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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 5
1997 4
1998 8
1999 17
2000 23
2001 14
2002 12
2003 11
2004 17
2005 18
2006 19
2007 14
2008 17
2009 15
2010 16
2011 23
2012 13
2013 17
2014 20
2015 8
2016 17
2017 19
2018 14
2019 18
2020 20
2021 17
2022 13
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381 results
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Lactobacillus reuteri induces gut intraepithelial CD4+CD8αα+ T cells.
Cervantes-Barragan L, Chai JN, Tianero MD, Di Luccia B, Ahern PP, Merriman J, Cortez VS, Caparon MG, Donia MS, Gilfillan S, Cella M, Gordon JI, Hsieh CS, Colonna M. Cervantes-Barragan L, et al. Science. 2017 Aug 25;357(6353):806-810. doi: 10.1126/science.aah5825. Epub 2017 Aug 3. Science. 2017. PMID: 28775213 Free PMC article.
The small intestine contains CD4(+)CD8alphaalpha(+) double-positive intraepithelial lymphocytes (DP IELs), which originate from intestinal CD4(+) T cells through down-regulation of the transcription factor Thpok and have regulatory functions. ...
The small intestine contains CD4(+)CD8alphaalpha(+) double-positive intraepithelial lymphocytes (DP IELs), which originate from intes …
CD8αα+T cells exert a pro-inflammatory role in patients with psoriasis.
Zhang YY, Lin YT, Wang L, Sun XW, Dang EL, Xue K, Zhang WG, Zhang KM, Wang G, Li B. Zhang YY, et al. Skin Health Dis. 2021 Nov 16;1(4):e64. doi: 10.1002/ski2.64. eCollection 2021 Dec. Skin Health Dis. 2021. PMID: 35663772 Free PMC article.
Flow cytometry was performed to detect their phenotype in peripheral blood. Thereafter, coculture of CD8alphaalpha(+)T cells with autogenous CD4(+)T cells was performed to investigate the function of CD8alphaalpha(+)T cells in patients with psoriasis. ...Moreover, e …
Flow cytometry was performed to detect their phenotype in peripheral blood. Thereafter, coculture of CD8alphaalpha(+)T cells with aut …
Development, ontogeny, and maintenance of TCRαβ+ CD8αα IEL.
Ruscher R, Hogquist KA. Ruscher R, et al. Curr Opin Immunol. 2019 Jun;58:83-88. doi: 10.1016/j.coi.2019.04.010. Epub 2019 May 28. Curr Opin Immunol. 2019. PMID: 31146182 Free PMC article. Review.
In this review we focus on the TCRalphabeta(+) subset of CD8alphaalpha IEL. We discuss recent studies that shed light on the development, ontogeny, maintenance, and functional characteristics of CD8alphaalpha IEL, and highlight yet unanswered questions for future st …
In this review we focus on the TCRalphabeta(+) subset of CD8alphaalpha IEL. We discuss recent studies that shed light on the developm …
CD8αα TCRαβ Intraepithelial Lymphocytes in the Mouse Gut.
Qiu Y, Peng K, Liu M, Xiao W, Yang H. Qiu Y, et al. Dig Dis Sci. 2016 Jun;61(6):1451-60. doi: 10.1007/s10620-015-4016-y. Epub 2016 Jan 14. Dig Dis Sci. 2016. PMID: 26769056 Review.
The epithelium of the mouse small intestine harbors an abundant CD8alphaalpha(+)TCRalphabeta(+) intraepithelial lymphocyte (IEL) population. ...Therefore, an increased understanding of CD8alphaalpha(+)TCRalphabeta(+) IELs in the gut will help us understand how these …
The epithelium of the mouse small intestine harbors an abundant CD8alphaalpha(+)TCRalphabeta(+) intraepithelial lymphocyte (IEL) popu …
CD8αα homodimers function as a coreceptor for KIR3DL1.
Geng J, Raghavan M. Geng J, et al. Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):17951-17956. doi: 10.1073/pnas.1905943116. Epub 2019 Aug 16. Proc Natl Acad Sci U S A. 2019. PMID: 31420518 Free PMC article.
CD8alphabeta is a coreceptor for the T cell receptor (TCR) and binds to the same cognate pMHC-I as the TCR, thus enabling or augmenting T cell responses. The function of CD8alphaalpha homodimers is largely unknown. While CD8alphabeta heterodimer is expressed exclusively on …
CD8alphabeta is a coreceptor for the T cell receptor (TCR) and binds to the same cognate pMHC-I as the TCR, thus enabling or augmenting T ce …
Intestinal CD8αα IELs derived from two distinct thymic precursors have staggered ontogeny.
Ruscher R, Lee ST, Salgado OC, Breed ER, Osum SH, Hogquist KA. Ruscher R, et al. J Exp Med. 2020 Aug 3;217(8):e20192336. doi: 10.1084/jem.20192336. J Exp Med. 2020. PMID: 32687575 Free PMC article.
CD8alphaalpha intraepithelial lymphocytes (IELs) are abundant T cells that protect the gut epithelium. ...These data provide novel insight into the ontogeny of CD8alphaalpha IELs....
CD8alphaalpha intraepithelial lymphocytes (IELs) are abundant T cells that protect the gut epithelium. ...These data provide novel in …
A cell atlas of human thymic development defines T cell repertoire formation.
Park JE, Botting RA, Domínguez Conde C, Popescu DM, Lavaert M, Kunz DJ, Goh I, Stephenson E, Ragazzini R, Tuck E, Wilbrey-Clark A, Roberts K, Kedlian VR, Ferdinand JR, He X, Webb S, Maunder D, Vandamme N, Mahbubani KT, Polanski K, Mamanova L, Bolt L, Crossland D, de Rita F, Fuller A, Filby A, Reynolds G, Dixon D, Saeb-Parsy K, Lisgo S, Henderson D, Vento-Tormo R, Bayraktar OA, Barker RA, Meyer KB, Saeys Y, Bonfanti P, Behjati S, Clatworthy MR, Taghon T, Haniffa M, Teichmann SA. Park JE, et al. Science. 2020 Feb 21;367(6480):eaay3224. doi: 10.1126/science.aay3224. Science. 2020. PMID: 32079746 Free PMC article.
We used single-cell RNA sequencing to create a cell census of the human thymus across the life span and to reconstruct T cell differentiation trajectories and T cell receptor (TCR) recombination kinetics. Using this approach, we identified and located in situ CD8alphaalpha …
We used single-cell RNA sequencing to create a cell census of the human thymus across the life span and to reconstruct T cell differentiatio …
Factors that influence the thymic selection of CD8αα intraepithelial lymphocytes.
Kurd NS, Hoover A, Yoon J, Weist BM, Lutes L, Chan SW, Robey EA. Kurd NS, et al. Mucosal Immunol. 2021 Jan;14(1):68-79. doi: 10.1038/s41385-020-0295-5. Epub 2020 Jun 1. Mucosal Immunol. 2021. PMID: 32483197
Among thymocytes bearing TCRs restricted to MHC class I, agonist selection can lead to the development of precursors that can home to the gut and give rise to CD8alphaalpha-expressing intraepithelial lymphocytes (CD8alphaalpha IELs). The factors that influence the c …
Among thymocytes bearing TCRs restricted to MHC class I, agonist selection can lead to the development of precursors that can home to the gu …
Generating CD4+CD8αα+ IELs.
Dempsey LA. Dempsey LA. Nat Immunol. 2017 Sep 19;18(10):1067. doi: 10.1038/ni.3841. Nat Immunol. 2017. PMID: 28926545 No abstract available.
CD4+ CD8αα+ T cells in the gastric epithelium mediate chronic inflammation induced by Helicobacter felis.
Ruan G, Huang A, Hu C, Xu N, Fan M, Zhang Z, Wang Y, Xing Y. Ruan G, et al. Microb Pathog. 2021 Oct;159:105151. doi: 10.1016/j.micpath.2021.105151. Epub 2021 Aug 24. Microb Pathog. 2021. PMID: 34450200
CD4(+) CD8alphaalpha(+) double-positive intraepithelial T lymphocytes (DP T cells), a newly characterized subset of intraepithelial T cells, are reported to contribute to local immunosuppression. ...
CD4(+) CD8alphaalpha(+) double-positive intraepithelial T lymphocytes (DP T cells), a newly characterized subset of intraepithelial T …
381 results