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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1897 1
1954 1
1962 1
1965 2
1970 1
1971 2
1972 2
1973 1
1974 1
1975 27
1976 16
1977 13
1978 10
1979 17
1980 16
1981 27
1982 26
1983 40
1984 50
1985 46
1986 50
1987 35
1988 51
1989 76
1990 68
1991 81
1992 80
1993 77
1994 84
1995 85
1996 85
1997 93
1998 128
1999 114
2000 105
2001 98
2002 132
2003 139
2004 132
2005 121
2006 143
2007 130
2008 150
2009 184
2010 159
2011 185
2012 200
2013 202
2014 194
2015 183
2016 226
2017 206
2018 263
2019 248
2020 264
2021 307
2022 296
2023 273
2024 326
2025 346
2026 277

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6,294 results

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Page 1
Multi-chamber cardioids unravel human heart development and cardiac defects.
Schmidt C, Deyett A, Ilmer T, Haendeler S, Torres Caballero A, Novatchkova M, Netzer MA, Ceci Ginistrelli L, Mancheno Juncosa E, Bhattacharya T, Mujadzic A, Pimpale L, Jahnel SM, Cirigliano M, Reumann D, Tavernini K, Papai N, Hering S, Hofbauer P, Mendjan S. Schmidt C, et al. Cell. 2023 Dec 7;186(25):5587-5605.e27. doi: 10.1016/j.cell.2023.10.030. Epub 2023 Nov 28. Cell. 2023. PMID: 38029745 Free article.
The number one cause of human fetal death are defects in heart development. Because the human embryonic heart is inaccessible and the impacts of mutations, drugs, and environmental factors on the specialized functions of different heart compartments ar …
The number one cause of human fetal death are defects in heart development. Because the human embryonic heart is inacce …
Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging.
Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, Flachskampf FA, Foster E, Goldstein SA, Kuznetsova T, Lancellotti P, Muraru D, Picard MH, Rietzschel ER, Rudski L, Spencer KT, Tsang W, Voigt JU. Lang RM, et al. J Am Soc Echocardiogr. 2015 Jan;28(1):1-39.e14. doi: 10.1016/j.echo.2014.10.003. J Am Soc Echocardiogr. 2015. PMID: 25559473 Free article.
The rapid technological developments of the past decade and the changes in echocardiographic practice brought about by these developments have resulted in the need for updated recommendations to the previously published guidelines for cardiac chamber q …
The rapid technological developments of the past decade and the changes in echocardiographic practice brought about by these devel …
Cardioids reveal self-organizing principles of human cardiogenesis.
Hofbauer P, Jahnel SM, Papai N, Giesshammer M, Deyett A, Schmidt C, Penc M, Tavernini K, Grdseloff N, Meledeth C, Ginistrelli LC, Ctortecka C, Šalic Š, Novatchkova M, Mendjan S. Hofbauer P, et al. Cell. 2021 Jun 10;184(12):3299-3317.e22. doi: 10.1016/j.cell.2021.04.034. Epub 2021 May 20. Cell. 2021. PMID: 34019794 Free article.
Organoids capable of forming tissue-like structures have transformed our ability to model human development and disease. With the notable exception of the human heart, lineage-specific self-organizing organoids have been reported for all major organs. ...We find tha …
Organoids capable of forming tissue-like structures have transformed our ability to model human development and disease. With the not …
Cardiac chamber formation: development, genes, and evolution.
Moorman AF, Christoffels VM. Moorman AF, et al. Physiol Rev. 2003 Oct;83(4):1223-67. doi: 10.1152/physrev.00006.2003. Physiol Rev. 2003. PMID: 14506305 Free article. Review.
Concepts of cardiac development have greatly influenced the description of the formation of the four-chambered vertebrate heart. ...Therefore, the current description needed reconsideration, and we decided to evaluate the essentialities of cardiac …
Concepts of cardiac development have greatly influenced the description of the formation of the four-chambered vertebra …
Development of the human heart.
Buijtendijk MFJ, Barnett P, van den Hoff MJB. Buijtendijk MFJ, et al. Am J Med Genet C Semin Med Genet. 2020 Mar;184(1):7-22. doi: 10.1002/ajmg.c.31778. Epub 2020 Feb 12. Am J Med Genet C Semin Med Genet. 2020. PMID: 32048790 Free PMC article. Review.
In 2014, an extensive review discussing the major steps of cardiac development focusing on growth, formation of primary and chamber myocardium and the development of the cardiac electrical system, was published. ...Despite the enormous ad …
In 2014, an extensive review discussing the major steps of cardiac development focusing on growth, formation of primary …
Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease.
Lewis-Israeli YR, Wasserman AH, Gabalski MA, Volmert BD, Ming Y, Ball KA, Yang W, Zou J, Ni G, Pajares N, Chatzistavrou X, Li W, Zhou C, Aguirre A. Lewis-Israeli YR, et al. Nat Commun. 2021 Aug 26;12(1):5142. doi: 10.1038/s41467-021-25329-5. Nat Commun. 2021. PMID: 34446706 Free PMC article.
Organoids are generated through a three-step Wnt signaling modulation strategy using chemical inhibitors and growth factors. Heart organoids are comparable to age-matched human fetal cardiac tissues at the transcriptomic, structural, and cellular level. They …
Organoids are generated through a three-step Wnt signaling modulation strategy using chemical inhibitors and growth factors. Heart …
Differential chamber-specific expression and regulation of long non-coding RNAs during cardiac development.
García-Padilla C, Domínguez JN, Aránega AE, Franco D. García-Padilla C, et al. Biochim Biophys Acta Gene Regul Mech. 2019 Oct;1862(10):194435. doi: 10.1016/j.bbagrm.2019.194435. Epub 2019 Nov 1. Biochim Biophys Acta Gene Regul Mech. 2019. PMID: 31678627 Review.
More recently long non-coding RNAs have been also reported to modulate gene expression and function in the developing heart, as exemplified by the embryonic lethal phenotypes of Fendrr and Braveheart knock out mice, respectively. In this study, we investigated the d …
More recently long non-coding RNAs have been also reported to modulate gene expression and function in the developing heart, a …
Cardiac Development and Animal Models of Congenital Heart Defects.
Kelly RG. Kelly RG. Adv Exp Med Biol. 2024;1441:77-85. doi: 10.1007/978-3-031-44087-8_3. Adv Exp Med Biol. 2024. PMID: 38884705 Review.
The major events of cardiac development, including early heart formation, chamber morphogenesis and septation, and conduction system and coronary artery development, are briefly reviewed together with a short introduction to the animal species c …
The major events of cardiac development, including early heart formation, chamber morphogenesis and septation, a …
Generation of human vascularized and chambered cardiac organoids for cardiac disease modelling and drug evaluation.
Yang J, Lei W, Xiao Y, Tan S, Yang J, Lin Y, Yang Z, Zhao D, Zhang C, Shen Z, Hu S. Yang J, et al. Cell Prolif. 2024 Aug;57(8):e13631. doi: 10.1111/cpr.13631. Epub 2024 Mar 7. Cell Prolif. 2024. PMID: 38453465 Free PMC article.
Human induced pluripotent stem cell (hiPSC)-derived cardiac organoids (COs) have shown great potential in modelling human heart development and cardiovascular diseases, a leading cause of global death. ...In addition, the human vcCOs exhibited an obvious drug …
Human induced pluripotent stem cell (hiPSC)-derived cardiac organoids (COs) have shown great potential in modelling human heart …
Development of the cardiac conduction system: a matter of chamber development.
Moorman AF, Christoffels VM. Moorman AF, et al. Novartis Found Symp. 2003;250:25-34; discussion 34-43, 276-9. Novartis Found Symp. 2003. PMID: 12956322 Review.
Within one day after the formation of the linear heart an adult type of electrocardiogram (ECG) can be monitored, reflecting the development of coordinated activation of the heart. The possibility that during evolution and ontogenesis of the heat, this dev …
Within one day after the formation of the linear heart an adult type of electrocardiogram (ECG) can be monitored, reflecting the d …
6,294 results