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(-)-Cannabidiolic Acid, a Still Overlooked Bioactive Compound: An Introductory Review and Preliminary Research.
Formato M, Crescente G, Scognamiglio M, Fiorentino A, Pecoraro MT, Piccolella S, Catauro M, Pacifico S. Formato M, et al. Molecules. 2020 Jun 5;25(11):2638. doi: 10.3390/molecules25112638. Molecules. 2020. PMID: 32517131 Free PMC article. Review.
Cannabidiolic acid (CBDA) is the main phytocannabinoid in fiber and seed-oil hemp (Cannabis sativa L.) plants, but its potential health-related capabilities have been masked for years by a greater scientific interest towards its neutral derivative cannabidiol (CBD).
Cannabidiolic acid (CBDA) is the main phytocannabinoid in fiber and seed-oil hemp (Cannabis sativa L.) plants, but its potenti
Cannabidiolic-acid synthase, the chemotype-determining enzyme in the fiber-type Cannabis sativa.
Taura F, Sirikantaramas S, Shoyama Y, Yoshikai K, Shoyama Y, Morimoto S. Taura F, et al. FEBS Lett. 2007 Jun 26;581(16):2929-34. doi: 10.1016/j.febslet.2007.05.043. Epub 2007 May 25. FEBS Lett. 2007. PMID: 17544411 Free article.
Cannabidiolic-acid (CBDA) synthase is the enzyme that catalyzes oxidative cyclization of cannabigerolic-acid into CBDA, the dominant cannabinoid constituent of the fiber-type Cannabis sativa. ...The structural and functional properties of CBDA synthase are qu
Cannabidiolic-acid (CBDA) synthase is the enzyme that catalyzes oxidative cyclization of cannabigerolic-acid into CBDA,
Pharmacokinetics of Cannabidiol, Cannabidiolic Acid, delta9-Tetrahydrocannabinol, Tetrahydrocannabinolic Acid and Related Metabolites in Canine Serum After Dosing With Three Oral Forms of Hemp Extract.
Wakshlag JJ, Schwark WS, Deabold KA, Talsma BN, Cital S, Lyubimov A, Iqbal A, Zakharov A. Wakshlag JJ, et al. Front Vet Sci. 2020 Sep 4;7:505. doi: 10.3389/fvets.2020.00505. eCollection 2020. Front Vet Sci. 2020. PMID: 33102539 Free PMC article.
Many products contain small amounts of delta9-tetrahydrocannabinol (THC), and precursor carboxylic acid forms of CBD and THC known as cannabidiolic acid (CBDA) and tetrahydrocannabinolic acid (THCA). ...
Many products contain small amounts of delta9-tetrahydrocannabinol (THC), and precursor carboxylic acid forms of CBD and THC known as …
Analysis of cannabinoids in commercial hemp seed oil and decarboxylation kinetics studies of cannabidiolic acid (CBDA).
Citti C, Pacchetti B, Vandelli MA, Forni F, Cannazza G. Citti C, et al. J Pharm Biomed Anal. 2018 Feb 5;149:532-540. doi: 10.1016/j.jpba.2017.11.044. Epub 2017 Nov 20. J Pharm Biomed Anal. 2018. PMID: 29182999
This work presents the development and validation of a highly sensitive, selective and rapid HPLC-UV method for the qualitative and quantitative determination of the main cannabinoids, namely cannabidiolic acid (CBDA), tetrahydrocannabinolic acid (THCA), cann …
This work presents the development and validation of a highly sensitive, selective and rapid HPLC-UV method for the qualitative and quantita …
Isolation, Purification, and Antimicrobial Characterization of Cannabidiolic Acid and Cannabidiol from Cannabis sativa L.
Martinenghi LD, Jønsson R, Lund T, Jenssen H. Martinenghi LD, et al. Biomolecules. 2020 Jun 12;10(6):900. doi: 10.3390/biom10060900. Biomolecules. 2020. PMID: 32545687 Free PMC article.
This study aimed at the development of a reliable method for the extraction, purification, characterization, and quantification of cannabidiolic acid (CBDA) and its decarboxylated form cannabidiol (CBD) present in the fiber type Cannabis sativa L. ...
This study aimed at the development of a reliable method for the extraction, purification, characterization, and quantification of cannab
Pharmacokinetics of Phytocannabinoid Acids and Anticonvulsant Effect of Cannabidiolic Acid in a Mouse Model of Dravet Syndrome.
Anderson LL, Low IK, Banister SD, McGregor IS, Arnold JC. Anderson LL, et al. J Nat Prod. 2019 Nov 22;82(11):3047-3055. doi: 10.1021/acs.jnatprod.9b00600. Epub 2019 Nov 5. J Nat Prod. 2019. PMID: 31686510
., delta(9)-tetrahydrocannabinol, THC; cannabidiol, CBD; etc.) or as acid precursors, which are dominant in the plant (e.g., delta(9)-tetrahydrocannabinolic acid, THCA; cannabidiolic acid, CBDA; etc.). ...Herein the brain and plasma pharmacokinetic pro …
., delta(9)-tetrahydrocannabinol, THC; cannabidiol, CBD; etc.) or as acid precursors, which are dominant in the plant (e.g., delta(9) …
Effect of cannabidiolic acid and (9)-tetrahydrocannabinol on carrageenan-induced hyperalgesia and edema in a rodent model of inflammatory pain.
Rock EM, Limebeer CL, Parker LA. Rock EM, et al. Psychopharmacology (Berl). 2018 Nov;235(11):3259-3271. doi: 10.1007/s00213-018-5034-1. Epub 2018 Sep 17. Psychopharmacology (Berl). 2018. PMID: 30225659
OBJECTIVES: The present study evaluates the anti-inflammatory and anti-hyperalgesia effects of CBD's potent acidic precursor, cannabidiolic acid (CBDA), in a rodent model of carrageenan-induced acute inflammation in the rat hind paw, when administered systemically ( …
OBJECTIVES: The present study evaluates the anti-inflammatory and anti-hyperalgesia effects of CBD's potent acidic precursor, cannabidiol
Cannabis sativa L. and Nonpsychoactive Cannabinoids: Their Chemistry and Role against Oxidative Stress, Inflammation, and Cancer.
Pellati F, Borgonetti V, Brighenti V, Biagi M, Benvenuti S, Corsi L. Pellati F, et al. Biomed Res Int. 2018 Dec 4;2018:1691428. doi: 10.1155/2018/1691428. eCollection 2018. Biomed Res Int. 2018. PMID: 30627539 Free PMC article. Review.
These activities seem to involve also alternative pathways, such as the interactions with TRPV and GRP55 receptor complexes. Moreover, the finding that the acidic precursor of CBD (cannabidiolic acid, CBDA) is able to inhibit the migration of breast cancer cells and …
These activities seem to involve also alternative pathways, such as the interactions with TRPV and GRP55 receptor complexes. Moreover, the f …
Complete biosynthesis of cannabinoids and their unnatural analogues in yeast.
Luo X, Reiter MA, d'Espaux L, Wong J, Denby CM, Lechner A, Zhang Y, Grzybowski AT, Harth S, Lin W, Lee H, Yu C, Shin J, Deng K, Benites VT, Wang G, Baidoo EEK, Chen Y, Dev I, Petzold CJ, Keasling JD. Luo X, et al. Nature. 2019 Mar;567(7746):123-126. doi: 10.1038/s41586-019-0978-9. Epub 2019 Feb 27. Nature. 2019. PMID: 30814733
Here we report the complete biosynthesis of the major cannabinoids cannabigerolic acid, delta(9)-tetrahydrocannabinolic acid, cannabidiolic acid, delta(9)-tetrahydrocannabivarinic acid and cannabidivarinic acid in Saccharomyces cerevisiae …
Here we report the complete biosynthesis of the major cannabinoids cannabigerolic acid, delta(9)-tetrahydrocannabinolic acid, …
Behavioural and molecular effects of cannabidiolic acid in mice.
Alegre-Zurano L, Martín-Sánchez A, Valverde O. Alegre-Zurano L, et al. Life Sci. 2020 Oct 15;259:118271. doi: 10.1016/j.lfs.2020.118271. Epub 2020 Aug 13. Life Sci. 2020. PMID: 32798553
AIMS: Cannabidiolic acid (CBDA) is one of the most abundant phytocannabinoid acids in the Cannabis sativa plant. ...
AIMS: Cannabidiolic acid (CBDA) is one of the most abundant phytocannabinoid acids in the Cannabis sativa plant. ...
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