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Study protocol for a randomised, double-blind, placebo-controlled study evaluating the Efficacy of cannabis-based Medicine Extract in slowing the disease pRogression of Amyotrophic Lateral sclerosis or motor neurone Disease: the EMERALD trial.
Urbi B, Broadley S, Bedlack R, Russo E, Sabet A. Urbi B, et al. BMJ Open. 2019 Nov 11;9(11):e029449. doi: 10.1136/bmjopen-2019-029449. BMJ Open. 2019. PMID: 31719072 Free PMC article.
INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with no known cure and with an average life expectancy of 3-5 years post diagnosis. ...METHODS AND ANALYSIS: The Efficacy of cannabis-based Medicine Extract in slowing the disea …
INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with no known cure and with an average life …
Cannabinoids and the expanded endocannabinoid system in neurological disorders.
Cristino L, Bisogno T, Di Marzo V. Cristino L, et al. Nat Rev Neurol. 2020 Jan;16(1):9-29. doi: 10.1038/s41582-019-0284-z. Epub 2019 Dec 12. Nat Rev Neurol. 2020. PMID: 31831863 Review.
Anecdotal evidence that cannabis preparations have medical benefits together with the discovery of the psychotropic plant cannabinoid Δ(9)-tetrahydrocannabinol (THC) initiated efforts to develop cannabinoid-based therapeutics. ...In this Review, we provide an overview of t …
Anecdotal evidence that cannabis preparations have medical benefits together with the discovery of the psychotropic plant cannabinoid …
Complementary and Alternative Therapies in Amyotrophic Lateral Sclerosis.
Bedlack RS, Joyce N, Carter GT, Paganoni S, Karam C. Bedlack RS, et al. Neurol Clin. 2015 Nov;33(4):909-36. doi: 10.1016/j.ncl.2015.07.008. Epub 2015 Sep 8. Neurol Clin. 2015. PMID: 26515629 Free PMC article. Review.
Given the severity of their illness and lack of effective disease-modifying agents, it is not surprising that most patients with amyotrophic lateral sclerosis (ALS) consider trying complementary and alternative therapies. Some of the most commonly considered alterna …
Given the severity of their illness and lack of effective disease-modifying agents, it is not surprising that most patients with amyotrop
Endocannabinoids in Multiple Sclerosis and Amyotrophic Lateral Sclerosis.
Pryce G, Baker D. Pryce G, et al. Handb Exp Pharmacol. 2015;231:213-31. doi: 10.1007/978-3-319-20825-1_7. Handb Exp Pharmacol. 2015. PMID: 26408162 Review.
There are numerous reports that people with multiple sclerosis (MS) have for many years been self-medicating with illegal street cannabis or more recently medicinal cannabis to alleviate the symptoms associated with MS and also amyotrophic lateral scle …
There are numerous reports that people with multiple sclerosis (MS) have for many years been self-medicating with illegal street cannabis
Pros and Cons of Medical Cannabis use by People with Chronic Brain Disorders.
Suryadevara U, Bruijnzeel DM, Nuthi M, Jagnarine DA, Tandon R, Bruijnzeel AW. Suryadevara U, et al. Curr Neuropharmacol. 2017;15(6):800-814. doi: 10.2174/1570159X14666161101095325. Curr Neuropharmacol. 2017. PMID: 27804883 Free PMC article. Review.
BACKGROUND: Cannabis is the most widely used illicit drug in the world and there is growing concern about the mental health effects of cannabis use. ...Cannabis is widely used to self-medicate by older people and people with brain disorders such as amyotro
BACKGROUND: Cannabis is the most widely used illicit drug in the world and there is growing concern about the mental health effects o …
Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review.
Deepmala, Slattery J, Kumar N, Delhey L, Berk M, Dean O, Spielholz C, Frye R. Deepmala, et al. Neurosci Biobehav Rev. 2015 Aug;55:294-321. doi: 10.1016/j.neubiorev.2015.04.015. Epub 2015 May 6. Neurosci Biobehav Rev. 2015. PMID: 25957927 Free article. Review.
In this systematic review we find favorable evidence for the use of NAC in several psychiatric and neurological disorders, particularly autism, Alzheimer's disease, cocaine and cannabis addiction, bipolar disorder, depression, trichotillomania, nail biting, skin picking, o …
In this systematic review we find favorable evidence for the use of NAC in several psychiatric and neurological disorders, particularly auti …
A Systematic Review of the Effectiveness of Medical Cannabis for Psychiatric, Movement and Neurodegenerative Disorders.
Lim K, See YM, Lee J. Lim K, et al. Clin Psychopharmacol Neurosci. 2017 Nov 30;15(4):301-312. doi: 10.9758/cpn.2017.15.4.301. Clin Psychopharmacol Neurosci. 2017. PMID: 29073741 Free PMC article. Review.
The discovery of endocannabinoid's role within the central nervous system and its potential therapeutic benefits have brought forth rising interest in the use of cannabis for medical purposes. ...There is a lack of evidence on the therapeutic effects of cannabinoids for …
The discovery of endocannabinoid's role within the central nervous system and its potential therapeutic benefits have brought forth rising i …
Cannabis and cannabinoids.
[No authors listed] [No authors listed] Med Lett Drugs Ther. 2019 Nov 18;61(1585):179-182. Med Lett Drugs Ther. 2019. PMID: 31770357 Review. No abstract available.
Neurological Aspects of Medical Use of Cannabidiol.
Mannucci C, Navarra M, Calapai F, Spagnolo EV, Busardò FP, Cas RD, Ippolito FM, Calapai G. Mannucci C, et al. CNS Neurol Disord Drug Targets. 2017;16(5):541-553. doi: 10.2174/1871527316666170413114210. CNS Neurol Disord Drug Targets. 2017. PMID: 28412918 Review.
BACKGROUND: Cannabidiol (CBD) is among the major secondary metabolites of Cannabis devoid of the delta-9-tetra-hydrocannabinol psychoactive effects. ...RESULTS: Laboratory and clinical studies on the potential role of CBD in Parkinson's disease (PD), Alzheimer's disease (A …
BACKGROUND: Cannabidiol (CBD) is among the major secondary metabolites of Cannabis devoid of the delta-9-tetra-hydrocannabinol psycho …
Can cannabinoids be a potential therapeutic tool in amyotrophic lateral sclerosis?
Giacoppo S, Mazzon E. Giacoppo S, et al. Neural Regen Res. 2016 Dec;11(12):1896-1899. doi: 10.4103/1673-5374.197125. Neural Regen Res. 2016. PMID: 28197175 Free PMC article. Review.
Amyotrophic lateral sclerosis (ALS) is the most common degenerative disease of the motor neuron system. Over the last years, a growing interest was aimed to discovery new innovative and safer therapeutic approaches in the ALS treatment. In this context, the bioactiv
Amyotrophic lateral sclerosis (ALS) is the most common degenerative disease of the motor neuron system. Over the last years, a
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