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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 5
1997 4
1998 8
1999 17
2000 23
2001 14
2002 12
2003 11
2004 17
2005 18
2006 19
2007 14
2008 17
2009 15
2010 16
2011 23
2012 13
2013 17
2014 20
2015 8
2016 17
2017 19
2018 14
2019 18
2020 20
2021 9
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360 results
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Lactobacillus reuteri induces gut intraepithelial CD4(+)CD8alphaalpha(+) T cells.
Cervantes-Barragan L, Chai JN, Tianero MD, Di Luccia B, Ahern PP, Merriman J, Cortez VS, Caparon MG, Donia MS, Gilfillan S, Cella M, Gordon JI, Hsieh CS, Colonna M. Cervantes-Barragan L, et al. Science. 2017 Aug 25;357(6353):806-810. doi: 10.1126/science.aah5825. Epub 2017 Aug 3. Science. 2017. PMID: 28775213 Free PMC article.
The small intestine contains CD4(+)CD8alphaalpha(+) double-positive intraepithelial lymphocytes (DP IELs), which originate from intestinal CD4(+) T cells through down-regulation of the transcription factor Thpok and have regulatory functions. ...
The small intestine contains CD4(+)CD8alphaalpha(+) double-positive intraepithelial lymphocytes (DP IELs), which originate from intes …
Development, ontogeny, and maintenance of TCRalphabeta(+) CD8alphaalpha IEL.
Ruscher R, Hogquist KA. Ruscher R, et al. Curr Opin Immunol. 2019 Jun;58:83-88. doi: 10.1016/j.coi.2019.04.010. Epub 2019 May 28. Curr Opin Immunol. 2019. PMID: 31146182 Free PMC article. Review.
In this review we focus on the TCRalphabeta(+) subset of CD8alphaalpha IEL. We discuss recent studies that shed light on the development, ontogeny, maintenance, and functional characteristics of CD8alphaalpha IEL, and highlight yet unanswered questions for future st …
In this review we focus on the TCRalphabeta(+) subset of CD8alphaalpha IEL. We discuss recent studies that shed light on the developm …
CD8alphaalpha TCRalphabeta Intraepithelial Lymphocytes in the Mouse Gut.
Qiu Y, Peng K, Liu M, Xiao W, Yang H. Qiu Y, et al. Dig Dis Sci. 2016 Jun;61(6):1451-60. doi: 10.1007/s10620-015-4016-y. Epub 2016 Jan 14. Dig Dis Sci. 2016. PMID: 26769056 Review.
The epithelium of the mouse small intestine harbors an abundant CD8alphaalpha(+)TCRalphabeta(+) intraepithelial lymphocyte (IEL) population. ...Therefore, an increased understanding of CD8alphaalpha(+)TCRalphabeta(+) IELs in the gut will help us understand how these …
The epithelium of the mouse small intestine harbors an abundant CD8alphaalpha(+)TCRalphabeta(+) intraepithelial lymphocyte (IEL) popu …
Intestinal CD8alphaalpha IELs derived from two distinct thymic precursors have staggered ontogeny.
Ruscher R, Lee ST, Salgado OC, Breed ER, Osum SH, Hogquist KA. Ruscher R, et al. J Exp Med. 2020 Aug 3;217(8):e20192336. doi: 10.1084/jem.20192336. J Exp Med. 2020. PMID: 32687575 Free PMC article.
CD8alphaalpha intraepithelial lymphocytes (IELs) are abundant T cells that protect the gut epithelium. ...These data provide novel insight into the ontogeny of CD8alphaalpha IELs....
CD8alphaalpha intraepithelial lymphocytes (IELs) are abundant T cells that protect the gut epithelium. ...These data provide novel in …
CD8alphaalpha homodimers function as a coreceptor for KIR3DL1.
Geng J, Raghavan M. Geng J, et al. Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):17951-17956. doi: 10.1073/pnas.1905943116. Epub 2019 Aug 16. Proc Natl Acad Sci U S A. 2019. PMID: 31420518 Free PMC article.
CD8alphabeta is a coreceptor for the T cell receptor (TCR) and binds to the same cognate pMHC-I as the TCR, thus enabling or augmenting T cell responses. The function of CD8alphaalpha homodimers is largely unknown. While CD8alphabeta heterodimer is expressed exclusively on …
CD8alphabeta is a coreceptor for the T cell receptor (TCR) and binds to the same cognate pMHC-I as the TCR, thus enabling or augmenting T ce …
A cell atlas of human thymic development defines T cell repertoire formation.
Park JE, Botting RA, Domínguez Conde C, Popescu DM, Lavaert M, Kunz DJ, Goh I, Stephenson E, Ragazzini R, Tuck E, Wilbrey-Clark A, Roberts K, Kedlian VR, Ferdinand JR, He X, Webb S, Maunder D, Vandamme N, Mahbubani KT, Polanski K, Mamanova L, Bolt L, Crossland D, de Rita F, Fuller A, Filby A, Reynolds G, Dixon D, Saeb-Parsy K, Lisgo S, Henderson D, Vento-Tormo R, Bayraktar OA, Barker RA, Meyer KB, Saeys Y, Bonfanti P, Behjati S, Clatworthy MR, Taghon T, Haniffa M, Teichmann SA. Park JE, et al. Science. 2020 Feb 21;367(6480):eaay3224. doi: 10.1126/science.aay3224. Science. 2020. PMID: 32079746 Free PMC article.
We used single-cell RNA sequencing to create a cell census of the human thymus across the life span and to reconstruct T cell differentiation trajectories and T cell receptor (TCR) recombination kinetics. Using this approach, we identified and located in situ CD8alphaalpha …
We used single-cell RNA sequencing to create a cell census of the human thymus across the life span and to reconstruct T cell differentiatio …
Hallmarks of Tissue-Resident Lymphocytes.
Fan X, Rudensky AY. Fan X, et al. Cell. 2016 Mar 10;164(6):1198-1211. doi: 10.1016/j.cell.2016.02.048. Cell. 2016. PMID: 26967286 Free PMC article. Review.
These specialized tissue-resident lymphocyte subsets span the innate-adaptive continuum and include innate lymphoid cells (ILCs), unconventional T cells (e.g., NKT, MAIT, gammadelta T cells, and CD8alphaalpha(+) IELs), and tissue-resident memory T (T(RM)) cells. Although t …
These specialized tissue-resident lymphocyte subsets span the innate-adaptive continuum and include innate lymphoid cells (ILCs), unconventi …
CD8alphaalpha(+) T cells show amoeboid shape and frequent morphological change in vitro, and localize to small intestinal intraepithelial region in vivo.
Takei Y, Nemoto Y, Morikawa R, Tanaka S, Oshima S, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Watanabe M. Takei Y, et al. Biochem Biophys Res Commun. 2020 Mar 5;523(2):328-335. doi: 10.1016/j.bbrc.2019.12.021. Epub 2019 Dec 19. Biochem Biophys Res Commun. 2020. PMID: 31864702
TCR signal, IL-15, gut microbes, CCL25, and integrin alphaEbeta7 expression were non-essential for IEL movement in vitro. CD8alphaalpha(+) cells showed higher motility and larger morphological changes than CD8alphaalpha(-) cells. Adoptive transferred CD8alphaalph …
TCR signal, IL-15, gut microbes, CCL25, and integrin alphaEbeta7 expression were non-essential for IEL movement in vitro. CD8alphaalpha …
Generating CD4(+)CD8alphaalpha(+) IELs.
Dempsey LA. Dempsey LA. Nat Immunol. 2017 Sep 19;18(10):1067. doi: 10.1038/ni.3841. Nat Immunol. 2017. PMID: 28926545 No abstract available.
Identification and Regulation of TCRalphabeta(+)CD8alphaalpha(+) Intraepithelial Lymphocytes in Murine Oral Mucosa.
Wu R, Zhang D, Zanvit P, Jin W, Wang H, Chen W. Wu R, et al. Front Immunol. 2020 Aug 4;11:1702. doi: 10.3389/fimmu.2020.01702. eCollection 2020. Front Immunol. 2020. PMID: 32849598 Free PMC article.
However, it is unknown whether TCRalphabeta(+)CD8alphaalpha(+) IELs exist in the oral mucosa and if yes, what controls their development. We here identified and characterized TCRalphabeta(+)CD8alphaalpha(+) IELs from the murine oral mucosa. We showed that the number …
However, it is unknown whether TCRalphabeta(+)CD8alphaalpha(+) IELs exist in the oral mucosa and if yes, what controls their developm …
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