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Asiaticoside-nitric oxide promoting diabetic wound healing through the miRNA-21-5p/TGF-β1/SMAD7/TIMP3 signaling pathway.
Liu Y, Zhao J, Mu X, Deng J, Wu X, He W, Liu Y, Gu R, Han F, Nie X. Liu Y, et al. J Ethnopharmacol. 2024 Jan 30;319(Pt 2):117266. doi: 10.1016/j.jep.2023.117266. Epub 2023 Sep 30. J Ethnopharmacol. 2024. PMID: 37783408
ETHNOPHARMACOLOGICAL RELEVANCE: Centella asiatica (L.) Urban is an ethnobotanical herb. The main bioactive components of Centella asiatica are pentacyclic triterpenoid glycosides, namely asiaticoside and hydroxyasiaticoside. Asiaticoside possess a dive …
ETHNOPHARMACOLOGICAL RELEVANCE: Centella asiatica (L.) Urban is an ethnobotanical herb. The main bioactive components of Ce
Guben Xiezhuo Decoction inhibits M1 polarization through the Raf1/p-Elk1 signaling axis to attenuate renal interstitial fibrosis.
Liu Y, Wu J, Liang S, Xu J, Wei M, Du Z, Qiang S. Liu Y, et al. J Ethnopharmacol. 2024 Jan 30;319(Pt 2):117189. doi: 10.1016/j.jep.2023.117189. Epub 2023 Sep 15. J Ethnopharmacol. 2024. PMID: 37716490 Free article.
Its main components are Astragalus membranaceus (Fisch.) Bunge, Codonopsis pilosula (Franch.) Nannf., Centella asiatica (L.) Urb., Salvia miltiorrhiza Bunge, Cuscuta chinensis Lam., and Rheum palmatum L.. ...RESULTS: Histopathological results showed that the UUO gro …
Its main components are Astragalus membranaceus (Fisch.) Bunge, Codonopsis pilosula (Franch.) Nannf., Centella asiatica (L.) U …
TMT quantitative proteomics and network pharmacology reveal the mechanism by which asiaticoside regulates the JAK2/STAT3 signaling pathway to inhibit peritoneal fibrosis.
Sun J, Tang L, Shan Y, Yu M, Sheng L, Huang L, Cao H, Dai H, Wang F, Zhao J, Sheng M. Sun J, et al. J Ethnopharmacol. 2023 Jun 12;309:116343. doi: 10.1016/j.jep.2023.116343. Epub 2023 Mar 10. J Ethnopharmacol. 2023. PMID: 36906159
ETHNOPHARMACOLOGICAL RELEVANCE: Traditional Chinese medicine, Centella asiatica (L.) Urb., has been extensively utilized in clinics to treat a variety of fibrotic disorders. ...
ETHNOPHARMACOLOGICAL RELEVANCE: Traditional Chinese medicine, Centella asiatica (L.) Urb., has been extensively utilized in cl …
Asiatic acid alleviates liver fibrosis via multiple signaling pathways based on integrated network pharmacology and lipidomics.
Li Y, He XL, Zhou LP, Huang XZ, Li S, Guan S, Li J, Zhang L. Li Y, et al. Eur J Pharmacol. 2022 Sep 15;931:175193. doi: 10.1016/j.ejphar.2022.175193. Epub 2022 Aug 10. Eur J Pharmacol. 2022. PMID: 35963324
Liver fibrosis is characterized by the abnormal deposition of the extracellular matrix with a severe inflammatory response and/or metabolic disorder. Asiatic acid (AA), a natural compound derived from Centella asiatica, exhibited potent anti-fibrosis effects. This i …
Liver fibrosis is characterized by the abnormal deposition of the extracellular matrix with a severe inflammatory response and/or metabolic …
Pycnogenol®-Centellicum® supplementation improves lung fibrosis and post-COVID-19 lung healing.
Cesarone MR, Hu S, Belcaro G, Cornelli U, Feragalli B, Corsi M, Bombardelli E, Cotellese R, Hosoi M, Rosenkvist L. Cesarone MR, et al. Minerva Med. 2022 Feb;113(1):135-140. doi: 10.23736/S0026-4806.20.07225-0. Epub 2021 Jun 28. Minerva Med. 2022. PMID: 34180638
BACKGROUND: The aim of this study was to evaluate the combination of Pycnogenol() (150 mg/day) (Horphag Research, London, UK) and Centella asiatica (Centellicum() 3225 mg/day; Horphag Research) (PY-CE) for 8 months in subjects with sequelae of idiopathic interstitia …
BACKGROUND: The aim of this study was to evaluate the combination of Pycnogenol() (150 mg/day) (Horphag Research, London, UK) and Centell
Ethanol Extract of Centella asiatica (Gotu Kola) Attenuates Tubular Injury Through Inhibition of Inflammatory Cytokines and Enhancement of Anti-Fibrotic Factor in Mice with 5/6 Subtotal Nephrectomy.
Arfian N, Setyaningsih WAW, Anggorowati N, Romi MM, Sari DCR. Arfian N, et al. Malays J Med Sci. 2019 Sep;26(5):53-63. doi: 10.21315/mjms2019.26.5.5. Epub 2019 Nov 4. Malays J Med Sci. 2019. PMID: 31728118 Free PMC article.
BACKGROUND: Chronic kidney disease (CKD) leads to inflammation, fibrosis and destruction of the renal architecture. Centella asiatica (CeA) is an herbaceous plant with anti-inflammatory effects. ...
BACKGROUND: Chronic kidney disease (CKD) leads to inflammation, fibrosis and destruction of the renal architecture. Centella asiat
Protective effect of asiatic acid in an experimental cerulein-induced model of acute pancreatitis in mice.
Xiao W, Jiang W, Li K, Hu Y, Li S, Zhou L, Wan R. Xiao W, et al. Am J Transl Res. 2017 Aug 15;9(8):3842-3852. eCollection 2017. Am J Transl Res. 2017. PMID: 28861174 Free PMC article.
Asiatic acid (AA), a triterpenoid derived from the medicinal plant Centella asiatica, is considered to have anti-inflammatory, anti-fibrotic and anti-tumor effects, but its effects in acute pancreatitis (AP) are unknown. ...
Asiatic acid (AA), a triterpenoid derived from the medicinal plant Centella asiatica, is considered to have anti-inflammatory, …
Asiatic acid ameliorates pulmonary fibrosis induced by bleomycin (BLM) via suppressing pro-fibrotic and inflammatory signaling pathways.
Dong SH, Liu YW, Wei F, Tan HZ, Han ZD. Dong SH, et al. Biomed Pharmacother. 2017 May;89:1297-1309. doi: 10.1016/j.biopha.2017.03.005. Epub 2017 Mar 17. Biomed Pharmacother. 2017. PMID: 28320097
In addition, the molecular mechanism by which pulmonary fibrosis developed is not fully understood. Asiatic acid (AA) is a triterpenoid, isolated from Centella asiatica, exhibiting efficient anti-inflammatory and anti-oxidative activities. ...
In addition, the molecular mechanism by which pulmonary fibrosis developed is not fully understood. Asiatic acid (AA) is a triterpenoid, iso …
Antifibrotic effect of Centella asiatica Linn and asiatic acid on arecoline-induced fibrosis in human buccal fibroblasts.
Adtani PN, Narasimhan M, Punnoose AM, Kambalachenu HR. Adtani PN, et al. J Investig Clin Dent. 2017 May;8(2). doi: 10.1111/jicd.12208. Epub 2016 Feb 3. J Investig Clin Dent. 2017. PMID: 26840561
AIM: The aim of the present study was to investigate the in vitro antifibrogenic effects of Centella asiatica Linn (CA) and its bioactive triterpene aglycone asiatic acid (AA) on arecoline-induced fibrosis in primary human buccal fibroblasts (HBF). ...Arecoline prod …
AIM: The aim of the present study was to investigate the in vitro antifibrogenic effects of Centella asiatica Linn (CA) and it …
Synthesis and evaluation of asiatic acid derivatives as anti-fibrotic agents: structure/activity studies.
Li Y, Yang F, Yuan M, Jiang L, Yuan L, Zhang X, Li Y, Dong L, Bao X, Yin S. Li Y, et al. Steroids. 2015 Apr;96:44-9. doi: 10.1016/j.steroids.2014.11.001. Epub 2014 Nov 20. Steroids. 2015. PMID: 25461275
Previously, we showed that asiaticoside, a bioactive triterpene glycoside from Centella asiatica, has anti-fibrotic properties. Here, the aglycone asiatic acid was chemically modified, and these derivatives were evaluated for their potential as anti-fibrot
Previously, we showed that asiaticoside, a bioactive triterpene glycoside from Centella asiatica, has anti-fibrotic pro …
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