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Combination of cannabinoids, delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), mitigates experimental autoimmune encephalomyelitis (EAE) by altering the gut microbiome.
Al-Ghezi ZZ, Busbee PB, Alghetaa H, Nagarkatti PS, Nagarkatti M. Al-Ghezi ZZ, et al. Brain Behav Immun. 2019 Nov;82:25-35. doi: 10.1016/j.bbi.2019.07.028. Epub 2019 Jul 26. Brain Behav Immun. 2019. PMID: 31356922 Free PMC article.
Currently, a combination of marijuana cannabinoids including delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) is used as a drug to treat muscle spasticity in patients with Multiple Sclerosis (MS). ...In the currently study, we used a murine model of MS, experimenta …
Currently, a combination of marijuana cannabinoids including delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) is used as a dr …
Immune Responses Regulated by Cannabidiol.
Nichols JM, Kaplan BLF. Nichols JM, et al. Cannabis Cannabinoid Res. 2020 Feb 27;5(1):12-31. doi: 10.1089/can.2018.0073. eCollection 2020 Mar 1. Cannabis Cannabinoid Res. 2020. PMID: 32322673 Free PMC article. Review.
Introduction: Cannabidiol (CBD) as Epidiolex() (GW Pharmaceuticals) was recently approved by the U.S. ...The review then provides a summary of in vivo and in vitro effects in the immune system, in autoimmune models, with a focus on experimental autoimmune enc …
Introduction: Cannabidiol (CBD) as Epidiolex() (GW Pharmaceuticals) was recently approved by the U.S. ...The review then provides a s …
Beyond THC and Endocannabinoids.
Pacher P, Kogan NM, Mechoulam R. Pacher P, et al. Annu Rev Pharmacol Toxicol. 2020 Jan 6;60:637-659. doi: 10.1146/annurev-pharmtox-010818-021441. Epub 2019 Oct 3. Annu Rev Pharmacol Toxicol. 2020. PMID: 31580774 Review.
Numerous endocannabinoid-like compounds have been discovered. The Cannabis plant constituent cannabidiol (CBD) was found to exert beneficial effects in many preclinical disease models ranging from epilepsy, cardiovascular disease, inflammation, and autoimmunity to n …
Numerous endocannabinoid-like compounds have been discovered. The Cannabis plant constituent cannabidiol (CBD) was found to exert ben …
A Critical Review of the Role of the Cannabinoid Compounds Δ9-Tetrahydrocannabinol (Δ9-THC) and Cannabidiol (CBD) and their Combination in Multiple Sclerosis Treatment.
Jones É, Vlachou S. Jones É, et al. Molecules. 2020 Oct 25;25(21):4930. doi: 10.3390/molecules25214930. Molecules. 2020. PMID: 33113776 Free PMC article. Review.
Many people with MS (pwMS) use unregulated cannabis or cannabis products to treat the symptoms associated with the disease. In line with this, Sativex, a synthetic combination of cannabidiol (CBD) and delta(9)-tetrahydrocannabinol (delta(9)-THC) has been approved to treat …
Many people with MS (pwMS) use unregulated cannabis or cannabis products to treat the symptoms associated with the disease. In line with thi …
Terpenoids, Cannabimimetic Ligands, beyond the Cannabis Plant.
Gonçalves ECD, Baldasso GM, Bicca MA, Paes RS, Capasso R, Dutra RC. Gonçalves ECD, et al. Molecules. 2020 Mar 29;25(7):1567. doi: 10.3390/molecules25071567. Molecules. 2020. PMID: 32235333 Free PMC article. Review.
Cannabimimetic ligands, beyond the Cannabis plant, can act as CBR agonists or antagonists, or ECS enzyme inhibitors, besides being able of playing a role in immune-mediated inflammatory and infectious diseases, neuroinflammatory, neurological, and neurodegenerative diseases, as w …
Cannabimimetic ligands, beyond the Cannabis plant, can act as CBR agonists or antagonists, or ECS enzyme inhibitors, besides being able of p …
Cannabidiol (CBD) Consumption and Perceived Impact on Extrahepatic Symptoms in Patients with Autoimmune Hepatitis.
Mathur K, Vuppalanchi V, Gelow K, Vuppalanchi R, Lammert C. Mathur K, et al. Dig Dis Sci. 2020 Jan;65(1):322-328. doi: 10.1007/s10620-019-05756-7. Epub 2019 Jul 30. Dig Dis Sci. 2020. PMID: 31363952 Free PMC article.
BACKGROUND AND AIMS: Utilization and safety of cannabidiol (CBD) in patients with autoimmune hepatitis (AIH) are currently unknown. ...METHODS: An invitation to complete a CBD-specific questionnaire was posted every other day to well-established autoimmune he …
BACKGROUND AND AIMS: Utilization and safety of cannabidiol (CBD) in patients with autoimmune hepatitis (AIH) are currently unk …
Cannabidiol Attenuates Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis Through Induction of Myeloid-Derived Suppressor Cells.
Elliott DM, Singh N, Nagarkatti M, Nagarkatti PS. Elliott DM, et al. Front Immunol. 2018 Aug 3;9:1782. doi: 10.3389/fimmu.2018.01782. eCollection 2018. Front Immunol. 2018. PMID: 30123217 Free PMC article.
Multiple sclerosis (MS) is a chronic debilitating autoimmune disease without a cure. While the use of marijuana cannabinoids for MS has recently been approved in some countries, the precise mechanism of action leading to attenuate neuroinflammation is not clear. We used ex …
Multiple sclerosis (MS) is a chronic debilitating autoimmune disease without a cure. While the use of marijuana cannabinoids for MS h …
Effects of Orally Administered Cannabidiol on Neuroinflammation and Intestinal Inflammation in the Attenuation of Experimental Autoimmune Encephalomyelitis.
Dopkins N, Miranda K, Wilson K, Holloman BL, Nagarkatti P, Nagarkatti M. Dopkins N, et al. J Neuroimmune Pharmacol. 2021 Nov 10. doi: 10.1007/s11481-021-10023-6. Online ahead of print. J Neuroimmune Pharmacol. 2021. PMID: 34757526
Cannabidiol (CBD) is a bioactive compound isolated from Cannabis plants that has garnered attention within the medical community due to its potent anti-inflammatory properties. ...These findings demonstrate the beneficial effect of CBD treatment on autoimmune neuroi
Cannabidiol (CBD) is a bioactive compound isolated from Cannabis plants that has garnered attention within the medical community due
Cannabidiol Limits T Cell-Mediated Chronic Autoimmune Myocarditis: Implications to Autoimmune Disorders and Organ Transplantation.
Lee WS, Erdelyi K, Matyas C, Mukhopadhyay P, Varga ZV, Liaudet L, Haskú G, Čiháková D, Mechoulam R, Pacher P. Lee WS, et al. Mol Med. 2016 Sep;22:136-146. doi: 10.2119/molmed.2016.00007. Epub 2016 Jan 8. Mol Med. 2016. PMID: 26772776 Free PMC article.
Conventional immunosuppressive therapies often provide unsatisfactory results and are associated with adverse toxicities during the treatment of autoimmune myocarditis. Cannabidiol (CBD) is a nonpsychoactive constituent of marijuana that exerts antiinflammatory effe …
Conventional immunosuppressive therapies often provide unsatisfactory results and are associated with adverse toxicities during the treatmen …
Immunomodulatory Potential of Cannabidiol in Multiple Sclerosis: a Systematic Review.
Furgiuele A, Cosentino M, Ferrari M, Marino F. Furgiuele A, et al. J Neuroimmune Pharmacol. 2021 Jun;16(2):251-269. doi: 10.1007/s11481-021-09982-7. Epub 2021 Jan 25. J Neuroimmune Pharmacol. 2021. PMID: 33492630 Free PMC article.
Multiple sclerosis (MS) is the most common chronic autoimmune disease of the central nervous system. Efficacy of treatments for MS is associated with risk of adverse effects, and effective and well-tolerated drugs remain a major unmet need. ...Cannabinoids are endowed with …
Multiple sclerosis (MS) is the most common chronic autoimmune disease of the central nervous system. Efficacy of treatments for MS is …
70 results