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Page 1
Carnosic Acid as a Promising Agent in Protecting Mitochondria of Brain Cells.
de Oliveira MR. de Oliveira MR. Mol Neurobiol. 2018 Aug;55(8):6687-6699. doi: 10.1007/s12035-017-0842-6. Epub 2018 Jan 15. Mol Neurobiol. 2018. PMID: 29335845 Review.
Carnosic acid (CA; C(20)H(28)O(4)), a phenolic diterpene characterized as an ortho-dihydroquinone-type molecule, is a pro-electrophile agent that becomes an electrophile after reacting with free radicals. ...In the present review, it is described and discussed the e …
Carnosic acid (CA; C(20)H(28)O(4)), a phenolic diterpene characterized as an ortho-dihydroquinone-type molecule, is a pro-elec …
Carnosic Acid Mitigates Depression-Like Behavior in Ovariectomized Mice via Activation of Nrf2/HO-1 Pathway.
Samy DM, Mostafa DK, Saleh SR, Hassaan PS, Zeitoun TM, Ammar GAG, Elsokkary NH. Samy DM, et al. Mol Neurobiol. 2023 Feb;60(2):610-628. doi: 10.1007/s12035-022-03093-x. Epub 2022 Nov 4. Mol Neurobiol. 2023. PMID: 36331794 Free PMC article.
This study investigated the possible perturbation of the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways as an underlying mechanism of post-ovariectomy depression and highlighted the potential benefits of carnosic acid (CA) on the associ …
This study investigated the possible perturbation of the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways as an …
Protection from cyanide-induced brain injury by the Nrf2 transcriptional activator carnosic acid.
Zhang D, Lee B, Nutter A, Song P, Dolatabadi N, Parker J, Sanz-Blasco S, Newmeyer T, Ambasudhan R, McKercher SR, Masliah E, Lipton SA. Zhang D, et al. J Neurochem. 2015 Jun;133(6):898-908. doi: 10.1111/jnc.13074. Epub 2015 Mar 11. J Neurochem. 2015. PMID: 25692407 Free PMC article.
Here, as a potential preemptive countermeasure against a bioterrorist attack with cyanide, we tested the CNS protective effect of carnosic acid (CA), a pro-electrophilic compound found in the herb rosemary. CA crosses the blood-brain barrier to up-regulate en …
Here, as a potential preemptive countermeasure against a bioterrorist attack with cyanide, we tested the CNS protective effect of carnosi …
Nrf2-ARE activator carnosic acid decreases mitochondrial dysfunction, oxidative damage and neuronal cytoskeletal degradation following traumatic brain injury in mice.
Miller DM, Singh IN, Wang JA, Hall ED. Miller DM, et al. Exp Neurol. 2015 Feb;264:103-10. doi: 10.1016/j.expneurol.2014.11.008. Epub 2014 Nov 26. Exp Neurol. 2015. PMID: 25432068 Free PMC article.
Previous research has shown that neuronal mitochondria are susceptible to oxidative damage post-TBI, and thus the current study investigates whether Nrf2-ARE activation protects mitochondrial function when activated post-TBI. It was hypothesized that administration of c …
Previous research has shown that neuronal mitochondria are susceptible to oxidative damage post-TBI, and thus the current study investigates …
Potential Therapeutic Use of the Rosemary Diterpene Carnosic Acid for Alzheimer's Disease, Parkinson's Disease, and Long-COVID through NRF2 Activation to Counteract the NLRP3 Inflammasome.
Satoh T, Trudler D, Oh CK, Lipton SA. Satoh T, et al. Antioxidants (Basel). 2022 Jan 6;11(1):124. doi: 10.3390/antiox11010124. Antioxidants (Basel). 2022. PMID: 35052628 Free PMC article. Review.
CA exerts antioxidant, anti-inflammatory, and neuroprotective effects via phase 2 enzyme induction initiated by activation of the KEAP1/NRF2 transcriptional pathway, which in turn attenuates NLRP3 activation. ...Because CA has been shown to not only act systemically …
CA exerts antioxidant, anti-inflammatory, and neuroprotective effects via phase 2 enzyme induction initiated by activation of the KEA …
Administration of the Nrf2-ARE activators sulforaphane and carnosic acid attenuates 4-hydroxy-2-nonenal-induced mitochondrial dysfunction ex vivo.
Miller DM, Singh IN, Wang JA, Hall ED. Miller DM, et al. Free Radic Biol Med. 2013 Apr;57:1-9. doi: 10.1016/j.freeradbiomed.2012.12.011. Epub 2012 Dec 27. Free Radic Biol Med. 2013. PMID: 23275005 Free PMC article.
Young adult male CF-1 mice were administered one of two known Nrf2-ARE activators as single intraperitoneal doses-sulforaphane (SFP; 5.0mg/kg) or carnosic acid (CA; 1.0mg/kg)-or their respective vehicles 48 h before Ficoll isolation of rat cerebral cortical m …
Young adult male CF-1 mice were administered one of two known Nrf2-ARE activators as single intraperitoneal doses-sulforaphane (SFP; …
Newer pharmacological approaches for antioxidant neuroprotection in traumatic brain injury.
Hall ED, Wang JA, Miller DM, Cebak JE, Hill RL. Hall ED, et al. Neuropharmacology. 2019 Feb;145(Pt B):247-258. doi: 10.1016/j.neuropharm.2018.08.005. Epub 2018 Aug 4. Neuropharmacology. 2019. PMID: 30086292 Review.
Reactive oxygen species-induced oxidative damage remains an extensively validated secondary injury mechanism in traumatic brain injury (TBI) as demonstrated by the efficacy of various pharmacological antioxidants agents in decreasing post-traumatic free radical-indu …
Reactive oxygen species-induced oxidative damage remains an extensively validated secondary injury mechanism in traumatic brain injur …
Modulation of neurotrophic signaling pathways by polyphenols.
Moosavi F, Hosseini R, Saso L, Firuzi O. Moosavi F, et al. Drug Des Devel Ther. 2015 Dec 21;10:23-42. doi: 10.2147/DDDT.S96936. eCollection 2016. Drug Des Devel Ther. 2015. PMID: 26730179 Free PMC article. Review.
Several polyphenols including flavonoids such as baicalein, daidzein, luteolin, and nobiletin as well as nonflavonoid polyphenols such as auraptene, carnosic acid, curcuminoids, and hydroxycinnamic acid derivatives including caffeic acid phentyl ester enhance neuron …
Several polyphenols including flavonoids such as baicalein, daidzein, luteolin, and nobiletin as well as nonflavonoid polyphenols such as au …
Multi-Target Effects of ss-Caryophyllene and Carnosic Acid at the Crossroads of Mitochondrial Dysfunction and Neurodegeneration: From Oxidative Stress to Microglia-Mediated Neuroinflammation.
Iorio R, Celenza G, Petricca S. Iorio R, et al. Antioxidants (Basel). 2022 Jun 18;11(6):1199. doi: 10.3390/antiox11061199. Antioxidants (Basel). 2022. PMID: 35740096 Free PMC article. Review.
In this scenario, ss-caryophyllene (BCP), a bicyclic sesquiterpene, and carnosic acid (CA), an ortho-diphenolic diterpene, were demonstrated to exhibit anti-inflammatory, and antioxidant activities, as well as neuroprotective and mitoprotective effects in dif …
In this scenario, ss-caryophyllene (BCP), a bicyclic sesquiterpene, and carnosic acid (CA), an ortho-diphenolic diterpene, wer …
Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1.
Satoh T, Kosaka K, Itoh K, Kobayashi A, Yamamoto M, Shimojo Y, Kitajima C, Cui J, Kamins J, Okamoto S, Izumi M, Shirasawa T, Lipton SA. Satoh T, et al. J Neurochem. 2008 Feb;104(4):1116-31. doi: 10.1111/j.1471-4159.2007.05039.x. Epub 2007 Nov 6. J Neurochem. 2008. PMID: 17995931 Free PMC article.
Catechol ring-containing compounds have attracted attention because they become electrophilic quinones upon oxidation, although they are not themselves electrophilic. In this study, we focused on the neuroprotective effects of one such compound, carnosic acid …
Catechol ring-containing compounds have attracted attention because they become electrophilic quinones upon oxidation, although they are not …
15 results