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Page 1
Review of neuroprotective potential of natural products against hypoxia-induced neuronal injury.
Zhang Y, Yi X, Wang D, Kong C, Xu Y, Xie J. Zhang Y, et al. Front Pharmacol. 2026 Feb 11;17:1746683. doi: 10.3389/fphar.2026.1746683. eCollection 2026. Front Pharmacol. 2026. PMID: 41756238 Free PMC article. Review.
Neurological disorders such as neurodegenerative diseases (NDDs) and stroke have become a major global health burden. ...Overall, we summarized the neuroprotective effects of these natural products against hypoxia-related neurological injury, focusing on the molecular mech …
Neurological disorders such as neurodegenerative diseases (NDDs) and stroke have become a major global health burden. ...Overall, we …
Thymoquinone and madecassoside improve motor function in a rotenone-induced mouse model of early Parkinson's disease: Role of dopamine, alpha-synuclein and mBDNF.
Kusumawati S, Endharti AT, Balafif F, Kurniawan SN, Rosidah A, Anaqah R, Barqillah IA, Khotimah H. Kusumawati S, et al. Narra J. 2025 Aug;5(2):e2439. doi: 10.52225/narra.v5i2.2439. Epub 2025 May 9. Narra J. 2025. PMID: 40951472 Free PMC article.
Parkinson's disease is a progressive, incurable neurodegenerative disorder characterized by the degeneration of dopaminergic neurons and pathological aggregation of alpha-synuclein in the midbrain, leading to motor dysfunction. ...Collectively, these results …
Parkinson's disease is a progressive, incurable neurodegenerative disorder characterized by the degeneration of dopamin …
Neuroprotective effects of Centella asiatica against LPS/amyloid beta-induced neurodegeneration through inhibition of neuroinflammation.
Ansari S, Maurya VK, Kumar S, Tiwari M, Abdel-Moneime AS, Saxena SK. Ansari S, et al. Neuroscience. 2025 May 24;575:19-35. doi: 10.1016/j.neuroscience.2025.04.011. Epub 2025 Apr 7. Neuroscience. 2025. PMID: 40204151
The outcomes of the study suggested that C. asiatica could be a promising candidate for neuroinflammation-mediated neurodegenerative diseases like Parkinson's and Alzheimer's....
The outcomes of the study suggested that C. asiatica could be a promising candidate for neuroinflammation-mediated neurodegenerative disease …
Centella asiatica improves cognitive function and alters the hippocampal metabolome of aged Tg2576 and wild-type mice.
Matthews DG, Khorani M, Bobe G, Caruso M, Magana AA, Gray NE, Quinn JF, Stevens JF, Maier CS, Soumyanath A. Matthews DG, et al. J Alzheimers Dis Rep. 2024 Dec 4;8(1):1611-1638. doi: 10.1177/25424823241296740. eCollection 2024. J Alzheimers Dis Rep. 2024. PMID: 40034352 Free PMC article.
BACKGROUND: Alzheimer's disease (AD) is a growing public health problem in the aging population, with limited treatment options. We previously reported that Centella asiatica herb water extract (CAW) attenuates cognitive decline in murine models of AD and aging. ...
BACKGROUND: Alzheimer's disease (AD) is a growing public health problem in the aging population, with limited treatment options. We p …
Oral Asiatic Acid Improves Cognitive Function and Modulates Antioxidant and Mitochondrial Pathways in Female 5xFAD Mice.
Varada S, Chamberlin SR, Bui L, Brandes MS, Gladen-Kolarsky N, Harris CJ, Hack W, Neff CJ, Brumbach BH, Soumyanath A, Quinn JF, Gray NE. Varada S, et al. Nutrients. 2025 Feb 19;17(4):729. doi: 10.3390/nu17040729. Nutrients. 2025. PMID: 40005058 Free PMC article.
Background/Objectives: Extracts of the plant Centella asiatica can enhance mitochondrial function, promote antioxidant activity and improve cognitive deficits. ...
Background/Objectives: Extracts of the plant Centella asiatica can enhance mitochondrial function, promote antioxidant activity and i …
Neuroprotective Action of Selected Natural Drugs Against Neurological Diseases and Mental Disorders: Potential Use Against Radiation Damage.
Akhlada, Siddiqui N, Anurag, Saifi A, Kesharwani A, Parihar VK, Sharma A. Akhlada, et al. Neurochem Res. 2024 Sep;49(9):2336-2351. doi: 10.1007/s11064-024-04184-y. Epub 2024 Jun 12. Neurochem Res. 2024. PMID: 38864943 Review.
This review covers neurodegenerative diseases such as Alzheimer's, Parkinson's, and neuroinflammation due to changes in neurons in the central nervous system, and the effects thereon of medicinal plants such as Allium cepa, Allium sativum, Centella asi …
This review covers neurodegenerative diseases such as Alzheimer's, Parkinson's, and neuroinflammation due to changes in …
Amelioration of age-related cognitive decline and anxiety in mice by Centella asiatica extract varies by sex, dose and mode of administration.
Gray NE, Hack W, Brandes MS, Zweig JA, Yang L, Marney L, Choi J, Magana AA, Cerruti N, McFerrin J, Koike S, Nguyen T, Raber J, Quinn JF, Maier CS, Soumyanath A. Gray NE, et al. Front Aging. 2024 May 6;5:1357922. doi: 10.3389/fragi.2024.1357922. eCollection 2024. Front Aging. 2024. PMID: 38770167 Free PMC article.
Background: A water extract (CAW) of the Ayurvedic plant Centella asiatica administered in drinking water has been shown to improve cognitive deficits in mouse models of aging and neurodegenerative diseases. ...
Background: A water extract (CAW) of the Ayurvedic plant Centella asiatica administered in drinking water has been shown to improve c …
Mode of administration influences plasma levels of active Centella asiatica compounds in 5xFAD mice while markers of neuroinflammation remain unaltered.
Speers AB, Wright KM, Brandes MS, Kedjejian N, Matthews DG, Caruso M, Harris CJ, Koike S, Nguyen T, Quinn JF, Soumyanath A, Gray NE. Speers AB, et al. Front Neurosci. 2024 Mar 25;18:1277626. doi: 10.3389/fnins.2024.1277626. eCollection 2024. Front Neurosci. 2024. PMID: 38591068 Free PMC article.
INTRODUCTION: A water extract of Centella asiatica (L.) Urban [Apiaceae] (CAW) has demonstrated cognitive-enhancing effects in mouse models of Alzheimer's disease and aging, the magnitude of which is influenced by whether CAW is delivered in the drinking water or th …
INTRODUCTION: A water extract of Centella asiatica (L.) Urban [Apiaceae] (CAW) has demonstrated cognitive-enhancing effects in mouse …
Asiaticoside exerts neuroprotection through targeting NLRP3 inflammasome activation.
He Z, Hu Y, Zhang Y, Xie J, Niu Z, Yang G, Zhang J, Zhao Z, Wei S, Wu H, Hu W. He Z, et al. Phytomedicine. 2024 May;127:155494. doi: 10.1016/j.phymed.2024.155494. Epub 2024 Feb 28. Phytomedicine. 2024. PMID: 38471370
BACKGROUND: Parkinson's disease (PD), a neurodegenerative disorder, is characterized by motor symptoms due to the progressive loss of dopaminergic neurons in the substantia nigra (SN) and striatum (STR), alongside neuroinflammation. Asiaticoside (AS), a prima …
BACKGROUND: Parkinson's disease (PD), a neurodegenerative disorder, is characterized by motor symptoms due to the progr …
Integrating High-Resolution Mass Spectral Data, Bioassays and Computational Models to Annotate Bioactives in Botanical Extracts: Case Study Analysis of C. asiatica Extract Associates Dicaffeoylquinic Acids with Protection against Amyloid-β Toxicity.
Alcázar Magaña A, Vaswani A, Brown KS, Jiang Y, Alam MN, Caruso M, Lak P, Cheong P, Gray NE, Quinn JF, Soumyanath A, Stevens JF, Maier CS. Alcázar Magaña A, et al. Molecules. 2024 Feb 13;29(4):838. doi: 10.3390/molecules29040838. Molecules. 2024. PMID: 38398590 Free PMC article.
We applied this strategy for discovering and identifying constituents of Centella asiatica (C. asiatica) that protect against Abeta cytotoxicity in vitro. C. asiatica has been associated with improving mental health and cognitive function, with potential use in Alzheimer's …
We applied this strategy for discovering and identifying constituents of Centella asiatica (C. asiatica) that protect against Abeta c …
52 results