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Page 1
Modulation of Oxidative Stress and Neuroinflammation by Cannabidiol (CBD): Promising Targets for the Treatment of Alzheimer's Disease.
Hickey JP, Collins AE, Nelson ML, Chen H, Kalisch BE. Hickey JP, et al. Curr Issues Mol Biol. 2024 May 6;46(5):4379-4402. doi: 10.3390/cimb46050266. Curr Issues Mol Biol. 2024. PMID: 38785534 Free PMC article. Review.
Although the direct cause of AD remains under debate, neuroinflammation and oxidative stress are critical components in its pathogenesis and progression. As a result, compounds like cannabidiol (CBD) are being increasingly investigated for their ability to provide a …
Although the direct cause of AD remains under debate, neuroinflammation and oxidative stress are critical components in its pathogene …
Therapeutic potential of cannabidiol (CBD) in anxiety disorders: A systematic review and meta-analysis.
Han K, Wang JY, Wang PY, Peng YC. Han K, et al. Psychiatry Res. 2024 Sep;339:116049. doi: 10.1016/j.psychres.2024.116049. Epub 2024 Jun 21. Psychiatry Res. 2024. PMID: 38924898 Free article.
Cannabidiol (CBD), as one of the phytocannabinoids, has a wide range of therapeutic properties for various neuropsychiatric disorders due to central nervous system effects. ...In addition, this meta-analysis focuses on the efficacy of CBD in treating anxiety disorde …
Cannabidiol (CBD), as one of the phytocannabinoids, has a wide range of therapeutic properties for various neuropsychiatric disorders …
CBD activation of TRPV1 induces oxidative signaling and subsequent ER stress in breast cancer cell lines.
de la Harpe A, Beukes N, Frost CL. de la Harpe A, et al. Biotechnol Appl Biochem. 2022 Apr;69(2):420-430. doi: 10.1002/bab.2119. Epub 2021 Mar 16. Biotechnol Appl Biochem. 2022. PMID: 33604949
The stressful conditions experienced in the tumor microenvironment facilitate chronic ER stress and UPR activation, which plays a pivotal role in tumour survival. ...Concomitant treatment with CBD and an antioxidant significantly increased cell viability and …
The stressful conditions experienced in the tumor microenvironment facilitate chronic ER stress and UPR activation, which play …
Amygdala-hippocampal innervation modulates stress-induced depressive-like behaviors through AMPA receptors.
Ma H, Li C, Wang J, Zhang X, Li M, Zhang R, Huang Z, Zhang Y. Ma H, et al. Proc Natl Acad Sci U S A. 2021 Feb 9;118(6):e2019409118. doi: 10.1073/pnas.2019409118. Proc Natl Acad Sci U S A. 2021. PMID: 33526688 Free PMC article.
Chronic stress is one of the most critical factors in the onset of depressive disorders; hence, environmental factors such as psychosocial stress are commonly used to induce depressive-like traits in animal models of depression. ...These findings demonstrate a criti …
Chronic stress is one of the most critical factors in the onset of depressive disorders; hence, environmental factors such as psychos …
Antioxidative and Anti-Inflammatory Properties of Cannabidiol.
Atalay S, Jarocka-Karpowicz I, Skrzydlewska E. Atalay S, et al. Antioxidants (Basel). 2019 Dec 25;9(1):21. doi: 10.3390/antiox9010021. Antioxidants (Basel). 2019. PMID: 31881765 Free PMC article. Review.
Cannabidiol (CBD) is one of the main pharmacologically active phytocannabinoids of Cannabis sativa L. ...In addition, preclinical and clinical studies have contributed to our understanding of the therapeutic potential of CBD for many diseases, including diseases ass …
Cannabidiol (CBD) is one of the main pharmacologically active phytocannabinoids of Cannabis sativa L. ...In addition, preclinical and …
Evaluating cannabidiol (CBD) expectancy effects on acute stress and anxiety in healthy adults: a randomized crossover study.
Spinella TC, Stewart SH, Naugler J, Yakovenko I, Barrett SP. Spinella TC, et al. Psychopharmacology (Berl). 2021 Jul;238(7):1965-1977. doi: 10.1007/s00213-021-05823-w. Epub 2021 Apr 4. Psychopharmacology (Berl). 2021. PMID: 33813611 Free PMC article. Clinical Trial.
RATIONALE: Cannabidiol (CBD) has been reported to attenuate stress and anxiety, but little is known about the extent to which such effects result from pharmacological versus expectancy factors. OBJECTIVES: We evaluated whether CBD expectancy alone could influ …
RATIONALE: Cannabidiol (CBD) has been reported to attenuate stress and anxiety, but little is known about the extent to which …
Cannabidiol (CBD) Protects Adipose-Derived Mesenchymal Stem Cells (ASCs) against Endoplasmic Reticulum Stress Development and Its Complications.
Kowalczuk A, Marycz K, Kornicka-Garbowska K, Kornicka J, Bujalska-Zadrożny M, Groborz S. Kowalczuk A, et al. Int J Environ Res Public Health. 2022 Aug 31;19(17):10864. doi: 10.3390/ijerph191710864. Int J Environ Res Public Health. 2022. PMID: 36078578 Free PMC article.
OBJECTIVES: This investigation aimed to elucidate whether pretreatment of ASCs with CBD can protect against ER stress development and maintain the cytophysiological properties of cells. ...Oxidative stress was analysed with flow cytometric assays. RESULTS: Ce …
OBJECTIVES: This investigation aimed to elucidate whether pretreatment of ASCs with CBD can protect against ER stress developm …
Cannabidiol as a Potential Treatment for Anxiety Disorders.
Blessing EM, Steenkamp MM, Manzanares J, Marmar CR. Blessing EM, et al. Neurotherapeutics. 2015 Oct;12(4):825-36. doi: 10.1007/s13311-015-0387-1. Neurotherapeutics. 2015. PMID: 26341731 Free PMC article. Review.
We found that existing preclinical evidence strongly supports CBD as a treatment for generalized anxiety disorder, panic disorder, social anxiety disorder, obsessive-compulsive disorder, and post-traumatic stress disorder when administered acutely; however, few stud …
We found that existing preclinical evidence strongly supports CBD as a treatment for generalized anxiety disorder, panic disorder, so …
A single dose of cannabidiol (CBD) positively influences measures of stress in dogs during separation and car travel.
Hunt ABG, Flint HE, Logan DW, King T. Hunt ABG, et al. Front Vet Sci. 2023 Feb 22;10:1112604. doi: 10.3389/fvets.2023.1112604. eCollection 2023. Front Vet Sci. 2023. PMID: 36908527 Free PMC article.
Cannabidiol (CBD) can alleviate stress and anxiety in humans but the effect it has on canine stress is less well-documented. ...The mitigating effect of CBD treatment varied by measure and test, with some indicating a significant reduction in canine …
Cannabidiol (CBD) can alleviate stress and anxiety in humans but the effect it has on canine stress is less well-docume …
Cannabidiol attenuates pulmonary arterial hypertension by improving vascular smooth muscle cells mitochondrial function.
Lu X, Zhang J, Liu H, Ma W, Yu L, Tan X, Wang S, Ren F, Li X, Li X. Lu X, et al. Theranostics. 2021 Mar 11;11(11):5267-5278. doi: 10.7150/thno.55571. eCollection 2021. Theranostics. 2021. PMID: 33859746 Free PMC article.
Additionally, CBD's roles in mitochondrial function and oxidant stress were also assessed in PASMCs. ...Moreover, CBD alleviated rodent PAH by recovering mitochondrial energy metabolism, normalizing the hypoxia-induced oxidant stress, reducing the lact …
Additionally, CBD's roles in mitochondrial function and oxidant stress were also assessed in PASMCs. ...Moreover, CBD a …
799 results