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Page 1
Cannabidiol: pharmacology and therapeutic targets.
Britch SC, Babalonis S, Walsh SL. Britch SC, et al. Psychopharmacology (Berl). 2021 Jan;238(1):9-28. doi: 10.1007/s00213-020-05712-8. Epub 2020 Nov 21. Psychopharmacology (Berl). 2021. PMID: 33221931 Free PMC article. Review.
The scientific evidence supporting these claims largely arises not from controlled clinical trials, but from the recognition that CBD has numerous biological targets. Yet, CBD is commonly consumed and often in over-the-counter products that are unapproved and …
The scientific evidence supporting these claims largely arises not from controlled clinical trials, but from the recognition that CBD …
Scientific Validation of Cannabidiol for Management of Dog and Cat Diseases.
Corsato Alvarenga I, Panickar KS, Hess H, McGrath S. Corsato Alvarenga I, et al. Annu Rev Anim Biosci. 2023 Feb 15;11:227-246. doi: 10.1146/annurev-animal-081122-070236. Annu Rev Anim Biosci. 2023. PMID: 36790884 Free article. Review.
Cannabidiol (CBD) is a non-psychotropic phytocannabinoid of the plant Cannabis sativa L. CBD is increasingly being explored as an alternative to conventional therapies to treat health disorders in dogs and cats. ...In companion animals, CBD appears to have go …
Cannabidiol (CBD) is a non-psychotropic phytocannabinoid of the plant Cannabis sativa L. CBD is increasingly being explored as …
Cannabidiol in canine epilepsy.
Potschka H, Bhatti SFM, Tipold A, McGrath S. Potschka H, et al. Vet J. 2022 Dec;290:105913. doi: 10.1016/j.tvjl.2022.105913. Epub 2022 Oct 6. Vet J. 2022. PMID: 36209995 Free article.
Pharmacokinetic studies in dogs have demonstrated a low oral bioavailability of CBD and a high first-pass effect through the liver. Administering CBD in oil-based formulations and/or with food has been shown to enhance the bioavailability in dogs, rats …
Pharmacokinetic studies in dogs have demonstrated a low oral bioavailability of CBD and a high first-pass effect through the l …
Pharmacokinetics and pharmacodynamics of cannabinoids.
Grotenhermen F. Grotenhermen F. Clin Pharmacokinet. 2003;42(4):327-60. doi: 10.2165/00003088-200342040-00003. Clin Pharmacokinet. 2003. PMID: 12648025 Review.
However, its acid metabolite THC-COOH, the non-psychotropic cannabidiol (CBD), several cannabinoid analogues and newly discovered modulators of the endogenous cannabinoid system are also promising candidates for clinical research and therapeutic uses. ...
However, its acid metabolite THC-COOH, the non-psychotropic cannabidiol (CBD), several cannabinoid analogues and newly discovered mod …
Mechanisms of Action and Pharmacokinetics of Cannabis.
Chayasirisobhon S. Chayasirisobhon S. Perm J. 2020 Dec;25:1-3. doi: 10.7812/TPP/19.200. Perm J. 2020. PMID: 33635755 Free PMC article.
The plasma half-life of THC is 1 to 3 days in occasional users and 5 to 13 days in chronic users. The bioavailability of CBD via inhalation is 11% to 45%, whereas that of oral CBD is 6%. CBD has high lipophilicity and therefore is rapidly distributed i …
The plasma half-life of THC is 1 to 3 days in occasional users and 5 to 13 days in chronic users. The bioavailability of CBD v …
A high-fat meal significantly impacts the bioavailability and biphasic absorption of cannabidiol (CBD) from a CBD-rich extract in men and women.
Saals BADF, De Bie TH, Osmanoglou E, van de Laar T, Tuin AW, van Orten-Luiten ACB, Witkamp RF. Saals BADF, et al. Sci Rep. 2025 Jan 29;15(1):3678. doi: 10.1038/s41598-025-87621-4. Sci Rep. 2025. PMID: 39880884 Free PMC article. Clinical Trial.
The present study aimed to investigate the pharmacokinetics of CBD and its primary metabolite, 7-hydroxy-cannabidiol (7-OH-CBD), following a single oral dose of a CBD-rich Cannabis sativa extract, equivalent to 70 mg CBD, in healthy male (n=5) and fema …
The present study aimed to investigate the pharmacokinetics of CBD and its primary metabolite, 7-hydroxy-cannabidiol (7-OH-CBD …
A randomized, double-blind, placebo-controlled study of daily cannabidiol for the treatment of canine osteoarthritis pain.
Verrico CD, Wesson S, Konduri V, Hofferek CJ, Vazquez-Perez J, Blair E, Dunner K Jr, Salimpour P, Decker WK, Halpert MM. Verrico CD, et al. Pain. 2020 Sep 1;161(9):2191-2202. doi: 10.1097/j.pain.0000000000001896. Pain. 2020. PMID: 32345916 Free PMC article.
Here, we evaluated CBD for its ability to modulate the production of proinflammatory cytokines in vitro and in murine models of induced inflammation and further validated the ability of a liposomal formulation to increase bioavailability in mice and in humans. ...Li …
Here, we evaluated CBD for its ability to modulate the production of proinflammatory cytokines in vitro and in murine models of induc …
Towards Better Delivery of Cannabidiol (CBD).
Millar SA, Maguire RF, Yates AS, O'Sullivan SE. Millar SA, et al. Pharmaceuticals (Basel). 2020 Aug 28;13(9):219. doi: 10.3390/ph13090219. Pharmaceuticals (Basel). 2020. PMID: 32872355 Free PMC article. Review.
Cannabidiol (CBD) has substantial therapeutic potential, but its development as an effective drug by the pharmaceutical industry is hindered by intrinsic characteristics such as low bioavailability, low water solubility, and variable pharmacokinetic profiles. ...Thi …
Cannabidiol (CBD) has substantial therapeutic potential, but its development as an effective drug by the pharmaceutical industry is h …
Cannabidiol-A friend or a foe?
Tihăuan BM, Onisei T, Slootweg W, Gună D, Iliescu C, Chifiriuc MC. Tihăuan BM, et al. Eur J Pharm Sci. 2025 May 1;208:107036. doi: 10.1016/j.ejps.2025.107036. Epub 2025 Feb 8. Eur J Pharm Sci. 2025. PMID: 39929375 Free article. Review.
Cannabidiol (CBD), one of the main actives from Cannabis sativa has been perpetually explored lately for its therapeutic effects. ...We highlighted key challenges and provided insights into CBD`s variable bioavailability based on different administration rout …
Cannabidiol (CBD), one of the main actives from Cannabis sativa has been perpetually explored lately for its therapeutic effects. ... …
Randomized single-dose crossover comparative bioavailability study of two novel oral cannabidiol (CBD) formulations in healthy volunteers under fed conditions, compared to a standard CBD isolate capsule.
Pisak MN, Bereket E, Erenmemisoglu A. Pisak MN, et al. J Cannabis Res. 2025 Aug 6;7(1):54. doi: 10.1186/s42238-025-00312-9. J Cannabis Res. 2025. PMID: 40770387 Free PMC article.
BACKGROUND: This study aimed to compare the pharmacokinetics and relative bioavailability of two novel cannabidiol (CBD) formulations including bioavailability-enhanced capsule (CBDNEXT Supra capsule) and a bioavailability-enhanced liquid (CBDNEXT Supr …
BACKGROUND: This study aimed to compare the pharmacokinetics and relative bioavailability of two novel cannabidiol (CBD) formu …
320 results