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Acute and prolonged toxicity assessment of Cannabis sativa extract in rodents and lagomorphs.
Costa AC, Gasparotto A Jr, Garcia AAK, Pereira CAC, Lourenço ELB, Joaquim HPG. Costa AC, et al. Toxicol Rep. 2025 Jan 25;14:101918. doi: 10.1016/j.toxrep.2025.101918. eCollection 2025 Jun. Toxicol Rep. 2025. PMID: 39917037 Free PMC article.
No significant safety concerns have been identified in preclinical studies involving CBD and THC. However, the available data on the toxicity of combined CBD and THC are still inconclusive. ...Given the growing interest in cannabinoid-containing products for human u …
No significant safety concerns have been identified in preclinical studies involving CBD and THC. However, the available data on the …
Genotoxicity study of Cannabis sativa L. extract.
Costa A, Gasparotto A Jr, Pereira C, Lourenço E, Garcia A, Joaquim H. Costa A, et al. Toxicol Rep. 2024 Dec 25;14:101864. doi: 10.1016/j.toxrep.2024.101864. eCollection 2025 Jun. Toxicol Rep. 2024. PMID: 39816045 Free PMC article. Review.
Cannabis sativa L., a member of the Cannabaceae family, has been thoroughly investigated for its diverse therapeutic properties, primarily attributed to cannabinoids such as delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Secondary, metabolites like terpenes also …
Cannabis sativa L., a member of the Cannabaceae family, has been thoroughly investigated for its diverse therapeutic properties, primarily a …
Thermal transformation of CBD, CBDA, and delta(9)-THC during e-cigarette vaping: Identification of conversion products by GC-MS.
Kim EJ, Kwon E, Oh SJ, Choi MR, Lee SR, Jung BH, Lee W, Hong J. Kim EJ, et al. J Chromatogr A. 2025 May 24;1749:465909. doi: 10.1016/j.chroma.2025.465909. Epub 2025 Mar 25. J Chromatogr A. 2025. PMID: 40158472
During the CBDA vaping process of the e-cigarette, most of the acidic CBDA was converted to neutral CBD through thermal decarboxylation and further degraded to produce several thermal products. Several interesting psychoactive delta(8)-iso and delta(9)-THC isomers, and can …
During the CBDA vaping process of the e-cigarette, most of the acidic CBDA was converted to neutral CBD through thermal decarboxylati …
Proteomic and metabolomic analyses reveal the antibacterial mechanism of Cannabidiol against gram-positive bacteria.
Zeng H, Wang X, Tang J, Liu P, Zhang S, Chu H, Chen B, Ma M. Zeng H, et al. J Proteomics. 2025 May 15;315:105411. doi: 10.1016/j.jprot.2025.105411. Epub 2025 Feb 18. J Proteomics. 2025. PMID: 39978755
Cannabidiol (CBD), the primary non-psychoactive cannabinoid isolated from cannabis, exhibits promising antibacterial effects. ...However, the antimicrobial mechanisms of CBD have not been well elucidated. This study provides a deep understanding of the antibacterial …
Cannabidiol (CBD), the primary non-psychoactive cannabinoid isolated from cannabis, exhibits promising antibacterial effects. ...Howe …
Cannabidiol/tetrahydrocannabinol-enrich extract decreases neuroinflammation and improves locomotor outcome following spinal cord injury.
Del Core J, Jure I, Silva Sofrás FM, Pietranera L, Ronchetti S, Roig P, Desimone MF, De Nicola AF, Labombarda F. Del Core J, et al. Neuroscience. 2025 May 7;573:468-481. doi: 10.1016/j.neuroscience.2025.03.055. Epub 2025 Mar 27. Neuroscience. 2025. PMID: 40157632
In this context, the anti-inflammatory effects of tetrahydrocannabinol (THC) and cannabidiol (CBD), the main phytocannabinoids of Cannabis sativa, are increasingly recognized. The aim of this work was to investigate the effects of a standardized Cannabis sativa extract (CS …
In this context, the anti-inflammatory effects of tetrahydrocannabinol (THC) and cannabidiol (CBD), the main phytocannabinoids of Can …
Enhanced Metabolic Syndrome Management Through Cannabidiol-Loaded PLGA Nanoparticles: Development and In Vitro Evaluation.
El-Hammadi MM, Martín-Navarro L, Berrocoso E, Álvarez-Fuentes J, Crespo-Facorro B, Suárez-Pereira I, Vázquez-Bourgon J, Martín-Banderas L. El-Hammadi MM, et al. J Biomed Mater Res A. 2025 May;113(5):e37916. doi: 10.1002/jbm.a.37916. J Biomed Mater Res A. 2025. PMID: 40277882
To address this, we developed polymeric nanoparticles (NPs), using poly(lactic-co-glycolic acid) (PLGA), encapsulating CBD using nanoprecipitation, aiming to create an effective CBD-nanoformulation for metabolic disorder treatment. ...Results showed an IC50 of 9.85 …
To address this, we developed polymeric nanoparticles (NPs), using poly(lactic-co-glycolic acid) (PLGA), encapsulating CBD using nano …
To increase or not to increase? The impact of terrestrial protected areas on tree cover and the risk of species extinction.
Martínez OA, Melo O. Martínez OA, et al. J Environ Manage. 2025 May;382:125386. doi: 10.1016/j.jenvman.2025.125386. Epub 2025 Apr 15. J Environ Manage. 2025. PMID: 40239347
Despite extensive research on PA, evaluation of their effectiveness has examined deforestation, poverty, and species impacts, mostly using discrete treatment methods; however, research using continuous treatment approaches, particularly with biodiversity indices set by the Conven …
Despite extensive research on PA, evaluation of their effectiveness has examined deforestation, poverty, and species impacts, mostly using d …
Laparoscopic cholecystectomy with common bile duct exploration for choledocholithiasis in a patient with situs inversus totalis - Case report and review of literature.
Krishna S, Raja K, Pottakkat B. Krishna S, et al. Int J Surg Case Rep. 2025 May;130:111238. doi: 10.1016/j.ijscr.2025.111238. Epub 2025 Mar 29. Int J Surg Case Rep. 2025. PMID: 40203625 Free PMC article.
INTRODUCTION AND IMPORTANCE: Laparoscopic common bile duct (CBD) exploration with cholecystectomy in patients with situs inversus totalis (SIT) is technically demanding and warrants comprehensive knowledge of the mirror image anatomy along with laparoscopic orientation of …
INTRODUCTION AND IMPORTANCE: Laparoscopic common bile duct (CBD) exploration with cholecystectomy in patients with situs inversus tot …
The impact of cannabinoids on reproductive function.
Cameron RS, Perono GA, Natale CD, Petrik JJ, Holloway AC, Hardy DB. Cameron RS, et al. Reproduction. 2025 Apr 3;169(5):e240369. doi: 10.1530/REP-24-0369. Print 2025 May 1. Reproduction. 2025. PMID: 40111139 Free PMC article. Review.
In particular, it addresses the gaps in knowledge regarding the specific contributions of the major constituents of cannabis, THC and CBD, on reproduction. ABSTRACT: With increased use of cannabis worldwide, especially in our young adult population, there is a great impetu …
In particular, it addresses the gaps in knowledge regarding the specific contributions of the major constituents of cannabis, THC and CBD …
Cannabidiol oil delays pancreatic islet dysfunction in Wistar rats under hypercaloric diet.
Cortes-Justo E, Ortiz-Butrón R, Vilches-Flores A. Cortes-Justo E, et al. Biomed Pharmacother. 2025 May;186:117993. doi: 10.1016/j.biopha.2025.117993. Epub 2025 Mar 18. Biomed Pharmacother. 2025. PMID: 40106970 Free article.
Our aim was to evaluate the effects of CBD oil on pancreatic islets, from Wistar rats under HCD. Male rats were divided in 4 groups: Normal diet vehicle-treated (control) and CBD-treated group. ...We assume CBD interacts with other receptors beside GPR55....
Our aim was to evaluate the effects of CBD oil on pancreatic islets, from Wistar rats under HCD. Male rats were divided in 4 groups: …
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