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2007 6
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Cepharanthine maintains integrity of the blood-brain barrier (BBB) in stroke via the VEGF/VEGFR2/ZO-1 signaling pathway.
Yang Y, Li C, Yang S, Zhang Z, Bai X, Tang H, Huang J. Yang Y, et al. Aging (Albany NY). 2024 Mar 21;16(7):5905-5915. doi: 10.18632/aging.205678. Epub 2024 Mar 21. Aging (Albany NY). 2024. PMID: 38517394 Free article.
Dysfunction of tight junctions such as zonula occludens protein-1 (ZO-1)-associated aggravation of blood-brain barrier (BBB) permeability plays an important role in the progression of stroke. Cepharanthine (CEP) is an extract from the plant Stephania cepharantha. ...
Dysfunction of tight junctions such as zonula occludens protein-1 (ZO-1)-associated aggravation of blood-brain barrier (BBB) permeability pl …
Cepharanthine suppresses APC-mutant colorectal cancers by down-regulating the expression of beta-catenin.
Su G, Wang D, Yang Q, Kong L, Ju X, Yang Q, Zhu Y, Zhang S, Li Y. Su G, et al. Nat Prod Bioprospect. 2024 Feb 29;14(1):18. doi: 10.1007/s13659-024-00443-1. Nat Prod Bioprospect. 2024. PMID: 38421454 Free PMC article.
The anti-tumor activity of the naturally occurring alkaloid cepharanthine (CEP) extracted from the plant Stephania cepharantha Hayata has been reported in various types of tumors. ...
The anti-tumor activity of the naturally occurring alkaloid cepharanthine (CEP) extracted from the plant Stephania cepharantha Hayata …
The genome of Stephania japonica provides insights into the biosynthesis of cepharanthine.
Liu Z, Shen S, Wang Y, Sun S, Yu T, Fu Y, Zhou R, Li C, Cao R, Zhang Y, Li N, Sun L, Song X. Liu Z, et al. Cell Rep. 2024 Mar 26;43(3):113832. doi: 10.1016/j.celrep.2024.113832. Epub 2024 Feb 20. Cell Rep. 2024. PMID: 38381605 Free article.
Stephania japonica is an early-diverging eudicotyledon plant with high levels of cepharanthine, proven to be effective in curing coronavirus infections. ...We further reconstruct ancestral karyotype of Ranunculales. Several cepharanthine biosynthesis genes are ident …
Stephania japonica is an early-diverging eudicotyledon plant with high levels of cepharanthine, proven to be effective in curing coro …
Cepharanthine analogs mining and genomes of Stephania accelerate anti-coronavirus drug discovery.
Leng L, Xu Z, Hong B, Zhao B, Tian Y, Wang C, Yang L, Zou Z, Li L, Liu K, Peng W, Liu J, An Z, Wang Y, Duan B, Hu Z, Zheng C, Zhang S, Li X, Li M, Liu Z, Bi Z, He T, Liu B, Fan H, Song C, Tong Y, Chen S. Leng L, et al. Nat Commun. 2024 Feb 20;15(1):1537. doi: 10.1038/s41467-024-45690-5. Nat Commun. 2024. PMID: 38378731 Free PMC article.
Cepharanthine is a secondary metabolite isolated from Stephania. It has been reported that it has anti-conronaviruses activities including severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). ...We also show that two other genera, Nelumbo and Thalictrum, can produ …
Cepharanthine is a secondary metabolite isolated from Stephania. It has been reported that it has anti-conronaviruses activities incl …
Highly sensitive detection of multiple antiviral drugs using graphitized hydroxylated multi-walled carbon nanotubes/ionic liquids-based electrochemical sensors.
Zhang Z, Zheng H, Liu Y, Ma S, Feng Q, Qu J, Zhu X. Zhang Z, et al. Environ Res. 2024 Feb 12;249:118466. doi: 10.1016/j.envres.2024.118466. Online ahead of print. Environ Res. 2024. PMID: 38354882
In this study, we developed a highly sensitive electrochemical sensor comprising a glassy carbon electrode (GCE) modified with graphitized hydroxylated multi-walled carbon nanotubes (G-MWCNT-OH) and 1-butyl-3-methylimidazolium hexafluorophosphate (BMIMPF(6), IL) for the detection …
In this study, we developed a highly sensitive electrochemical sensor comprising a glassy carbon electrode (GCE) modified with graphitized h …
The Bis(1,2,3,4-tetrahydroisoquinoline) Alkaloids Cepharanthine and Berbamine Are Ligands of SK Channels.
Vitello R, Taouba H, Derand M, Liégeois JF. Vitello R, et al. ACS Med Chem Lett. 2024 Jan 9;15(2):215-220. doi: 10.1021/acsmedchemlett.3c00452. eCollection 2024 Feb 8. ACS Med Chem Lett. 2024. PMID: 38352826
Cepharanthine, a multitarget alkaloid which has recently been shown to be effective against SARS-Cov-2, and berbamine, an alkaloid characterized as a calcium channel blocker, both share key structural elements with known small conductance calcium-activated potassium (SK) c …
Cepharanthine, a multitarget alkaloid which has recently been shown to be effective against SARS-Cov-2, and berbamine, an alkaloid ch …
The role of ABCC10/MRP7 in anti-cancer drug resistance and beyond.
Chen DQ, Xie Y, Cao LQ, Fleishman JS, Chen Y, Wu T, Yang DH. Chen DQ, et al. Drug Resist Updat. 2024 Mar;73:101062. doi: 10.1016/j.drup.2024.101062. Epub 2024 Jan 29. Drug Resist Updat. 2024. PMID: 38330827 Review.
The transport substrates of ABCC10/MRP7 include antineoplastic drugs such as taxanes, vinca alkaloids, and epothilone B, as well as endobiotics such as leukotriene C4 (LTC(4)) and estradiol 17 beta-D-glucuronide. A variety of ABCC10/MRP7 inhibitors, including cepharanthine …
The transport substrates of ABCC10/MRP7 include antineoplastic drugs such as taxanes, vinca alkaloids, and epothilone B, as well as endobiot …
Molecular docking as a tool for the discovery of novel insight about the role of acid sphingomyelinase inhibitors in SARS- CoV-2 infectivity.
Alkafaas SS, Abdallah AM, Hassan MH, Hussien AM, Elkafas SS, Loutfy SA, Mikhail A, Murad OG, Elsalahaty MI, Hessien M, Elshazli RM, Alsaeed FA, Ahmed AE, Kamal HK, Hafez W, El-Saadony MT, El-Tarabily KA, Ghosh S. Alkafaas SS, et al. BMC Public Health. 2024 Feb 6;24(1):395. doi: 10.1186/s12889-024-17747-z. BMC Public Health. 2024. PMID: 38321448 Free PMC article. Review.
In silico molecular docking analyses of FIASMAs with inhibitors revealed that dilazep (S = - 12.58 kcal/mol), emetine (S = - 11.65 kcal/mol), pimozide (S = - 11.29 kcal/mol), carvedilol (S = - 11.28 kcal/mol), mebeverine (S = - 11.14 kcal/mol), cepharanthine (S = - 11.06 k …
In silico molecular docking analyses of FIASMAs with inhibitors revealed that dilazep (S = - 12.58 kcal/mol), emetine (S = - 11.65 kcal/mol) …
Cepharanthine suppresses proliferation and metastasis and enhances apoptosis by regulating JAK2/Stat3 pathway in hepatocellular carcinoma.
Liang Y, Li J, Xu H, Pang M, Hu C, Weng X, Xie W. Liang Y, et al. Cell Mol Biol (Noisy-le-grand). 2023 Dec 20;69(14):94-100. doi: 10.14715/cmb/2023.69.14.15. Cell Mol Biol (Noisy-le-grand). 2023. PMID: 38279472
Hepatocellular carcinoma (HCC) is a familiar malignant tumor, and cepharanthine (CEP) was proven to prevent the malignant activity of multiple cancer cells, including HCC. ...
Hepatocellular carcinoma (HCC) is a familiar malignant tumor, and cepharanthine (CEP) was proven to prevent the malignant activity of …
Novel antiviral discoveries for Japanese encephalitis virus infections through reporter virus-based high-throughput screening.
Yin C, Yang P, Xiao Q, Sun P, Zhang X, Zhao J, Hu X, Shan C. Yin C, et al. J Med Virol. 2024 Jan;96(1):e29382. doi: 10.1002/jmv.29382. J Med Virol. 2024. PMID: 38235833
Remarkably, this screening process led to the discovery of five drugs with outstanding antiviral activity. Further mechanism of action analysis revealed that cepharanthine, an old clinically approved drug, directly inhibited virus replication by blocking GTP binding to the …
Remarkably, this screening process led to the discovery of five drugs with outstanding antiviral activity. Further mechanism of action analy …
Network pharmacology, molecular docking and experimental study of CEP in nasopharyngeal carcinoma.
Yang J, Qin L, Zhou S, Li J, Tu Y, Mo M, Liu X, Huang J, Qin X, Jiao A, Wei W, Yang P. Yang J, et al. J Ethnopharmacol. 2024 Apr 6;323:117667. doi: 10.1016/j.jep.2023.117667. Epub 2023 Dec 28. J Ethnopharmacol. 2024. PMID: 38159821
ETHNOPHARMACOLOGICAL RELEVANCE: The Stephania cephalantha Hayata is an important traditional medicinal plant widely used in traditional medicine to treat cancer. Cepharanthine (CEP) was extracted from the roots of Stephania cephalantha Hayata. ...
ETHNOPHARMACOLOGICAL RELEVANCE: The Stephania cephalantha Hayata is an important traditional medicinal plant widely used in traditional medi …
Inhibition of porcine deltacoronavirus entry and replication by Cepharanthine.
Sun Y, Liu Z, Shen S, Zhang M, Liu L, Ghonaim AH, Li Y, Zhang S, Li W. Sun Y, et al. Virus Res. 2024 Feb;340:199303. doi: 10.1016/j.virusres.2023.199303. Epub 2023 Dec 30. Virus Res. 2024. PMID: 38145807 Free PMC article.
However, there are currently no proven effective antiviral agents against PDCoV. Cepharanthine (CEP) is a naturally occurring alkaloid used as a traditional remedy for radiation-induced symptoms, but its underlying mechanism of CEP against PDCoV has remained elusive. ...
However, there are currently no proven effective antiviral agents against PDCoV. Cepharanthine (CEP) is a naturally occurring alkaloi …
Cepharanthine, a regulator of keap1-Nrf2, inhibits gastric cancer growth through oxidative stress and energy metabolism pathway.
Lu YY, Zhu CY, Ding YX, Wang B, Zhao SF, Lv J, Chen SM, Wang SS, Wang Y, Wang R, Qiu WS, Qi WW. Lu YY, et al. Cell Death Discov. 2023 Dec 12;9(1):450. doi: 10.1038/s41420-023-01752-z. Cell Death Discov. 2023. PMID: 38086844 Free PMC article.
Cepharanthine (CEP), a bioactive compound derived from Stephania Cephalantha Hayata, is cytotoxic to various malignancies. ...
Cepharanthine (CEP), a bioactive compound derived from Stephania Cephalantha Hayata, is cytotoxic to various malignancies. ...
Cepharanthine synergizes with photodynamic therapy for boosting ROS-driven DNA damage and suppressing MTH1 as a potential anti-cancer strategy.
Yang ZY, Li LG, Xiong YL, Chen NN, Yu TT, Li HT, Ren T, You H, Wang X, Li TF, Wang MF, Hu J. Yang ZY, et al. Photodiagnosis Photodyn Ther. 2024 Feb;45:103917. doi: 10.1016/j.pdpdt.2023.103917. Epub 2023 Nov 30. Photodiagnosis Photodyn Ther. 2024. PMID: 38042236 Free article.
To tackle this problem, the present study was carried out to improve the efficacy of chlorin e6 (Ce6)-PDT using Cepharanthine (CEP) as well as to reveal the potential molecular mechanism. ...
To tackle this problem, the present study was carried out to improve the efficacy of chlorin e6 (Ce6)-PDT using Cepharanthine (CEP) a …
Herbal compound cepharanthine attenuates inflammatory arthritis by blocking macrophage M1 polarization.
Lu C, Cheng RJ, Zhang Q, Hu Y, Pu Y, Wen J, Zhong Y, Tang Z, Wu L, Wei S, Tsou PS, Fox DA, Li S, Luo Y, Liu Y. Lu C, et al. Int Immunopharmacol. 2023 Dec;125(Pt B):111175. doi: 10.1016/j.intimp.2023.111175. Epub 2023 Nov 16. Int Immunopharmacol. 2023. PMID: 37976601
OBJECTIVE: Cepharanthine (CEP) is a drug candidate for tumor, viral infection, and some inflammatory diseases, but its effect on rheumatoid arthritis (RA) and the underlying mechanism are incompletely understood. ...
OBJECTIVE: Cepharanthine (CEP) is a drug candidate for tumor, viral infection, and some inflammatory diseases, but its effect on rheu …
Cepharanthine Inhibits Doxorubicin-Induced Cellular Senescence by Activating Autophagy via the mTOR Signaling Pathway.
Chen J, Xia CL, Dong R, Liu XG, Xia J. Chen J, et al. Discov Med. 2023 Oct;35(178):777-786. doi: 10.24976/Discov.Med.202335178.72. Discov Med. 2023. PMID: 37811615
Recent research indicates that Dox-induced cardiotoxicity is associated with senescent cell accumulation and that antiaging therapy can alleviate aging-related disorders. Cepharanthine (Cep) is commonly used to treat various acute and chronic illnesses, including leukopeni …
Recent research indicates that Dox-induced cardiotoxicity is associated with senescent cell accumulation and that antiaging therapy can alle …
Cepharanthine Exerts Antioxidant and Anti-Inflammatory Effects in Lipopolysaccharide (LPS)-Induced Macrophages and DSS-Induced Colitis Mice.
Chen G, Wen D, Shen L, Feng Y, Xiong Q, Li P, Zhao Z. Chen G, et al. Molecules. 2023 Aug 15;28(16):6070. doi: 10.3390/molecules28166070. Molecules. 2023. PMID: 37630322 Free PMC article.
Cepharanthine (CEP), a biscoclaurine alkaloid extracted from Stephania cepharantha Hayata, has been widely used for the treatment of various acute and chronic diseases, including leukopenia, and snake bites. ...
Cepharanthine (CEP), a biscoclaurine alkaloid extracted from Stephania cepharantha Hayata, has been widely used for the treatment of …
Identifying STRN3-RARA as a new fusion gene for acute promyelocytic leukemia.
Zhang Q, Li H, Chen X, Gu F, Zhang L, Zhang L, Chen T, Chen Q, Meng W, Wu Y, Chang H, Liu T, Chen C, Ma H, Liu Y. Zhang Q, et al. Blood. 2023 Oct 26;142(17):1494-1499. doi: 10.1182/blood.2023020619. Blood. 2023. PMID: 37624915
Although STRN3-RARA leukemia quickly relapses after all-trans retinoic acid treatment, it can be restrained by cepharanthine....
Although STRN3-RARA leukemia quickly relapses after all-trans retinoic acid treatment, it can be restrained by cepharanthine....
The role of cepharanthine as an anti-atherosclerotic agent in rats.
Adnan Iqbal -, Rahila Najam -, Saira Saeed Khan -, Sumera Imran -, Muhammad Osama -, Anosh Tahir -, Muhammad Imran -, Bilal Jawed -, Zeeshan Ahmed -, Azfar Athar Ishaqui -. Adnan Iqbal -, et al. Pak J Pharm Sci. 2023 Jul;36(4):1073-1077. Pak J Pharm Sci. 2023. PMID: 37599480
This investigation assessed the potential of cepharanthine (CEP), a compound from Stephania cepharantha Hayata, in mitigating atherosclerosis in a hyperlipidemic rat model. Using Wistar rats, four distinct diet and drug treatment groups were established: a high-fat high su …
This investigation assessed the potential of cepharanthine (CEP), a compound from Stephania cepharantha Hayata, in mitigating atheros …
Cepharanthine and Oral Lichen Planus Efficacy (COLE) study: protocol for a multicentre randomised controlled study assessing the efficacy and safety of cepharanthine with topical corticosteroids in oral lichen planus.
Yagyuu T, Isogawa M, Yamamoto K, Sugiura T, Matsusue Y, Kasahara M, Kirita T. Yagyuu T, et al. BMJ Open. 2023 Aug 16;13(8):e074279. doi: 10.1136/bmjopen-2023-074279. BMJ Open. 2023. PMID: 37586860 Free PMC article.
Standard therapy involves the use of topical corticosteroids, although some patients respond insufficiently or develop resistance to therapy. We aim to explore if adding cepharanthine, an herbal extract from Stephania cepharantha Hayata, can enhance the efficacy of cortico …
Standard therapy involves the use of topical corticosteroids, although some patients respond insufficiently or develop resistance to therapy …
The brief overview, antivirus and anti-SARS-CoV-2 activity, quantitative methods, and pharmacokinetics of cepharanthine: a potential small-molecule drug against COVID-19.
Xia B, Zheng L, Li Y, Sun W, Liu Y, Li L, Pang J, Chen J, Li J, Cheng H. Xia B, et al. Front Pharmacol. 2023 Jul 31;14:1098972. doi: 10.3389/fphar.2023.1098972. eCollection 2023. Front Pharmacol. 2023. PMID: 37583901 Free PMC article. Review.
To effectively respond to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), an increasing number of researchers are focusing on the antiviral activity of cepharanthine (CEP), which is a clinically approved drug being used for over 70 years. ...
To effectively respond to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), an increasing number of researchers are focusing on …
Pharmacological Activity of Cepharanthine.
Liu K, Hong B, Wang S, Lou F, You Y, Hu R, Shafqat A, Fan H, Tong Y. Liu K, et al. Molecules. 2023 Jun 27;28(13):5019. doi: 10.3390/molecules28135019. Molecules. 2023. PMID: 37446681 Free PMC article. Review.
Recently, cepharanthine has been confirmed to greatly inhibit SARS-CoV-2 infection. ...At the same time, we analyzed and summarized the potential antiviral mechanism of cepharanthine and concluded that one of the most important anti-viral mechanisms of cepharanth …
Recently, cepharanthine has been confirmed to greatly inhibit SARS-CoV-2 infection. ...At the same time, we analyzed and summarized t …
A mechanistic updated overview on Cepharanthine as potential anticancer agent.
Wang Y, Wang T, Wang H, Liu W, Li X, Wang X, Zhang Y. Wang Y, et al. Biomed Pharmacother. 2023 Sep;165:115107. doi: 10.1016/j.biopha.2023.115107. Epub 2023 Jul 7. Biomed Pharmacother. 2023. PMID: 37423171 Free article. Review.
The antitumor effects of traditional drugs have received increasing attention and active antitumor components extracted from traditional drugs have shown good efficacy with minimal adverse events. Cepharanthine(CEP for short) is an active component derived from the Stephan …
The antitumor effects of traditional drugs have received increasing attention and active antitumor components extracted from traditional dru …
Research progress on pharmacological effects and mechanisms of cepharanthine and its derivatives.
Shi L, Wang S, Zhang S, Wang J, Chen Y, Li Y, Liu Z, Zhao S, Wei B, Zhang L. Shi L, et al. Naunyn Schmiedebergs Arch Pharmacol. 2023 Nov;396(11):2843-2860. doi: 10.1007/s00210-023-02537-y. Epub 2023 Jun 20. Naunyn Schmiedebergs Arch Pharmacol. 2023. PMID: 37338575 Review.
Cepharanthine (CEP) is a bisbenzylisoquinoline alkaloid compound found in plants of the Stephania genus, which has biological functions such as regulating autophagy, inhibiting inflammation, oxidative stress, and apoptosis. ...
Cepharanthine (CEP) is a bisbenzylisoquinoline alkaloid compound found in plants of the Stephania genus, which has biological functio …
Cepharanthine Dry Powder Inhaler for the Treatment of Acute Lung Injury.
Liang D, Wang W, Chen G, Li J, Dou G, Gan H, Han P, Du L, Gu R. Liang D, et al. Molecules. 2023 May 30;28(11):4441. doi: 10.3390/molecules28114441. Molecules. 2023. PMID: 37298919 Free PMC article.
Severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) induces a severe cytokine storm that may cause acute lung injury/acute respiratory distress syndrome (ALI/ARDS) with high clinical morbidity and mortality in infected individuals. Cepharanthine (CEP) is a bisbenz …
Severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) induces a severe cytokine storm that may cause acute lung injury/acute respirat …
Bench-to-bedside: Innovation of small molecule anti-SARS-CoV-2 drugs in China.
Yang L, Wang Z. Yang L, et al. Eur J Med Chem. 2023 Sep 5;257:115503. doi: 10.1016/j.ejmech.2023.115503. Epub 2023 May 18. Eur J Med Chem. 2023. PMID: 37229831 Free PMC article. Review.
We review development of small molecule anti-SARS-CoV-2 drugs (azvudine [approved by the NMPA of China on July 25, 2022], VV116 [approved by the NMPA of China on January 29, 2023], FB2001, WPV01, pentarlandir, and cepharanthine) in China and summarize their pharmacological …
We review development of small molecule anti-SARS-CoV-2 drugs (azvudine [approved by the NMPA of China on July 25, 2022], VV116 [approved by …
Repurposing FIASMAs against Acid Sphingomyelinase for COVID-19: A Computational Molecular Docking and Dynamic Simulation Approach.
Naz A, Asif S, Alwutayd KM, Sarfaraz S, Abbasi SW, Abbasi A, Alenazi AM, Hasan ME. Naz A, et al. Molecules. 2023 Mar 27;28(7):2989. doi: 10.3390/molecules28072989. Molecules. 2023. PMID: 37049752 Free PMC article.
The docking results were analyzed and the inhibitors were screened based on their binding affinity scores and ADME properties. Among the 257 functional inhibitors, Dutasteride, Cepharanthine, and Zafirlukast presented the lowest binding affinity scores of -9.7, -9.6, and - …
The docking results were analyzed and the inhibitors were screened based on their binding affinity scores and ADME properties. Among the 257 …
Total alkaloids in Stephania tetrandra induce apoptosis by regulating BBC3 in human non-small cell lung cancer cells.
Li B, Chen J, He J, Peng J, Wang Y, Liu S, Jiang Y. Li B, et al. Biomed Pharmacother. 2023 Jun;162:114635. doi: 10.1016/j.biopha.2023.114635. Epub 2023 Apr 10. Biomed Pharmacother. 2023. PMID: 37044023 Free article.
PURPOSE: This study investigated the effects of total alkaloids in Stephania tetrandra (TAS) and the main alkaloid components tetrandrine, fangchinoline and cepharanthine on the biological function of lung cancer cells and the mechanism underlying the synergistic antitumor …
PURPOSE: This study investigated the effects of total alkaloids in Stephania tetrandra (TAS) and the main alkaloid components tetrandrine, f …
Modulation of in Vitro SARS-CoV-2 Infection by Stephania tetrandra and Its Alkaloid Constituents.
Khadilkar A, Bunch ZL, Wagoner J, Ravindran V, Oda JM, Vidar WS, Clark TN, Manwill PK, Todd DA, Barr SA, Olinger LK, Fink SL, Strangman WK, Linington RG, MacMillan JB, Cech NB, Polyak SJ. Khadilkar A, et al. J Nat Prod. 2023 Apr 28;86(4):1061-1073. doi: 10.1021/acs.jnatprod.3c00159. Epub 2023 Apr 12. J Nat Prod. 2023. PMID: 37043739 Free PMC article.
Extract fractionation, liquid chromatography-mass spectrometry (LC-MS), antiviral assays, and computational analyses revealed that the alkaloid fraction and purified alkaloids tetrandrine, fangchinoline, and cepharanthine inhibited WT SARS-CoV-2 infection. The alkaloids an …
Extract fractionation, liquid chromatography-mass spectrometry (LC-MS), antiviral assays, and computational analyses revealed that the alkal …
Unraveling the mechanism of action of cepharanthine for the treatment of novel coronavirus pneumonia (COVID-19) from the perspectives of systematic pharmacology.
Sun F, Liu J, Tariq A, Wang Z, Wu Y, Li L. Sun F, et al. Arab J Chem. 2023 Jun;16(6):104722. doi: 10.1016/j.arabjc.2023.104722. Epub 2023 Mar 6. Arab J Chem. 2023. PMID: 36910427 Free PMC article.
This study aims to explore the potential targets of action and signaling pathways of cepharanthine for the treatment of COVID-19. This study revealed that a total of 173 potential targets of action for Cepharanthine and 86 intersectional targets for Cepharanthine …
This study aims to explore the potential targets of action and signaling pathways of cepharanthine for the treatment of COVID-19. Thi …
Evaluation of the interaction between potent small molecules against the Nipah virus Glycoprotein in Malaysia and Bangladesh strains, accompanied by the human Ephrin-B2 and Ephrin-B3 receptors; a simulation approach.
Ebrahimi M, Alijanianzadeh M. Ebrahimi M, et al. Mol Divers. 2023 Feb 20:1-24. doi: 10.1007/s11030-023-10624-8. Online ahead of print. Mol Divers. 2023. PMID: 36808582 Free PMC article.
Consequently, in this study annealing simulations, pharmacophore modeling, molecular docking, and molecular dynamics were used to evaluate seven potential drugs (Pemirolast, Nitrofurantoin, Isoniazid Pyruvate, Eriodictyol, Cepharanthine, Ergoloid, and Hypericin) against Ni …
Consequently, in this study annealing simulations, pharmacophore modeling, molecular docking, and molecular dynamics were used to evaluate s …
Cepharanthine Alleviates DSS-Induced Ulcerative Colitis via Regulating Aconitate Decarboxylase 1 Expression and Macrophage Infiltration.
Zhang MN, Xie R, Wang HG, Wen X, Wang JY, He L, Zhang MH, Yang XZ. Zhang MN, et al. Molecules. 2023 Jan 20;28(3):1060. doi: 10.3390/molecules28031060. Molecules. 2023. PMID: 36770726 Free PMC article.
Cepharanthine (CEP), a bisbenzylisoquinoline alkaloid from tubers of Stephania, protects against some inflammatory diseases. ...
Cepharanthine (CEP), a bisbenzylisoquinoline alkaloid from tubers of Stephania, protects against some inflammatory diseases. ...
Differential Regulation of Glucosylceramide Synthesis and Efflux by Golgi and Plasma Membrane Bound ABCC10.
Iqbal J, Otaibi AA, Mubarak SA, Alqarni A, Bakillah A. Iqbal J, et al. Nutrients. 2023 Jan 10;15(2):346. doi: 10.3390/nu15020346. Nutrients. 2023. PMID: 36678216 Free PMC article.
In this study, we found that treatment of Huh-7 cells with an ABCC10 inhibitor, sorafenib, decreased the synthesis and efflux of GlcCer. However, treatment of cells with cepharanthine reduced only the efflux, but not synthesis, of GlcCer. ...
In this study, we found that treatment of Huh-7 cells with an ABCC10 inhibitor, sorafenib, decreased the synthesis and efflux of GlcCer. How …
Cepharanthine Ameliorates Pulmonary Fibrosis by Inhibiting the NF-kappaB/NLRP3 Pathway, Fibroblast-to-Myofibroblast Transition and Inflammation.
Chen G, Li J, Liu H, Zhou H, Liu M, Liang D, Meng Z, Gan H, Wu Z, Zhu X, Han P, Liu T, Gu R, Liu S, Dou G. Chen G, et al. Molecules. 2023 Jan 11;28(2):753. doi: 10.3390/molecules28020753. Molecules. 2023. PMID: 36677811 Free PMC article.
We investigated the therapeutic effects of an approved botanical drug, cepharanthine (CEP), in a cell culture model of transforming growth factor-beta1 (TGF-beta1) and bleomycin (BLM)-induced pulmonary fibrosis rat models both in vitro and in vivo. ...
We investigated the therapeutic effects of an approved botanical drug, cepharanthine (CEP), in a cell culture model of transforming g …
Cepharanthine action in preventing obesity and hyperlipidemia in rats on a high-fat high sucrose diet.
Iqbal A, Najam R, Simjee S, Athar Ishaqui A, Ashfaq Ahmad S, Ahmed Z, Ahmed S, Ahmed S, Jaweed L, Maboos M, Muhammad Uzairullah M, Jabeen S, Imran M. Iqbal A, et al. Saudi Pharm J. 2022 Dec;30(12):1683-1690. doi: 10.1016/j.jsps.2022.09.013. Epub 2022 Sep 21. Saudi Pharm J. 2022. PMID: 36601507 Free PMC article.
BACKGROUND: It was demonstrated that cepharanthine (CEP), derived from Stephania cepharantha hayata, is a potent inhibitor of the ABCC10 transmembrane protein. It is approved to be a natural product or remedy. The present study focuses on investigating whether cepharant …
BACKGROUND: It was demonstrated that cepharanthine (CEP), derived from Stephania cepharantha hayata, is a potent inhibitor of the ABC …
Current status and future challenges in extraction, purification and identification of Cepharanthine (a potential drug against COVID-19).
Wang Y, Zhou X, Wei S, Wang G, Xi J. Wang Y, et al. Sep Purif Technol. 2023 Mar 15;309:123038. doi: 10.1016/j.seppur.2022.123038. Epub 2022 Dec 29. Sep Purif Technol. 2023. PMID: 36593875 Free PMC article. Review.
So far, we have entered the third year of the epidemic and there is an urgent need to provide more anti-viral treatment along with vaccination. Recent studies have confirmed that Cepharanthine (CEP) has strong antiviral efficacy, which is a potential drug against COVID-19. …
So far, we have entered the third year of the epidemic and there is an urgent need to provide more anti-viral treatment along with vaccinati …
Plants' bioactive secondary metabolites in the management of sepsis: Recent findings on their mechanism of action.
Mahomoodally MF, Aumeeruddy MZ, Legoabe LJ, Dall'Acqua S, Zengin G. Mahomoodally MF, et al. Front Pharmacol. 2022 Dec 16;13:1046523. doi: 10.3389/fphar.2022.1046523. eCollection 2022. Front Pharmacol. 2022. PMID: 36588685 Free PMC article. Review.
A variety of secondary metabolites were found to be effective in sepsis management including allicin, aloin, cepharanthine, chrysin, curcumin, cyanidin, gallic acid, gingerol, ginsenoside, glycyrrhizin, hesperidin, kaempferol, narciclasine, naringenin, naringin, piperine, …
A variety of secondary metabolites were found to be effective in sepsis management including allicin, aloin, cepharanthine, chrysin, …
Cepharanthine inhibits dengue virus production and cytokine secretion.
Phumesin P, Panaampon J, Kariya R, Limjindaporn T, Yenchitsomanus PT, Okada S. Phumesin P, et al. Virus Res. 2023 Feb;325:199030. doi: 10.1016/j.virusres.2022.199030. Epub 2022 Dec 29. Virus Res. 2023. PMID: 36587870 Free PMC article.
An anti-DENV agent that demonstrates inhibitory effects on both DENV replication and cytokine secretion is urgently needed. In this study, cepharanthine (CEP), which is an anti-inflammatory, anti-HIV, and anti-tumor compound isolated from Stephania cepharantha Hayata, was …
An anti-DENV agent that demonstrates inhibitory effects on both DENV replication and cytokine secretion is urgently needed. In this study, …
Pharmacological Effects and Clinical Prospects of Cepharanthine.
Liang D, Li Q, Du L, Dou G. Liang D, et al. Molecules. 2022 Dec 15;27(24):8933. doi: 10.3390/molecules27248933. Molecules. 2022. PMID: 36558061 Free PMC article. Review.
Cepharanthine is an active ingredient separated and extracted from Stephania cepharantha Hayata, a Menispermaceae plant. ...Following the emergence of coronavirus disease 2019 (COVID-19), cepharanthine has been found to have excellent anti-COVID-19 activity. ...
Cepharanthine is an active ingredient separated and extracted from Stephania cepharantha Hayata, a Menispermaceae plant. ...Following …
Effect of Cepharanthine on the Stemness of Lung Squamous Cell Carcinoma Based on Network Pharmacology and Bioinformatics.
Liu B, Deng JX. Liu B, et al. Biomed Res Int. 2022 Nov 28;2022:5956526. doi: 10.1155/2022/5956526. eCollection 2022. Biomed Res Int. 2022. PMID: 36483630 Free PMC article.
We urgently need to explore new therapeutic drugs in clinical practice. Cepharanthine (CEP) has been shown to have anticancer effects in several tumors, but the mechanism of CEP in treating LUSC has not been reported. ...
We urgently need to explore new therapeutic drugs in clinical practice. Cepharanthine (CEP) has been shown to have anticancer effects …
Disturbing effect of cepharanthine on valve interstitial cells calcification via regulating glycolytic metabolism pathways.
Xie F, Han J, Wang D, Liu P, Liu C, Sun F, Xu K. Xie F, et al. Front Pharmacol. 2022 Nov 17;13:1070922. doi: 10.3389/fphar.2022.1070922. eCollection 2022. Front Pharmacol. 2022. PMID: 36467082 Free PMC article.
The purpose of this study was to explore the effect and molecular mechanism of cepharanthine (CEP), a natural product, on inhibiting the osteogenic differentiation of VICs. ...
The purpose of this study was to explore the effect and molecular mechanism of cepharanthine (CEP), a natural product, on inhibiting …
Identification of a group of bisbenzylisoquinoline (BBIQ) compounds as ferroptosis inhibitors.
Fan Y, Zhang Y, Shi K, Cheng S, Pei D, Shu X. Fan Y, et al. Cell Death Dis. 2022 Nov 26;13(11):1000. doi: 10.1038/s41419-022-05447-8. Cell Death Dis. 2022. PMID: 36435804 Free PMC article.
Several BBIQ compounds are approved drugs in Japan and China for traditional uses and cepharanthine is currently in clinical trials against SARS-CoV-2, our discovery of BBIQs as in vivo applicable ferroptosis inhibitors will expand their usage to prevent ferroptotic tissue …
Several BBIQ compounds are approved drugs in Japan and China for traditional uses and cepharanthine is currently in clinical trials a …
Dissecting the molecular mechanism of cepharanthine against COVID-19, based on a network pharmacology strategy combined with RNA-sequencing analysis, molecular docking, and molecular dynamics simulation.
Liu J, Sun T, Liu S, Liu J, Fang S, Tan S, Zeng Y, Zhang B, Li W. Liu J, et al. Comput Biol Med. 2022 Dec;151(Pt A):106298. doi: 10.1016/j.compbiomed.2022.106298. Epub 2022 Nov 11. Comput Biol Med. 2022. PMID: 36403355 Free PMC article.
OBJECTIVES: Recently, it has been reported that cepharanthine (CEP) is highly likely to be an agent against Coronavirus disease 2019 (COVID-19). ...
OBJECTIVES: Recently, it has been reported that cepharanthine (CEP) is highly likely to be an agent against Coronavirus disease 2019 …
Network analysis-based strategy to investigate the protective effect of cepharanthine on rat acute respiratory distress syndrome.
Chen C, Wang N, Wang B, Zhang Q, Hu Y, Cheng G, Tao S, Huang J, Wang C, Zhang Y. Chen C, et al. Front Pharmacol. 2022 Oct 26;13:1054339. doi: 10.3389/fphar.2022.1054339. eCollection 2022. Front Pharmacol. 2022. PMID: 36386130 Free PMC article.
Combined with Network Analysis (NA) and in vivo experimental methods, we explored and verified the mechanism of Cepharanthine (CEP) involved in the treatment of acute respiratory distress syndrome (ARDS). ...
Combined with Network Analysis (NA) and in vivo experimental methods, we explored and verified the mechanism of Cepharanthine (CEP) i …
Prevalence, comorbidities, and treatment patterns of Japanese patients with alopecia areata: A descriptive study using Japan medical data center claims database.
Campos-Alberto E, Hirose T, Napatalung L, Ohyama M. Campos-Alberto E, et al. J Dermatol. 2023 Jan;50(1):37-45. doi: 10.1111/1346-8138.16615. Epub 2022 Nov 2. J Dermatol. 2023. PMID: 36321512 Free PMC article.
The principal treatments were topical corticosteroids, followed by carpronium chloride and cepharanthine. The use of systemic corticosteroids and antihistamines is increased in severe disease. ...
The principal treatments were topical corticosteroids, followed by carpronium chloride and cepharanthine. The use of systemic cortico …
Targeting PI4KA sensitizes refractory leukemia to chemotherapy by modulating the ERK/AMPK/OXPHOS axis.
Jiang X, Huang X, Zheng G, Jia G, Li Z, Ding X, Lei L, Yuan L, Xu S, Gao N. Jiang X, et al. Theranostics. 2022 Oct 3;12(16):6972-6988. doi: 10.7150/thno.76563. eCollection 2022. Theranostics. 2022. PMID: 36276647 Free PMC article.
Enzyme-linked immunosorbent assay (ELISA) and molecular mechanics/generalized born surface area (MM/GBSA) method were employed to identify cepharanthine (CEP) as a novel PI4KA inhibitor. Results: High expression of PI4KA was observed in drug-resistant leukemia cells or in …
Enzyme-linked immunosorbent assay (ELISA) and molecular mechanics/generalized born surface area (MM/GBSA) method were employed to identify …
Antiviral Drugs Screening for Swine Acute Diarrhea Syndrome Coronavirus.
Chen Y, You Y, Wang S, Jiang L, Tian L, Zhu S, An X, Song L, Tong Y, Fan H. Chen Y, et al. Int J Mol Sci. 2022 Sep 24;23(19):11250. doi: 10.3390/ijms231911250. Int J Mol Sci. 2022. PMID: 36232553 Free PMC article.
We identified five compounds (gemcitabine, mycophenolate mofetil, mycophenolic acid, methylene blue and cepharanthine) exhibiting inhibitory effects against SADS-CoV in a dose-dependent manner. Cepharanthine and methylene blue were confirmed to block viral entry, an …
We identified five compounds (gemcitabine, mycophenolate mofetil, mycophenolic acid, methylene blue and cepharanthine) exhibiting inh …
Lung-Targeted Delivery of Cepharanthine by an Erythrocyte-Anchoring Strategy for the Treatment of Acute Lung Injury.
Zheng J, Lu C, Yang M, Sun J, Zhang J, Meng Y, Wang Y, Li Z, Yang Y, Gong W, Gao C. Zheng J, et al. Pharmaceutics. 2022 Aug 29;14(9):1820. doi: 10.3390/pharmaceutics14091820. Pharmaceutics. 2022. PMID: 36145566 Free PMC article.
As one of the most frequent complications of critical illness, acute lung injury (ALI) carries a high risk of clinical morbidity and mortality. Cepharanthine (CPA) has significant anti-inflammatory activity, however, due to poor water solubility, low bioavailability, and s …
As one of the most frequent complications of critical illness, acute lung injury (ALI) carries a high risk of clinical morbidity and mortali …
The common regulatory pathway of COVID-19 and multiple inflammatory diseases and the molecular mechanism of cepharanthine in the treatment of COVID-19.
Jiang P, Ye J, Jia M, Li X, Wei S, Li N. Jiang P, et al. Front Pharmacol. 2022 Jul 22;13:960267. doi: 10.3389/fphar.2022.960267. eCollection 2022. Front Pharmacol. 2022. PMID: 35935817 Free PMC article.
In addition, "new use of old drugs" is an important short-term strategy for the treatment of COVID-19. Cepharanthine (CEP), a monomer component of traditional Chinese medicine (TCM), is mainly used in the treatment of leukopenia and has recently been proved to have a good …
In addition, "new use of old drugs" is an important short-term strategy for the treatment of COVID-19. Cepharanthine (CEP), a monomer …
N-glycoproteomic profiling revealing novel coronavirus therapeutic targets potentially involved in Cepharanthine's intervention.
An W, Tian F, Li J, Chen J, Tong Y. An W, et al. Med Nov Technol Devices. 2022 Dec;16:100156. doi: 10.1016/j.medntd.2022.100156. Epub 2022 Jul 21. Med Nov Technol Devices. 2022. PMID: 35879945 Free PMC article.
Antiviral therapies targeting coronavirus are urgently required. The Cepharanthine (CEP) is a traditional Chinese herbal extract. Our previous research revealed that CEP has a very potent anti-coronavirus effect, but its mechanism of action was not fully understood. ...
Antiviral therapies targeting coronavirus are urgently required. The Cepharanthine (CEP) is a traditional Chinese herbal extract. Our …
Cepharanthine Ameliorates Chondrocytic Inflammation and Osteoarthritis via Regulating the MAPK/NF-kappaB-Autophagy Pathway.
Yao M, Zhang C, Ni L, Ji X, Hong J, Chen Y, Wang J, Li C, Lin J, Lu T, Sheng Y, Sun M, Shi M, Zhou C, Cai X. Yao M, et al. Front Pharmacol. 2022 Jun 21;13:854239. doi: 10.3389/fphar.2022.854239. eCollection 2022. Front Pharmacol. 2022. PMID: 35800437 Free PMC article.
However, traditional therapeutic methods aimed at anti-inflammation for early-stage disease are palliative. In the present study, we demonstrated that cepharanthine (CEP), extracted from the plant Stephania cepharantha, exerted protective medicinal efficacy on osteoarthrit …
However, traditional therapeutic methods aimed at anti-inflammation for early-stage disease are palliative. In the present study, we demonst …
[Progress in the study of antiviral activity of cepharanthine against SARS-CoV-2].
Fan H, Liu K, Hong B, He S, Han P, Li M, Wang S, Tong Y. Fan H, et al. Nan Fang Yi Ke Da Xue Xue Bao. 2022 Jun 20;42(6):955-956. doi: 10.12122/j.issn.1673-4254.2022.06.22. Nan Fang Yi Ke Da Xue Xue Bao. 2022. PMID: 35790449 Free PMC article. Chinese.
As the original discoverer of the anti-SARS-CoV-2 activity of cepharanthine, here we briefly summarize the discovery of cepharanthine and review important progress in relevant studies concerning the discovery and validation of anti-SARS-CoV-2 activity of cepharathin …
As the original discoverer of the anti-SARS-CoV-2 activity of cepharanthine, here we briefly summarize the discovery of cepharanth …
Cepharanthine: A Promising Old Drug against SARS-CoV-2.
Fan H, He ST, Han P, Hong B, Liu K, Li M, Wang S, Tong Y. Fan H, et al. Adv Biol (Weinh). 2022 Dec;6(12):e2200148. doi: 10.1002/adbi.202200148. Epub 2022 Jul 1. Adv Biol (Weinh). 2022. PMID: 35775953 Free PMC article.
This paper aims to introduce a brief history of studies on the effects of cepharanthine against SARS-CoV-2, including "discovery of anti-SARS-CoV-2 activity of cepharanthine in vitro", "potential mechanisms of cepharanthine against SARS-CoV-2", "confirmation …
This paper aims to introduce a brief history of studies on the effects of cepharanthine against SARS-CoV-2, including "discovery of a …
Bis-Benzylisoquinoline Alkaloids Inhibit Porcine Epidemic Diarrhea Virus In Vitro and In Vivo.
Dong S, Yu R, Wang X, Chen B, Si F, Zhou J, Xie C, Li Z, Zhang D. Dong S, et al. Viruses. 2022 Jun 6;14(6):1231. doi: 10.3390/v14061231. Viruses. 2022. PMID: 35746702 Free PMC article.
Currently, there is no effective medication against this pathogen. Cepharanthine (CEP), tetrandrine (TET), and fangchinoline (FAN) are natural bis-benzylisoquinoline alkaloids with anti-inflammatory, antitumor, and antiviral properties. ...
Currently, there is no effective medication against this pathogen. Cepharanthine (CEP), tetrandrine (TET), and fangchinoline (FAN) ar …
Antinociceptive activities and mechanism of action of Cepharanthine.
Wei XY, Long JD, Chai JR, Chen J, Gao JP, Wang YJ, Liu JG. Wei XY, et al. Biochem Biophys Res Commun. 2022 Jul 23;614:219-224. doi: 10.1016/j.bbrc.2022.04.083. Epub 2022 May 6. Biochem Biophys Res Commun. 2022. PMID: 35636221
Cepharanthine is an alkaloid that isolated from Stephania cepharantha Hayata, however,its analgesic properties are unclear and the molecular targets that mediating Cepharanthine-induced analgesia are not explored yet. ...Cepharanthine-induced constipation was …
Cepharanthine is an alkaloid that isolated from Stephania cepharantha Hayata, however,its analgesic properties are unclear and the mo …
Identification of potential COVID-19 treatment compounds which inhibit SARS Cov2 prototypic, Delta and Omicron variant infection.
Kumar P, Mathayan M, Smieszek SP, Przychodzen BP, Koprivica V, Birznieks G, Polymeropoulos MH, Prabhakar BS. Kumar P, et al. Virology. 2022 Jul;572:64-71. doi: 10.1016/j.virol.2022.05.004. Epub 2022 May 16. Virology. 2022. PMID: 35598394 Free PMC article.
Using this approach, we screened a library of FDA-approved and clinical-stage drugs and identified four compounds, apilimod, berbamine, cepharanthine and (S)-crizotinib which potently inhibited SARS CoV2-induced cell death. ...
Using this approach, we screened a library of FDA-approved and clinical-stage drugs and identified four compounds, apilimod, berbamine, c …
Bioavailability Enhancement of Cepharanthine via Pulmonary Administration in Rats and Its Therapeutic Potential for Pulmonary Fibrosis Associated with COVID-19 Infection.
Li J, Chen G, Meng Z, Wu Z, Gan H, Zhu X, Han P, Liu T, Wang F, Gu R, Dou G. Li J, et al. Molecules. 2022 Apr 24;27(9):2745. doi: 10.3390/molecules27092745. Molecules. 2022. PMID: 35566097 Free PMC article.
Cepharanthine (CEP) has excellent anti-SARS-CoV-2 properties, indicating its favorable potential for COVID-19 treatment. ...
Cepharanthine (CEP) has excellent anti-SARS-CoV-2 properties, indicating its favorable potential for COVID-19 treatment. ...
Docking Analysis of Some Bioactive Compounds from Traditional Plants against SARS-CoV-2 Target Proteins.
Abd El-Aziz NM, Khalifa I, Darwish AMG, Badr AN, Aljumayi H, Hafez ES, Shehata MG. Abd El-Aziz NM, et al. Molecules. 2022 Apr 20;27(9):2662. doi: 10.3390/molecules27092662. Molecules. 2022. PMID: 35566014 Free PMC article.
Prediction of drug-likeness properties revealed that all tested ligands have no violations to Lipinski's Rule of Five except cepharanthine, chicoric acid, and theaflavin. Regarding the pharmacokinetic behavior, all ligand predicted to have high GI-absorption except chicori …
Prediction of drug-likeness properties revealed that all tested ligands have no violations to Lipinski's Rule of Five except cepharanthin …
Screening and identification of HTNVpv entry inhibitors with high-throughput pseudovirus-based chemiluminescence.
Wen X, Zhang L, Liu Q, Xiao X, Huang W, Wang Y. Wen X, et al. Virol Sin. 2022 Aug;37(4):531-537. doi: 10.1016/j.virs.2022.04.015. Epub 2022 May 2. Virol Sin. 2022. PMID: 35513270 Free PMC article.
We identified six compounds with in vitro anti-HTNV(pv) activities in the low-micromolar range (EC(50) values of 0.1-2.2 mumol/L; selectivity index of 40-900). Among the six selected compounds, cepharanthine not only showed good anti-HTNV(pv) activity in vitro but also inh …
We identified six compounds with in vitro anti-HTNV(pv) activities in the low-micromolar range (EC(50) values of 0.1-2.2 mumol/L; selectivit …
Cepharanthine ameliorates dextran sulphate sodium-induced colitis through modulating gut microbiota.
Wang HG, Zhang MN, Wen X, He L, Zhang MH, Zhang JL, Yang XZ. Wang HG, et al. Microb Biotechnol. 2022 Aug;15(8):2208-2222. doi: 10.1111/1751-7915.14059. Epub 2022 Apr 19. Microb Biotechnol. 2022. PMID: 35439340 Free PMC article.
Cepharanthine (CEP) is an active alkaloid isolated from Stephania Cepharantha Hayata. ...
Cepharanthine (CEP) is an active alkaloid isolated from Stephania Cepharantha Hayata. ...
Cepharanthine hydrochloride inhibits the Wnt/beta-catenin/Hedgehog signaling axis in liver cancer.
Su GF, Huang ZX, Huang DL, Chen PX, Wang Y, Wang YF. Su GF, et al. Oncol Rep. 2022 Apr;47(4):83. doi: 10.3892/or.2022.8294. Epub 2022 Feb 25. Oncol Rep. 2022. PMID: 35211762 Free PMC article.
Cepharanthine, a biscoclaurine alkaloid isolated from the roots of Stephania cephalantha Hayata, has been reported to demonstrate antitumor activity across multiple cancer types; however, the mechanisms are still under investigation. ...To investigate whether these signali …
Cepharanthine, a biscoclaurine alkaloid isolated from the roots of Stephania cephalantha Hayata, has been reported to demonstrate ant …
Cepharanthine Attenuates Early Brain Injury after Subarachnoid Hemorrhage in Mice via Inhibiting 15-Lipoxygenase-1-Mediated Microglia and Endothelial Cell Ferroptosis.
Gao S, Zhou L, Lu J, Fang Y, Wu H, Xu W, Pan Y, Wang J, Wang X, Zhang J, Shao A. Gao S, et al. Oxid Med Cell Longev. 2022 Feb 9;2022:4295208. doi: 10.1155/2022/4295208. eCollection 2022. Oxid Med Cell Longev. 2022. PMID: 35186185 Free PMC article.
Our study was designed to determine the expression patterns and role of 15-lipoxygenase-1 (ALOX15) in subarachnoid hemorrhage (SAH) and to investigate whether cepharanthine (CEP) can inhibit ferroptosis by inhibiting ALOX15 in specific cell types. ...
Our study was designed to determine the expression patterns and role of 15-lipoxygenase-1 (ALOX15) in subarachnoid hemorrhage (SAH) and to i …
Cepharanthine Blocks Presentation of Thyroid and Islet Peptides in a Novel Humanized Autoimmune Diabetes and Thyroiditis Mouse Model.
Li CW, Osman R, Menconi F, Faustino LC, Kim K, Clarke OB, Hou H, Tomer Y. Li CW, et al. Front Immunol. 2021 Dec 20;12:796552. doi: 10.3389/fimmu.2021.796552. eCollection 2021. Front Immunol. 2021. PMID: 34987519 Free PMC article.
Using the APS3v mouse model, we showed that one of the 4 small molecules, Cepharanthine (S53), blocked T-cell activation by thyroid/islet peptides ex vivo and in vivo. These findings suggested Cepharanthine may have a therapeutic potential in APS3v patients carrying …
Using the APS3v mouse model, we showed that one of the 4 small molecules, Cepharanthine (S53), blocked T-cell activation by thyroid/i …
Cepharanthine Suppresses Herpes Simplex Virus Type 1 Replication Through the Downregulation of the PI3K/Akt and p38 MAPK Signaling Pathways.
Liu Y, Chen L, Liu W, Li D, Zeng J, Tang Q, Zhang Y, Luan F, Zeng N. Liu Y, et al. Front Microbiol. 2021 Dec 9;12:795756. doi: 10.3389/fmicb.2021.795756. eCollection 2021. Front Microbiol. 2021. PMID: 34956164 Free PMC article.
Cepharanthine (CEP) is a naturally occurring isoquinoline alkaloid extracted from Stephania cepharantha Hayata. ...
Cepharanthine (CEP) is a naturally occurring isoquinoline alkaloid extracted from Stephania cepharantha Hayata. ...
In Silico Screening of Natural Products as Potential Inhibitors of SARS-CoV-2 Using Molecular Docking Simulation.
Hossain R, Sarkar C, Hassan SMH, Khan RA, Arman M, Ray P, Islam MT, Daştan SD, Sharifi-Rad J, Almarhoon ZM, Martorell M, Setzer WN, Calina D. Hossain R, et al. Chin J Integr Med. 2022 Mar;28(3):249-256. doi: 10.1007/s11655-021-3504-5. Epub 2021 Dec 15. Chin J Integr Med. 2022. PMID: 34913151 Free PMC article.
ABL1 and calcineurin-NFAT; berbamine with hACE2R and ABL1; cepharanthine with nsp10, nsp14, nsp16, S protein and ABL1; glucogallin with nsp15; and papyriflavonol A with PL(PRO) protein. ...
ABL1 and calcineurin-NFAT; berbamine with hACE2R and ABL1; cepharanthine with nsp10, nsp14, nsp16, S protein and ABL1; glucogallin wi …
Large Screening Identifies ACE2 Positively Correlates With NF-κB Signaling Activity and Targeting NF-κB Signaling Drugs Suppress ACE2 Levels.
Yan M, Dong Y, Bo X, Cheng Y, Cheng J. Yan M, et al. Front Pharmacol. 2021 Nov 19;12:771555. doi: 10.3389/fphar.2021.771555. eCollection 2021. Front Pharmacol. 2021. PMID: 34867400 Free PMC article.
Furthermore, using an approved clinical durgs library, we found two clinical drugs, Cepharanthine and Glucosamine, significantly inhibited ACE2 level, IFNbeta level, and NF-kappaB signaling downstream TNFalpha and IL6 levels. Our finding suggested the possible inhibitory e …
Furthermore, using an approved clinical durgs library, we found two clinical drugs, Cepharanthine and Glucosamine, significantly inhi …
Cepharanthine loaded nanoparticles coated with macrophage membranes for lung inflammation therapy.
Lu C, Zheng J, Ding Y, Meng Y, Tan F, Gong W, Chu X, Kong X, Gao C. Lu C, et al. Drug Deliv. 2021 Dec;28(1):2582-2593. doi: 10.1080/10717544.2021.2009936. Drug Deliv. 2021. PMID: 34866533 Free PMC article.
MM-CEP/NLCs were made with nanostructured lipid carriers (NLCs) coated with natural macrophage membranes (MMs) to achieve effective accumulation of cepharanthine (CEP) in lung inflammation to achieve the effect of treating ALI. ...
MM-CEP/NLCs were made with nanostructured lipid carriers (NLCs) coated with natural macrophage membranes (MMs) to achieve effective accumula …
A case of improvement of clozapine-induced low leukocyte counts by adenine, cepharanthin and ninjin-yoei-to in a patient with treatment-resistant schizophrenia.
Kamei S, Tanaka R, Hirakawa H, Iwao M, Kawanaka R, Tatsuta R, Terao T, Itoh H. Kamei S, et al. J Pharm Health Care Sci. 2021 Dec 2;7(1):45. doi: 10.1186/s40780-021-00227-6. J Pharm Health Care Sci. 2021. PMID: 34852834 Free PMC article.
BACKGROUND: Although clozapine is the optimal drug for patients with treatment-resistant schizophrenia, the drug has harmful adverse effects such as leukopenia. Adenine and cepharanthine are known to be effective for radiation- or drug-induced leukopenia. ...CONCLUSIONS: T …
BACKGROUND: Although clozapine is the optimal drug for patients with treatment-resistant schizophrenia, the drug has harmful adverse effects …
Evaluating cepharanthine analogues as natural drugs against SARS-CoV-2.
Hijikata A, Shionyu-Mitsuyama C, Nakae S, Shionyu M, Ota M, Kanaya S, Hirokawa T, Nakajima S, Watashi K, Shirai T. Hijikata A, et al. FEBS Open Bio. 2022 Jan;12(1):285-294. doi: 10.1002/2211-5463.13337. Epub 2021 Dec 9. FEBS Open Bio. 2022. PMID: 34850606 Free PMC article.
Cepharanthine (CEP) is a natural biscoclaurine alkaloid of plant origin and was recently demonstrated to have anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) activity. ...
Cepharanthine (CEP) is a natural biscoclaurine alkaloid of plant origin and was recently demonstrated to have anti-severe acute respi …
Cepharanthine inhibits hepatocellular carcinoma cell growth and proliferation by regulating amino acid metabolism and suppresses tumorigenesis in vivo.
Feng F, Pan L, Wu J, Li L, Xu H, Yang L, Xu K, Wang C. Feng F, et al. Int J Biol Sci. 2021 Oct 22;17(15):4340-4352. doi: 10.7150/ijbs.64675. eCollection 2021. Int J Biol Sci. 2021. PMID: 34803502 Free PMC article.
Cepharanthine (CEP), a natural compound extracted from Stephania cepharantha Hayata, has been found to have the potential to treat a variety of tumors in recent years. ...
Cepharanthine (CEP), a natural compound extracted from Stephania cepharantha Hayata, has been found to have the potential to treat a …
ACE2 : S1 RBD Interaction-Targeted Peptides and Small Molecules as Potential COVID-19 Therapeutics.
Chitsike L, Krstenansky J, Duerksen-Hughes PJ. Chitsike L, et al. Adv Pharmacol Pharm Sci. 2021 Nov 2;2021:1828792. doi: 10.1155/2021/1828792. eCollection 2021. Adv Pharmacol Pharm Sci. 2021. PMID: 34746794 Free PMC article.
Using our optimized AlphaScreen assay, we evaluated the activity and specificity of these peptides and small molecules in inhibiting the binding of ACE2 : S1 RBD. This screen identified cepharanthine as a promising candidate for development as a SARS-CoV-2 entry inhibitor. …
Using our optimized AlphaScreen assay, we evaluated the activity and specificity of these peptides and small molecules in inhibiting the bin …
Comparison of viral RNA-host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2.
Zhang S, Huang W, Ren L, Ju X, Gong M, Rao J, Sun L, Li P, Ding Q, Wang J, Zhang QC. Zhang S, et al. Cell Res. 2022 Jan;32(1):9-23. doi: 10.1038/s41422-021-00581-y. Epub 2021 Nov 4. Cell Res. 2022. PMID: 34737357 Free PMC article.
Our interactome-informed drug repurposing efforts identified several FDA-approved drugs (e.g., Cepharanthine) as broad-spectrum antivirals in cells and hACE2 transgenic mice. A co-treatment comprising Cepharanthine and Trifluoperazine was highly potent against the n …
Our interactome-informed drug repurposing efforts identified several FDA-approved drugs (e.g., Cepharanthine) as broad-spectrum antiv …
Establishment and Characterization of a Novel Multidrug Resistant Human Ovarian Cancer Cell Line With Heterogenous MRP7 Overexpression.
Wang JQ, Wu ZX, Yang Y, Li JS, Yang DH, Fan YF, Chen ZS. Wang JQ, et al. Front Oncol. 2021 Sep 24;11:731260. doi: 10.3389/fonc.2021.731260. eCollection 2021. Front Oncol. 2021. PMID: 34631561 Free PMC article.
Additionally, MTT results showed that the drug resistance of the SKOV3/MRP7 cells was reversed by cepharanthine, a known inhibitor of MRP7. Moreover, we also found that the overexpression of MRP7 enhanced the migration and epithelial-mesenchymal transition (EMT) induction. …
Additionally, MTT results showed that the drug resistance of the SKOV3/MRP7 cells was reversed by cepharanthine, a known inhibitor of …
Preparation and Evaluation of Self-emulsifying Drug Delivery System (SEDDS) of Cepharanthine.
Gao P, Jiang Z, Luo Q, Mu C, Cui M, Yang X. Gao P, et al. AAPS PharmSciTech. 2021 Oct 5;22(7):245. doi: 10.1208/s12249-021-02085-9. AAPS PharmSciTech. 2021. PMID: 34611770 Free PMC article.
The aim of this article was to design a self-emulsifying drug delivery system (SEDDS) of loaded cepharanthine (CEP) to improve the oral bioavailability in rats. Based on the solubility determination and pseudo-ternary phase diagram, isopropyl palmitate (IPP) was chosen as …
The aim of this article was to design a self-emulsifying drug delivery system (SEDDS) of loaded cepharanthine (CEP) to improve the or …
Candidate antiviral drugs for COVID-19 and their environmental implications: a comprehensive analysis.
Biswas P, Hasan MM, Dey D, Dos Santos Costa AC, Polash SA, Bibi S, Ferdous N, Kaium MA, Rahman MDH, Jeet FK, Papadakos S, Islam K, Uddin MS. Biswas P, et al. Environ Sci Pollut Res Int. 2021 Nov;28(42):59570-59593. doi: 10.1007/s11356-021-16096-3. Epub 2021 Sep 12. Environ Sci Pollut Res Int. 2021. PMID: 34510341 Free PMC article. Review.
Recent clinical reports revealed promising therapeutic efficiency of several drugs such as remdesivir, tenofovir disoproxil fumarate, azithromycin, lopinavir/ritonavir, chloroquine, baricitinib, and cepharanthine. Besides, plasma therapies were used to treat patients and p …
Recent clinical reports revealed promising therapeutic efficiency of several drugs such as remdesivir, tenofovir disoproxil fumarate, azithr …
Cepharanthine Regulates Autophagy via Activating the p38 Signaling Pathway in Lung Adenocarcinoma Cells.
Li G, Qiao K, Xu X, Wang C. Li G, et al. Anticancer Agents Med Chem. 2022;22(8):1523-1529. doi: 10.2174/1871520621666210903163407. Anticancer Agents Med Chem. 2022. PMID: 34477532
BACKGROUND: Cepharanthine (CEP) is an alkaloid extracted from Stephania cepharantha Hayata. ...
BACKGROUND: Cepharanthine (CEP) is an alkaloid extracted from Stephania cepharantha Hayata. ...
Cepharanthine, a novel selective ANO1 inhibitor with potential for lung adenocarcinoma therapy.
Zhang X, Zhang G, Zhao Z, Xiu R, Jia J, Chen P, Liu Y, Wang Y, Yi J. Zhang X, et al. Biochim Biophys Acta Mol Cell Res. 2021 Nov;1868(12):119132. doi: 10.1016/j.bbamcr.2021.119132. Epub 2021 Aug 25. Biochim Biophys Acta Mol Cell Res. 2021. PMID: 34450215 Free article.
The Lys(384), Arg(535), Thr(539), and Glu(624) in ANO1 are critical for the inhibitory effect of cepharanthine. Similar to its effect on ANO1, cepharanthine inhibits ANO2, the closest analog of TMEM16A. ...Moreover, animal experiments have shown that cepharanthin …
The Lys(384), Arg(535), Thr(539), and Glu(624) in ANO1 are critical for the inhibitory effect of cepharanthine. Similar to its effect …
Inhibition of herpes simplex virus 1 by cepharanthine via promoting cellular autophagy through up-regulation of STING/TBK1/P62 pathway.
Liu Y, Tang Q, Rao Z, Fang Y, Jiang X, Liu W, Luan F, Zeng N. Liu Y, et al. Antiviral Res. 2021 Sep;193:105143. doi: 10.1016/j.antiviral.2021.105143. Epub 2021 Jul 23. Antiviral Res. 2021. PMID: 34303748
Cepharanthine (CEP), a naturally occurring isoquinoline alkaloid extracted from the genus CEP of the Tetrandrine family, was reported to possess many biological activities such as anti-inflammatory, antitumor, antiviral, and immune-enhancing effects. ...
Cepharanthine (CEP), a naturally occurring isoquinoline alkaloid extracted from the genus CEP of the Tetrandrine family, was reported …
Cepharanthine sensitizes human triple negative breast cancer cells to chemotherapeutic agent epirubicin via inducing cofilin oxidation-mediated mitochondrial fission and apoptosis.
Shen LW, Jiang XX, Li ZQ, Li J, Wang M, Jia GF, Ding X, Lei L, Gong QH, Gao N. Shen LW, et al. Acta Pharmacol Sin. 2022 Jan;43(1):177-193. doi: 10.1038/s41401-021-00715-3. Epub 2021 Jul 22. Acta Pharmacol Sin. 2022. PMID: 34294886 Free PMC article.
In human breast cancer MDA-MB-231 and BT549 cells, application of CEP (2 muM) greatly enhanced cepharanthine-induced inhibition on cell viability and colony formation. ...Taken together, our results implicate that a combination of cepharanthine with chemotherapeutic …
In human breast cancer MDA-MB-231 and BT549 cells, application of CEP (2 muM) greatly enhanced cepharanthine-induced inhibition on ce …
Natural Products, Alone or in Combination with FDA-Approved Drugs, to Treat COVID-19 and Lung Cancer.
Yang L, Wang Z. Yang L, et al. Biomedicines. 2021 Jun 18;9(6):689. doi: 10.3390/biomedicines9060689. Biomedicines. 2021. PMID: 34207313 Free PMC article. Review.
A wide range of natural products can be considered promising anti-COVID-19 or anti-lung cancer agents have gained widespread attention, including natural products as monotherapy for the treatment of SARS-CoV-2 (ginkgolic acid, shiraiachrome A, resveratrol, and baicalein) or lung …
A wide range of natural products can be considered promising anti-COVID-19 or anti-lung cancer agents have gained widespread attention, incl …
Screening carbonic anhydrase IX inhibitors in traditional Chinese medicine based on electrophoretically mediated microanalysis.
Li W, Zhang B, Chen Z. Li W, et al. Talanta. 2021 Sep 1;232:122444. doi: 10.1016/j.talanta.2021.122444. Epub 2021 May 1. Talanta. 2021. PMID: 34074429
Finally, 4 natural compounds of 15 traditional Chinese medicine standards were discovered to exhibit enzyme inhibitory activity, including polydatin, matrine, dauricine and cepharanthine, proving that the EMMA method is an effective means for screening carbonic anhydrase I …
Finally, 4 natural compounds of 15 traditional Chinese medicine standards were discovered to exhibit enzyme inhibitory activity, including p …
Potential anti-COVID-19 agents, cepharanthine and nelfinavir, and their usage for combination treatment.
Ohashi H, Watashi K, Saso W, Shionoya K, Iwanami S, Hirokawa T, Shirai T, Kanaya S, Ito Y, Kim KS, Nomura T, Suzuki T, Nishioka K, Ando S, Ejima K, Koizumi Y, Tanaka T, Aoki S, Kuramochi K, Suzuki T, Hashiguchi T, Maenaka K, Matano T, Muramatsu M, Saijo M, Aihara K, Iwami S, Takeda M, McKeating JA, Wakita T. Ohashi H, et al. iScience. 2021 Apr 23;24(4):102367. doi: 10.1016/j.isci.2021.102367. Epub 2021 Mar 26. iScience. 2021. PMID: 33817567 Free PMC article.
Cepharanthine inhibited SARS-CoV-2 entry through the blocking of viral binding to target cells, while nelfinavir suppressed viral replication partly by protease inhibition. ...Mathematical modeling in vitro antiviral activity coupled with the calculated total drug concentr …
Cepharanthine inhibited SARS-CoV-2 entry through the blocking of viral binding to target cells, while nelfinavir suppressed viral rep …
Small molecule screening identified cepharanthine as an inhibitor of porcine reproductive and respiratory syndrome virus infection in vitro by suppressing integrins/ILK/RACK1/PKCalpha/NF-kappaB signalling axis.
Yang C, Zuo Q, Liu X, Zhao Q, Pu H, Gao L, Zhao L, Guo Z, Lin Y, Liu J, Bi J, Yin G. Yang C, et al. Vet Microbiol. 2021 Apr;255:109016. doi: 10.1016/j.vetmic.2021.109016. Epub 2021 Feb 17. Vet Microbiol. 2021. PMID: 33677370
From an in vitro small molecule screening with the TargetMol Natural Compound Library comprising 623 small molecules, cytopathic effect (CPE) observations and RT-qPCR analysis of viral ORF7 gene expression identified cepharanthine (CEP) to be one of the most protent inhibi …
From an in vitro small molecule screening with the TargetMol Natural Compound Library comprising 623 small molecules, cytopathic effect (CPE …
Structural insights into SARS-CoV-2 spike protein and its natural mutants found in Mexican population.
Sixto-López Y, Correa-Basurto J, Bello M, Landeros-Rivera B, Garzón-Tiznado JA, Montaño S. Sixto-López Y, et al. Sci Rep. 2021 Feb 25;11(1):4659. doi: 10.1038/s41598-021-84053-8. Sci Rep. 2021. PMID: 33633229 Free PMC article.
To understand if these mutations could affect the structural behavior of S protein of SARS-CoV-2, as well as the binding with S protein inhibitors (cepharanthine, nelfinavir, and hydroxychloroquine), molecular dynamic simulations and molecular docking were employed. ...
To understand if these mutations could affect the structural behavior of S protein of SARS-CoV-2, as well as the binding with S protein inhi …
Antiviral drugs against severe acute respiratory syndrome coronavirus 2 infection triggering the coronavirus disease-19 pandemic.
Noor R. Noor R. Tzu Chi Med J. 2020 Aug 25;33(1):7-12. doi: 10.4103/tcmj.tcmj_100_20. eCollection 2021 Jan-Mar. Tzu Chi Med J. 2020. PMID: 33505872 Free PMC article. Review.
The other drugs such as favipiravir and lopinavir/ritonavir under the antiviral category, the angiotensin-converting enzyme 2 (the renin-angiotensin system inhibitors), remdesivir (RNA polymerase inhibitor) from antiviral category, cepharanthine from anti-inflammatory cate …
The other drugs such as favipiravir and lopinavir/ritonavir under the antiviral category, the angiotensin-converting enzyme 2 (the renin-ang …
Transcriptome analysis of cepharanthine against a SARS-CoV-2-related coronavirus.
Li S, Liu W, Chen Y, Wang L, An W, An X, Song L, Tong Y, Fan H, Lu C. Li S, et al. Brief Bioinform. 2021 Mar 22;22(2):1378-1386. doi: 10.1093/bib/bbaa387. Brief Bioinform. 2021. PMID: 33423067 Free PMC article.
Antiviral therapies targeting the pandemic coronavirus disease 2019 (COVID-19) are urgently required. We studied an already-approved botanical drug cepharanthine (CEP) in a cell culture model of GX_P2V, a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related …
Antiviral therapies targeting the pandemic coronavirus disease 2019 (COVID-19) are urgently required. We studied an already-approved botanic …
Cepharanthine as a Potential Novel Tumor-Regional Therapy in Treating Cutaneous Melanoma: Altering the Expression of Cathepsin B, Tumor Suppressor Genes and Autophagy-Related Proteins.
Liu Y, Xie Y, Lin Y, Xu Q, Huang Y, Peng M, Lai W, Zheng Y. Liu Y, et al. Front Bioeng Biotechnol. 2020 Dec 1;8:601969. doi: 10.3389/fbioe.2020.601969. eCollection 2020. Front Bioeng Biotechnol. 2020. PMID: 33335896 Free PMC article.
Autophagy and cathepsin B targeted therapy was reported to improve melanoma treatment. Cepharanthine (CEP), a natural alkaloid extracted from the genus Cephalophyllum has been reported to have the function of inhibiting cancers. ...
Autophagy and cathepsin B targeted therapy was reported to improve melanoma treatment. Cepharanthine (CEP), a natural alkaloid extrac …
Identifying SARS-CoV-2 Entry Inhibitors through Drug Repurposing Screens of SARS-S and MERS-S Pseudotyped Particles.
Chen CZ, Xu M, Pradhan M, Gorshkov K, Petersen JD, Straus MR, Zhu W, Shinn P, Guo H, Shen M, Klumpp-Thomas C, Michael SG, Zimmerberg J, Zheng W, Whittaker GR. Chen CZ, et al. ACS Pharmacol Transl Sci. 2020 Oct 19;3(6):1165-1175. doi: 10.1021/acsptsci.0c00112. eCollection 2020 Dec 11. ACS Pharmacol Transl Sci. 2020. PMID: 33330839 Free PMC article.
Here, inhibitors of spike (S) mediated cell entry were identified in a high throughput screen of an approved drugs library with SARS-S and MERS-S pseudotyped particle entry assays. We discovered six compounds (cepharanthine, abemaciclib, osimertinib, trimipramine, colforsi …
Here, inhibitors of spike (S) mediated cell entry were identified in a high throughput screen of an approved drugs library with SARS-S and M …
Cepharanthine induces the proliferation of human dermal papilla cells and stimulates vascular endothelial growth factor expression through increased intracellular calcium mobilization and hypoxia-inducible factor activation.
Iwabuchi T, Ogura K, Tamba K, Tsunekawa Y, Sugano M, Hagiwara K, Kiso A. Iwabuchi T, et al. Clin Exp Dermatol. 2021 Jun;46(4):694-703. doi: 10.1111/ced.14533. Epub 2021 Jan 22. Clin Exp Dermatol. 2021. PMID: 33296524
BACKGROUND: Cepharanthine (CEP), a compound extracted from the vine Stephania cephalantha, is commonly prescribed to treat alopecia areata; however, the scientific evidence for its efficacy is limited. ...
BACKGROUND: Cepharanthine (CEP), a compound extracted from the vine Stephania cephalantha, is commonly prescribed to treat alopecia a …
Cepharanthine induces ROS stress in glioma and neuronal cells via modulation of VDAC permeability.
Cierluk K, Szlasa W, Rossowska J, Tarek M, Szewczyk A, Saczko J, Kulbacka J. Cierluk K, et al. Saudi Pharm J. 2020 Nov;28(11):1364-1373. doi: 10.1016/j.jsps.2020.08.026. Epub 2020 Sep 4. Saudi Pharm J. 2020. PMID: 33250643 Free PMC article.
Molecular dynamics simulations were carried out to examine the interactions of cepharanthine with VDAC. The obtained results prove that cepharanthine enhances the apoptosis in glioma and neuronal cells by the release of reactive oxygen species. Cepharanthine …
Molecular dynamics simulations were carried out to examine the interactions of cepharanthine with VDAC. The obtained results prove th …
Thirteen bisbenzylisoquinoline alkaloids in five Chinese medicinal plants: Botany, traditional uses, phytochemistry, pharmacokinetic and toxicity studies.
Zhang H, Wang X, Guo Y, Liu X, Zhao X, Teka T, Lv C, Han L, Huang Y, Pan G. Zhang H, et al. J Ethnopharmacol. 2021 Mar 25;268:113566. doi: 10.1016/j.jep.2020.113566. Epub 2020 Nov 7. J Ethnopharmacol. 2021. PMID: 33166629
RESULTS: Botany, traditional uses, phytochemistry, pharmacokinetic and toxicity of 13 alkaloids, namely, tetrandrine, dauricine, curine, trilobine, isotrilobine, cepharanthine, daurisoline, thalicarpine, thalidasine, isotetrandrine, liensinine, neferine and isoliensinine, …
RESULTS: Botany, traditional uses, phytochemistry, pharmacokinetic and toxicity of 13 alkaloids, namely, tetrandrine, dauricine, curine, tri …
Reversal of Tetracycline Resistance by Cepharanthine, Cinchonidine, Ellagic Acid and Propyl Gallate in a Multi-drug Resistant Escherichia coli.
Jenic D, Waller H, Collins H, Erridge C. Jenic D, et al. Nat Prod Bioprospect. 2021 Jun;11(3):345-355. doi: 10.1007/s13659-020-00280-y. Epub 2020 Nov 3. Nat Prod Bioprospect. 2021. PMID: 33141306 Free PMC article.
Four compounds; ellagic acid, propyl gallate, cinchonidine and cepharanthine, lowered the minimum inhibitory concentrations (MICs) of tetracycline, chloramphenicol and tobramycin by up to fourfold, and when combined up to eightfold. ...Although cepharanthine showed …
Four compounds; ellagic acid, propyl gallate, cinchonidine and cepharanthine, lowered the minimum inhibitory concentrations (MICs) of …
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