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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1970 1
1972 1
1974 2
1975 8
1976 9
1977 4
1978 7
1979 3
1980 9
1981 9
1982 8
1983 13
1984 13
1985 14
1986 12
1987 13
1988 13
1989 20
1990 18
1991 20
1992 9
1993 16
1994 16
1995 22
1996 15
1997 31
1998 12
1999 15
2000 29
2001 21
2002 26
2003 18
2004 20
2005 16
2006 30
2007 21
2008 24
2009 26
2010 30
2011 27
2012 24
2013 22
2014 31
2015 29
2016 28
2017 22
2018 25
2019 15
2020 26
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2022 29
2023 19
2024 14
2025 19
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901 results

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Page 1
Immediate-early transcriptional response to insulin receptor stimulation.
Thiel G, Wagner L, Ulrich M, Rössler OG. Thiel G, et al. Biochem Pharmacol. 2021 Oct;192:114696. doi: 10.1016/j.bcp.2021.114696. Epub 2021 Jul 22. Biochem Pharmacol. 2021. PMID: 34302794
As a result, multiple biological functions of the cells are changed. Here, we analyzed the regulation and signaling cascades leading to insulin-induced activation of the stimulus-responsive transcription factors. For the analyses, we used chromatin-emb …
As a result, multiple biological functions of the cells are changed. Here, we analyzed the regulation and signaling cascades leading …
Insulin potentiates the response to capsaicin in dorsal root ganglion neurons in vitro and muscle afferents ex vivo in normal healthy rodents.
Hori A, Hotta N, Fukazawa A, Estrada JA, Katanosaka K, Mizumura K, Sato J, Ishizawa R, Kim HK, Iwamoto GA, Vongpatanasin W, Mitchell JH, Smith SA, Mizuno M. Hori A, et al. J Physiol. 2022 Feb;600(3):531-545. doi: 10.1113/JP282740. Epub 2022 Jan 13. J Physiol. 2022. PMID: 34967443 Free PMC article.
Furthermore, insulin receptor blockade with GSK1838705 significantly suppressed the insulin-induced augmentation in CAP-activated currents (n = 13) as well as the response magnitude of CAP-induced action potentials (n = 9). ...In addition, it is demonstrated …
Furthermore, insulin receptor blockade with GSK1838705 significantly suppressed the insulin-induced augmentation in CAP-activa …
Beta-cell protein kinases and the dynamics of the insulin response to glucose.
Nesher R, Anteby E, Yedovizky M, Warwar N, Kaiser N, Cerasi E. Nesher R, et al. Diabetes. 2002 Feb;51 Suppl 1:S68-73. doi: 10.2337/diabetes.51.2007.s68. Diabetes. 2002. PMID: 11815461 Review.
A full biphasic insulin response is the most sensitive index for well-coupled beta-cell signal transduction. While first-phase insulin response is extremely sensitive to potentiating and inhibiting modulations, full expression of second-phase respon …
A full biphasic insulin response is the most sensitive index for well-coupled beta-cell signal transduction. While first-phase …
Insulin potentiates the response to mechanical stimuli in small dorsal root ganglion neurons and thin fibre muscle afferents in vitro.
Hotta N, Katanosaka K, Mizumura K, Iwamoto GA, Ishizawa R, Kim HK, Vongpatanasin W, Mitchell JH, Smith SA, Mizuno M. Hotta N, et al. J Physiol. 2019 Oct;597(20):5049-5062. doi: 10.1113/JP278527. Epub 2019 Oct 1. J Physiol. 2019. PMID: 31468522 Free article.
Importantly, pretreatment with the insulin receptor antagonist, GSK1838705, significantly suppressed the insulin-induced potentiation of the mechanical response. ...Using a muscle-nerve preparation, we recorded single group IV fibre activity to a ramp-shaped …
Importantly, pretreatment with the insulin receptor antagonist, GSK1838705, significantly suppressed the insulin-induced poten …
Diminished phosphodiesterase-8B potentiates biphasic insulin response to glucose.
Dov A, Abramovitch E, Warwar N, Nesher R. Dov A, et al. Endocrinology. 2008 Feb;149(2):741-8. doi: 10.1210/en.2007-0968. Epub 2007 Nov 8. Endocrinology. 2008. PMID: 17991719
Specific depletion of PDE3A with small interfering (si) RNA (siPDE3A) led to a small (67%) increase in the insulin response to glucose in INS-1E cells but not rat islets. siPDE3A had no effect on the glucagon-like peptide-1 (10 nmol/liter) potentiated insu …
Specific depletion of PDE3A with small interfering (si) RNA (siPDE3A) led to a small (67%) increase in the insulin response to …
Amylin: history and overview.
Ludvik B, Kautzky-Willer A, Prager R, Thomaseth K, Pacini G. Ludvik B, et al. Diabet Med. 1997 Jun;14 Suppl 2:S9-13. doi: 10.1002/(sici)1096-9136(199706)14:2+3.3.co;2-4. Diabet Med. 1997. PMID: 9212323 Review.
Amylin is a 37-amino-acid peptide hormone that is co-secreted with insulin by the pancreatic beta-cells in response to a nutrient stimulus. It is deficient in patients with Type 1 diabetes and elevated in patients in the early stages of Type 2 diabetes …
Amylin is a 37-amino-acid peptide hormone that is co-secreted with insulin by the pancreatic beta-cells in response to …
The elusive cephalic phase insulin response: triggers, mechanisms, and functions.
Langhans W, Watts AG, Spector AC. Langhans W, et al. Physiol Rev. 2023 Apr 1;103(2):1423-1485. doi: 10.1152/physrev.00025.2022. Epub 2022 Nov 24. Physiol Rev. 2023. PMID: 36422994 Free PMC article. Review.
The cephalic phase insulin response (CPIR) is classically defined as a head receptor-induced early release of insulin during eating that precedes a postabsorptive rise in blood glucose. ...These points are critical for the interpretation of the existing data, …
The cephalic phase insulin response (CPIR) is classically defined as a head receptor-induced early release of insulin d …
Glucagon release precedes insulin release in response to common secretagogues.
Pek S, Tai TY, Crowther R, Fajans SS. Pek S, et al. Diabetes. 1976 Sep;25(9):764-70. doi: 10.2337/diab.25.9.764. Diabetes. 1976. PMID: 782985
The release of glucagon preceded that of insulin in response to all compounds tested. The rapidity of glucagon release varied in response to different secretagogues; the time course of insulin release was fairly constant. The timing and the magnitude o …
The release of glucagon preceded that of insulin in response to all compounds tested. The rapidity of glucagon release varied …
Inhibition of Protein Phosphatase 2A Sensitizes Mucoepidermoid Carcinoma to Chemotherapy via the PI3K-AKT Pathway in Response to Insulin Stimulus.
Liu L, Wang H, Cui J, Zhang Q, Zhang W, Xu W, Lu H, Liu S, Shen S, Fang F, Li L, Yang W, Zhuang Z, Li J. Liu L, et al. Cell Physiol Biochem. 2018;50(1):317-331. doi: 10.1159/000494008. Epub 2018 Oct 3. Cell Physiol Biochem. 2018. PMID: 30282066 Free PMC article.
In addition, with LB100 treatment and in response to an insulin stimulus, the expression levels and phosphorylation levels of targets in the PI3K-AKT pathway were determined using western blot analysis and immunoblotting. ...PP2A inhibition by LB100 increased …
In addition, with LB100 treatment and in response to an insulin stimulus, the expression levels and phosphorylation lev …
Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis.
Huber MK, Widener AE, Cuaycal AE, Smurlick D, Butterworth EA, Lenchik NI, Chen J, Beery M, Hiller H, Verney E, Kusmartseva I, Rupnik MS, Campbell-Thompson M, Gerling IC, Atkinson MA, Mathews CE, Phelps EA. Huber MK, et al. Cell Rep. 2025 Sep 23;44(9):116174. doi: 10.1016/j.celrep.2025.116174. Epub 2025 Aug 27. Cell Rep. 2025. PMID: 40875294 Free PMC article.
The loss of insulin secretory function associated with type 1 diabetes (T1D) is attributed to the immune-mediated destruction of beta cells. ...Beta cells in slices from donors with T1D have significantly diminished Ca(2+) mobilization and insulin secr …
The loss of insulin secretory function associated with type 1 diabetes (T1D) is attributed to the immune-mediated destruction of beta …
901 results