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Mitochondrial fatty acid oxidation alterations in heart failure, ischaemic heart disease and diabetic cardiomyopathy.
Fillmore N, Mori J, Lopaschuk GD. Fillmore N, et al. Br J Pharmacol. 2014 Apr;171(8):2080-90. doi: 10.1111/bph.12475. Br J Pharmacol. 2014. PMID: 24147975 Free PMC article. Review.
Heart disease is a leading cause of death worldwide. In many forms of heart disease, including heart failure, ischaemic heart disease and diabetic cardiomyopathies, changes in cardiac mitochondrial energy metabolism contribu
Heart disease is a leading cause of death worldwide. In many forms of heart disease, including heart failure, ischaemic
Mitochondrial uncoupling, ROS generation and cardioprotection.
Cadenas S. Cadenas S. Biochim Biophys Acta Bioenerg. 2018 Sep;1859(9):940-950. doi: 10.1016/j.bbabio.2018.05.019. Epub 2018 May 31. Biochim Biophys Acta Bioenerg. 2018. PMID: 29859845 Free article. Review.
It is well established that mitochondrial superoxide production is steeply dependent on Δp in isolated mitochondria and, correspondingly, mitochondrial uncoupling has been identified as a cytoprotective strategy under conditions of oxidative stress, including diabetes, dru …
It is well established that mitochondrial superoxide production is steeply dependent on Δp in isolated mitochondria and, correspondingly, mi …
Lipopolysaccharide (LPS) Aggravates High Glucose- and Hypoxia/Reoxygenation-Induced Injury through Activating ROS-Dependent NLRP3 Inflammasome-Mediated Pyroptosis in H9C2 Cardiomyocytes.
Qiu Z, He Y, Ming H, Lei S, Leng Y, Xia ZY. Qiu Z, et al. J Diabetes Res. 2019 Feb 17;2019:8151836. doi: 10.1155/2019/8151836. eCollection 2019. J Diabetes Res. 2019. PMID: 30911553 Free PMC article.
Diabetes aggravates myocardial ischemia-reperfusion (I/R) injury because of the combination effects of changes in glucose and lipid energy metabolism, oxidative stress, and systemic inflammatory response. ...The results indicated that pretreatment LPS
Diabetes aggravates myocardial ischemia-reperfusion (I/R) injury because of the combination effects of changes in glucose and
Inhibition of sodium-glucose cotransporter-2 preserves cardiac function during regional myocardial ischemia independent of alterations in myocardial substrate utilization.
Baker HE, Kiel AM, Luebbe ST, Simon BR, Earl CC, Regmi A, Roell WC, Mather KJ, Tune JD, Goodwill AG. Baker HE, et al. Basic Res Cardiol. 2019 Apr 19;114(3):25. doi: 10.1007/s00395-019-0733-2. Basic Res Cardiol. 2019. PMID: 31004234 Free PMC article.
The goal of the present study was to evaluate the effects of SGLT2i on cardiac contractile function, substrate utilization, and efficiency before and during regional myocardial ischemia/reperfusion injury in normal, metabolically healthy swine. ...These data …
The goal of the present study was to evaluate the effects of SGLT2i on cardiac contractile function, substrate utilization, and ef
Fibroblast growth factor 19 improves cardiac function and mitochondrial energy homoeostasis in the diabetic heart.
Xu W, Wang Y, Guo Y, Liu J, Ma L, Cao W, Yu B, Zhou Y. Xu W, et al. Biochem Biophys Res Commun. 2018 Oct 20;505(1):242-248. doi: 10.1016/j.bbrc.2018.09.046. Epub 2018 Sep 20. Biochem Biophys Res Commun. 2018. PMID: 30243718
In this study, we investigated the effects of FGF19 on energy metabolism. FGF19 treatment of diabetic hearts exhibited higher glucose uptake and lower lipid profiles, suggesting changes in energy metabolism. ...Taken together, these resul …
In this study, we investigated the effects of FGF19 on energy metabolism. FGF19 treatment of diabetic hearts exh …
Impact of Nutrition on Cardiovascular Function.
Bianchi VE. Bianchi VE. Curr Probl Cardiol. 2020 Jan;45(1):100391. doi: 10.1016/j.cpcardiol.2018.08.003. Epub 2018 Sep 11. Curr Probl Cardiol. 2020. PMID: 30318107 Review.
However, myocardial efficiency is influenced by metabolic condition, overload, and ischemia. During cardiac stress, cardiomyocytes increase glucose oxidation and reduce FFA oxidation. ...An energy-restricted diet improves myocardial efficiency b …
However, myocardial efficiency is influenced by metabolic condition, overload, and ischemia. During cardiac stress, car …
Insulin and the heart.
Iliadis F, Kadoglou N, Didangelos T. Iliadis F, et al. Diabetes Res Clin Pract. 2011 Aug;93 Suppl 1:S86-91. doi: 10.1016/S0168-8227(11)70019-5. Diabetes Res Clin Pract. 2011. PMID: 21864757 Review.
Insulin, promoting glucose as the main cardiac energy substrate, reduces myocardial O(2) consumption and increases cardiac efficiency. ...Thus, insulin acts directly on heart muscle, and this action is mediated principally through PKB/Akt signal …
Insulin, promoting glucose as the main cardiac energy substrate, reduces myocardial O(2) consumption and increases cardiac
Metabolism, hypoxia and the diabetic heart.
Heather LC, Clarke K. Heather LC, et al. J Mol Cell Cardiol. 2011 Apr;50(4):598-605. doi: 10.1016/j.yjmcc.2011.01.007. Epub 2011 Jan 22. J Mol Cell Cardiol. 2011. PMID: 21262230 Review.
Fatty acid uptake and metabolism are increased in the type 2 diabetic heart, resulting in accumulation of intracellular lipid intermediates and an increased contribution of fatty acids towards energy generation. ...These metabolic changes decrease c
Fatty acid uptake and metabolism are increased in the type 2 diabetic heart, resulting in accumulation of intracellular …
Ablation of LKB1 in the heart leads to energy deprivation and impaired cardiac function.
Jessen N, Koh HJ, Folmes CD, Wagg C, Fujii N, Løfgren B, Wolf CM, Berul CI, Hirshman MF, Lopaschuk GD, Goodyear LJ. Jessen N, et al. Biochim Biophys Acta. 2010 Jul-Aug;1802(7-8):593-600. doi: 10.1016/j.bbadis.2010.04.008. Epub 2010 May 2. Biochim Biophys Acta. 2010. PMID: 20441792 Free PMC article.
Heart rates of LKB1-KO mice were reduced and ventricle diameter was increased. Ex vivo, cardiac function was impaired during aerobic perfusion of isolated working hearts, and recovery of function after ischemia was reduced. ...Ablation of LKB1 leads to
Heart rates of LKB1-KO mice were reduced and ventricle diameter was increased. Ex vivo, cardiac function was impaired during a
Rosiglitazone treatment improves cardiac efficiency in hearts from diabetic mice.
How OJ, Larsen TS, Hafstad AD, Khalid A, Myhre ES, Murray AJ, Boardman NT, Cole M, Clarke K, Severson DL, Aasum E. How OJ, et al. Arch Physiol Biochem. 2007 Oct-Dec;113(4-5):211-20. doi: 10.1080/13813450701783281. Arch Physiol Biochem. 2007. PMID: 18158644
Isolated perfused hearts from type 2 diabetic (db/db) mice show impaired ventricular function, as well as altered cardiac metabolism. ...Rosiglitazone treatment also improved functional recovery after low-flow ischemia. In conclusion, the presen …
Isolated perfused hearts from type 2 diabetic (db/db) mice show impaired ventricular function, as well as altered cardiac
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