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Page 1
Canine degenerative myelopathy.
Coates JR, Wininger FA. Coates JR, et al. Vet Clin North Am Small Anim Pract. 2010 Sep;40(5):929-50. doi: 10.1016/j.cvsm.2010.05.001. Vet Clin North Am Small Anim Pract. 2010. PMID: 20732599 Review.
Canine degenerative myelopathy (DM) is an adult-onset fatal neurodegenerative disease that occurs in many breeds. ...This article reviews the current knowledge of canine DM with regard to its signalment, clinical spectrum, diagnostic approach, and trea
Canine degenerative myelopathy (DM) is an adult-onset fatal neurodegenerative disease that occurs in many breeds. ...Th
Molecular Surveillance of Canine Degenerative Myelopathy in Breeding Kennels from Romania.
Cocostîrc V, Paștiu AI, Doboși AA, Lucaci FD, Turcu MC, Borzan MM, Pusta DL. Cocostîrc V, et al. Animals (Basel). 2023 Apr 19;13(8):1403. doi: 10.3390/ani13081403. Animals (Basel). 2023. PMID: 37106965 Free PMC article.
Canine degenerative myelopathy (CDM) is a spontaneous neurodegenerative disease. Genetically, CDM is an autosomal recessive disease with incomplete penetrance, most commonly caused by a genetic mutation in exon 2 of gene SOD1 (c.118G > A). ...The results r
Canine degenerative myelopathy (CDM) is a spontaneous neurodegenerative disease. Genetically, CDM is an autosomal reces
The role of cannabinoids in pain modulation in companion animals.
Miranda-Cortés A, Mota-Rojas D, Crosignani-Outeda N, Casas-Alvarado A, Martínez-Burnes J, Olmos-Hernández A, Mora-Medina P, Verduzco-Mendoza A, Hernández-Ávalos I. Miranda-Cortés A, et al. Front Vet Sci. 2023 Jan 4;9:1050884. doi: 10.3389/fvets.2022.1050884. eCollection 2022. Front Vet Sci. 2023. PMID: 36686189 Free PMC article. Review.
However, the endocannabinoid system interacts with different endogenous ligands and neurotransmitters, thus offering other therapeutic possibilities in dogs and cats, such is the case of those patients who suffer from seizures or epilepsy, contact and atopic dermatitis, …
However, the endocannabinoid system interacts with different endogenous ligands and neurotransmitters, thus offering other therapeutic possi …
Prevalence of SOD1 allele associated with degenerative myelopathy in canine population in Greece.
Kountourantzis A, Minoudi S, Karaiskou N, Papakostas S, Moulistanos A, Baka RD, Tsartsianidou V, Vlachavas A, Aivaliotis M, Polizopoulou ZS, Triantafyllidis A. Kountourantzis A, et al. Res Vet Sci. 2023 Sep;162:104959. doi: 10.1016/j.rvsc.2023.104959. Epub 2023 Jul 17. Res Vet Sci. 2023. PMID: 37480717
Canine degenerative myelopathy (CDM) is a late-onset fatal disorder associated with a point mutation of the superoxide dismutase 1 (SOD1) gene (c.118G > A). ...The mutant allele was not common in the Belgian Malinois dogs (allele frequency = 0.029),
Canine degenerative myelopathy (CDM) is a late-onset fatal disorder associated with a point mutation of the superoxide
Intrinsic structural vulnerability in the hydrophobic core induces species-specific aggregation of canine SOD1 with degenerative myelopathy-linked E40K mutation.
Hashimoto K, Watanabe S, Akutsu M, Muraki N, Kamishina H, Furukawa Y, Yamanaka K. Hashimoto K, et al. J Biol Chem. 2023 Jun;299(6):104798. doi: 10.1016/j.jbc.2023.104798. Epub 2023 May 6. J Biol Chem. 2023. PMID: 37156398 Free PMC article.
Canine degenerative myelopathy (DM), a fatal neurodegenerative disease in dogs, shares clinical and genetic features with amyotrophic lateral sclerosis, a human motor neuron disease. ...However, the mechanism through which canine E40K mutation i
Canine degenerative myelopathy (DM), a fatal neurodegenerative disease in dogs, shares clinical and genetic feat
Intensive neurorehabilitation and allogeneic stem cells transplantation in canine degenerative myelopathy.
Gouveia D, Correia J, Cardoso A, Carvalho C, Oliveira AC, Almeida A, Gamboa Ó, Ribeiro L, Branquinho M, Sousa A, Lopes B, Sousa P, Moreira A, Coelho A, Rêma A, Alvites R, Ferreira A, Maurício AC, Martins Â. Gouveia D, et al. Front Vet Sci. 2023 Jul 13;10:1192744. doi: 10.3389/fvets.2023.1192744. eCollection 2023. Front Vet Sci. 2023. PMID: 37520009 Free PMC article.
INTRODUCTION: Degenerative myelopathy (DM) is a neurodegenerative spinal cord disease with upper motor neurons, with progressive and chronic clinical signs, similar to amyotrophic lateral sclerosis (ALS). ...DISCUSSION: This INSCP showed to be safe, fe …
INTRODUCTION: Degenerative myelopathy (DM) is a neurodegenerative spinal cord disease with upper motor neurons, …
Canine degenerative myelopathy: biochemical characterization of superoxide dismutase 1 in the first naturally occurring non-human amyotrophic lateral sclerosis model.
Crisp MJ, Beckett J, Coates JR, Miller TM. Crisp MJ, et al. Exp Neurol. 2013 Oct;248:1-9. doi: 10.1016/j.expneurol.2013.05.009. Epub 2013 May 23. Exp Neurol. 2013. PMID: 23707216 Free PMC article.
Mutations in canine superoxide dismutase 1 (SOD1) have recently been shown to cause canine degenerative myelopathy, a disabling neurodegenerative disorder affecting specific breeds of dogs characterized by progressive motor neuron loss and paral …
Mutations in canine superoxide dismutase 1 (SOD1) have recently been shown to cause canine degenerative myelopathy
Breed distribution of SOD1 alleles previously associated with canine degenerative myelopathy.
Zeng R, Coates JR, Johnson GC, Hansen L, Awano T, Kolicheski A, Ivansson E, Perloski M, Lindblad-Toh K, O'Brien DP, Guo J, Katz ML, Johnson GS. Zeng R, et al. J Vet Intern Med. 2014 Mar-Apr;28(2):515-21. doi: 10.1111/jvim.12317. Epub 2014 Feb 13. J Vet Intern Med. 2014. PMID: 24524809 Free PMC article.
OBJECTIVE: To describe the distribution of SOD1:c.118A and SOD1:c.52T in 222 breeds. ANIMALS: DNA from 33,747 dogs was genotyped at SOD1:c.118, SOD1:c.52, or both. Spinal cord sections from 249 of these dogs were examined. ...Most of the dogs wi …
OBJECTIVE: To describe the distribution of SOD1:c.118A and SOD1:c.52T in 222 breeds. ANIMALS: DNA from 33,747 dogs was genotyped at S …
Electrical Impedance Myography in Dogs With Degenerative Myelopathy.
Kowal JB, Verga SA, Pandeya SR, Cochran RJ, Sabol JC, Rutkove SB, Coates JR. Kowal JB, et al. Front Vet Sci. 2022 May 27;9:874277. doi: 10.3389/fvets.2022.874277. eCollection 2022. Front Vet Sci. 2022. PMID: 35711791 Free PMC article.
Canine degenerative myelopathy (DM) leads to disuse and neurogenic muscle atrophy. Currently there is a lack of non-invasive quantitative measures of muscle health in dogs with DM. ...The objective of this study was to compare EIM between DM-affected a
Canine degenerative myelopathy (DM) leads to disuse and neurogenic muscle atrophy. Currently there is a lack of non-inv
Protein disulphide isomerase is associated with mutant SOD1 in canine degenerative myelopathy.
Chang RC, Parakh S, Coates JR, Long S, Atkin JD. Chang RC, et al. Neuroreport. 2019 Jan 2;30(1):8-13. doi: 10.1097/WNR.0000000000001151. Neuroreport. 2019. PMID: 30422940
Canine degenerative myelopathy (DM) is a fatal neurodegenerative disorder prevalent in the canine population. ...Immunohistochemical staining was also carried out to examine co-localization between endogenous PDI and SOD1 inclusions in spinal
Canine degenerative myelopathy (DM) is a fatal neurodegenerative disorder prevalent in the canine population. ..
88 results