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Page 1
Canine degenerative myelopathy.
Coates JR, Wininger FA. Coates JR, et al. Vet Clin North Am Small Anim Pract. 2010 Sep;40(5):929-50. doi: 10.1016/j.cvsm.2010.05.001. Vet Clin North Am Small Anim Pract. 2010. PMID: 20732599 Review.
Canine degenerative myelopathy (DM) is an adult-onset fatal neurodegenerative disease that occurs in many breeds. ...This article reviews the current knowledge of canine DM with regard to its signalment, clinical spectrum, diagnostic approach, and trea …
Canine degenerative myelopathy (DM) is an adult-onset fatal neurodegenerative disease that occurs in many breeds. ...Th …
Molecular Surveillance of Canine Degenerative Myelopathy in Breeding Kennels from Romania.
Cocostîrc V, Paștiu AI, Doboși AA, Lucaci FD, Turcu MC, Borzan MM, Pusta DL. Cocostîrc V, et al. Animals (Basel). 2023 Apr 19;13(8):1403. doi: 10.3390/ani13081403. Animals (Basel). 2023. PMID: 37106965 Free PMC article.
Canine degenerative myelopathy (CDM) is a spontaneous neurodegenerative disease. Genetically, CDM is an autosomal recessive disease with incomplete penetrance, most commonly caused by a genetic mutation in exon 2 of gene SOD1 (c.118G > A). ...The results r …
Canine degenerative myelopathy (CDM) is a spontaneous neurodegenerative disease. Genetically, CDM is an autosomal reces …
Prevalence of SOD1 allele associated with degenerative myelopathy in canine population in Greece.
Kountourantzis A, Minoudi S, Karaiskou N, Papakostas S, Moulistanos A, Baka RD, Tsartsianidou V, Vlachavas A, Aivaliotis M, Polizopoulou ZS, Triantafyllidis A. Kountourantzis A, et al. Res Vet Sci. 2023 Sep;162:104959. doi: 10.1016/j.rvsc.2023.104959. Epub 2023 Jul 17. Res Vet Sci. 2023. PMID: 37480717
Canine degenerative myelopathy (CDM) is a late-onset fatal disorder associated with a point mutation of the superoxide dismutase 1 (SOD1) gene (c.118G > A). ...The mutant allele was not common in the Belgian Malinois dogs (allele frequency = 0.029), …
Canine degenerative myelopathy (CDM) is a late-onset fatal disorder associated with a point mutation of the superoxide …
Intrinsic structural vulnerability in the hydrophobic core induces species-specific aggregation of canine SOD1 with degenerative myelopathy-linked E40K mutation.
Hashimoto K, Watanabe S, Akutsu M, Muraki N, Kamishina H, Furukawa Y, Yamanaka K. Hashimoto K, et al. J Biol Chem. 2023 Jun;299(6):104798. doi: 10.1016/j.jbc.2023.104798. Epub 2023 May 6. J Biol Chem. 2023. PMID: 37156398 Free PMC article.
Canine degenerative myelopathy (DM), a fatal neurodegenerative disease in dogs, shares clinical and genetic features with amyotrophic lateral sclerosis, a human motor neuron disease. ...However, the mechanism through which canine E40K mutation i …
Canine degenerative myelopathy (DM), a fatal neurodegenerative disease in dogs, shares clinical and genetic feat …
Disulfide-mediated oligomerization of mutant Cu/Zn-superoxide dismutase associated with canine degenerative myelopathy.
Shino Y, Muraki N, Kobatake Y, Kamishina H, Kato R, Furukawa Y. Shino Y, et al. Protein Sci. 2024 Dec;33(12):e5210. doi: 10.1002/pro.5210. Protein Sci. 2024. PMID: 39548731 Free PMC article.
A homozygous E40K mutation in the gene coding canine Cu/Zn-superoxide dismutase (cSOD1) causes degenerative myelopathy (DM) in dogs. ...
A homozygous E40K mutation in the gene coding canine Cu/Zn-superoxide dismutase (cSOD1) causes degenerative myelopathy …
Negative Selection on a SOD1 Mutation Limits Canine Degenerative Myelopathy While Avoiding Inbreeding.
Ukawa H, Akiyama N, Yamamoto F, Ohashi K, Ishihara G, Matsumoto Y. Ukawa H, et al. Genome Biol Evol. 2024 Jan 5;16(1):evad231. doi: 10.1093/gbe/evad231. Genome Biol Evol. 2024. PMID: 38109923 Free PMC article.
Here, we aimed to evaluate the influence of genetic testing on the frequency of mutations responsible for canine degenerative myelopathy and assess the changes in the genetic structure of a Pembroke Welsh corgi population from Japan. ...This combined strategy …
Here, we aimed to evaluate the influence of genetic testing on the frequency of mutations responsible for canine degenerative …
Intensive neurorehabilitation and allogeneic stem cells transplantation in canine degenerative myelopathy.
Gouveia D, Correia J, Cardoso A, Carvalho C, Oliveira AC, Almeida A, Gamboa Ó, Ribeiro L, Branquinho M, Sousa A, Lopes B, Sousa P, Moreira A, Coelho A, Rêma A, Alvites R, Ferreira A, Maurício AC, Martins Â. Gouveia D, et al. Front Vet Sci. 2023 Jul 13;10:1192744. doi: 10.3389/fvets.2023.1192744. eCollection 2023. Front Vet Sci. 2023. PMID: 37520009 Free PMC article.
INTRODUCTION: Degenerative myelopathy (DM) is a neurodegenerative spinal cord disease with upper motor neurons, with progressive and chronic clinical signs, similar to amyotrophic lateral sclerosis (ALS). ...DISCUSSION: This INSCP showed to be safe, fe …
INTRODUCTION: Degenerative myelopathy (DM) is a neurodegenerative spinal cord disease with upper motor neurons, …
Activation of the unfolded protein response in canine degenerative myelopathy.
Yokota S, Kobatake Y, Noda Y, Nakata K, Yamato O, Hara H, Sakai H, Nishida H, Maeda S, Kamishina H. Yokota S, et al. Neurosci Lett. 2018 Nov 20;687:216-222. doi: 10.1016/j.neulet.2018.09.040. Epub 2018 Sep 29. Neurosci Lett. 2018. PMID: 30273700
Canine degenerative myelopathy (DM) is an adult-onset progressive and fatal neurodegenerative disorder. ...The present study demonstrated the up-regulated expression of the ER stress marker GRP78/BiP (BiP) in the spinal cords of DM-affected dogs …
Canine degenerative myelopathy (DM) is an adult-onset progressive and fatal neurodegenerative disorder. ...The present …
Breed distribution of SOD1 alleles previously associated with canine degenerative myelopathy.
Zeng R, Coates JR, Johnson GC, Hansen L, Awano T, Kolicheski A, Ivansson E, Perloski M, Lindblad-Toh K, O'Brien DP, Guo J, Katz ML, Johnson GS. Zeng R, et al. J Vet Intern Med. 2014 Mar-Apr;28(2):515-21. doi: 10.1111/jvim.12317. Epub 2014 Feb 13. J Vet Intern Med. 2014. PMID: 24524809 Free PMC article.
OBJECTIVE: To describe the distribution of SOD1:c.118A and SOD1:c.52T in 222 breeds. ANIMALS: DNA from 33,747 dogs was genotyped at SOD1:c.118, SOD1:c.52, or both. Spinal cord sections from 249 of these dogs were examined. ...Most of the dogs wi …
OBJECTIVE: To describe the distribution of SOD1:c.118A and SOD1:c.52T in 222 breeds. ANIMALS: DNA from 33,747 dogs was genotyped at S …
Protein disulphide isomerase is associated with mutant SOD1 in canine degenerative myelopathy.
Chang RC, Parakh S, Coates JR, Long S, Atkin JD. Chang RC, et al. Neuroreport. 2019 Jan 2;30(1):8-13. doi: 10.1097/WNR.0000000000001151. Neuroreport. 2019. PMID: 30422940
Canine degenerative myelopathy (DM) is a fatal neurodegenerative disorder prevalent in the canine population. ...Immunohistochemical staining was also carried out to examine co-localization between endogenous PDI and SOD1 inclusions in spinal …
Canine degenerative myelopathy (DM) is a fatal neurodegenerative disorder prevalent in the canine population. .. …
94 results