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1996 5
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433 results

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Page 1
Lactobacillus reuteri induces gut intraepithelial CD4(+)CD8alphaalpha(+) T cells.
Cervantes-Barragan L, Chai JN, Tianero MD, Di Luccia B, Ahern PP, Merriman J, Cortez VS, Caparon MG, Donia MS, Gilfillan S, Cella M, Gordon JI, Hsieh CS, Colonna M. Cervantes-Barragan L, et al. Science. 2017 Aug 25;357(6353):806-810. doi: 10.1126/science.aah5825. Epub 2017 Aug 3. Science. 2017. PMID: 28775213 Free PMC article.
The small intestine contains CD4(+)CD8alphaalpha(+) double-positive intraepithelial lymphocytes (DP IELs), which originate from intestinal CD4(+) T cells through down-regulation of the transcription factor Thpok and have regulatory functions. ...
The small intestine contains CD4(+)CD8alphaalpha(+) double-positive intraepithelial lymphocytes (DP IELs), which originate from intes …
Development and function of natural TCR(+) CD8alphaalpha(+) intraepithelial lymphocytes.
Gui Y, Cheng H, Zhou J, Xu H, Han J, Zhang D. Gui Y, et al. Front Immunol. 2022 Dec 7;13:1059042. doi: 10.3389/fimmu.2022.1059042. eCollection 2022. Front Immunol. 2022. PMID: 36569835 Free PMC article. Review.
Intestinal intraepithelial lymphocytes (IELs) are a unique cell population embedded within the intestinal epithelial layer, contributing to the formation of the mucosal epithelial barrier and serving as a first-line defense against microbial invasion. TCRalphabeta(+) CD4(-) CD …
Intestinal intraepithelial lymphocytes (IELs) are a unique cell population embedded within the intestinal epithelial layer, contributing to …
CD8alphaalpha TCRalphabeta Intraepithelial Lymphocytes in the Mouse Gut.
Qiu Y, Peng K, Liu M, Xiao W, Yang H. Qiu Y, et al. Dig Dis Sci. 2016 Jun;61(6):1451-60. doi: 10.1007/s10620-015-4016-y. Epub 2016 Jan 14. Dig Dis Sci. 2016. PMID: 26769056 Review.
These interactions tune the antigen sensitivity of the TCR and maintain the quiescence of the CD8alphaalpha(+)TCRalphabeta(+) IELs. Finally, we discuss how these cells might contribute to tolerance and immunopathological responses in the gut. Therefore, an increased unders …
These interactions tune the antigen sensitivity of the TCR and maintain the quiescence of the CD8alphaalpha(+)TCRalphabeta(+) IELs. F …
Development, ontogeny, and maintenance of TCRalphabeta(+) CD8alphaalpha IEL.
Ruscher R, Hogquist KA. Ruscher R, et al. Curr Opin Immunol. 2019 Jun;58:83-88. doi: 10.1016/j.coi.2019.04.010. Epub 2019 May 28. Curr Opin Immunol. 2019. PMID: 31146182 Free PMC article. Review.
In this review we focus on the TCRalphabeta(+) subset of CD8alphaalpha IEL. We discuss recent studies that shed light on the development, ontogeny, maintenance, and functional characteristics of CD8alphaalpha IEL, and highlight yet unanswered questions for future st …
In this review we focus on the TCRalphabeta(+) subset of CD8alphaalpha IEL. We discuss recent studies that shed light on the developm …
Pathways and mechanisms of CD4(+)CD8alphaalpha(+) intraepithelial T cell development.
Li C, Lanasa D, Park JH. Li C, et al. Trends Immunol. 2024 Apr;45(4):288-302. doi: 10.1016/j.it.2024.02.006. Epub 2024 Mar 20. Trends Immunol. 2024. PMID: 38514370 Free PMC article. Review.
The mammalian small intestine epithelium harbors a peculiar population of CD4(+)CD8alphaalpha(+) T cells that are derived from mature CD4(+) T cells through reprogramming of lineage-specific transcription factors. CD4(+)CD8alphaalpha(+) T cells occupy a unique niche …
The mammalian small intestine epithelium harbors a peculiar population of CD4(+)CD8alphaalpha(+) T cells that are derived from mature …
Downregulation of chemokine receptor 9 facilitates CD4(+)CD8alphaalpha(+) intraepithelial lymphocyte development.
Ono K, Sujino T, Miyamoto K, Harada Y, Kojo S, Yoshimatsu Y, Tanemoto S, Koda Y, Zheng J, Sayama K, Koide T, Teratani T, Mikami Y, Takabayashi K, Nakamoto N, Hosoe N, London M, Ogata H, Mucida D, Taniuchi I, Kanai T. Ono K, et al. Nat Commun. 2023 Aug 24;14(1):5152. doi: 10.1038/s41467-023-40950-2. Nat Commun. 2023. PMID: 37620389 Free PMC article.
Here, we show that chemokine receptor 9 (CCR9) expression is low in epithelial CD4(+)CD8alphaalpha(+) IELs, but CCR9 deficiency results in CD4(+)CD8alphaalpha(+) over-differentiation in both the epithelium and the LP. ...These results implicate a link between CCR9 d …
Here, we show that chemokine receptor 9 (CCR9) expression is low in epithelial CD4(+)CD8alphaalpha(+) IELs, but CCR9 deficiency resul …
A cell atlas of human thymic development defines T cell repertoire formation.
Park JE, Botting RA, Domínguez Conde C, Popescu DM, Lavaert M, Kunz DJ, Goh I, Stephenson E, Ragazzini R, Tuck E, Wilbrey-Clark A, Roberts K, Kedlian VR, Ferdinand JR, He X, Webb S, Maunder D, Vandamme N, Mahbubani KT, Polanski K, Mamanova L, Bolt L, Crossland D, de Rita F, Fuller A, Filby A, Reynolds G, Dixon D, Saeb-Parsy K, Lisgo S, Henderson D, Vento-Tormo R, Bayraktar OA, Barker RA, Meyer KB, Saeys Y, Bonfanti P, Behjati S, Clatworthy MR, Taghon T, Haniffa M, Teichmann SA. Park JE, et al. Science. 2020 Feb 21;367(6480):eaay3224. doi: 10.1126/science.aay3224. Science. 2020. PMID: 32079746 Free PMC article.
Using this approach, we identified and located in situ CD8alphaalpha(+) T cell populations, thymic fibroblast subtypes, and activated dendritic cell states. ...
Using this approach, we identified and located in situ CD8alphaalpha(+) T cell populations, thymic fibroblast subtypes, and activated …
Destined for the intestine: thymic selection of TCRalphabeta CD8alphaalpha intestinal intraepithelial lymphocytes.
Joannou K, Baldwin TA. Joannou K, et al. Clin Exp Immunol. 2023 Jul 5;213(1):67-75. doi: 10.1093/cei/uxad049. Clin Exp Immunol. 2023. PMID: 37137518 Free PMC article. Review.
This review focuses on T-cell receptor alphabeta (TCRalphabeta) CD8alphaalpha intraepithelial lymphocytes, and how recent advances in the field clarify how this unique T-cell subset is selected, matures, and functions in the intestines. ...We conclude with how this story r …
This review focuses on T-cell receptor alphabeta (TCRalphabeta) CD8alphaalpha intraepithelial lymphocytes, and how recent advances in …
Gut Microbiota-Derived Tryptophan Metabolites Maintain Gut and Systemic Homeostasis.
Su X, Gao Y, Yang R. Su X, et al. Cells. 2022 Jul 25;11(15):2296. doi: 10.3390/cells11152296. Cells. 2022. PMID: 35892593 Free PMC article. Review.
They can not only promote the differentiation and function of anti-inflammatory macrophages, Treg cells, CD4(+)CD8alphaalpha(+) regulatory cells, IL-10(+) and/or IL-35(+)B regulatory cells but also IL-22-producing innate lymphoid cells 3 (ILC3), which are involved in maint …
They can not only promote the differentiation and function of anti-inflammatory macrophages, Treg cells, CD4(+)CD8alphaalpha(+) regul …
Generating CD4(+)CD8alphaalpha(+) IELs.
Dempsey LA. Dempsey LA. Nat Immunol. 2017 Sep 19;18(10):1067. doi: 10.1038/ni.3841. Nat Immunol. 2017. PMID: 28926545 No abstract available.
433 results