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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1968 1
1975 2
1976 1
1979 1
1980 1
1982 1
1983 1
1984 14
1985 36
1986 75
1987 163
1988 274
1989 378
1990 528
1991 600
1992 759
1993 838
1994 956
1995 1129
1996 1231
1997 1222
1998 1402
1999 1559
2000 1794
2001 1866
2002 1913
2003 2136
2004 2161
2005 2341
2006 2404
2007 2386
2008 2410
2009 2382
2010 2515
2011 2634
2012 2711
2013 2869
2014 2786
2015 2840
2016 2548
2017 2548
2018 2513
2019 2455
2020 2503
2021 2294
2022 2196
2023 1747
2024 1830
2025 1899
2026 1091

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66,102 results

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Page 1
Cytokines and autoimmunity.
O'Shea JJ, Ma A, Lipsky P. O'Shea JJ, et al. Nat Rev Immunol. 2002 Jan;2(1):37-45. doi: 10.1038/nri702. Nat Rev Immunol. 2002. PMID: 11905836 Review.
Cytokines have crucial functions in the development, differentiation and regulation of immune cells. As a result, dysregulation of cytokine production or action is thought to have a central role in the development of autoimmunity and autoimmune disease. Some cytokines, suc …
Cytokines have crucial functions in the development, differentiation and regulation of immune cells. As a result, dysregulation of cy …
Analysis of tumor necrosis factor promoter responses to ultraviolet light.
Bazzoni F, Kruys V, Shakhov A, Jongeneel CV, Beutler B. Bazzoni F, et al. J Clin Invest. 1994 Jan;93(1):56-62. doi: 10.1172/JCI116984. J Clin Invest. 1994. PMID: 8282822 Free PMC article.
All cells tested were found to be UV responsive, and in NIH 3T3 cells, induction was found to depend upon two general regions of the promoter. ...Second, cell fusion studies showed that while the LPS signaling pathway is extinguished by fusion of RAW 264.7 …
All cells tested were found to be UV responsive, and in NIH 3T3 cells, induction was found to depend upon two general r …
[Crystal-induced joint inflammation].
Oliviero F, Punzi L. Oliviero F, et al. Reumatismo. 2003;55(1):16-27. doi: 10.4081/reumatismo.2003.16. Reumatismo. 2003. PMID: 12649696 Free article. Review. Italian.
Type and duration of the inflammatory reactions are mainly influenced by crystals characteristics, including shape and size, which, in turn may involve the crystal- binding of several proteins, essential for the modulation of cellular responses. Cells most in …
Type and duration of the inflammatory reactions are mainly influenced by crystals characteristics, including shape and size, which, in turn …
What does tumour necrosis factor excess do to the immune system long term?
Clark J, Vagenas P, Panesar M, Cope AP. Clark J, et al. Ann Rheum Dis. 2005 Nov;64 Suppl 4(Suppl 4):iv70-6. doi: 10.1136/ard.2005.042523. Ann Rheum Dis. 2005. PMID: 16239393 Free PMC article. Review.
Members of the tumour necrosis factor (TNF)/TNF-receptor (TNF-R) superfamily coordinate the immune response at multiple levels. For example, TNF, LTalpha, LTbeta and RANKL provide signals required for lymphoid neogenesis, CD27, OX-40, 4-1BB and CD30 de …
Members of the tumour necrosis factor (TNF)/TNF-receptor (TNF-R) superfamily coordinate the immune response at m …
Differential tumor necrosis factor alpha expression and release from peritoneal mouse macrophages in vitro in response to proliferating gram-positive versus gram-negative bacteria.
Cui W, Morrison DC, Silverstein R. Cui W, et al. Infect Immun. 2000 Aug;68(8):4422-9. doi: 10.1128/IAI.68.8.4422-4429.2000. Infect Immun. 2000. PMID: 10899839 Free PMC article.
Viable Escherichia coli and Staphylococcus aureus bacteria elicited markedly different in vitro tumor necrosis factor alpha (TNF-alpha) responses when placed in coculture with peritoneal murine macrophages. These include quantitative differences …
Viable Escherichia coli and Staphylococcus aureus bacteria elicited markedly different in vitro tumor necrosis factor …
Langerhans cell migration.
Cumberbatch M, Dearman RJ, Griffiths CE, Kimber I. Cumberbatch M, et al. Clin Exp Dermatol. 2000 Jul;25(5):413-8. doi: 10.1046/j.1365-2230.2000.00678.x. Clin Exp Dermatol. 2000. PMID: 11012599 Review.
During their movement from the skin LC acquire the characteristics of immunostimulatory dendritic cells (DC) such that the antigen-bearing cells which accumulate in lymph nodes are able to provoke specific T-lymphocyte responses. Epidermal cytokines initiate …
During their movement from the skin LC acquire the characteristics of immunostimulatory dendritic cells (DC) such that the antigen-be …
Tumor necrosis factor and lymphotoxin. Qualitative and quantitative differences in the mediation of early and late cellular response.
Chaturvedi MM, LaPushin R, Aggarwal BB. Chaturvedi MM, et al. J Biol Chem. 1994 May 20;269(20):14575-83. J Biol Chem. 1994. PMID: 8182064 Free article.
Tumor necrosis factor (TNF) is a 17-kDa protein produced by monocytes and a wide variety of other cell types in response to endotoxin and other cytokines. ...As they have common cell surface receptors, it is generally assumed that all cellular …
Tumor necrosis factor (TNF) is a 17-kDa protein produced by monocytes and a wide variety of other cell types in resp …
The deubiquitinating enzyme USP11 controls an IkappaB kinase alpha (IKKalpha)-p53 signaling pathway in response to tumor necrosis factor alpha (TNFalpha).
Yamaguchi T, Kimura J, Miki Y, Yoshida K. Yamaguchi T, et al. J Biol Chem. 2007 Nov 23;282(47):33943-8. doi: 10.1074/jbc.M706282200. Epub 2007 Sep 26. J Biol Chem. 2007. PMID: 17897950 Free article.
However, down-regulation of USP11 dramatically enhances NF-kappaB activity in response to tumor necrosis factor-alpha, indicating that IKKalpha does not require activation of NF-kappaB. Instead, knock down of USP11 or IKKalpha is associated with …
However, down-regulation of USP11 dramatically enhances NF-kappaB activity in response to tumor necrosis factor- …
Production and regulation of tumor necrosis factor alpha. A cellular and molecular analysis.
Kunkel SL, Spengler M, Kwon G, May MA, Remick DG. Kunkel SL, et al. Methods Achiev Exp Pathol. 1988;13:240-59. Methods Achiev Exp Pathol. 1988. PMID: 3137425
Tumor necrosis factor alpha is increasingly being recognized as an important macrophage-derived cytokine that possesses pleomorphic effects in both physiologic and immunologic systems. Current evidence has demonstrated that tumor necrosis …
Tumor necrosis factor alpha is increasingly being recognized as an important macrophage-derived cytokine that po …
The use of computer-assisted video image analysis for the quantification of CD8+ T lymphocytes producing tumor necrosis factor alpha spots in response to peptide antigens.
Herr W, Linn B, Leister N, Wandel E, Meyer zum Büschenfelde KH, Wölfel T. Herr W, et al. J Immunol Methods. 1997 Apr 25;203(2):141-52. doi: 10.1016/s0022-1759(97)00019-7. J Immunol Methods. 1997. PMID: 9149807
Herein computer-assisted video image analysis (CVIA) was applied to automatically determine the number and size of tumor necrosis factor alpha (TNF-alpha) spots formed by single blood-derived CD8+ T cells after contact with peptide-loaded target …
Herein computer-assisted video image analysis (CVIA) was applied to automatically determine the number and size of tumor necrosis …
66,102 results
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