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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2006 1
2007 1
2008 6
2009 5
2010 8
2011 11
2012 21
2013 24
2014 35
2015 41
2016 42
2017 36
2018 52
2019 38
2020 18
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303 results
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Page 1
Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets.
Tham YK, Bernardo BC, Ooi JY, Weeks KL, McMullen JR. Tham YK, et al. Arch Toxicol. 2015 Sep;89(9):1401-38. doi: 10.1007/s00204-015-1477-x. Epub 2015 Feb 24. Arch Toxicol. 2015. PMID: 25708889 Review.
The onset of heart failure is typically preceded by cardiac hypertrophy, a response of the heart to increased workload, a cardiac insult such as a heart attack or genetic mutation. ...We also highlight mediators and processes which contri …
The onset of heart failure is typically preceded by cardiac hypertrophy, a response of the heart to increased wo …
Physiological and pathological cardiac hypertrophy.
Shimizu I, Minamino T. Shimizu I, et al. J Mol Cell Cardiol. 2016 Aug;97:245-62. doi: 10.1016/j.yjmcc.2016.06.001. Epub 2016 Jun 2. J Mol Cell Cardiol. 2016. PMID: 27262674 Review.
Cardiac hypertrophy is classified as physiological when it is associated with normal cardiac function or as pathological when associated with cardiac dysfunction. ...Pathological hypertrophy is associated with fibrosis, capillary rarefaction, increased produc
Cardiac hypertrophy is classified as physiological when it is associated with normal cardiac function or as pathological when
Diabetic Cardiomyopathy: An Update of Mechanisms Contributing to This Clinical Entity.
Jia G, Hill MA, Sowers JR. Jia G, et al. Circ Res. 2018 Feb 16;122(4):624-638. doi: 10.1161/CIRCRESAHA.117.311586. Circ Res. 2018. PMID: 29449364 Free PMC article. Review.
In people with diabetes mellitus, the presence of myocardial dysfunction in the absence of overt clinical coronary artery disease, valvular disease, and other conventional cardiovascular risk factors, such as hypertension and dyslipidemia, has led to the desc …
In people with diabetes mellitus, the presence of myocardial dysfunction in the absence of overt clinical coronary artery disease, va …
Reverse remodelling and myocardial recovery in heart failure.
Kim GH, Uriel N, Burkhoff D. Kim GH, et al. Nat Rev Cardiol. 2018 Feb;15(2):83-96. doi: 10.1038/nrcardio.2017.139. Epub 2017 Sep 21. Nat Rev Cardiol. 2018. PMID: 28933783 Review.
Among heart failure therapies, durable mechanical circulatory support is most consistently associated with the largest degree of reverse remodelling. ...In this Review, we summarize the latest findings on reverse remodelling and myocardial recovery. Ac …
Among heart failure therapies, durable mechanical circulatory support is most consistently associated with the largest degree …
Myocardial infarction-induced microRNA-enriched exosomes contribute to cardiac Nrf2 dysregulation in chronic heart failure.
Tian C, Gao L, Zimmerman MC, Zucker IH. Tian C, et al. Am J Physiol Heart Circ Physiol. 2018 May 1;314(5):H928-H939. doi: 10.1152/ajpheart.00602.2017. Epub 2018 Jan 26. Am J Physiol Heart Circ Physiol. 2018. PMID: 29373037 Free PMC article.
The imbalance between the synthesis of reactive oxygen species and their elimination by antioxidant defense systems results in macromolecular damage and disruption of cellular redox signaling, affecting cardiac structure and function, thus contributing to contractile dysfu …
The imbalance between the synthesis of reactive oxygen species and their elimination by antioxidant defense systems results in macromolecula …
MicroRNAs in Cardiac Hypertrophy.
Wehbe N, Nasser SA, Pintus G, Badran A, Eid AH, Baydoun E. Wehbe N, et al. Int J Mol Sci. 2019 Sep 23;20(19):4714. doi: 10.3390/ijms20194714. Int J Mol Sci. 2019. PMID: 31547607 Free PMC article. Review.
Like other organs, the heart undergoes normal adaptive remodeling, such as cardiac hypertrophy, with age. This remodeling, however, is intensified under stress and pathological conditions. Cardiac remodeling could be beneficial for a shor …
Like other organs, the heart undergoes normal adaptive remodeling, such as cardiac hypertrophy, with age. This remod
MicroRNA-31 promotes adverse cardiac remodeling and dysfunction in ischemic heart disease.
Martinez EC, Lilyanna S, Wang P, Vardy LA, Jiang X, Armugam A, Jeyaseelan K, Richards AM. Martinez EC, et al. J Mol Cell Cardiol. 2017 Nov;112:27-39. doi: 10.1016/j.yjmcc.2017.08.013. Epub 2017 Sep 1. J Mol Cell Cardiol. 2017. PMID: 28865712
OBJECTIVE: We aimed to identify novel aberrantly expressed cardiac microRNAs post-MI with potential roles in adverse remodeling in a rat model, and to provide post-ischemic therapeutic inhibition of a candidate pathological microRNA in vivo. ...CONCLUS …
OBJECTIVE: We aimed to identify novel aberrantly expressed cardiac microRNAs post-MI with potential roles in adverse remode
microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential.
Qiao L, Hu S, Liu S, Zhang H, Ma H, Huang K, Li Z, Su T, Vandergriff A, Tang J, Allen T, Dinh PU, Cores J, Yin Q, Li Y, Cheng K. Qiao L, et al. J Clin Invest. 2019 Apr 29;129(6):2237-2250. doi: 10.1172/JCI123135. eCollection 2019 Apr 29. J Clin Invest. 2019. PMID: 31033484 Free PMC article.
We isolated exosomes from explant-derived cardiac stromal cells from patients with heart failure (FEXO) or from normal donor hearts (NEXO) and compared their regenerative activities in vitro and in vivo. ...In contrast, FEXO therapy exacerbated cardiac
We isolated exosomes from explant-derived cardiac stromal cells from patients with heart failure (FEXO) or from normal …
A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223.
Wang K, Long B, Liu F, Wang JX, Liu CY, Zhao B, Zhou LY, Sun T, Wang M, Yu T, Gong Y, Liu J, Dong YH, Li N, Li PF. Wang K, et al. Eur Heart J. 2016 Sep 1;37(33):2602-11. doi: 10.1093/eurheartj/ehv713. Epub 2016 Jan 21. Eur Heart J. 2016. PMID: 26802132
AIMS: Sustained cardiac hypertrophy accompanied by maladaptive cardiac remodelling represents an early event in the clinical course leading to heart failure. ...Modulation of their levels provides an attractive therapeutic target for the treatme …
AIMS: Sustained cardiac hypertrophy accompanied by maladaptive cardiac remodelling represents an early event in the cli …
Molecular Mechanisms of Cardiac Remodeling and Regeneration in Physical Exercise.
Schüttler D, Clauss S, Weckbach LT, Brunner S. Schüttler D, et al. Cells. 2019 Sep 23;8(10):1128. doi: 10.3390/cells8101128. Cells. 2019. PMID: 31547508 Free PMC article. Review.
Regular physical activity with aerobic and muscle-strengthening training protects against the occurrence and progression of cardiovascular disease and can improve cardiac function in heart failure patients. ...These may open up innovative strate …
Regular physical activity with aerobic and muscle-strengthening training protects against the occurrence and progression of cardiovascula
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