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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 6
1976 4
1977 3
1978 3
1979 3
1980 3
1981 1
1982 2
1983 2
1984 4
1985 4
1986 5
1987 3
1988 5
1989 1
1990 3
1991 4
1993 3
1994 1
1995 1
1998 1
1999 6
2000 3
2001 2
2002 7
2003 4
2004 2
2005 6
2006 10
2007 6
2008 4
2009 9
2010 7
2011 15
2012 16
2013 16
2014 21
2015 19
2016 27
2017 26
2018 20
2019 42
2020 46
2021 57
2022 60
2023 59
2024 20

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499 results

Results by year

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Page 1
Cannabinol (CBN; 30 and 300 mg) effects on sleep and next-day function in insomnia disorder ('CUPID' study): protocol for a randomised, double-blind, placebo-controlled, cross-over, three-arm, proof-of-concept trial.
Lavender I, McCartney D, Marshall N, Suraev A, Irwin C, D'Rozario AL, Gordon CJ, Saini B, Grunstein RR, Yee B, McGregor I, Hoyos CM. Lavender I, et al. BMJ Open. 2023 Aug 23;13(8):e071148. doi: 10.1136/bmjopen-2022-071148. BMJ Open. 2023. PMID: 37612115 Free PMC article.
OBJECTIVE: Insomnia is the most prevalent sleep disorder, with few effective pharmacotherapies. Anecdotal reports and recent preclinical research suggest that cannabinol (CBN), a constituent of Cannabis sativa derived from delta-9-tetrahydrocannabinol, could be an …
OBJECTIVE: Insomnia is the most prevalent sleep disorder, with few effective pharmacotherapies. Anecdotal reports and recent preclini …
Cannabinol and Sleep: Separating Fact from Fiction.
Corroon J. Corroon J. Cannabis Cannabinoid Res. 2021 Oct;6(5):366-371. doi: 10.1089/can.2021.0006. Epub 2021 Aug 31. Cannabis Cannabinoid Res. 2021. PMID: 34468204 Free PMC article. Review.
In recent years, marketers of cannabis (i.e., marijuana) products have claimed that cannabinol (CBN) has unique sleep-promoting effects. Despite a plausible mechanism, it is possible that such claims are merely rooted in cannabis lore. ...In addition, evidence demon …
In recent years, marketers of cannabis (i.e., marijuana) products have claimed that cannabinol (CBN) has unique sleep-promoting ef …
Anti-Inflammatory Effects of Minor Cannabinoids CBC, THCV, and CBN in Human Macrophages.
Gojani EG, Wang B, Li DP, Kovalchuk O, Kovalchuk I. Gojani EG, et al. Molecules. 2023 Sep 7;28(18):6487. doi: 10.3390/molecules28186487. Molecules. 2023. PMID: 37764262 Free PMC article.
In this study, we investigate the mechanisms underlying the anti-inflammatory effects of three minor phytocannabinoids including tetrahydrocannabivarin (THCV), cannabichromene (CBC), and cannabinol (CBN) using an in vitro system. ...In summary, THCV, CBC, and CBN …
In this study, we investigate the mechanisms underlying the anti-inflammatory effects of three minor phytocannabinoids including tetr …
Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity.
Nava Lauson CB, Tiberti S, Corsetto PA, Conte F, Tyagi P, Machwirth M, Ebert S, Loffreda A, Scheller L, Sheta D, Mokhtari Z, Peters T, Raman AT, Greco F, Rizzo AM, Beilhack A, Signore G, Tumino N, Vacca P, McDonnell LA, Raimondi A, Greenberg PD, Huppa JB, Cardaci S, Caruana I, Rodighiero S, Nezi L, Manzo T. Nava Lauson CB, et al. Cell Metab. 2023 Apr 4;35(4):633-650.e9. doi: 10.1016/j.cmet.2023.02.013. Epub 2023 Mar 9. Cell Metab. 2023. PMID: 36898381 Free article.
The metabolic state represents a major hurdle for an effective adoptive T cell therapy (ACT). Indeed, specific lipids can harm CD8(+) T cell (CTL) mitochondrial integrity, leading to defective antitumor responses. ...
The metabolic state represents a major hurdle for an effective adoptive T cell therapy (ACT). Indeed, specific lipids can harm CD8(+) …
Massage for low-back pain.
Furlan AD, Giraldo M, Baskwill A, Irvin E, Imamura M. Furlan AD, et al. Cochrane Database Syst Rev. 2015 Sep 1;2015(9):CD001929. doi: 10.1002/14651858.CD001929.pub3. Cochrane Database Syst Rev. 2015. PMID: 26329399 Free PMC article. Review.
DATA COLLECTION AND ANALYSIS: We used standard Cochrane methodological procedures and followed CBN guidelines. Two independent authors performed article selection, data extraction and critical appraisal. ...Functional improvement was observed in participants with sub-acute …
DATA COLLECTION AND ANALYSIS: We used standard Cochrane methodological procedures and followed CBN guidelines. Two independent author …
A double-blind, randomized, placebo-controlled study of the safety and effects of CBN with and without CBD on sleep quality.
Bonn-Miller MO, Feldner MT, Bynion TM, Eglit GML, Brunstetter M, Kalaba M, Zvorsky I, Peters EN, Hennesy M. Bonn-Miller MO, et al. Exp Clin Psychopharmacol. 2023 Oct 5. doi: 10.1037/pha0000682. Online ahead of print. Exp Clin Psychopharmacol. 2023. PMID: 37796540
The present study sought to determine the effects of cannabinol (CBN) alone and in combination with cannabidiol (CBD) on sleep quality. ...The addition of CBD did not positively augment CBN treatment effects. No differences were observed for latency to …
The present study sought to determine the effects of cannabinol (CBN) alone and in combination with cannabidiol (CBD) on sleep …
The McKenzie method for (sub)acute non-specific low back pain.
Almeida MO, Narciso Garcia A, Menezes Costa LC, van Tulder MW, Lin CC, Machado LA. Almeida MO, et al. Cochrane Database Syst Rev. 2023 Apr 5;4(4):CD009711. doi: 10.1002/14651858.CD009711.pub2. Cochrane Database Syst Rev. 2023. PMID: 37017272 Free PMC article. Review.
AUTHORS' CONCLUSIONS: Based on low- to very low-certainty evidence, the treatment effects for pain and disability found in our review were not clinically important. Thus, we can conclude that the McKenzie method is not an effective treatment for (sub)acute NSLBP....
AUTHORS' CONCLUSIONS: Based on low- to very low-certainty evidence, the treatment effects for pain and disability found in our review …
Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes.
De Petrocellis L, Ligresti A, Moriello AS, Allarà M, Bisogno T, Petrosino S, Stott CG, Di Marzo V. De Petrocellis L, et al. Br J Pharmacol. 2011 Aug;163(7):1479-94. doi: 10.1111/j.1476-5381.2010.01166.x. Br J Pharmacol. 2011. PMID: 21175579 Free PMC article.
KEY RESULTS: CBD, CBG, CBGV and THCV stimulated and desensitized human TRPV1. CBC, CBD and CBN were potent rat TRPA1 agonists and desensitizers, but THCV-BDS was the most potent compound at this target. ...CONCLUSIONS AND IMPLICATIONS: These results are relevant to the ana …
KEY RESULTS: CBD, CBG, CBGV and THCV stimulated and desensitized human TRPV1. CBC, CBD and CBN were potent rat TRPA1 agonists and des …
Motor control exercise for chronic non-specific low-back pain.
Saragiotto BT, Maher CG, Yamato TP, Costa LO, Menezes Costa LC, Ostelo RW, Macedo LG. Saragiotto BT, et al. Cochrane Database Syst Rev. 2016 Jan 8;2016(1):CD012004. doi: 10.1002/14651858.CD012004. Cochrane Database Syst Rev. 2016. PMID: 26742533 Free PMC article. Review.
When compared with minimal intervention, there is low to moderate quality evidence that MCE is effective for improving pain at short, intermediate and long-term follow-up with medium effect sizes (long-term, MD -12.97; 95% CI -18.51 to -7.42). ...Finally, there is v …
When compared with minimal intervention, there is low to moderate quality evidence that MCE is effective for improving pain at short, …
In Search of Biomarkers to Guide Interventions in Autism Spectrum Disorder: A Systematic Review.
Parellada M, Andreu-Bernabeu Á, Burdeus M, San José Cáceres A, Urbiola E, Carpenter LL, Kraguljac NV, McDonald WM, Nemeroff CB, Rodriguez CI, Widge AS, State MW, Sanders SJ. Parellada M, et al. Am J Psychiatry. 2023 Jan 1;180(1):23-40. doi: 10.1176/appi.ajp.21100992. Epub 2022 Dec 7. Am J Psychiatry. 2023. PMID: 36475375 Free PMC article. Review.
With a median total sample size of 64, almost all of the reviewed studies were only powered to identify biomarkers with large effect sizes. Reporting of individual-level values and summary statistics was inconsistent, hampering mega- and meta-analysis. ...
With a median total sample size of 64, almost all of the reviewed studies were only powered to identify biomarkers with large effect …
499 results