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Year Number of Results
2001 2
2004 1
2007 1
2008 1
2014 1
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2017 1
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2021 4
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2025 7
2026 2

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Page 1
Opioids for Chronic Noncancer Pain: A Systematic Review and Meta-analysis.
Busse JW, Wang L, Kamaleldin M, Craigie S, Riva JJ, Montoya L, Mulla SM, Lopes LC, Vogel N, Chen E, Kirmayr K, De Oliveira K, Olivieri L, Kaushal A, Chaparro LE, Oyberman I, Agarwal A, Couban R, Tsoi L, Lam T, Vandvik PO, Hsu S, Bala MM, Schandelmaier S, Scheidecker A, Ebrahim S, Ashoorion V, Rehman Y, Hong PJ, Ross S, Johnston BC, Kunz R, Sun X, Buckley N, Sessler DI, Guyatt GH. Busse JW, et al. JAMA. 2018 Dec 18;320(23):2448-2460. doi: 10.1001/jama.2018.18472. JAMA. 2018. PMID: 30561481 Free PMC article.
DATA SOURCES AND STUDY SELECTION: The databases of CENTRAL, CINAHL, EMBASE, MEDLINE, AMED, and PsycINFO were searched from inception to April 2018 for RCTs of opioids for chronic noncancer pain vs any nonopioid control. ...Of the included studies, there were 25 trials of n …
DATA SOURCES AND STUDY SELECTION: The databases of CENTRAL, CINAHL, EMBASE, MEDLINE, AMED, and PsycINFO were searched from inception …
2022 ISFM Consensus Guidelines on the Management of Acute Pain in Cats.
Steagall PV, Robertson S, Simon B, Warne LN, Shilo-Benjamini Y, Taylor S. Steagall PV, et al. J Feline Med Surg. 2022 Jan;24(1):4-30. doi: 10.1177/1098612X211066268. J Feline Med Surg. 2022. PMID: 34937455 Free PMC article.
The unique challenges of feline metabolism and comorbidities may lead to undertreatment of pain and the development of peripheral and central sensitisation. Lack of availability or experience with various analgesic drugs may compromise effective pain management. ...
The unique challenges of feline metabolism and comorbidities may lead to undertreatment of pain and the development of peripheral and cen …
Cannabinoids in headache: helpful or harmful?
Kuruvilla DE. Kuruvilla DE. Curr Opin Neurol. 2025 Jun 1;38(3):277-280. doi: 10.1097/WCO.0000000000001364. Epub 2025 Mar 29. Curr Opin Neurol. 2025. PMID: 40152937 Review.
Additionally, emerging studies suggest that cannabinoids may enhance neuronal resilience and mitigate central sensitization in chronic migraine. Research into optimal delivery mechanisms, including inhaled, sublingual, and transdermal formulations, is also expanding …
Additionally, emerging studies suggest that cannabinoids may enhance neuronal resilience and mitigate central sensitization in …
Neuronal substrates and functional consequences of prenatal cannabis exposure.
Calvigioni D, Hurd YL, Harkany T, Keimpema E. Calvigioni D, et al. Eur Child Adolesc Psychiatry. 2014 Oct;23(10):931-41. doi: 10.1007/s00787-014-0550-y. Epub 2014 May 3. Eur Child Adolesc Psychiatry. 2014. PMID: 24793873 Free PMC article. Review.
In this review, we emphasize the importance of maternal programming, defined as the intrauterine presentation of maternal stimuli to the foetus, in neurodevelopment. In particular, we focus on cannabis-mediated maternal adverse effects, resulting in direct central …
In this review, we emphasize the importance of maternal programming, defined as the intrauterine presentation of maternal stimuli to the foe …
The role of cannabinoids in pain modulation in companion animals.
Miranda-Cortés A, Mota-Rojas D, Crosignani-Outeda N, Casas-Alvarado A, Martínez-Burnes J, Olmos-Hernández A, Mora-Medina P, Verduzco-Mendoza A, Hernández-Ávalos I. Miranda-Cortés A, et al. Front Vet Sci. 2023 Jan 4;9:1050884. doi: 10.3389/fvets.2022.1050884. eCollection 2022. Front Vet Sci. 2023. PMID: 36686189 Free PMC article. Review.
On the other hand, CB2 receptors are associated with anti-inflammatory and analgesic reactions and effects on the immune system. Cannabis extracts and their synthetic derivatives are an effective therapeutic tool that contributes to compassionate pain care and parti …
On the other hand, CB2 receptors are associated with anti-inflammatory and analgesic reactions and effects on the immune system. C …
Cannabis-Based Medicines and Medical Cannabis in the Treatment of Nociplastic Pain.
Fitzcharles MA, Petzke F, Tölle TR, Häuser W. Fitzcharles MA, et al. Drugs. 2021 Dec;81(18):2103-2116. doi: 10.1007/s40265-021-01602-1. Epub 2021 Nov 20. Drugs. 2021. PMID: 34800285 Review.
Nociplastic pain is defined as pain due to sensitization of the nervous system, without a sufficient underlying anatomical abnormality to explain the severity of pain. Nociplastic pain may be manifest in various organ systems, is often perceived as being more …
Nociplastic pain is defined as pain due to sensitization of the nervous system, without a sufficient underlying anatomi …
The impact of tetrahydrocannabinol on central pain modulation in chronic pain: a randomized clinical comparative study of offset analgesia and conditioned pain modulation in fibromyalgia.
Agbaria Y, Preger R, Aloush V, Ablin JN, Sharon H, Jacob G. Agbaria Y, et al. J Cannabis Res. 2025 Nov 6;7(1):86. doi: 10.1186/s42238-025-00348-x. J Cannabis Res. 2025. PMID: 41199355 Free PMC article.
BACKGROUND: Tetrahydrocannabinol (THC) has shown efficacy in alleviating chronic pain, particularly in disorders characterized by central sensitization. Offset analgesia (OA) and conditioned pain modulation (CPM) are key biomarkers used to evaluate central pa …
BACKGROUND: Tetrahydrocannabinol (THC) has shown efficacy in alleviating chronic pain, particularly in disorders characterized by central …
Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes.
Russo EB. Russo EB. Cannabis Cannabinoid Res. 2016 Jul 1;1(1):154-165. doi: 10.1089/can.2016.0009. eCollection 2016. Cannabis Cannabinoid Res. 2016. PMID: 28861491 Free PMC article. Review.
The commonality in symptomatology in these conditions displaying hyperalgesia and central sensitization with possible common underlying pathophysiology suggests that a clinical endocannabinoid deficiency might characterize their origin. ...When first proposed in 200 …
The commonality in symptomatology in these conditions displaying hyperalgesia and central sensitization with possible common u …
UK Medical Cannabis Registry: a case series analysing clinical outcomes of medicinal cannabis therapy for fibromyalgia.
Varadpande M, Erridge S, Aggarwal A, Clarke E, McLachlan K, Coomber R, Barnes S, Darweish Medniuk A, Guru R, Holden W, Sajad M, Searle R, Usmani A, Varma S, Rucker JJ, Platt M, Sodergren MH. Varadpande M, et al. Clin Rheumatol. 2026 Mar;45(3):1927-1938. doi: 10.1007/s10067-025-07846-6. Epub 2025 Dec 4. Clin Rheumatol. 2026. PMID: 41343025 Free PMC article.

Higher CBD doses (> 25.00 mg/day) and previous cannabis use were associated with increased odds of improvement on fibromyalgia-specific scales (p < 0.050). 227 patients (45.67%) reported 2100 AEs (422.54%). ...The high incidence of AEs in relation to other patient co

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Higher CBD doses (> 25.00 mg/day) and previous cannabis use were associated with increased odds of improvement on fibromyalgia-spe …
25 results