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Page 1
Phlebotonics for venous insufficiency.
Martinez-Zapata MJ, Vernooij RW, Simancas-Racines D, Uriona Tuma SM, Stein AT, Moreno Carriles RMM, Vargas E, Bonfill Cosp X. Martinez-Zapata MJ, et al. Cochrane Database Syst Rev. 2020 Nov 3;11(11):CD003229. doi: 10.1002/14651858.CD003229.pub4. Cochrane Database Syst Rev. 2020. PMID: 33141449 Free PMC article.
SELECTION CRITERIA: We included randomised, double-blind, placebo-controlled trials (RCTs) assessing the efficacy of phlebotonics (rutosides, hidrosmine, diosmine, calcium dobesilate, chromocarbe, Centella asiatica, disodium flavodate, French maritime pine bark extr …
SELECTION CRITERIA: We included randomised, double-blind, placebo-controlled trials (RCTs) assessing the efficacy of phlebotonics (rutosides …
Efficacy of Centella asiatica on mitigating temporomandibular pain and improving functionality: a randomized, double blind, pilot clinical trial.
Potewiratnanond P, Surarit R, Tantisira MH, Samaranayake L, Rotpenpian N, Wanasuntronwong A. Potewiratnanond P, et al. Head Face Med. 2025 Apr 19;21(1):28. doi: 10.1186/s13005-025-00503-y. Head Face Med. 2025. PMID: 40253389 Free PMC article. Clinical Trial.
OBJECTIVE: To determine the efficacy of Centella asiatica extract, ECa233, on alleviating pain symptoms and functional improvement of acute temporomandibular disorders (TMD). ...Additionally, those receiving 500 mg of ECa233 displayed the highest perce …
OBJECTIVE: To determine the efficacy of Centella asiatica extract, ECa233, on alleviating pain symptoms and func …
Standardized Centella asiatica (ECa 233) extract decreased pain hypersensitivity development in a male mouse model of chronic inflammatory temporomandibular disorder.
Rotpenpian N, Wanasuntronwong A, Tapechum S, Vattarakorn A, Care C, Chindasri W, Tilokskulchai K, Tantisira MH, Pakaprot N. Rotpenpian N, et al. Sci Rep. 2023 Apr 24;13(1):6642. doi: 10.1038/s41598-023-33769-w. Sci Rep. 2023. PMID: 37095163 Free PMC article.
Chronic inflammatory temporomandibular disorder (TMD) pain has a high prevalence, and available nonspecific treatments have adverse side effects. ECa 233, a standardized Centella asiatica extract, is highly anti-inflammatory and safe. We investigated i …
Chronic inflammatory temporomandibular disorder (TMD) pain has a high prevalence, and available nonspecific treatments have adverse s …
Anti-nociceptive effects of ECa 233 a standardized extract of Centella asiatica (L.) Urban on chronic neuropathic orofacial pain in mice.
Buapratoom A, Wanasuntronwong A, Khongsombat O, Tantisira MH. Buapratoom A, et al. J Ethnopharmacol. 2022 Jan 30;283:114737. doi: 10.1016/j.jep.2021.114737. Epub 2021 Oct 11. J Ethnopharmacol. 2022. PMID: 34648902
ETHNOPHARMACOLOGICAL RELEVANCE: ECa 233 is a standardized extract of Centella asiatica (L.) Urban, a herb traditionally used to treat a number of diseases including neurological disorders. ...Further clinical trial to proof ECa 233's efficacy in neuropathic pain …
ETHNOPHARMACOLOGICAL RELEVANCE: ECa 233 is a standardized extract of Centella asiatica (L.) Urban, a herb traditionally used t …
Standardized Centella asiatica extract ECa 233 alleviates pain hypersensitivity by modulating P2X3 in trigeminal neuropathic pain.
Wanasuntronwong A, Kaewsrisung S, Lakkhanachatpan N, Meepong R, Arayapisit T, Tantisira M. Wanasuntronwong A, et al. J Appl Oral Sci. 2024 Jan 5;32:e20230337. doi: 10.1590/1678-7757-2023-0337. eCollection 2024. J Appl Oral Sci. 2024. PMID: 38198371 Free PMC article.
This study aimed to investigate the effects of ECa 233, a Centella asiatica-standardized extract, on the development of mechanical hyperalgesia and allodynia induced by chronic constriction injury of the infraorbital nerve in mice. ...CONCLUSION: Carbamazepine and E …
This study aimed to investigate the effects of ECa 233, a Centella asiatica-standardized extract, on the development of mechan …
Intra-Articular Route for the System of Molecules 14G1862 from Centella Asiatica: Pain Relieving and Protective Effects in a Rat Model of Osteoarthritis.
Micheli L, Di Cesare Mannelli L, Mattoli L, Tamimi S, Flamini E, Garetto S, Lucci J, Giovagnoni E, Cinci L, D'Ambrosio M, Luceri C, Ghelardini C. Micheli L, et al. Nutrients. 2020 May 31;12(6):1618. doi: 10.3390/nu12061618. Nutrients. 2020. PMID: 32486519 Free PMC article.
Current pharmacological therapies for the management of chronic articular diseases are far from being satisfactory, so new strategies need to be investigated. We tested the intra-articular pain relieving properties of a system of molecules from a characterized Centella …
Current pharmacological therapies for the management of chronic articular diseases are far from being satisfactory, so new strategies need t …
Effectiveness of Fractional CO2 Laser and Topical Centella asiatica Combination Therapy in Striae Distensae (Stretch Marks).
Kurniawati Y, Yahya YF, Fadhila A, Rahmanda MR, Nursyarifah N, Alisa NS. Kurniawati Y, et al. J Lasers Med Sci. 2024 Nov 24;15:e56. doi: 10.34172/jlms.2024.56. eCollection 2024. J Lasers Med Sci. 2024. PMID: 39650780 Free PMC article.
This study aimed to determine the effectiveness of combination therapy with fractional CO(2) laser and Centella asiatica in SD. Results: This study included 22 SD patients who met the inclusion criteria and received combination therapy with fractional CO(2) laser an …
This study aimed to determine the effectiveness of combination therapy with fractional CO(2) laser and Centella asiatica in SD …
Pumpkin seeds, Centella asiatica, Boswellia, Helichrysum, acetate vitamin E, Melaleuca alternifolia and hyaluronic acid phytocomplex monotherapy effects in patients with chronic pelvic pain syndrome.
Di Vico T, Durante J, Polito C, Tognarelli A, Canale D, Caglieresi C, Morelli G, Bartoletti R. Di Vico T, et al. Minerva Urol Nefrol. 2020 Apr;72(2):236-242. doi: 10.23736/S0393-2249.19.03450-7. Epub 2019 Sep 26. Minerva Urol Nefrol. 2020. PMID: 31558010 Free article.
Aim of the present study was to investigate the effects of Proxelan monotherapy on pain symptoms of patients with chronic prostatitis (CP) or chronic pelvic pain syndrome (CPPS) in a prospective pilot study. ...Effects on semen parameters such as leukocytospermia, s …
Aim of the present study was to investigate the effects of Proxelan monotherapy on pain symptoms of patients with chronic prostatitis …
Centella asiatica triterpenes for diabetic neuropathy: a randomized, double-blind, placebo-controlled, pilot clinical study.
Lou JS, Dimitrova DM, Murchison C, Arnold GC, Belding H, Seifer N, Le N, Andrea SB, Gray NE, Wright KM, Caruso M, Soumyanath A. Lou JS, et al. Esper Dermatol. 2018 Jun;20(2 Suppl 1):12-22. doi: 10.23736/S1128-9155.18.00455-7. Esper Dermatol. 2018. PMID: 31080345 Free PMC article.
Currently available treatments relieve symptoms, but do not modify the neurodegeneration underlying DN. Centella asiatica (CA) triterpenes improved microcirculation in earlier clinical studies, and showed neurotropic effects in preclinical models suggesting a potent …
Currently available treatments relieve symptoms, but do not modify the neurodegeneration underlying DN. Centella asiatica (CA) …
51 results