380-2. J Nanobiotechnology. 2022. PMID: 35361226 Free PMC article.
BACKGROUND: Mebendazole (MBZ) is a well-known anti-parasite drug with significant anti-cancer properties. ...In addition, the CS-FA-MBZ treated mice exhibited about 52.1%, 27.3%, and 17% more survival days after the cancer cells injection in comparison with t …
BACKGROUND: Mebendazole (MBZ) is a well-known anti-parasite drug with significant anti-cancer properties. ...In addition, the …
Effect of Clinically Used Microtubule Targeting Drugs on Viral Infection and Transport Function.
Oliva MÁ, Tosat-Bitrián C, Barrado-Gil L, Bonato F, Galindo I, Garaigorta U, Álvarez-Bernad B, París-Ogáyar R, Lucena-Agell D, Giménez-Abián JF, García-Dorival I, Urquiza J, Gastaminza P, Díaz JF, Palomo V, Alonso C. Oliva MÁ, et al. Int J Mol Sci. 2022 Mar 22;23(7):3448. doi: 10.3390/ijms23073448. Int J Mol Sci. 2022. PMID: 35408808 Free PMC article.
Microtubule targeting agents (MTAs) have been exploited mainly as anti-cancer drugs because of their impact on cellular division and angiogenesis. Additionally, microtubules (MTs) are key structures for intracellular transport, which is frequently hijacked during viral inf …
Microtubule targeting agents (MTAs) have been exploited mainly as anti-cancer drugs because of their impact on cellular division and …
Extensive improvement of oral bioavailability of mebendazole, a brick dust, by polymer-containing SNEDDS preparation: Disruption of high crystallinity by utilizing its counter ion.
Sumimoto Y, Okawa S, Inoue T, Masuda K, Maruyama M, Higaki K. Sumimoto Y, et al. Eur J Pharm Biopharm. 2022 Mar;172:213-227. doi: 10.1016/j.ejpb.2022.02.002. Epub 2022 Feb 5. Eur J Pharm Biopharm. 2022. PMID: 35134511
Poorly water-soluble and poorly lipid-soluble drugs are called as "brick dust" and it is very hard for them to be formulated as some dosage form which can provide an effective bioavailability after oral administration. Mebendazole (MBZ), an anti-helminthic drug having anti …
Poorly water-soluble and poorly lipid-soluble drugs are called as "brick dust" and it is very hard for them to be formulated as some dosage …
Adverse reactions with levamisole vary according to its indications and misuse: A systematic pharmacovigilance study.
Campillo JT, Eiden C, Boussinesq M, Pion SDS, Faillie JL, Chesnais CB. Campillo JT, et al. Br J Clin Pharmacol. 2022 Mar;88(3):1094-1106. doi: 10.1111/bcp.15037. Epub 2021 Sep 15. Br J Clin Pharmacol. 2022. PMID: 34390273 Free PMC article.
Because of immunomodulatory properties, levamisole has been used in inflammatory pathologies and in cancers in association with 5-fluorouracil. Levamisole is misused as a cocaine adulterant. ...In secondary analyses, we compared the frequency of ADRs between levamisole and …
Because of immunomodulatory properties, levamisole has been used in inflammatory pathologies and in cancers in association with 5-flu …
Hot-melt extrudability of amorphous solid dispersions of flubendazole-copovidone: An exploratory study of the effect of drug loading and the balance of adjuvants on extrudability and dissolution.
de Assis JMC, Barbosa EJ, Bezzon VDN, Lourenço FR, Carvalho FMS, Matos JR, Araci Bou-Chacra N, Benmore CJ, Byrn SR, Costa FN, de Araujo GLB. de Assis JMC, et al. Int J Pharm. 2022 Feb 25;614:121456. doi: 10.1016/j.ijpharm.2022.121456. Epub 2022 Jan 10. Int J Pharm. 2022. PMID: 35017024 Free article.
The FDA-approved anthelmintic flubendazole has shown potential to be repositioned to treat cancer and dry macular degeneration; however, its poor water solubility limits its use. ...
The FDA-approved anthelmintic flubendazole has shown potential to be repositioned to treat cancer and dry macular degeneration; howev …
European Mistletoe (Viscum album) Extract Is Cytotoxic to Canine High-Grade Astrocytoma Cells In Vitro and Has Additive Effects with Mebendazole.
Wright A, Watanabe R, Koehler JW. Wright A, et al. Vet Sci. 2022 Jan 15;9(1):31. doi: 10.3390/vetsci9010031. Vet Sci. 2022. PMID: 35051115 Free PMC article.
In separate experiments, cells were exposed to mebendazole at a previously determined IC50 (0.03 M) alone or in conjunction with varying concentrations of mistletoe extract to determine the additive effects. ...The addition of mistletoe at 5 mug/mL to mebendazole at …
In separate experiments, cells were exposed to mebendazole at a previously determined IC50 (0.03 M) alone or in conjunction with vary …
In Silico and In Vitro Studies for Benzimidazole Anthelmintics Repurposing as VEGFR-2 Antagonists: Novel Mebendazole-Loaded Mixed Micelles with Enhanced Dissolution and Anticancer Activity.
Elmaaty AA, Darwish KM, Chrouda A, Boseila AA, Tantawy MA, Elhady SS, Shaik AB, Mustafa M, Al-Karmalawy AA. Elmaaty AA, et al. ACS Omega. 2021 Dec 22;7(1):875-899. doi: 10.1021/acsomega.1c05519. eCollection 2022 Jan 11. ACS Omega. 2021. PMID: 35036753 Free PMC article.
Cancer is a leading cause of death worldwide and its incidence is unfortunately anticipated to rise in the next years. ...Besides, the anticancer activity of the aforementioned drugs was tested in vitro against three different cancer cell lines, including liver c …
Cancer is a leading cause of death worldwide and its incidence is unfortunately anticipated to rise in the next years. ...Besides, th …
Flubendazole Plays an Important Anti-Tumor Role in Different Types of Cancers.
Chen C, Ding Y, Liu H, Sun M, Wang H, Wu D. Chen C, et al. Int J Mol Sci. 2022 Jan 4;23(1):519. doi: 10.3390/ijms23010519. Int J Mol Sci. 2022. PMID: 35008943 Free PMC article. Review.
In recent years, many studies have shown that flubendazole plays an anti-tumor role in different types of cancers, including breast cancer, melanoma, prostate cancer, colorectal cancer, and lung cancer. ...In this review, we summarized the recen …
In recent years, many studies have shown that flubendazole plays an anti-tumor role in different types of cancers, including breast …
Benzimidazoles induce concurrent apoptosis and pyroptosis of human glioblastoma cells via arresting cell cycle.
Ren LW, Li W, Zheng XJ, Liu JY, Yang YH, Li S, Zhang S, Fu WQ, Xiao B, Wang JH, Du GH. Ren LW, et al. Acta Pharmacol Sin. 2022 Jan;43(1):194-208. doi: 10.1038/s41401-021-00752-y. Epub 2021 Aug 25. Acta Pharmacol Sin. 2022. PMID: 34433903 Free PMC article.
By analyzing the hub genes of GBM via weighted gene co-expression network analysis (WGCNA) of the cancer genome atlas (TCGA) dataset, and using the connectivity map (CMAP) platform for drug repurposing, we found that multiple azole compounds had potential anti-GBM activity …
By analyzing the hub genes of GBM via weighted gene co-expression network analysis (WGCNA) of the cancer genome atlas (TCGA) dataset, …
Emerging insights on functions of the anthelmintic flubendazole as a repurposed anticancer agent.
Khachigian LM. Khachigian LM. Cancer Lett. 2021 Dec 1;522:57-62. doi: 10.1016/j.canlet.2021.09.013. Epub 2021 Sep 11. Cancer Lett. 2021. PMID: 34520820 Review.
This article reviews recent studies in a range of tumor types indicating novel functions for flubendazole in its control of processes associated with tumor growth, spread and renewal including ferroptosis, autophagy, cancer stem-like cell killing and suppression of intratu …
This article reviews recent studies in a range of tumor types indicating novel functions for flubendazole in its control of processes associ …
Disulfiram and metformin combination anticancer effect reversible partly by antioxidant nitroglycerin and completely by NF-kappaB activator mebendazole in hamster fibrosarcoma.
Popović KJ, Popović DJ, Miljković D, Popović JK, Lalošević D, Poša M, Čapo I. Popović KJ, et al. Biomed Pharmacother. 2021 Nov;143:112168. doi: 10.1016/j.biopha.2021.112168. Epub 2021 Sep 15. Biomed Pharmacother. 2021. PMID: 34536762 Free article.
Validation and rescue grups were treated by double doses of the single therapy and by the combination with addition of rescue daily doses of ROS inhibitor nitroglycerin 25 mg/kg or NF-kappaB stimulator mebendazole 460 mg/kg, via a gastric probe after tumor inoculation. Aft …
Validation and rescue grups were treated by double doses of the single therapy and by the combination with addition of rescue daily doses of …
Computational repurposing of benzimidazole anthelmintic drugs as potential colchicine binding site inhibitors.
Khattab M, Al-Karmalawy AA. Khattab M, et al. Future Med Chem. 2021 Oct;13(19):1623-1638. doi: 10.4155/fmc-2020-0273. Epub 2021 Sep 10. Future Med Chem. 2021. PMID: 34505541
Methodology: In this study, we aimed to investigate the binding interactions and electronic configurations of nine benzimidazole-based anthelmintics against one of the well-known cancer targets (tubulin protein). Results: Binding affinities of docked benzimidazole drugs in …
Methodology: In this study, we aimed to investigate the binding interactions and electronic configurations of nine benzimidazole-based anthe …
Treatment of breast and colon cancer cell lines with anti-helmintic benzimidazoles mebendazole or albendazole results in selective apoptotic cell death.
Petersen JSSM, Baird SK. Petersen JSSM, et al. J Cancer Res Clin Oncol. 2021 Oct;147(10):2945-2953. doi: 10.1007/s00432-021-03698-0. Epub 2021 Jun 20. J Cancer Res Clin Oncol. 2021. PMID: 34148157 Free PMC article.
They have recently shown some promising results in pre-clinical in vitro and in vivo anti-cancer studies. METHODS: We compare their efficacy in breast and colon cancer cell lines as well as in non-cancerous cells and elucidate their mechanism of action. ...Th …
They have recently shown some promising results in pre-clinical in vitro and in vivo anti-cancer studies. METHODS: We compare their e …
Anticancer Effect of Benzimidazole Derivatives, Especially Mebendazole, on Triple-Negative Breast Cancer (TNBC) and Radiotherapy-Resistant TNBC In Vivo and In Vitro.
Choi HS, Ko YS, Jin H, Kang KM, Ha IB, Jeong H, Song HN, Kim HJ, Jeong BK. Choi HS, et al. Molecules. 2021 Aug 24;26(17):5118. doi: 10.3390/molecules26175118. Molecules. 2021. PMID: 34500557 Free PMC article.
In this study, we aimed to evaluate the anticancer effect of benzimidazole derivatives on triple-negative breast cancer (TNBC) and investigate its underlying mechanism of action. Several types of cancer and normal breast cells including MDA-MB-231, radiotherapy-resi …
In this study, we aimed to evaluate the anticancer effect of benzimidazole derivatives on triple-negative breast cancer (TNBC) and in …
HPMA-Based Polymer Conjugates for Repurposed Drug Mebendazole and Other Imidazole-Based Therapeutics.
Studenovský M, Rumlerová A, Kostka L, Etrych T. Studenovský M, et al. Polymers (Basel). 2021 Jul 30;13(15):2530. doi: 10.3390/polym13152530. Polymers (Basel). 2021. PMID: 34372133 Free PMC article.
This study describes the design, synthesis, and physico-chemical properties of polymer-mebendazole nanomedicines for drug repurposing in cancer therapy. The conjugation of mebendazole to water-soluble and biocompatible polymer carrier was carried out via biod …
This study describes the design, synthesis, and physico-chemical properties of polymer-mebendazole nanomedicines for drug repurposing …
Peritoneal lesions caused by Enterobius vermicularis suspected to be metastases of ovarian malignancy.
Croonen B, Oei A, Mol S, Schneeberger P. Croonen B, et al. BMJ Case Rep. 2021 Jul 8;14(7):e238618. doi: 10.1136/bcr-2020-238618. BMJ Case Rep. 2021. PMID: 34244195 Free PMC article.
On investigation, a transvaginal ultrasound showed a multilocular cyst in the left ovary, along with elevated levels of cancer antigen 125. Consequently, a laparoscopic salpingo-oophorectomy was performed. A biopsy of atypical peritoneal lesions revealed remains of E. verm …
On investigation, a transvaginal ultrasound showed a multilocular cyst in the left ovary, along with elevated levels of cancer antige …
Antiparasitic mebendazole (MBZ) effectively overcomes cisplatin resistance in human ovarian cancer cells by inhibiting multiple cancer-associated signaling pathways.
Huang L, Zhao L, Zhang J, He F, Wang H, Liu Q, Shi D, Ni N, Wagstaff W, Chen C, Reid RR, Haydon RC, Luu HH, Shen L, He TC, Tang L. Huang L, et al. Aging (Albany NY). 2021 Jul 7;13(13):17407-17427. doi: 10.18632/aging.203232. Epub 2021 Jul 7. Aging (Albany NY). 2021. PMID: 34232919 Free PMC article.
Ovarian cancer is the third most common cancer and the second most common cause of gynecologic cancer death in women. ...Repurposing previously-approved drugs is a cost-effective strategy for cancer drug discovery. The antiparasitic drug mebendazole …
Ovarian cancer is the third most common cancer and the second most common cause of gynecologic cancer death in women. . …
Mebendazole disrupts stromal desmoplasia and tumorigenesis in two models of pancreatic cancer.
Williamson T, de Abreu MC, Trembath DG, Brayton C, Kang B, Mendes TB, de Assumpção PP, Cerutti JM, Riggins GJ. Williamson T, et al. Oncotarget. 2021 Jul 6;12(14):1326-1338. doi: 10.18632/oncotarget.28014. eCollection 2021 Jul 6. Oncotarget. 2021. PMID: 34262644 Free PMC article.
Here we evaluated repurposed mebendazole, an approved anthelminthic drug, to determine how mebendazole might work at the different stages of pancreatic cancer formation and progression. ...Mebendazole reduced the overall incidence of pancreatic canc …
Here we evaluated repurposed mebendazole, an approved anthelminthic drug, to determine how mebendazole might work at the diffe …
Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update.
Chai JY, Jung BK, Hong SJ. Chai JY, et al. Korean J Parasitol. 2021 Jun;59(3):189-225. doi: 10.3347/kjp.2021.59.3.189. Epub 2021 Jun 21. Korean J Parasitol. 2021. PMID: 34218593 Free PMC article. Review.
The use of albendazole and mebendazole, i.e., benzimidazole broad-spectrum anthelmintics, in treatment of parasitic infections, as well as cancers, is briefly reviewed. ...It is of particular note that albendazole and mebendazole have been repositioned as pro …
The use of albendazole and mebendazole, i.e., benzimidazole broad-spectrum anthelmintics, in treatment of parasitic infections, as we …
Antimicrobial and anticancer properties of Carica papaya leaves derived di-methyl flubendazole mediated silver nanoparticles.
Devanesan S, Jayamala M, AlSalhi MS, Umamaheshwari S, Ranjitsingh AJA. Devanesan S, et al. J Infect Public Health. 2021 May;14(5):577-587. doi: 10.1016/j.jiph.2021.02.004. Epub 2021 Feb 20. J Infect Public Health. 2021. PMID: 33848887 Free article.
The AgNPs with plant sources an alternative therapeutic agent for synthetic compound used in cancer chemotherapy. METHODS: The AgNPs were characterized using UV, FT-IR, XRD, FESEM with EDX and TEM. ...Studies on the antiproliferative potential of bioinspired AgNPs in ca …
The AgNPs with plant sources an alternative therapeutic agent for synthetic compound used in cancer chemotherapy. METHODS: The AgNPs …
A phase 2a clinical study on the safety and efficacy of individualized dosed mebendazole in patients with advanced gastrointestinal cancer.
Mansoori S, Fryknäs M, Alvfors C, Loskog A, Larsson R, Nygren P. Mansoori S, et al. Sci Rep. 2021 Apr 26;11(1):8981. doi: 10.1038/s41598-021-88433-y. Sci Rep. 2021. PMID: 33903692 Free PMC article. Clinical Trial.
Anticancer effects of mebendazole have been shown in experimental cancer models and in case studies in patients with advanced cancer. Given these observations, the aims of this study were to investigate safety and efficacy of individualized dosed mebendazo …
Anticancer effects of mebendazole have been shown in experimental cancer models and in case studies in patients with advanced …
Screening of Benzimidazole-Based Anthelmintics and Their Enantiomers as Repurposed Drug Candidates in Cancer Therapy.
Florio R, Carradori S, Veschi S, Brocco D, Di Genni T, Cirilli R, Casulli A, Cama A, De Lellis L. Florio R, et al. Pharmaceuticals (Basel). 2021 Apr 17;14(4):372. doi: 10.3390/ph14040372. Pharmaceuticals (Basel). 2021. PMID: 33920661 Free PMC article.
In this study, we explored the effects of a large series of benzimidazole-based anthelmintics (and some enantiomerically pure forms of those containing a stereogenic center) on the viability of different tumor cell lines derived from paraganglioma, pancreatic and colorectal ca …
In this study, we explored the effects of a large series of benzimidazole-based anthelmintics (and some enantiomerically pure forms of those …
Revisiting Activity of Some Nocodazole Analogues as a Potential Anticancer Drugs Using Molecular Docking and DFT Calculations.
Khattab M, Al-Karmalawy AA. Khattab M, et al. Front Chem. 2021 Mar 24;9:628398. doi: 10.3389/fchem.2021.628398. eCollection 2021. Front Chem. 2021. PMID: 33842429 Free PMC article.
Order of binding affinities of tested benzimidazole drugs toward colchicine binding site on tubulin protein is as follows: Flubendazole > Oxfendazole > Nocodazole > Mebendazole > Albendazole > Oxibendazole > Fenbendazole > Ciclobendazole > Thiabenda …
Order of binding affinities of tested benzimidazole drugs toward colchicine binding site on tubulin protein is as follows: Flubendazole > …
Flubendazole, FDA-approved anthelmintic, elicits valid antitumor effects by targeting P53 and promoting ferroptosis in castration-resistant prostate cancer.
Zhou X, Zou L, Chen W, Yang T, Luo J, Wu K, Shu F, Tan X, Yang Y, Cen S, Li C, Mao X. Zhou X, et al. Pharmacol Res. 2021 Feb;164:105305. doi: 10.1016/j.phrs.2020.105305. Epub 2020 Nov 14. Pharmacol Res. 2021. PMID: 33197601
On account of incurable castration-resistant prostate cancer (CRPC) inevitably developing after treating with androgen deprivation therapy, it is an urgent need to find new therapeutic strategies. Flubendazole is a well-known anti-malarial drug that is recently reported to …
On account of incurable castration-resistant prostate cancer (CRPC) inevitably developing after treating with androgen deprivation th …
Targeting Cancer Stem Cells with Repurposed Drugs to Improve Current Therapies.
Fong D, Christensen CT, Chan MM. Fong D, et al. Recent Pat Anticancer Drug Discov. 2021;16(2):136-160. doi: 10.2174/1574892816666210208232251. Recent Pat Anticancer Drug Discov. 2021. PMID: 33563159 Review.
BACKGROUND: Cancer is a multistep process involving genetic and epigenetic changes in the somatic genome. Genetic mutations as well as environmental factors lead to the initiation, promotion, and progression of cancer. Metastasis allows cancer cells to spread …
BACKGROUND: Cancer is a multistep process involving genetic and epigenetic changes in the somatic genome. Genetic mutations as well a …
Mebendazole and temozolomide in patients with newly diagnosed high-grade gliomas: results of a phase 1 clinical trial.
Gallia GL, Holdhoff M, Brem H, Joshi AD, Hann CL, Bai RY, Staedtke V, Blakeley JO, Sengupta S, Jarrell TC, Wollett J, Szajna K, Helie N, Mattox AK, Ye X, Rudek MA, Riggins GJ. Gallia GL, et al. Neurooncol Adv. 2020 Nov 12;3(1):vdaa154. doi: 10.1093/noajnl/vdaa154. eCollection 2021 Jan-Dec. Neurooncol Adv. 2020. PMID: 33506200 Free PMC article.
BACKGROUND: Mebendazole is an anthelmintic drug introduced for human use in 1971 that extends survival in preclinical models of glioblastoma and other brain cancers. ...Further studies are needed to determine mebendazole's efficacy in patients with malignant …
BACKGROUND: Mebendazole is an anthelmintic drug introduced for human use in 1971 that extends survival in preclinical models of gliob …
Potential and mechanism of mebendazole for treatment and maintenance of ovarian cancer.
Elayapillai S, Ramraj S, Benbrook DM, Bieniasz M, Wang L, Pathuri G, Isingizwe ZR, Kennedy AL, Zhao YD, Lightfoot S, Hunsucker LA, Gunderson CC. Elayapillai S, et al. Gynecol Oncol. 2021 Jan;160(1):302-311. doi: 10.1016/j.ygyno.2020.10.010. Epub 2020 Oct 31. Gynecol Oncol. 2021. PMID: 33131904 Free PMC article.
OBJECTIVE: Mebendazole and other anti-parasitic drugs are being used off-prescription based on social media and unofficial accounts of their anti-cancer activity. ...CONCLUSION: This work demonstrates the therapeutic potential of repurposing mebendazole and s …
OBJECTIVE: Mebendazole and other anti-parasitic drugs are being used off-prescription based on social media and unofficial accounts o …
Repurposing of Benzimidazole Scaffolds for HER2 Positive Breast Cancer Therapy: An In-Silico Approach.
Jubie S, Durai U, Latha S, Ayyamperumal S, Wadhwani A, Prabha T. Jubie S, et al. Curr Drug Res Rev. 2021;13(1):73-83. doi: 10.2174/2589977512999200821170221. Curr Drug Res Rev. 2021. PMID: 32955008
BACKGROUND: A newer trend has been seen recently to reuse the conventional drugs with distinct indications for the newer applications to speed up the drug discovery and development based on earlier records and safety data. Most of the non-cancerous agents could afford a li …
BACKGROUND: A newer trend has been seen recently to reuse the conventional drugs with distinct indications for the newer applications to spe …
In silico molecular target prediction unveils mebendazole as a potent MAPK14 inhibitor.
Ariey-Bonnet J, Carrasco K, Le Grand M, Hoffer L, Betzi S, Feracci M, Tsvetkov P, Devred F, Collette Y, Morelli X, Ballester P, Pasquier E. Ariey-Bonnet J, et al. Mol Oncol. 2020 Dec;14(12):3083-3099. doi: 10.1002/1878-0261.12810. Epub 2020 Oct 18. Mol Oncol. 2020. PMID: 33021050 Free PMC article.
Validation experiments were performed on three major kinases involved in cancer biology: ABL1, MAPK1/ERK2, and MAPK14/p38alpha. Mebendazole could inhibit the activity of these kinases in vitro in a dose-dependent manner, with a high potency against MAPK14 (IC(50) = …
Validation experiments were performed on three major kinases involved in cancer biology: ABL1, MAPK1/ERK2, and MAPK14/p38alpha. Me …
A Clinical Genomics-Guided Prioritizing Strategy Enables Selecting Proper Cancer Cell Lines for Biomedical Research.
Shao X, Wang Y, Lu X, Hu Y, Liao J, Li J, Chen X, Yu Y, Ai N, Ying M, Fan X. Shao X, et al. iScience. 2020 Oct 28;23(11):101748. doi: 10.1016/j.isci.2020.101748. eCollection 2020 Nov 20. iScience. 2020. PMID: 33225250 Free PMC article.
Here we developed a clinical Genomics-guided Prioritizing Strategy for Cancer Cell Lines (CCL-cGPS) and help to guide this process. Statistical analyses revealed CCL-cGPS selected cell lines were among the most appropriate models. Moreover, we observed a linear correlation …
Here we developed a clinical Genomics-guided Prioritizing Strategy for Cancer Cell Lines (CCL-cGPS) and help to guide this process. S …
The Antihelminthic Drug, Mebendazole, Induces Apoptosis in Adult T-Cell Leukemia/Lymphoma Cancer Cells: In-Vitro Trial.
Maali A, Ferdosi-Shahandashti E, Sadeghi F, Aali E. Maali A, et al. Int J Hematol Oncol Stem Cell Res. 2020 Oct 1;14(4):257-264. doi: 10.18502/ijhoscr.v14i4.4482. Int J Hematol Oncol Stem Cell Res. 2020. PMID: 33603987 Free PMC article.
Our aim is evaluating the antiproliferative and apoptotic effect of Mebendazole (MBZ) on ATLL cancer cells in in-vitro conditions. Materials and Methods: We used Jurkat cell-line as ATLL cancer cells. ...Also, we suggest that indirectly inhibition of Glucose …
Our aim is evaluating the antiproliferative and apoptotic effect of Mebendazole (MBZ) on ATLL cancer cells in in-vitro conditi …
Drug repurposing and relabeling for cancer therapy: Emerging benzimidazole antihelminthics with potent anticancer effects.
Nath J, Paul R, Ghosh SK, Paul J, Singha B, Debnath N. Nath J, et al. Life Sci. 2020 Oct 1;258:118189. doi: 10.1016/j.lfs.2020.118189. Epub 2020 Aug 8. Life Sci. 2020. PMID: 32781060 Review.
Origin of drug and radio-refractory clones, cancer stem-like cells, and rapid angiogenesis and metastasis are among the primary concerns that limit the efficacy of anticancer treatments, emphasizing the urgency of developing new therapeutics. ...The effective anticancer pr …
Origin of drug and radio-refractory clones, cancer stem-like cells, and rapid angiogenesis and metastasis are among the primary conce …
Co-treatment with nitroglycerin and metformin exhibits physicochemically and pathohistologically detectable anticancer effects on fibrosarcoma in hamsters.
Popović KJ, Popović DJ, Miljković D, Popović JK, Lalošević D, Čapo I. Popović KJ, et al. Biomed Pharmacother. 2020 Oct;130:110510. doi: 10.1016/j.biopha.2020.110510. Epub 2020 Jul 21. Biomed Pharmacother. 2020. PMID: 32707437 Free article.
Co-treatment with mebendazole inhibited anticancer activity of the nitroglycerin and metformin combination. Mebendazole rescued tumor progression suppressed by the combination of nitroglycerin and metformin. ...
Co-treatment with mebendazole inhibited anticancer activity of the nitroglycerin and metformin combination. Mebendazole rescue …
Preparation and Evaluation of Mebendazole Microemulsion for Intranasal Delivery: an Alternative Approach for Glioblastoma Treatment.
Mena-Hernández J, Jung-Cook H, Llaguno-Munive M, García-López P, Ganem-Rondero A, López-Ramírez S, Barragán-Aroche F, Rivera-Huerta M, Mayet-Cruz L. Mena-Hernández J, et al. AAPS PharmSciTech. 2020 Sep 27;21(7):264. doi: 10.1208/s12249-020-01805-x. AAPS PharmSciTech. 2020. PMID: 32980937
Although mebendazole (MBZ) has demonstrated antitumor activity in glioblastoma models, the drug has low aqueous solubility and therefore is poorly absorbed. ...Results suggest that the intranasal administration of mebendazole-loaded microemulsion might be appropriat …
Although mebendazole (MBZ) has demonstrated antitumor activity in glioblastoma models, the drug has low aqueous solubility and theref …
The Antitumor Potentials of Benzimidazole Anthelmintics as Repurposing Drugs.
Son DS, Lee ES, Adunyah SE. Son DS, et al. Immune Netw. 2020 Aug 4;20(4):e29. doi: 10.4110/in.2020.20.e29. eCollection 2020 Aug. Immune Netw. 2020. PMID: 32895616 Free PMC article. Review.
The development of refractory tumor cells limits therapeutic efficacy in cancer by activating mechanisms that promote cellular proliferation, migration, invasion, metastasis, and survival. ...Above all, these anthelmintics may offer a broad, safe spectrum to treat cance …
The development of refractory tumor cells limits therapeutic efficacy in cancer by activating mechanisms that promote cellular prolif …
Mebendazole is unique among tubulin-active drugs in activating the MEK-ERK pathway.
Andersson CR, Selvin T, Blom K, Rubin J, Berglund M, Jarvius M, Lenhammar L, Parrow V, Loskog A, Fryknäs M, Nygren P, Larsson R. Andersson CR, et al. Sci Rep. 2020 Aug 4;10(1):13124. doi: 10.1038/s41598-020-68986-0. Sci Rep. 2020. PMID: 32753665 Free PMC article.
We recently showed that the anti-helminthic compound mebendazole (MBZ) has immunomodulating activity in monocyte/macrophage models and induces ERK signalling. ...
We recently showed that the anti-helminthic compound mebendazole (MBZ) has immunomodulating activity in monocyte/macrophage models an …
Preventative Effect of Mebendazole against Malignancies in Neurofibromatosis 1.
Staedtke V, Gray-Bethke T, Riggins GJ, Bai RY. Staedtke V, et al. Genes (Basel). 2020 Jul 8;11(7):762. doi: 10.3390/genes11070762. Genes (Basel). 2020. PMID: 32650362 Free PMC article.
Malignant tumors are often recalcitrant to treatments and associated with poor survival; however, no chemopreventative strategies currently exist. We thus evaluated the effect of mebendazole, alone or in combination with cyclooxygenase-2 (COX-2) inhibitors, on the preventi …
Malignant tumors are often recalcitrant to treatments and associated with poor survival; however, no chemopreventative strategies currently …
Flubendazole elicits anti-cancer effects via targeting EVA1A-modulated autophagy and apoptosis in Triple-negative Breast Cancer.
Zhen Y, Zhao R, Wang M, Jiang X, Gao F, Fu L, Zhang L, Zhou XL. Zhen Y, et al. Theranostics. 2020 Jul 2;10(18):8080-8097. doi: 10.7150/thno.43473. eCollection 2020. Theranostics. 2020. PMID: 32724459 Free PMC article.
Background: Triple-negative breast cancer (TNBC) is one of the most prevalent neoplastic diseases worldwide, but efficacious treatments for this pathological condition are still challenging. ...Altogether, this study highlights the possibility of this repurposed autophagic …
Background: Triple-negative breast cancer (TNBC) is one of the most prevalent neoplastic diseases worldwide, but efficacious treatmen …
Reverse swing-M, phase 1 study of repurposing mebendazole in recurrent high-grade glioma.
Patil VM, Bhelekar A, Menon N, Bhattacharjee A, Simha V, Abhinav R, Abhyankar A, Sridhar E, Mahajan A, Puranik AD, Purandare N, Janu A, Ahuja A, Krishnatry R, Gupta T, Jalali R. Patil VM, et al. Cancer Med. 2020 Jul;9(13):4676-4685. doi: 10.1002/cam4.3094. Epub 2020 May 13. Cancer Med. 2020. PMID: 32400117 Free PMC article. Clinical Trial.
Hence, we undertook a phase 1 study to repurpose mebendazole in the treatment of glioblastoma. METHODS: We conducted a phase 1 study (accelerated titrated design 4) of mebendazole in patients with recurrent glioblastoma (GBM). Patients eligible for re-irradiation we …
Hence, we undertook a phase 1 study to repurpose mebendazole in the treatment of glioblastoma. METHODS: We conducted a phase 1 study …
Structure and function of USP5: Insight into physiological and pathophysiological roles.
Ning F, Xin H, Liu J, Lv C, Xu X, Wang M, Wang Y, Zhang W, Zhang X. Ning F, et al. Pharmacol Res. 2020 Jul;157:104557. doi: 10.1016/j.phrs.2019.104557. Epub 2019 Nov 19. Pharmacol Res. 2020. PMID: 31756387 Review.
In the present review, we focus on USP5 and provide a comprehensive overview of the current knowledge regarding its structure, physiological roles in multiple cellular events, and pathophysiological roles in relevant diseases, especially cancer. Signaling pathways and emer …
In the present review, we focus on USP5 and provide a comprehensive overview of the current knowledge regarding its structure, physiological …
Alvaxanthone, a Thymidylate Synthase Inhibitor with Nematocidal and Tumoricidal Activities.
Maj P, Mori M, Sobich J, Markowicz J, Uram Ł, Zieliński Z, Quaglio D, Calcaterra A, Cau Y, Botta B, Rode W. Maj P, et al. Molecules. 2020 Jun 23;25(12):2894. doi: 10.3390/molecules25122894. Molecules. 2020. PMID: 32586022 Free PMC article.
The results pointed to alvaxanthone as a relatively strong TS inhibitor that causes C. elegans population growth reduction with nematocidal potency similar to the anthelmintic drug mebendazole. Alvaxanthone also demonstrated an antiproliferative effect in tumor cells, asso …
The results pointed to alvaxanthone as a relatively strong TS inhibitor that causes C. elegans population growth reduction with nematocidal …
Mebendazole is a potent inhibitor to chemoresistant T cell acute lymphoblastic leukemia cells.
Wang X, Lou K, Song X, Ma H, Zhou X, Xu H, Wang W. Wang X, et al. Toxicol Appl Pharmacol. 2020 Jun 1;396:115001. doi: 10.1016/j.taap.2020.115001. Epub 2020 Apr 8. Toxicol Appl Pharmacol. 2020. PMID: 32277947
Mebendazole (MBZ) is a tubulin-suppressive antihelmintic agent with low toxicity, which has been repurposed to treat different types of tumors. ...
Mebendazole (MBZ) is a tubulin-suppressive antihelmintic agent with low toxicity, which has been repurposed to treat different types …
[Flubendazole Inhibits the Proliferation of A549 and H460 Cells and Promotes Autophagy].
Dong T, Lu Z, Li J, Liu Y, Wen J. Dong T, et al. Zhongguo Fei Ai Za Zhi. 2020 May 20;23(5):306-313. doi: 10.3779/j.issn.1009-3419.2020.104.17. Zhongguo Fei Ai Za Zhi. 2020. PMID: 32429634 Free PMC article. Chinese.
Previous evidence indicates its suppression on proliferation of colon cancer and breast cancer cells. Our study aims to explore the effects of flubendazole on non-small cell lung cancer A549 and H460 cell lines and the underlying mechanism. ...
Previous evidence indicates its suppression on proliferation of colon cancer and breast cancer cells. Our study aims to explor …
Rapid drug detection in whole blood droplets using a desorption electrospray ionization static profiling approach - a proof-of-concept.
Fresnais M, Haefeli WE, Burhenne J, Longuespée R. Fresnais M, et al. Rapid Commun Mass Spectrom. 2020 Mar 30;34(6):e8614. doi: 10.1002/rcm.8614. Rapid Commun Mass Spectrom. 2020. PMID: 31657865
RESULTS: The results suggested that DESI imaging mode was not appropriate for the detection of mebendazole in blood droplets as an initial solvation time was necessary before the obtention of signal. A profiling approach consisting of analyzing a single position of the blo …
RESULTS: The results suggested that DESI imaging mode was not appropriate for the detection of mebendazole in blood droplets as an in …
Rapid and Sensitive Drug Quantification in Tissue Sections Using Matrix Assisted Laser Desorption Ionization-Ion Mobility-Mass Spectrometry Profiling.
Fresnais M, Muck A, Majewsky M, Statz B, Krausert S, Benzel J, Castel D, Le Dret L, Pfister S, Haefeli WE, Burhenne J, Longuespée R. Fresnais M, et al. J Am Soc Mass Spectrom. 2020 Mar 4;31(3):742-751. doi: 10.1021/jasms.0c00005. Epub 2020 Jan 23. J Am Soc Mass Spectrom. 2020. PMID: 31971791
To illustrate our proof-of-concept, we used the anthelmintic drug mebendazole (MBZ) as a model. Using this exemplary drug, we demonstrated the possibility of using ion mobility to discriminate a drug in tissues from the biological background that masked its signal at low c …
To illustrate our proof-of-concept, we used the anthelmintic drug mebendazole (MBZ) as a model. Using this exemplary drug, we demonst …
Mebendazole inhibits tumor growth and prevents lung metastasis in models of advanced thyroid cancer.
Williamson T, Mendes TB, Joe N, Cerutti JM, Riggins GJ. Williamson T, et al. Endocr Relat Cancer. 2020 Mar;27(3):123-136. doi: 10.1530/ERC-19-0341. Endocr Relat Cancer. 2020. PMID: 31846433
In vitro, mebendazole potently inhibited the growth of a panel of human papillary and anaplastic thyroid cancer cells. ...Most importantly, daily oral mebendazole prevented established thyroid tumors from metastasizing to the lung. Given the low toxicity and …
In vitro, mebendazole potently inhibited the growth of a panel of human papillary and anaplastic thyroid cancer cells. ...Most …
Repurposing screen identifies mebendazole as a clinical candidate to synergise with docetaxel for prostate cancer treatment.
Rushworth LK, Hewit K, Munnings-Tomes S, Somani S, James D, Shanks E, Dufès C, Straube A, Patel R, Leung HY. Rushworth LK, et al. Br J Cancer. 2020 Feb;122(4):517-527. doi: 10.1038/s41416-019-0681-5. Epub 2019 Dec 17. Br J Cancer. 2020. PMID: 31844184 Free PMC article.
We sought to develop a novel therapeutic strategy to tackle chemoresistant prostate cancer by enhancing the efficacy of docetaxel. METHODS: We performed a drug-repurposing screen by using murine-derived prostate cancer cell lines driven by clinically relevant genoty …
We sought to develop a novel therapeutic strategy to tackle chemoresistant prostate cancer by enhancing the efficacy of docetaxel. ME …
Excretion of Ascaris lumbricoides following reduced-intensity allogeneic hematopoietic stem cell transplantation and consecutive treatment with mebendazole.
Luber V, Lutz M, Abele-Horn M, Einsele H, Grigoleit GU, Mielke S. Luber V, et al. Transpl Infect Dis. 2020 Feb;22(1):e13224. doi: 10.1111/tid.13224. Epub 2020 Feb 19. Transpl Infect Dis. 2020. PMID: 31782899
The patient was commenced on a three-day treatment with mebendazole, which was well tolerated. No serious interactions with the concomitant post-transplant medication or negative effects on the hematopoiesis were observed, and the myeloma still is in complete remission. .. …
The patient was commenced on a three-day treatment with mebendazole, which was well tolerated. No serious interactions with the conco …
Mebendazole augments sensitivity to sorafenib by targeting MAPK and BCL-2 signalling in n-nitrosodiethylamine-induced murine hepatocellular carcinoma.
Younis NS, Ghanim AMH, Saber S. Younis NS, et al. Sci Rep. 2019 Dec 13;9(1):19095. doi: 10.1038/s41598-019-55666-x. Sci Rep. 2019. PMID: 31836811 Free PMC article.
Drug resistance and transient survival benefits are the main obstacles associated with SO treatment in Hepatocellular carcinoma (HCC) patients. Mebendazole (MBZ), an anthelmintic agent, has demonstrated activity against various cancer types. ...
Drug resistance and transient survival benefits are the main obstacles associated with SO treatment in Hepatocellular carcinoma (HCC) patien …
Mebendazole in simultaneous combination with dexamethasone-(C(21)-phosphoramidate)-[anti-EGFR] generated utilizing a novel synthesis regimen: dual anti-neoplastic cytotoxicity against pulmonary adenocarcinoma (A549).
Coyne CP, Narayanan L. Coyne CP, et al. J Exp Ther Oncol. 2019 Dec;13(2):81-118. J Exp Ther Oncol. 2019. PMID: 31881126
A second strategy is the identification of synergistic or additive combinations of chemotherapeutics and pharmaceutical agents, in addition to the discovery of re-purposed pharmaceutical agents that possess anti-cancer properties. DISCUSSION: Mebendazole evoked anti …
A second strategy is the identification of synergistic or additive combinations of chemotherapeutics and pharmaceutical agents, in addition …
Mebendazole elicits potent antimyeloma activity by inhibiting the USP5/c-Maf axis.
Chen XH, Xu YJ, Wang XG, Lin P, Cao BY, Zeng YY, Wang Q, Zhang ZB, Mao XL, Zhang T. Chen XH, et al. Acta Pharmacol Sin. 2019 Dec;40(12):1568-1577. doi: 10.1038/s41401-019-0249-1. Epub 2019 Jun 13. Acta Pharmacol Sin. 2019. PMID: 31197245 Free PMC article.
Moreover, oral administration of mebendazole delayed the growth of human myeloma xenografts in nude mice but did not show overt toxicity. ...In summary, this study identified mebendazole as a USP5/c-Maf inhibitor that could be developed as a novel antimyeloma agent. …
Moreover, oral administration of mebendazole delayed the growth of human myeloma xenografts in nude mice but did not show overt toxic …
DNA methyltransferase 1-mediated CpG methylation of the miR-150-5p promoter contributes to fibroblast growth factor receptor 1-driven leukemogenesis.
Hu T, Chong Y, Cai B, Liu Y, Lu S, Cowell JK. Hu T, et al. J Biol Chem. 2019 Nov 29;294(48):18122-18130. doi: 10.1074/jbc.RA119.010144. Epub 2019 Oct 18. J Biol Chem. 2019. PMID: 31628193 Free PMC article.
One of the known targets of miR-150-5p is MYB, and treatment of leukemic cells with the MYB inhibitor mebendazole dose-dependently increased apoptosis and reduced cell viability. Moreover, mebendazole treatment of murine xenografts models of FGFR1-driven leukemias e …
One of the known targets of miR-150-5p is MYB, and treatment of leukemic cells with the MYB inhibitor mebendazole dose-dependently in …
Antitumor and anti-nematode activities of α-mangostin.
Markowicz J, Uram Ł, Sobich J, Mangiardi L, Maj P, Rode W. Markowicz J, et al. Eur J Pharmacol. 2019 Nov 15;863:172678. doi: 10.1016/j.ejphar.2019.172678. Epub 2019 Sep 19. Eur J Pharmacol. 2019. PMID: 31542481 Free article.
In the present study, alpha-mangostin' anti-cancer and anti-parasitic properties were tested in vitro against three human cell lines, including squamous carcinoma (SCC-15) and glioblastoma multiforme (U-118 MG), compared to normal skin fibroblasts (BJ), and in vivo against …
In the present study, alpha-mangostin' anti-cancer and anti-parasitic properties were tested in vitro against three human cell lines, …
Mebendazole for Differentiation Therapy of Acute Myeloid Leukemia Identified by a Lineage Maturation Index.
Li Y, Thomas D, Deutzmann A, Majeti R, Felsher DW, Dill DL. Li Y, et al. Sci Rep. 2019 Nov 14;9(1):16775. doi: 10.1038/s41598-019-53290-3. Sci Rep. 2019. PMID: 31727951 Free PMC article.
Furthermore, mebendazole treatment significantly extended the survival of leukemia-bearing mice in a xenograft model. These findings suggest that mebendazole may be utilized as a low toxicity therapeutic for human acute myeloid leukemia and confirm the LMI approach …
Furthermore, mebendazole treatment significantly extended the survival of leukemia-bearing mice in a xenograft model. These findings …
ADAMTS8 Promotes the Development of Pulmonary Arterial Hypertension and Right Ventricular Failure: A Possible Novel Therapeutic Target.
Omura J, Satoh K, Kikuchi N, Satoh T, Kurosawa R, Nogi M, Ohtsuki T, Al-Mamun ME, Siddique MAH, Yaoita N, Sunamura S, Miyata S, Hoshikawa Y, Okada Y, Shimokawa H. Omura J, et al. Circ Res. 2019 Oct 25;125(10):884-906. doi: 10.1161/CIRCRESAHA.119.315398. Epub 2019 Sep 26. Circ Res. 2019. PMID: 31556812 Free article.
Finally, high-throughput screening revealed that mebendazole, which is used for treatment of parasite infections, reduced ADAMTS8 expression and cell proliferation in PAH-PASMCs and ameliorated PH and RV failure in PH rodent models. ...
Finally, high-throughput screening revealed that mebendazole, which is used for treatment of parasite infections, reduced ADAMTS8 exp …
Mebendazole induces apoptosis via C-MYC inactivation in malignant ascites cell line (AGP01).
Pinto LC, Mesquita FP, Soares BM, da Silva EL, Puty B, de Oliveira EHC, Burbano RR, Montenegro RC. Pinto LC, et al. Toxicol In Vitro. 2019 Oct;60:305-312. doi: 10.1016/j.tiv.2019.06.010. Epub 2019 Jun 14. Toxicol In Vitro. 2019. PMID: 31207347
Therefore, our results show the evidence of C-MYC gene as one of the pathways by which MBZ induces cell death in gastric cancer cells....
Therefore, our results show the evidence of C-MYC gene as one of the pathways by which MBZ induces cell death in gastric cancer cells …
The anthelmintic flubendazole blocks human melanoma growth and metastasis and suppresses programmed cell death protein-1 and myeloid-derived suppressor cell accumulation.
Li Y, Acharya G, Elahy M, Xin H, Khachigian LM. Li Y, et al. Cancer Lett. 2019 Sep 10;459:268-276. doi: 10.1016/j.canlet.2019.05.026. Epub 2019 May 23. Cancer Lett. 2019. PMID: 31128215
The incidence of melanoma is increasing faster than any other cancer. In recent years, treatment of melanoma and a range of other deadly cancers has involved immunotherapy with programmed cell death protein-1 (PD-1)/PD-1 ligand (PD-L1) checkpoint blockade which has …
The incidence of melanoma is increasing faster than any other cancer. In recent years, treatment of melanoma and a range of other dea …
Mebendazole as a Candidate for Drug Repurposing in Oncology: An Extensive Review of Current Literature.
Guerini AE, Triggiani L, Maddalo M, Bonù ML, Frassine F, Baiguini A, Alghisi A, Tomasini D, Borghetti P, Pasinetti N, Bresciani R, Magrini SM, Buglione M. Guerini AE, et al. Cancers (Basel). 2019 Aug 31;11(9):1284. doi: 10.3390/cancers11091284. Cancers (Basel). 2019. PMID: 31480477 Free PMC article. Review.
The present review summarizes the current literature regarding the use of the anthelmintic mebendazole (MBZ) as a repurposed drug in oncology with a focus on cells resistant to approved therapies, including so called "cancer stem cells". Mebendazole meets man …
The present review summarizes the current literature regarding the use of the anthelmintic mebendazole (MBZ) as a repurposed drug in …
Magnetic resonance imaging findings and clinical manifestations in cerebral angiostrongyliasis from Dali, China.
Yang B, Yang L, Chen Y, Lu G. Yang B, et al. Brain Behav. 2019 Aug;9(8):e01361. doi: 10.1002/brb3.1361. Epub 2019 Jul 17. Brain Behav. 2019. PMID: 31313505 Free PMC article.
CONCLUSION: The possibility of A. cantonensis infection should be considered in the effective use of albendazole or mebendazole as a treatment. Combining clinical history with laboratory examination is helpful in diagnosing A. cantonensis infection. ...
CONCLUSION: The possibility of A. cantonensis infection should be considered in the effective use of albendazole or mebendazole as a …
Flubendazole demonstrates valid antitumor effects by inhibiting STAT3 and activating autophagy.
Lin S, Yang L, Yao Y, Xu L, Xiang Y, Zhao H, Wang L, Zuo Z, Huang X, Zhao C. Lin S, et al. J Exp Clin Cancer Res. 2019 Jul 8;38(1):293. doi: 10.1186/s13046-019-1303-z. J Exp Clin Cancer Res. 2019. PMID: 31287013 Free PMC article.
BACKGROUND: Signal transducer and activator of transcription 3 (STAT3) is an oncogene, which upregulates in approximately 70% of human cancers. Autophagy is an evolutionarily conserved process which maintains cellular homeostasis and eliminates damaged cellular components. …
BACKGROUND: Signal transducer and activator of transcription 3 (STAT3) is an oncogene, which upregulates in approximately 70% of human ca …
A New Method for Ethical and Efficient Evidence Generation for Off-Label Medication Use in Oncology (A Case Study in Glioblastoma).
Agrawal S, Vamadevan P, Mazibuko N, Bannister R, Swery R, Wilson S, Edwards S. Agrawal S, et al. Front Pharmacol. 2019 Jun 27;10:681. doi: 10.3389/fphar.2019.00681. eCollection 2019. Front Pharmacol. 2019. PMID: 31316378 Free PMC article.
In oncology, preclinical and early clinical data increasingly support the use of a number of candidate "non-cancer" drugs in an off-label setting against multiple tumor types. In particular, metabolically targeted drugs show promise as adjuvant chemo and radiosensitizers, …
In oncology, preclinical and early clinical data increasingly support the use of a number of candidate "non-cancer" drugs in an off-l …
The importance of being parasiticidal… an update on drug development for the treatment of alveolar echinococcosis.
Lundström-Stadelmann B, Rufener R, Ritler D, Zurbriggen R, Hemphill A. Lundström-Stadelmann B, et al. Food Waterborne Parasitol. 2019 Mar 14;15:e00040. doi: 10.1016/j.fawpar.2019.e00040. eCollection 2019 Jun. Food Waterborne Parasitol. 2019. PMID: 32095613 Free PMC article.
Current chemotherapeutical treatment of AE relies on albendazole and mebendazole, with the caveat that these compounds are not parasiticidal. Drugs have to be taken for a prolonged period of time, often life-long, which can cause adverse effects and reduces the patients' q …
Current chemotherapeutical treatment of AE relies on albendazole and mebendazole, with the caveat that these compounds are not parasi …
Mebendazole-induced M1 polarisation of THP-1 macrophages may involve DYRK1B inhibition.
Blom K, Rubin J, Berglund M, Jarvius M, Lenhammar L, Parrow V, Andersson C, Loskog A, Fryknäs M, Nygren P, Larsson R. Blom K, et al. BMC Res Notes. 2019 Apr 22;12(1):234. doi: 10.1186/s13104-019-4273-5. BMC Res Notes. 2019. PMID: 31010428 Free PMC article.
OBJECTIVE: We recently showed that the anti-helminthic compound mebendazole (MBZ) has immunomodulating activity by inducing a M2 to M1 phenotype switch in monocyte/macrophage models. ...
OBJECTIVE: We recently showed that the anti-helminthic compound mebendazole (MBZ) has immunomodulating activity by inducing a M2 to M …
Bioelectronics of The Cellular Cytoskeleton: Monitoring Cytoskeletal Conductance Variation for Sensing Drug Resistance.
Gharooni M, Alikhani A, Moghtaderi H, Abiri H, Mashaghi A, Abbasvandi F, Khayamian MA, Miripour ZS, Zandi A, Abdolahad M. Gharooni M, et al. ACS Sens. 2019 Feb 22;4(2):353-362. doi: 10.1021/acssensors.8b01142. Epub 2019 Jan 4. ACS Sens. 2019. PMID: 30572702
Actin and microtubules form cellular cytoskeletal network, which mediates cell shape, motility and proliferation and are key targets for cancer therapy. Changes in cytoskeletal organization dramatically affect mechanical properties of the cells and correlate with prolifera …
Actin and microtubules form cellular cytoskeletal network, which mediates cell shape, motility and proliferation and are key targets for …
Autophagy Is a Potential Target for Enhancing the Anti-Angiogenic Effect of Mebendazole in Endothelial Cells.
Sung SJ, Kim HK, Hong YK, Joe YA. Sung SJ, et al. Biomol Ther (Seoul). 2019 Jan 1;27(1):117-125. doi: 10.4062/biomolther.2018.222. Biomol Ther (Seoul). 2019. PMID: 30642153 Free PMC article.
Mebendazole (MBZ), a microtubule depolymerizing drug commonly used for the treatment of helminthic infections, has recently been noted as a repositioning candidate for angiogenesis inhibition and cancer therapy. ...Consequently, we suggest that MBZ induces autophagy …
Mebendazole (MBZ), a microtubule depolymerizing drug commonly used for the treatment of helminthic infections, has recently been note …
Mebendazole Potentiates Radiation Therapy in Triple-Negative Breast Cancer.
Zhang L, Bochkur Dratver M, Yazal T, Dong K, Nguyen A, Yu G, Dao A, Bochkur Dratver M, Duhachek-Muggy S, Bhat K, Alli C, Pajonk F, Vlashi E. Zhang L, et al. Int J Radiat Oncol Biol Phys. 2019 Jan 1;103(1):195-207. doi: 10.1016/j.ijrobp.2018.08.046. Epub 2018 Sep 7. Int J Radiat Oncol Biol Phys. 2019. PMID: 30196056 Free PMC article.
PURPOSE: The lack of a molecular target in triple-negative breast cancer (TNBC) makes it one of the most challenging breast cancers to treat. Radiation therapy (RT) is an important treatment modality for managing breast cancer; however, we previously showed t …
PURPOSE: The lack of a molecular target in triple-negative breast cancer (TNBC) makes it one of the most challenging breast cancer …
Mebendazole and radiation in combination increase survival through anticancer mechanisms in an intracranial rodent model of malignant meningioma.
Skibinski CG, Williamson T, Riggins GJ. Skibinski CG, et al. J Neurooncol. 2018 Dec;140(3):529-538. doi: 10.1007/s11060-018-03009-7. Epub 2018 Nov 9. J Neurooncol. 2018. PMID: 30414098 Free PMC article.
Recently, the brain penetrant anthelmintic drug, mebendazole, has shown promise as an anticancer agent in rodent models of glioblastoma and medulloblastoma. ...RESULTS: In vitro experiments on meningioma cell lines showed the IC(50) for mebendazole in the range of 0 …
Recently, the brain penetrant anthelmintic drug, mebendazole, has shown promise as an anticancer agent in rodent models of glioblasto …
Drug repurposing: mebendazole as effective antitumor agent. Are we seeing the whole story?
Banovic P, Stankov S, Vranjes N, Zurkovic O, Capo I, Lalosevic D. Banovic P, et al. J BUON. 2018 Nov-Dec;23(6):1904-1911. J BUON. 2018. PMID: 30610820 Free article.
PURPOSE: To examine the antitumor effects of Mebendazole (MZ) in a model of experimental fibrosarcoma induced by inoculation of BHK-21/C13 cells in Syrian golden hamster. ...
PURPOSE: To examine the antitumor effects of Mebendazole (MZ) in a model of experimental fibrosarcoma induced by inoculation of BHK-2 …
Flubendazole elicits anti-metastatic effects in triple-negative breast cancer via STAT3 inhibition.
Oh E, Kim YJ, An H, Sung D, Cho TM, Farrand L, Jang S, Seo JH, Kim JY. Oh E, et al. Int J Cancer. 2018 Oct 15;143(8):1978-1993. doi: 10.1002/ijc.31585. Epub 2018 Jul 10. Int J Cancer. 2018. PMID: 29744876
Tumor metastasis remains the cause of 90% of cancer-related deaths. Cancer stem cells (CSC) are thought to be responsible for the aggressive and metastatic nature of triple-negative breast cancers (TNBC), and new therapeutic strategies are being devised to ta …
Tumor metastasis remains the cause of 90% of cancer-related deaths. Cancer stem cells (CSC) are thought to be responsible for …
Flubendazole and mebendazole impair migration and epithelial to mesenchymal transition in oral cell lines.
Kralova V, Hanušová V, Caltová K, Špaček P, Hochmalová M, Skálová L, Rudolf E. Kralova V, et al. Chem Biol Interact. 2018 Sep 25;293:124-132. doi: 10.1016/j.cbi.2018.07.026. Epub 2018 Jul 31. Chem Biol Interact. 2018. PMID: 30075109
Benzimidazole anthelmintics flubendazole and mebendazole are microtubule-targeting drugs that showed considerable anti-cancer activity in different preclinical models. In this study, the effects of flubendazole and mebendazole on proliferation, migration and …
Benzimidazole anthelmintics flubendazole and mebendazole are microtubule-targeting drugs that showed considerable anti-cancer …
Mebendazole exhibits potent anti-leukemia activity on acute myeloid leukemia.
He L, Shi L, Du Z, Huang H, Gong R, Ma L, Chen L, Gao S, Lyu J, Gu H. He L, et al. Exp Cell Res. 2018 Aug 1;369(1):61-68. doi: 10.1016/j.yexcr.2018.05.006. Epub 2018 May 8. Exp Cell Res. 2018. PMID: 29750898
Here through screening more than 1000 drugs approved by the Food and Drug Administration (FDA) of United States, the anthelmintic drug mebendazole (MBZ) was found to inhibit the growth of AML cell lines (THP-1, U937, NB4 and K562) and bone marrow mononuclear cells (BM-MNCs …
Here through screening more than 1000 drugs approved by the Food and Drug Administration (FDA) of United States, the anthelmintic drug me …
Mebendazole stimulates CD14+ myeloid cells to enhance T-cell activation and tumour cell killing.
Rubin J, Mansoori S, Blom K, Berglund M, Lenhammar L, Andersson C, Loskog A, Fryknäs M, Nygren P, Larsson R. Rubin J, et al. Oncotarget. 2018 Jul 20;9(56):30805-30813. doi: 10.18632/oncotarget.25713. eCollection 2018 Jul 20. Oncotarget. 2018. PMID: 30112108 Free PMC article.
Mebendazole (MBZ) was recently shown to induce a tumor suppressive M1 phenotype in THP-1 monocytes and macrophages. ...Moreover, when PBMC cultures were functionally tested for immune cell killing of lung cancer A549NucLightRed cells, MBZ significantly increased tum …
Mebendazole (MBZ) was recently shown to induce a tumor suppressive M1 phenotype in THP-1 monocytes and macrophages. ...Moreover, when …
N-Substituted Prodrugs of Mebendazole Provide Improved Aqueous Solubility and Oral Bioavailability in Mice and Dogs.
Zimmermann SC, Tichý T, Vávra J, Dash RP, Slusher CE, Gadiano AJ, Wu Y, Jančařík A, Tenora L, Monincová L, Prchalová E, Riggins GJ, Majer P, Slusher BS, Rais R. Zimmermann SC, et al. J Med Chem. 2018 May 10;61(9):3918-3929. doi: 10.1021/acs.jmedchem.7b01792. Epub 2018 Apr 19. J Med Chem. 2018. PMID: 29648826
Mebendazole (MBZ) was developed as a broad-spectrum anthelmintic but has recently shown efficacy as an anticancer agent. The use of MBZ for cancer, however, is challenging due to its poor solubility leading to poor bioavailability. ...
Mebendazole (MBZ) was developed as a broad-spectrum anthelmintic but has recently shown efficacy as an anticancer agent. The use of M …
Evaluation of kinase-inhibitors nilotinib and everolimus against alveolar echinococcosis in vitro and in a mouse model.
Joekel DE, Lundström-Stadelmann B, Müllhaupt B, Hemphill A, Deplazes P. Joekel DE, et al. Exp Parasitol. 2018 May;188:65-72. doi: 10.1016/j.exppara.2018.04.002. Epub 2018 Apr 3. Exp Parasitol. 2018. PMID: 29625098
In cases where complete parasite resection by surgery is not feasible, the current treatment regimens of AE consist of chemotherapy with the parasitostatic benzimidazoles albendazole or mebendazole over decades. Kinase-inhibitors currently administered in various cancer …
In cases where complete parasite resection by surgery is not feasible, the current treatment regimens of AE consist of chemotherapy with the …
Targeting acute myeloid leukemia by drug-induced c-MYB degradation.
Walf-Vorderwülbecke V, Pearce K, Brooks T, Hubank M, van den Heuvel-Eibrink MM, Zwaan CM, Adams S, Edwards D, Bartram J, Samarasinghe S, Ancliff P, Khwaja A, Goulden N, Williams G, de Boer J, Williams O. Walf-Vorderwülbecke V, et al. Leukemia. 2018 Apr;32(4):882-889. doi: 10.1038/leu.2017.317. Epub 2017 Nov 1. Leukemia. 2018. PMID: 29089643
Furthermore, mebendazole is effective at impairing AML progression in vivo in mouse xenotransplantation experiments. In the context of widespread human use of mebendazole, our data indicate that mebendazole-induced c-MYB degradation represents a safe and nove …
Furthermore, mebendazole is effective at impairing AML progression in vivo in mouse xenotransplantation experiments. In the context o …
Vinblastine and antihelmintic mebendazole potentiate temozolomide in resistant gliomas.
Kipper FC, Silva AO, Marc AL, Confortin G, Junqueira AV, Neto EP, Lenz G. Kipper FC, et al. Invest New Drugs. 2018 Apr;36(2):323-331. doi: 10.1007/s10637-017-0503-7. Epub 2017 Aug 29. Invest New Drugs. 2018. PMID: 28852916
To search for molecular predictors of TMZ resistance, the TCGA (The Cancer Genome Atlas) database was utilized to assess the impact of specific genes on TMZ response. ...Combination treatment of vinblastine (VBL) plus mebendazole (MBZ) with TMZ was more effective in …
To search for molecular predictors of TMZ resistance, the TCGA (The Cancer Genome Atlas) database was utilized to assess the impact o …
Discovery of genomic intervals that underlie nematode responses to benzimidazoles.
Zamanian M, Cook DE, Zdraljevic S, Brady SC, Lee D, Lee J, Andersen EC. Zamanian M, et al. PLoS Negl Trop Dis. 2018 Mar 30;12(3):e0006368. doi: 10.1371/journal.pntd.0006368. eCollection 2018 Mar. PLoS Negl Trop Dis. 2018. PMID: 29601575 Free PMC article.
High-throughput phenotyping of albendazole, fenbendazole, mebendazole, and thiabendazole responses in panels of recombinant lines led to the discovery of over 15 QTL in C. elegans and four QTL in C. briggsae associated with divergent responses to these anthelmintics. ...
High-throughput phenotyping of albendazole, fenbendazole, mebendazole, and thiabendazole responses in panels of recombinant lines led …
Systematic identification of suspected anthelmintic benzimidazole metabolites using LC-MS/MS.
Majewsky M, Castel D, Le Dret L, Johann P, Jones DT, Pfister SM, Haefeli WE, Burhenne J. Majewsky M, et al. J Pharm Biomed Anal. 2018 Mar 20;151:151-158. doi: 10.1016/j.jpba.2017.12.056. Epub 2017 Dec 28. J Pharm Biomed Anal. 2018. PMID: 29328982
The approach was integrated into a rapid MS(e) QTOF workflow and tested in mouse plasma for mebendazole and its metabolites. The presented scheme allows the prediction of characteristic product ions for suspected unknown metabolites. ...
The approach was integrated into a rapid MS(e) QTOF workflow and tested in mouse plasma for mebendazole and its metabolites. The pres …
Flubendazole induces mitotic catastrophe and apoptosis in melanoma cells.
Čáňová K, Rozkydalová L, Vokurková D, Rudolf E. Čáňová K, et al. Toxicol In Vitro. 2018 Feb;46:313-322. doi: 10.1016/j.tiv.2017.10.025. Epub 2017 Oct 26. Toxicol In Vitro. 2018. PMID: 29107018
Recently, several studies have been published demonstrating its potential to inhibit growth of various tumor cells including those derived from colorectal cancer, breast cancer or leukemia via several mechanisms. In the present study we have investigated cytotoxic e …
Recently, several studies have been published demonstrating its potential to inhibit growth of various tumor cells including those derived f …
The Effect of Flubendazole on Adhesion and Migration in SW480 and SW620 Colon Cancer Cells.
Hanušová V, Skálová L, Králová V, Matoušková P. Hanušová V, et al. Anticancer Agents Med Chem. 2018;18(6):837-846. doi: 10.2174/1871520618666171213141911. Anticancer Agents Med Chem. 2018. PMID: 29237383
BACKGROUND: Colon cancer is the most common type of gastrointestinal cancer. Despite advances during the last two decades, the efficacy of colorectal cancer treatment is still insufficient and new anticancer agents are necessary. METHODS: In our study, colon …
BACKGROUND: Colon cancer is the most common type of gastrointestinal cancer. Despite advances during the last two decades, the …
Flubendazole overcomes trastuzumab resistance by targeting cancer stem-like properties and HER2 signaling in HER2-positive breast cancer.
Kim YJ, Sung D, Oh E, Cho Y, Cho TM, Farrand L, Seo JH, Kim JY. Kim YJ, et al. Cancer Lett. 2018 Jan 1;412:118-130. doi: 10.1016/j.canlet.2017.10.020. Epub 2017 Nov 5. Cancer Lett. 2018. PMID: 29080749
Although trastuzumab provides significant clinical benefit for HER2-positive breast cancers, responses are limited by the emergence of resistance. Trastuzumab resistance is a multi-factorial phenomenon thought to arise from the presence of cancer stem cells and inte …
Although trastuzumab provides significant clinical benefit for HER2-positive breast cancers, responses are limited by the emergence o …
In vitro anti-tubulin effects of mebendazole and fenbendazole on canine glioma cells.
Lai SR, Castello SA, Robinson AC, Koehler JW. Lai SR, et al. Vet Comp Oncol. 2017 Dec;15(4):1445-1454. doi: 10.1111/vco.12288. Epub 2017 Jan 12. Vet Comp Oncol. 2017. PMID: 28078780
The purpose of this study was to evaluate the in vitro chemosensitivity of three canine glioma cell lines to mebendazole and fenbendazole. The mean inhibitory concentration (IC(50) ) (SD) obtained from performing the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliu …
The purpose of this study was to evaluate the in vitro chemosensitivity of three canine glioma cell lines to mebendazole and fenbenda …
Microtubule-targeting agents can sensitize cancer cells to ionizing radiation by an interphase-based mechanism.
Markowitz D, Ha G, Ruggieri R, Symons M. Markowitz D, et al. Onco Targets Ther. 2017 Nov 24;10:5633-5642. doi: 10.2147/OTT.S143096. eCollection 2017. Onco Targets Ther. 2017. PMID: 29200877 Free PMC article.
To address this, we combined IR with an established MTA, mebendazole (MBZ), to treat glioma cells exclusively during interphase. MATERIALS AND METHODS: To test whether MTAs can sensitize interphase cells to IR, we treated GL261 and GBM14 glioma cells with MBZ during 3-9 ho …
To address this, we combined IR with an established MTA, mebendazole (MBZ), to treat glioma cells exclusively during interphase. MATE …
Species differences in hepatic biotransformation of the anthelmintic drug flubendazole.
Maté ML, Geary T, Mackenzie C, Lanusse C, Virkel G. Maté ML, et al. J Vet Pharmacol Ther. 2017 Oct;40(5):493-499. doi: 10.1111/jvp.12383. Epub 2017 Jan 16. J Vet Pharmacol Ther. 2017. PMID: 28092103
It has been proposed as a candidate for development for use in elimination programmes for lymphatic filariasis and onchocerciasis in humans. Moreover, FLBZ has shown promise in cancer chemotherapy, particularly for neuroblastoma. This work investigated the hepatic carbonyl …
It has been proposed as a candidate for development for use in elimination programmes for lymphatic filariasis and onchocerciasis in humans. …
Bioelectrical impedimetric sensor for single cell analysis based on nanoroughened quartz substrate; suitable for cancer therapeutic purposes.
Gharooni M, Abdolahad M. Gharooni M, et al. J Pharm Biomed Anal. 2017 Aug 5;142:315-323. doi: 10.1016/j.jpba.2017.05.024. Epub 2017 May 15. J Pharm Biomed Anal. 2017. PMID: 28531834
Cells were dropped on the sensor without the assistance of any micropipette or microfluidic systems and just individual regions for attachment of one cell has been opened on the sensing region arrays. MCF-7 cancer cells were time tracked under the effect of Paclitaxel and …
Cells were dropped on the sensor without the assistance of any micropipette or microfluidic systems and just individual regions for attachme …
The anticancer effect of mebendazole may be due to M1 monocyte/macrophage activation via ERK1/2 and TLR8-dependent inflammasome activation.
Blom K, Senkowski W, Jarvius M, Berglund M, Rubin J, Lenhammar L, Parrow V, Andersson C, Loskog A, Fryknäs M, Nygren P, Larsson R. Blom K, et al. Immunopharmacol Immunotoxicol. 2017 Aug;39(4):199-210. doi: 10.1080/08923973.2017.1320671. Epub 2017 May 4. Immunopharmacol Immunotoxicol. 2017. PMID: 28472897
Mebendazole (MBZ), a drug commonly used for helminitic infections, has recently gained substantial attention as a repositioning candidate for cancer treatment. ...Finally, MBZ induced tumor-suppressive effects in a coculture model with differentiated THP-1 macrophag …
Mebendazole (MBZ), a drug commonly used for helminitic infections, has recently gained substantial attention as a repositioning candi …
Emergence of TNIK inhibitors in cancer therapeutics.
Yamada T, Masuda M. Yamada T, et al. Cancer Sci. 2017 May;108(5):818-823. doi: 10.1111/cas.13203. Epub 2017 Apr 24. Cancer Sci. 2017. PMID: 28208209 Free PMC article. Review.
The great majority of colorectal cancers (>90%) have mutations in at least one Wnt signaling pathway gene. Aberrant activation of Wnt signaling is a major force driving colorectal carcinogenesis. ...Several small-molecule compounds targeting this protein kinase have bee …
The great majority of colorectal cancers (>90%) have mutations in at least one Wnt signaling pathway gene. Aberrant activation of …
Repurposing Mebendazole as a Replacement for Vincristine for the Treatment of Brain Tumors.
De Witt M, Gamble A, Hanson D, Markowitz D, Powell C, Al Dimassi S, Atlas M, Boockvar J, Ruggieri R, Symons M. De Witt M, et al. Mol Med. 2017 Apr;23:50-56. doi: 10.2119/molmed.2017.00011. Epub 2017 Apr 5. Mol Med. 2017. PMID: 28386621 Free PMC article.
In addition, using mebendazole as a seed for the National Cancer Institute (NCI) COMPARE program revealed that the top-scoring drugs were highly enriched in microtubule-targeting drugs. Taken together, these results indicate that the cell toxicity of mebendazole …
In addition, using mebendazole as a seed for the National Cancer Institute (NCI) COMPARE program revealed that the top-scoring …
The repurposed anthelmintic mebendazole in combination with trametinib suppresses refractory NRASQ61K melanoma.
Simbulan-Rosenthal CM, Dakshanamurthy S, Gaur A, Chen YS, Fang HB, Abdussamad M, Zhou H, Zapas J, Calvert V, Petricoin EF, Atkins MB, Byers SW, Rosenthal DS. Simbulan-Rosenthal CM, et al. Oncotarget. 2017 Feb 21;8(8):12576-12595. doi: 10.18632/oncotarget.14990. Oncotarget. 2017. PMID: 28157711 Free PMC article.
Proteochemometric computational methods coupled with kinase assays showed that mebendazole (MBZ) binds and inhibits kinases important in cancer, especially both BRAFWT and BRAFV600E. ...
Proteochemometric computational methods coupled with kinase assays showed that mebendazole (MBZ) binds and inhibits kinases important …
The purpose of repurposing.
Barrett JE, Kim FJ. Barrett JE, et al. Oncotarget. 2017 Feb 21;8(8):12534-12535. doi: 10.18632/oncotarget.14806. Oncotarget. 2017. PMID: 28129642 Free PMC article. No abstract available.
Anthelmintic mebendazole enhances cisplatin's effect on suppressing cell proliferation and promotes differentiation of head and neck squamous cell carcinoma (HNSCC).
Zhang F, Li Y, Zhang H, Huang E, Gao L, Luo W, Wei Q, Fan J, Song D, Liao J, Zou Y, Liu F, Liu J, Huang J, Guo D, Ma C, Hu X, Li L, Qu X, Chen L, Yu X, Zhang Z, Wu T, Luu HH, Haydon RC, Song J, He TC, Ji P. Zhang F, et al. Oncotarget. 2017 Feb 21;8(8):12968-12982. doi: 10.18632/oncotarget.14673. Oncotarget. 2017. PMID: 28099902 Free PMC article.
Head and neck squamous cell carcinoma (HNSCC) is one of the most common and aggressive types of human cancers worldwide. Nearly a half of HNSCC patients experience recurrence within five years of treatment and develop resistance to chemotherapy. ...Here, we investigate the …
Head and neck squamous cell carcinoma (HNSCC) is one of the most common and aggressive types of human cancers worldwide. Nearly a hal …
Anthelmintic Flubendazole and Its Potential Use in Anticancer Therapy.
Čáňová K, Rozkydalová L, Rudolf E. Čáňová K, et al. Acta Medica (Hradec Kralove). 2017;60(1):5-11. doi: 10.14712/18059694.2017.44. Epub 2017 Apr 11. Acta Medica (Hradec Kralove). 2017. PMID: 28399389 Free article. Review.
The microtubule-disrupting properties of benzimidazole derivatives raised recently interest in these compounds as possible anti-cancer agents. In this minireview flubendazole effects towards selected human malignant cells including myeloma, leukemia, neuroblastoma, breast …
The microtubule-disrupting properties of benzimidazole derivatives raised recently interest in these compounds as possible anti-cancer …
New World's old disease: cardiac hydatid disease and surgical principles.
Tanyeli O, Dereli Y, Mercan I, Gormus N, Yuksek T. Tanyeli O, et al. Cardiovasc J Afr. 2017 Sep/Oct 23;28(5):304-308. doi: 10.5830/CVJA-2017-006. Epub 2017 Feb 20. Cardiovasc J Afr. 2017. PMID: 28218769 Free PMC article.
All patients were discharged with medical therapy (mebendazole or albendazole) for the duration of six months. No recurrences were observed in their follow ups. ...
All patients were discharged with medical therapy (mebendazole or albendazole) for the duration of six months. No recurrences were ob …
Mating Ancylostoma duodenale under magnifying endoscopy.
Cai MY, Huang Y, Xu JX, Zhou PH. Cai MY, et al. Gastrointest Endosc. 2016 Dec;84(6):1067. doi: 10.1016/j.gie.2016.07.025. Epub 2016 Jul 19. Gastrointest Endosc. 2016. PMID: 27449192 No abstract available.
Silicon nanowire based biosensing platform for electrochemical sensing of Mebendazole drug activity on breast cancer cells.
Shashaani H, Faramarzpour M, Hassanpour M, Namdar N, Alikhani A, Abdolahad M. Shashaani H, et al. Biosens Bioelectron. 2016 Nov 15;85:363-370. doi: 10.1016/j.bios.2016.04.081. Epub 2016 May 9. Biosens Bioelectron. 2016. PMID: 27196254
Here we applied Silicon Nanowire (SiNW) array electrodes (in an integrated architecture of working, counter and reference electrodes) grown by low pressure chemical vapor deposition (LPCVD) system with VLS procedure to electrochemically diagnose the presence of breast cancer …
Here we applied Silicon Nanowire (SiNW) array electrodes (in an integrated architecture of working, counter and reference electrodes) grown …
Mebendazole and a non-steroidal anti-inflammatory combine to reduce tumor initiation in a colon cancer preclinical model.
Williamson T, Bai RY, Staedtke V, Huso D, Riggins GJ. Williamson T, et al. Oncotarget. 2016 Oct 18;7(42):68571-68584. doi: 10.18632/oncotarget.11851. Oncotarget. 2016. PMID: 27612418 Free PMC article.
Inheritance of a gene mutation leads to the initiation of 5 to 10% of most cancers, including colon cancer cases. We developed a chemoprevention strategy using a novel combination of the non-steroidal anti-inflammatory (NSAID) sulindac plus the anthelminthic benzimi …
Inheritance of a gene mutation leads to the initiation of 5 to 10% of most cancers, including colon cancer cases. We developed …
Electrochemical approach for monitoring the effect of anti tubulin drugs on breast cancer cells based on silicon nanograss electrodes.
Zanganeh S, Khosravi S, Namdar N, Amiri MH, Gharooni M, Abdolahad M. Zanganeh S, et al. Anal Chim Acta. 2016 Sep 28;938:72-81. doi: 10.1016/j.aca.2016.07.042. Epub 2016 Aug 2. Anal Chim Acta. 2016. PMID: 27619088
One of the most interested molecular research in the field of cancer detection is the mechanism of drug effect on cancer cells. Translating molecular evidence into electrochemical profiles would open new opportunities in cancer research. ...Reduction of the m …
One of the most interested molecular research in the field of cancer detection is the mechanism of drug effect on cancer cells …
Comprehensive Modeling and Discovery of Mebendazole as a Novel TRAF2- and NCK-interacting Kinase Inhibitor.
Tan Z, Chen L, Zhang S. Tan Z, et al. Sci Rep. 2016 Sep 21;6:33534. doi: 10.1038/srep33534. Sci Rep. 2016. PMID: 27650168 Free PMC article.
Upon experimental evaluations, we discovered that mebendazole, an approved anthelmintic drug, could selectively inhibit TNIK kinase activity with a dissociation constant Kd = ~1 muM. The subsequent CoMSIA and kNN analyses indicated that mebendazole bears the favorab …
Upon experimental evaluations, we discovered that mebendazole, an approved anthelmintic drug, could selectively inhibit TNIK kinase a …
[Transverse myelitis associated with toxocariasis and the importance of locally produced antibodies for diagnosis].
Ural S, Özer B, Gelal F, Dirim Erdoğan D, Sezak N, Balık R, Demirdal T, Korkmaz M. Ural S, et al. Mikrobiyol Bul. 2016 Jul;50(3):478-83. doi: 10.5578/mb.25234. Mikrobiyol Bul. 2016. PMID: 27525404 Free article. Turkish.
Therefore the patient was diagnosed as neurotoxocariasis, and treated with steroid and mebendazole for six weeks. Clinical improvement was detected in the case and thoracic MRI revealed significant improvement in myelitis signs two months after treatment. ...
Therefore the patient was diagnosed as neurotoxocariasis, and treated with steroid and mebendazole for six weeks. Clinical improvemen …
Flubendazole induces mitotic catastrophe and senescence in colon cancer cells in vitro.
Králová V, Hanušová V, Rudolf E, Čáňová K, Skálová L. Králová V, et al. J Pharm Pharmacol. 2016 Feb;68(2):208-18. doi: 10.1111/jphp.12503. Epub 2016 Jan 4. J Pharm Pharmacol. 2016. PMID: 26730435
OBJECTIVES: Flubendazole (FLU), a member of benzimidazole family of anthelmintic drugs, is able to inhibit proliferation of various cancer cells. The aim of present study was to elucidate the mechanisms of antiproliferative effect of FLU on colorectal cancer cells i …
OBJECTIVES: Flubendazole (FLU), a member of benzimidazole family of anthelmintic drugs, is able to inhibit proliferation of various cance …
Revisiting Non-Cancer Drugs for Cancer Therapy.
Yang EJ, Wu C, Liu Y, Lv J, Sup Shim J. Yang EJ, et al. Curr Top Med Chem. 2016;16(19):2144-55. doi: 10.2174/1568026616666160216154441. Curr Top Med Chem. 2016. PMID: 26881712 Review.
Although tremendous effort has been made over the past century to treat cancer effectively, the pace of drug development is far behind the increasing rate of cancer incidence and mortality. ...Here we review the recent examples of drug repositioning of existing non- …
Although tremendous effort has been made over the past century to treat cancer effectively, the pace of drug development is far behin …
The anthelmintic drug mebendazole inhibits growth, migration and invasion in gastric cancer cell model.
Pinto LC, Soares BM, Pinheiro Jde J, Riggins GJ, Assumpção PP, Burbano RM, Montenegro RC. Pinto LC, et al. Toxicol In Vitro. 2015 Dec;29(8):2038-44. doi: 10.1016/j.tiv.2015.08.007. Epub 2015 Aug 24. Toxicol In Vitro. 2015. PMID: 26315676 Free article.
The present study aimed to investigate the effects of MBZ on a human malignant ascites cell line derived from a primary gastric cancer tumor. Our data reveal that MBZ showed high cytotoxicity in vitro, displaying an IC50 of 0.39 muM and 1.25 muM in ACP-02 and ACP-03, respe …
The present study aimed to investigate the effects of MBZ on a human malignant ascites cell line derived from a primary gastric cancer …
Enterobius vermicularis infection of the liver in a patient with colorectal carcinoma with suspected liver metastasis.
Furnée EJ, Spoto C, de Graaf MJ, Smakman N. Furnée EJ, et al. BMJ Case Rep. 2015 Nov 5;2015:bcr2015212271. doi: 10.1136/bcr-2015-212271. BMJ Case Rep. 2015. PMID: 26546623 Free PMC article.
The patient was subsequently treated with the anthelmintic drug mebendazole 100 mg once a week for 2 weeks. Histopathological assessment of the rectal specimen showed complete regression after neoadjuvant chemoradiotherapy without evidence of remaining E. vermicularis, sug …
The patient was subsequently treated with the anthelmintic drug mebendazole 100 mg once a week for 2 weeks. Histopathological assessm …
Systems biology-based discovery of a potential Atg4B agonist (Flubendazole) that induces autophagy in breast cancer.
Zhang L, Guo M, Li J, Zheng Y, Zhang S, Xie T, Liu B. Zhang L, et al. Mol Biosyst. 2015 Nov;11(11):2860-6. doi: 10.1039/c5mb00466g. Mol Biosyst. 2015. PMID: 26299935
The aim of this study was to explore the autophagy-related protein 4B(ATG4B) and its targeted candidate agonist in triple-negative breast cancer (TNBC) therapy. In this study, the identification of Atg4B as a novel breast cancer target for screening candidate small …
The aim of this study was to explore the autophagy-related protein 4B(ATG4B) and its targeted candidate agonist in triple-negative breast …
A Bystander Effect of Lung Cancer Chemotherapy on Chronic Echinococcal Disease.
Bangaru SD, Kozarsky PE, Lee DJ, Sica GL, Owonikoko TK. Bangaru SD, et al. World J Oncol. 2015 Aug;6(4):416-420. doi: 10.14740/wjon920w. Epub 2015 Aug 27. World J Oncol. 2015. PMID: 28983340 Free PMC article.
Disseminated disease is usually palliated using systemic anti-parasitic agents such as benzimidazoles, albendazole and mebendazole but worsening of disease post-systemic treatment is frequent in 14-25% of patients. In this report, we share our experience of a patient with …
Disseminated disease is usually palliated using systemic anti-parasitic agents such as benzimidazoles, albendazole and mebendazole bu …
Brain Penetration and Efficacy of Different Mebendazole Polymorphs in a Mouse Brain Tumor Model.
Bai RY, Staedtke V, Wanjiku T, Rudek MA, Joshi A, Gallia GL, Riggins GJ. Bai RY, et al. Clin Cancer Res. 2015 Aug 1;21(15):3462-3470. doi: 10.1158/1078-0432.CCR-14-2681. Epub 2015 Apr 10. Clin Cancer Res. 2015. PMID: 25862759 Free PMC article.
Three different mebendazole polymorphs (A, B, and C) exist, and a detailed assessment of the brain penetration, pharmacokinetics, and antitumor properties of each individual mebendazole polymorph is necessary to improve mebendazole-based brain cancer t …
Three different mebendazole polymorphs (A, B, and C) exist, and a detailed assessment of the brain penetration, pharmacokinetics, and …
In vivo and in vitro efficacies of mebendazole, mefloquine and nitazoxanide against cyst echinococcosis.
Liu C, Zhang H, Yin J, Hu W. Liu C, et al. Parasitol Res. 2015 Jun;114(6):2213-22. doi: 10.1007/s00436-015-4412-4. Epub 2015 Mar 15. Parasitol Res. 2015. PMID: 25773183
In this study, we investigated the in vitro and in vivo efficacy of mebendazole, mefloquine, and nitazoxanide against E. granulosus protoscoleces, germinal cells, and infected mice. The effect of mebendazole on protoscoleces and germinal cell was proved to be dose-d …
In this study, we investigated the in vitro and in vivo efficacy of mebendazole, mefloquine, and nitazoxanide against E. granulosus p …
Effective treatment of diverse medulloblastoma models with mebendazole and its impact on tumor angiogenesis.
Bai RY, Staedtke V, Rudin CM, Bunz F, Riggins GJ. Bai RY, et al. Neuro Oncol. 2015 Apr;17(4):545-54. doi: 10.1093/neuonc/nou234. Epub 2014 Sep 24. Neuro Oncol. 2015. PMID: 25253417 Free PMC article.
The identification of 4 molecular groups of medulloblastoma improved the clinical management with the development of targeted therapies; however, the tumor acquires resistance quickly. Mebendazole (MBZ) has a long safety record as antiparasitic in children and has been rec …
The identification of 4 molecular groups of medulloblastoma improved the clinical management with the development of targeted therapies; how …
Flubendazole, FDA-approved anthelmintic, targets breast cancer stem-like cells.
Hou ZJ, Luo X, Zhang W, Peng F, Cui B, Wu SJ, Zheng FM, Xu J, Xu LZ, Long ZJ, Wang XT, Li GH, Wan XY, Yang YL, Liu Q. Hou ZJ, et al. Oncotarget. 2015 Mar 20;6(8):6326-40. doi: 10.18632/oncotarget.3436. Oncotarget. 2015. PMID: 25811972 Free PMC article.
Cancer stem-like cell (CS-like cell) is considered to be responsible for recurrence and drug resistance events in breast cancer, which makes it a potential target for novel cancer therapeutic strategy. ...Furthermore, flubendazole enhanced cytotoxic activity …
Cancer stem-like cell (CS-like cell) is considered to be responsible for recurrence and drug resistance events in breast cancer …
Identification of flubendazole as potential anti-neuroblastoma compound in a large cell line screen.
Michaelis M, Agha B, Rothweiler F, Löschmann N, Voges Y, Mittelbronn M, Starzetz T, Harter PN, Abhari BA, Fulda S, Westermann F, Riecken K, Spek S, Langer K, Wiese M, Dirks WG, Zehner R, Cinatl J, Wass MN, Cinatl J Jr. Michaelis M, et al. Sci Rep. 2015 Feb 3;5:8202. doi: 10.1038/srep08202. Sci Rep. 2015. PMID: 25644037 Free PMC article.
Here, flubendazole was tested for its effects on the viability of in total 461 cancer cell lines. Neuroblastoma was identified as highly flubendazole-sensitive cancer entity in a screen of 321 cell lines from 26 cancer entities. ...Resistance acquisition is a …
Here, flubendazole was tested for its effects on the viability of in total 461 cancer cell lines. Neuroblastoma was identified as hig …
RepurposeVS: A Drug Repurposing-Focused Computational Method for Accurate Drug-Target Signature Predictions.
Issa NT, Peters OJ, Byers SW, Dakshanamurthy S. Issa NT, et al. Comb Chem High Throughput Screen. 2015;18(8):784-94. doi: 10.2174/1386207318666150803130138. Comb Chem High Throughput Screen. 2015. PMID: 26234515 Free PMC article.
Validity was confirmed by the following: (1) providing the greatest enrichment of known drug binders for multiple protein targets in virtual screening experiments, (2) determining that similarly shaped protein target pockets are predicted to bind drugs of similar 3D shapes when R …
Validity was confirmed by the following: (1) providing the greatest enrichment of known drug binders for multiple protein targets in virtual …
Potential anti-cancer drugs commonly used for other indications.
Hanusova V, Skalova L, Kralova V, Matouskova P. Hanusova V, et al. Curr Cancer Drug Targets. 2015;15(1):35-52. doi: 10.2174/1568009615666141229152812. Curr Cancer Drug Targets. 2015. PMID: 25544649 Review.
An increasing resistance of mammalian tumor cells to chemotherapy along with the severe side effects of commonly used cytostatics has raised the urgency in the search for new anti-cancer agents. Several drugs originally approved for indications other than cancer tre …
An increasing resistance of mammalian tumor cells to chemotherapy along with the severe side effects of commonly used cytostatics has raised …
Repurposing the antihelmintic mebendazole as a hedgehog inhibitor.
Larsen AR, Bai RY, Chung JH, Borodovsky A, Rudin CM, Riggins GJ, Bunz F. Larsen AR, et al. Mol Cancer Ther. 2015 Jan;14(1):3-13. doi: 10.1158/1535-7163.MCT-14-0755-T. Epub 2014 Nov 5. Mol Cancer Ther. 2015. PMID: 25376612 Free PMC article.
As an antiparasitic, mebendazole avidly binds nematode tubulin and causes inhibition of intestinal microtubule synthesis. ...Combination of vismodegib and mebendazole resulted in additive Hh signaling inhibition. Because mebendazole can be safely administered …
As an antiparasitic, mebendazole avidly binds nematode tubulin and causes inhibition of intestinal microtubule synthesis. ...Combinat …
Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase.
Liu Y, Asnani A, Zou L, Bentley VL, Yu M, Wang Y, Dellaire G, Sarkar KS, Dai M, Chen HH, Sosnovik DE, Shin JT, Haber DA, Berman JN, Chao W, Peterson RT. Liu Y, et al. Sci Transl Med. 2014 Dec 10;6(266):266ra170. doi: 10.1126/scitranslmed.3010189. Sci Transl Med. 2014. PMID: 25504881 Free PMC article.
As with VIS, treatment with the MDH2 inhibitors mebendazole, thyroxine, and iodine prevented doxorubicin cardiotoxicity, as did treatment with malate itself, suggesting that modulation of MDH2 activity is responsible for VIS' cardioprotective effects. ...
As with VIS, treatment with the MDH2 inhibitors mebendazole, thyroxine, and iodine prevented doxorubicin cardiotoxicity, as did treat …
EFFECT OF THE ANTIPARASITIC DRUG MEBENDAZOLE ON CHOLANGIOCARCINOMA GROWTH.
Sawanyawisuth K, Williamson T, Wongkham S, Riggins GJ. Sawanyawisuth K, et al. Southeast Asian J Trop Med Public Health. 2014 Nov;45(6):1264-70. Southeast Asian J Trop Med Public Health. 2014. PMID: 26466412
Mebendazole (MBZ) is an anthelmintic drug which inhibits tubulin polymerization and eventually causes apoptosis in target organisms. Antitumor activity of MBZ has been reported in various cancers. The aim of this study was to investigate the effect of MBZ on cholang …
Mebendazole (MBZ) is an anthelmintic drug which inhibits tubulin polymerization and eventually causes apoptosis in target organisms. …
Repurposing Drugs in Oncology (ReDO)-mebendazole as an anti-cancer agent.
Pantziarka P, Bouche G, Meheus L, Sukhatme V, Sukhatme VP. Pantziarka P, et al. Ecancermedicalscience. 2014 Jul 10;8:443. doi: 10.3332/ecancer.2014.443. eCollection 2014. Ecancermedicalscience. 2014. PMID: 25075217 Free PMC article.
Mebendazole, a well-known anti-helminthic drug in wide clinical use, has anti-cancer properties that have been elucidated in a broad range of pre-clinical studies across a number of different cancer types. ...Based on the evidence presented, it is proposed th …
Mebendazole, a well-known anti-helminthic drug in wide clinical use, has anti-cancer properties that have been elucidated in a …
Anti-Neoplastic Cytotoxicity of Gemcitabine-(C(4)-amide)-[anti-EGFR] in Dual-combination with Epirubicin-(C(3)-amide)-[anti-HER2/neu] against Chemotherapeutic-Resistant Mammary Adenocarcinoma (SKBr-3) and the Complementary Effect of Mebendazole.
Coyne CP, Jones T, Bear R. Coyne CP, et al. J Cancer Res Ther Oncol. 2014 Apr 9;2(1):203. doi: 10.17303/jcrto.2014.203. J Cancer Res Ther Oncol. 2014. PMID: 25844392 Free PMC article.
Lastly, the tubulin/microtubule inhibitor mebendazole evaluated to determine if it's potential to complemented the anti-neoplastic cytotoxic properties of gemcitabine-(C4-amide)-[anti-EGFR] in dual-combination with epirubicin-(C(3)-amide)-[anti-HER2/neu]. ...The benzimidaz …
Lastly, the tubulin/microtubule inhibitor mebendazole evaluated to determine if it's potential to complemented the anti-neoplastic cy …
Primary posterior mediastinum hydatid cyst.
Ahmed MU, Eid AF, Al-Hawashim N, Sheikh MY, Yiannakou N. Ahmed MU, et al. J Coll Physicians Surg Pak. 2014 Apr;24(4):288-9. J Coll Physicians Surg Pak. 2014. PMID: 24709247
Enterobiasis-related inflammatory caecal polyp masquerading as a malignancy.
Elsaid N, Mahmood H, Tekkis P, Tan E. Elsaid N, et al. BMJ Case Rep. 2014 Jan 15;2014:bcr2013201599. doi: 10.1136/bcr-2013-201599. BMJ Case Rep. 2014. PMID: 24429050 Free PMC article.
The patient was subsequently discharged with a 3-day course of antihelminthic mebendazole and reassured that his per rectal bleeding was most likely due to haemorrhoids discovered at rectal examination....
The patient was subsequently discharged with a 3-day course of antihelminthic mebendazole and reassured that his per rectal bleeding …
Treatment of echinococcosis: albendazole and mebendazole--what else?
Hemphill A, Stadelmann B, Rufener R, Spiliotis M, Boubaker G, Müller J, Müller N, Gorgas D, Gottstein B. Hemphill A, et al. Parasite. 2014;21:70. doi: 10.1051/parasite/2014073. Epub 2014 Dec 22. Parasite. 2014. PMID: 25526545 Free PMC article. Review.
Clearly, the current focus is targeted towards broad-spectrum anti-parasitic or anti-cancer drugs and compound classes that are already marketed, or that are in development for other applications. ...
Clearly, the current focus is targeted towards broad-spectrum anti-parasitic or anti-cancer drugs and compound classes that are alrea …
Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer.
Nygren P, Fryknäs M, Agerup B, Larsson R. Nygren P, et al. J Cancer Res Clin Oncol. 2013 Dec;139(12):2133-40. doi: 10.1007/s00432-013-1539-5. Epub 2013 Oct 18. J Cancer Res Clin Oncol. 2013. PMID: 24135855 Free PMC article.
Analysis of the diagnosis-specific activity of MBZ showed activity in 80 % of the colon cancer cell lines in the NCI 60 panel. Three additional colon cancer cell lines and three cell models with non-malignant phenotypes were subsequently tested, confirming selective …
Analysis of the diagnosis-specific activity of MBZ showed activity in 80 % of the colon cancer cell lines in the NCI 60 panel. Three …
Antiproliferative effect of benzimidazole anthelmintics albendazole, ricobendazole, and flubendazole in intestinal cancer cell lines.
Králová V, Hanušová V, Staňková P, Knoppová K, Čáňová K, Skálová L. Králová V, et al. Anticancer Drugs. 2013 Oct;24(9):911-9. doi: 10.1097/CAD.0b013e3283648c69. Anticancer Drugs. 2013. PMID: 23884106
Four intestinal cancer cell lines, SW480, SW620, HCT8, and Caco2, with different origins and growth characteristics were used. ...The anthelmintic benzimidazole drugs ABZ and FLU show a significant cytostatic effect and potentiate the efficacy of PTX in intestinal cance …
Four intestinal cancer cell lines, SW480, SW620, HCT8, and Caco2, with different origins and growth characteristics were used. ...The …
Novel albendazole-chitosan nanoparticles for intestinal absorption enhancement and hepatic targeting improvement in rats.
Liu Y, Wang XQ, Ren WX, Chen YL, Yu Y, Zhang JK, Bawudong D, Gu JP, Xu XD, Zhang XN. Liu Y, et al. J Biomed Mater Res B Appl Biomater. 2013 Aug;101(6):998-1005. doi: 10.1002/jbm.b.32908. Epub 2013 Mar 26. J Biomed Mater Res B Appl Biomater. 2013. PMID: 23529958
To improve the treatment of helminthiasis, filariasis, and colorectal cancer, albendazole-associated chitosan nanoparticles (ABZ-CS-NPs) were prepared using the emulsion crosslinking volatile technique with contained sodium tripolyphosphate as the crosslinking agent and Po …
To improve the treatment of helminthiasis, filariasis, and colorectal cancer, albendazole-associated chitosan nanoparticles (ABZ-CS-N …
XIAP downregulation accompanies mebendazole growth inhibition in melanoma xenografts.
Doudican NA, Byron SA, Pollock PM, Orlow SJ. Doudican NA, et al. Anticancer Drugs. 2013 Feb;24(2):181-8. doi: 10.1097/CAD.0b013e32835a43f1. Anticancer Drugs. 2013. PMID: 23059386
Mebendazole (MBZ) was identified as a promising therapeutic on the basis of its ability to induce apoptosis in melanoma cell lines through a B-cell lymphoma 2 (BCL2)-dependent mechanism. ...
Mebendazole (MBZ) was identified as a promising therapeutic on the basis of its ability to induce apoptosis in melanoma cell lines th …
Gemcitabine-(C(4)-amide)-[anti-HER2/neu] Anti-Neoplastic Cytotoxicity in Dual Combination with Mebendazole against Chemotherapeutic-Resistant Mammary Adenocarcinoma.
Coyne CP, Jones T, Bear R. Coyne CP, et al. J Clin Exp Oncol. 2013;2(2):1000109. J Clin Exp Oncol. 2013. PMID: 26251840 Free PMC article.
Cytotoxic anti-neoplastic potency of gemcitabine-(C(4)-amide)-[anti-HER2/neu] and the benzimidazole tubulin/microtubule inhibitors, albendazole, flubendazole and mebendazole was established against chemotherapeutic-resistant mammary adenocarcinoma (SKBr-3). Related investi …
Cytotoxic anti-neoplastic potency of gemcitabine-(C(4)-amide)-[anti-HER2/neu] and the benzimidazole tubulin/microtubule inhibitors, albendaz …
Influence of Alternative Tubulin Inhibitors on the Potency of a Epirubicin-Immunochemotherapeutic Synthesized with an Ultra Violet Light-Activated Intermediate: Influence of incorporating an internal/integral disulfide bond structure and Alternative Tubulin/Microtubule Inhibitors on the Cytotoxic Anti-Neoplastic Potency of Epirubicin-(C3-amide)-Anti-HER2/neu Synthesized Utilizing a UV-Photoactivated Anthracycline Intermediate.
Coyne CP, Jones T, Bear R. Coyne CP, et al. Cancer Clin Oncol. 2012 Nov;1(2):49-80. doi: 10.5539/cco.v1n2p49. Cancer Clin Oncol. 2012. PMID: 26225190 Free PMC article.
Cytotoxic anti-neoplastic potency of benzimidazoles (albendazole, flubendazole, membendazole) and griseofulvin were assessed between 0-to-2 mug/ml and 0-to-100 mug/ml respectively while mebendazole and griseofulvin were analyzed at fixed concentrations of 0.35 mug/ml and 3 …
Cytotoxic anti-neoplastic potency of benzimidazoles (albendazole, flubendazole, membendazole) and griseofulvin were assessed between 0-to-2 …
Predicting new indications for approved drugs using a proteochemometric method.
Dakshanamurthy S, Issa NT, Assefnia S, Seshasayee A, Peters OJ, Madhavan S, Uren A, Brown ML, Byers SW. Dakshanamurthy S, et al. J Med Chem. 2012 Aug 9;55(15):6832-48. doi: 10.1021/jm300576q. Epub 2012 Jul 25. J Med Chem. 2012. PMID: 22780961 Free PMC article.
Furthermore, we used the TMFS method to discover that mebendazole, an antiparasitic with recently discovered and unexpected anticancer properties, has the structural potential to inhibit VEGFR2. We confirmed experimentally that mebendazole inhibits VEGFR2 kinase act …
Furthermore, we used the TMFS method to discover that mebendazole, an antiparasitic with recently discovered and unexpected anticance …
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