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Single-Dose Pharmacokinetics and Preliminary Safety Assessment with Use of CBD-Rich Hemp Nutraceutical in Healthy Dogs and Cats.
Deabold KA, Schwark WS, Wolf L, Wakshlag JJ. Deabold KA, et al. Animals (Basel). 2019 Oct 19;9(10):832. doi: 10.3390/ani9100832. Animals (Basel). 2019. PMID: 31635105 Free PMC article.
The use of CBD-rich hemp products is becoming popular among pet owners with no long-term safety data related to consumption in adult dogs and cats. ...Cats do appear to absorb or eliminate CBD differently than dogs, showing lower serum concentrations a …
The use of CBD-rich hemp products is becoming popular among pet owners with no long-term safety data related to consumption in adult …
Pharmacokinetics, Safety, and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs.
Gamble LJ, Boesch JM, Frye CW, Schwark WS, Mann S, Wolfe L, Brown H, Berthelsen ES, Wakshlag JJ. Gamble LJ, et al. Front Vet Sci. 2018 Jul 23;5:165. doi: 10.3389/fvets.2018.00165. eCollection 2018. Front Vet Sci. 2018. PMID: 30083539 Free PMC article.
Objectives: The objectives of this study were to determine basic oral pharmacokinetics, and assess safety and analgesic efficacy of a cannabidiol (CBD) based oil in dogs with osteoarthritis (OA). Methods: Single-dose pharmacokinetics was performed using two d …
Objectives: The objectives of this study were to determine basic oral pharmacokinetics, and assess safety and analgesic efficacy of a cannab …
Pharmacokinetics of cannabidiol administered by 3 delivery methods at 2 different dosages to healthy dogs.
Bartner LR, McGrath S, Rao S, Hyatt LK, Wittenburg LA. Bartner LR, et al. Can J Vet Res. 2018 Jul;82(3):178-183. Can J Vet Res. 2018. PMID: 30026641 Free PMC article. Clinical Trial.
The purpose of this study was to determine the pharmacokinetics of cannabidiol (CBD) in healthy dogs. Thirty, healthy research dogs were assigned to receive 1 of 3 formulations (oral microencapsulated oil beads, oral CBD-infused oil, or …
The purpose of this study was to determine the pharmacokinetics of cannabidiol (CBD) in healthy dogs. Thirty, healthy research …
Randomized blinded controlled clinical trial to assess the effect of oral cannabidiol administration in addition to conventional antiepileptic treatment on seizure frequency in dogs with intractable idiopathic epilepsy.
McGrath S, Bartner LR, Rao S, Packer RA, Gustafson DL. McGrath S, et al. J Am Vet Med Assoc. 2019 Jun 1;254(11):1301-1308. doi: 10.2460/javma.254.11.1301. J Am Vet Med Assoc. 2019. PMID: 31067185
The CBD group received CBD-infused oil (2.5 mg/kg [1.1 mg/lb], PO) twice daily for 12 weeks in addition to existing antiepileptic treatments, and the placebo group received noninfused oil under the same conditions. ...Dogs in the CBD grou …
The CBD group received CBD-infused oil (2.5 mg/kg [1.1 mg/lb], PO) twice daily for 12 weeks in addition to existing ant …
Oral Transmucosal Cannabidiol Oil Formulation as Part of a Multimodal Analgesic Regimen: Effects on Pain Relief and Quality of Life Improvement in Dogs Affected by Spontaneous Osteoarthritis.
Brioschi FA, Di Cesare F, Gioeni D, Rabbogliatti V, Ferrari F, D'Urso ES, Amari M, Ravasio G. Brioschi FA, et al. Animals (Basel). 2020 Aug 26;10(9):1505. doi: 10.3390/ani10091505. Animals (Basel). 2020. PMID: 32858828 Free PMC article.
The aim of this study was to evaluate the efficacy of oral transmucosal (OTM) cannabidiol (CBD), in addition to a multimodal pharmacological treatment for chronic osteoarthritis-related pain in dogs. Twenty-one dogs were randomly divided into two groups: in g …
The aim of this study was to evaluate the efficacy of oral transmucosal (OTM) cannabidiol (CBD), in addition to a multimodal pharmaco …
Pharmacokinetics of Bedrocan, a cannabis oil extract, in fasting and fed dogs: An explorative study.
Łebkowska-Wieruszewska B, Stefanelli F, Chericoni S, Owen H, Poapolathep A, Lisowski A, Giorgi M. Łebkowska-Wieruszewska B, et al. Res Vet Sci. 2019 Apr;123:26-28. doi: 10.1016/j.rvsc.2018.12.003. Epub 2018 Dec 17. Res Vet Sci. 2019. PMID: 30580232
The aim of this study was to explore the pharmacokinetics of the two main active compounds (THC and CBD) contained in the cannabis oil extract Bedrocan in fasting and fed dogs. Bedrocan (20% delta-9-tetrahydrocannabinol [THC] and 0.5% cannabidiol [CBD] …
The aim of this study was to explore the pharmacokinetics of the two main active compounds (THC and CBD) contained in the cannabis …
Preliminary Investigation of the Safety of Escalating Cannabinoid Doses in Healthy Dogs.
Vaughn D, Kulpa J, Paulionis L. Vaughn D, et al. Front Vet Sci. 2020 Feb 11;7:51. doi: 10.3389/fvets.2020.00051. eCollection 2020. Front Vet Sci. 2020. PMID: 32118071 Free PMC article.
Objective: To determine the safety and tolerability of escalating doses of three cannabis oil formulations, containing predominantly CBD, THC, or CBD and THC (1.5:1) vs. placebo in dogs. Design: Randomized, placebo-controlled, blinded, parallel study. …
Objective: To determine the safety and tolerability of escalating doses of three cannabis oil formulations, containing predominantly …
US Veterinarians' Knowledge, Experience, and Perception Regarding the Use of Cannabidiol for Canine Medical Conditions.
Kogan L, Schoenfeld-Tacher R, Hellyer P, Rishniw M. Kogan L, et al. Front Vet Sci. 2019 Jan 10;5:338. doi: 10.3389/fvets.2018.00338. eCollection 2018. Front Vet Sci. 2019. PMID: 30687726 Free PMC article.
Recent veterinary graduates were less likely to recommend or prescribe CBD. The most commonly used CBD formulations were oil/extract and edibles. ...Recent graduates and those practicing in states with legalized recreational marijuana were more likely to agre …
Recent veterinary graduates were less likely to recommend or prescribe CBD. The most commonly used CBD formulations were oi
Cannabis sativa L. may reduce aggressive behaviour towards humans in shelter dogs.
Corsetti S, Borruso S, Malandrucco L, Spallucci V, Maragliano L, Perino R, D'Agostino P, Natoli E. Corsetti S, et al. Sci Rep. 2021 Feb 2;11(1):2773. doi: 10.1038/s41598-021-82439-2. Sci Rep. 2021. PMID: 33531559 Free PMC article.
Among the phytocomplex components of Cannabis sativa L., cannabidiol (CBD) has a recognised therapeutic effect on chronic pain. Little is known about the veterinary use of CBD in dogs. ...Extra virgin olive oil, titrated to 5% in CBD was given t …
Among the phytocomplex components of Cannabis sativa L., cannabidiol (CBD) has a recognised therapeutic effect on chronic pain. Littl …
Randomized, placebo-controlled, 28-day safety and pharmacokinetics evaluation of repeated oral cannabidiol administration in healthy dogs.
Vaughn DM, Paulionis LJ, Kulpa JE. Vaughn DM, et al. Am J Vet Res. 2021 May;82(5):405-416. doi: 10.2460/ajvr.82.5.405. Am J Vet Res. 2021. PMID: 33904801
PROCEDURES: In a randomized, blinded, placebo-controlled trial, dogs were randomized to 5 groups balanced in body weight and sex (n = 4 dogs/group) and received a CBD (1, 2, 4, or 12 mg/kg; from cannabis extract) or placebo oil formulation PO once dail …
PROCEDURES: In a randomized, blinded, placebo-controlled trial, dogs were randomized to 5 groups balanced in body weight and sex (n = …