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1969 1
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2019 14
2020 15
2021 6
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71 results
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Cannabidivarin Treatment Ameliorates Autism-Like Behaviors and Restores Hippocampal Endocannabinoid System and Glia Alterations Induced by Prenatal Valproic Acid Exposure in Rats.
Zamberletti E, Gabaglio M, Woolley-Roberts M, Bingham S, Rubino T, Parolaro D. Zamberletti E, et al. Front Cell Neurosci. 2019 Aug 9;13:367. doi: 10.3389/fncel.2019.00367. eCollection 2019. Front Cell Neurosci. 2019. PMID: 31447649 Free PMC article.
In this scenario, phytocannabinoids could hold great pharmacological potential due to their combined capacities to act either directly or indirectly on components of the endocannabinoid system and to modulate immune functions. Among all plant-cannabinoids, the phytocannabinoid …
In this scenario, phytocannabinoids could hold great pharmacological potential due to their combined capacities to act either directly or in …
Nonpsychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: potential for the treatment of neuronal hyperexcitability.
Iannotti FA, Hill CL, Leo A, Alhusaini A, Soubrane C, Mazzarella E, Russo E, Whalley BJ, Di Marzo V, Stephens GJ. Iannotti FA, et al. ACS Chem Neurosci. 2014 Nov 19;5(11):1131-41. doi: 10.1021/cn5000524. Epub 2014 Jul 29. ACS Chem Neurosci. 2014. PMID: 25029033
Recent evidence suggests that the transient receptor potential cation channel subfamily V member 1 (TRPV1) may contribute to the onset and progression of some forms of epilepsy. Since the two nonpsychotropic cannabinoids cannabidivarin (CBDV) and cannabidiol (CBD) exert an …
Recent evidence suggests that the transient receptor potential cation channel subfamily V member 1 (TRPV1) may contribute to the onset and p …
Low doses of widely consumed cannabinoids (cannabidiol and cannabidivarin) cause DNA damage and chromosomal aberrations in human-derived cells.
Russo C, Ferk F, Mišík M, Ropek N, Nersesyan A, Mejri D, Holzmann K, Lavorgna M, Isidori M, Knasmüller S. Russo C, et al. Arch Toxicol. 2019 Jan;93(1):179-188. doi: 10.1007/s00204-018-2322-9. Epub 2018 Oct 19. Arch Toxicol. 2019. PMID: 30341733 Free PMC article.
Cannabidiol (CBD) and cannabidivarin (CBDV) are natural cannabinoids which are consumed in increasing amounts worldwide in cannabis extracts, as they prevent epilepsy, anxiety, and seizures. ...
Cannabidiol (CBD) and cannabidivarin (CBDV) are natural cannabinoids which are consumed in increasing amounts worldwide in cannabis e …
Effects of cannabidivarin (CBDV) on brain excitation and inhibition systems in adults with and without Autism Spectrum Disorder (ASD): a single dose trial during magnetic resonance spectroscopy.
Pretzsch CM, Voinescu B, Lythgoe D, Horder J, Mendez MA, Wichers R, Ajram L, Ivin G, Heasman M, Edden RAE, Williams S, Murphy DGM, Daly E, McAlonan GM. Pretzsch CM, et al. Transl Psychiatry. 2019 Nov 20;9(1):313. doi: 10.1038/s41398-019-0654-8. Transl Psychiatry. 2019. PMID: 31748505 Free PMC article. Clinical Trial.
This has led some families and researchers to trial alternative remedies - including the non-intoxicating Cannabis sativa-derived compound cannabidivarin (CBDV). However, how CBDV affects the human brain is unknown. ...
This has led some families and researchers to trial alternative remedies - including the non-intoxicating Cannabis sativa-derived compound …
Pharmacology of cannabinoids in the treatment of epilepsy.
Gaston TE, Friedman D. Gaston TE, et al. Epilepsy Behav. 2017 May;70(Pt B):313-318. doi: 10.1016/j.yebeh.2016.11.016. Epub 2017 Jan 10. Epilepsy Behav. 2017. PMID: 28087250 Review.
This article summarizes the available scientific data of pharmacology from human and animal studies on the major cannabinoids which have been of interest in the treatment of epilepsy, including 9-tetrahydrocannabinol (9-THC), cannabidiol (CBD), 9-tetrahydrocannabivarin (9-THCV), …
This article summarizes the available scientific data of pharmacology from human and animal studies on the major cannabinoids which have bee …
Molecular Pharmacology of Phytocannabinoids.
Turner SE, Williams CM, Iversen L, Whalley BJ. Turner SE, et al. Prog Chem Org Nat Prod. 2017;103:61-101. doi: 10.1007/978-3-319-45541-9_3. Prog Chem Org Nat Prod. 2017. PMID: 28120231 Review.
This chapter presents an overview of the molecular pharmacology of the seven most thoroughly investigated phytocannabinoids, namely delta(9)-tetrahydrocannabinol, delta(9)-tetrahydrocannabivarin, cannabinol, cannabidiol, cannabidivarin, cannabigerol, and cannabichromene. T …
This chapter presents an overview of the molecular pharmacology of the seven most thoroughly investigated phytocannabinoids, namely delta(9) …
Cannabidivarin for HIV-Associated Neuropathic Pain: A Randomized, Blinded, Controlled Clinical Trial.
Eibach L, Scheffel S, Cardebring M, Lettau M, Özgür Celik M, Morguet A, Roehle R, Stein C. Eibach L, et al. Clin Pharmacol Ther. 2021 Apr;109(4):1055-1062. doi: 10.1002/cpt.2016. Epub 2020 Sep 6. Clin Pharmacol Ther. 2021. PMID: 32770831
Because current treatment strategies often lack satisfying pain relief, cannabinoids (CBs) are discussed as a new option. We investigated cannabidivarin (CBDV) as treatment for HIV-associated neuropathic pain. ...
Because current treatment strategies often lack satisfying pain relief, cannabinoids (CBs) are discussed as a new option. We investigated …
Cannabidivarin completely rescues cognitive deficits and delays neurological and motor defects in male Mecp2 mutant mice.
Zamberletti E, Gabaglio M, Piscitelli F, Brodie JS, Woolley-Roberts M, Barbiero I, Tramarin M, Binelli G, Landsberger N, Kilstrup-Nielsen C, Rubino T, Di Marzo V, Parolaro D. Zamberletti E, et al. J Psychopharmacol. 2019 Jul;33(7):894-907. doi: 10.1177/0269881119844184. Epub 2019 May 14. J Psychopharmacol. 2019. PMID: 31084246 Free article.
BACKGROUND: Recent evidence suggests that 2-week treatment with the non-psychotomimetic cannabinoid cannabidivarin (CBDV) could be beneficial towards neurological and social deficits in early symptomatic Mecp2 mutant mice, a model of Rett syndrome (RTT). ...
BACKGROUND: Recent evidence suggests that 2-week treatment with the non-psychotomimetic cannabinoid cannabidivarin (CBDV) could be be …
Preclinical safety and efficacy of cannabidivarin for early life seizures.
Huizenga MN, Sepulveda-Rodriguez A, Forcelli PA. Huizenga MN, et al. Neuropharmacology. 2019 Apr;148:189-198. doi: 10.1016/j.neuropharm.2019.01.002. Epub 2019 Jan 10. Neuropharmacology. 2019. PMID: 30633929 Free PMC article.
There is growing interest in new targets, such as cannabidiol (CBD) and its propyl analog cannabidivarin (CBDV) for early life indications. While CBD was recently approved for treatment of refractory childhood epilepsies, little is known about the efficacy or safety of CBD …
There is growing interest in new targets, such as cannabidiol (CBD) and its propyl analog cannabidivarin (CBDV) for early life indica …
A systematic review of minor phytocannabinoids with promising neuroprotective potential.
Stone NL, Murphy AJ, England TJ, O'Sullivan SE. Stone NL, et al. Br J Pharmacol. 2020 Oct;177(19):4330-4352. doi: 10.1111/bph.15185. Epub 2020 Sep 1. Br J Pharmacol. 2020. PMID: 32608035 Free PMC article. Review.
Embase and PubMed were systematically searched for articles addressing the neuroprotective properties of phytocannabinoids, apart from cannabidiol and delta(9) -tetrahydrocannabinol, including delta(9) -tetrahydrocannabinolic acid, delta(9) -tetrahydrocannabivarin, cannabidiolic …
Embase and PubMed were systematically searched for articles addressing the neuroprotective properties of phytocannabinoids, apart from canna …
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