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2006 1
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91 results

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Page 1
Home Training for Cerebellar Ataxias: A Randomized Clinical Trial.
Barbuto S, Lee S, Stein J, Kuo SH, Quinn L, Spinner M, Stern Y. Barbuto S, et al. JAMA Neurol. 2025 Nov 1;82(11):1162-1170. doi: 10.1001/jamaneurol.2025.3421. JAMA Neurol. 2025. PMID: 40946705 Free PMC article. Clinical Trial.
IMPORTANCE: Clinical practice guidelines advise balance training for cerebellar ataxia, but little is known regarding high-intensity aerobic exercise. OBJECTIVE: To compare home high-intensity aerobic training to home balance training on improvements of ataxia …
IMPORTANCE: Clinical practice guidelines advise balance training for cerebellar ataxia, but little is known regarding high-int …
Scale for the assessment and rating of ataxia: development of a new clinical scale.
Schmitz-Hübsch T, du Montcel ST, Baliko L, Berciano J, Boesch S, Depondt C, Giunti P, Globas C, Infante J, Kang JS, Kremer B, Mariotti C, Melegh B, Pandolfo M, Rakowicz M, Ribai P, Rola R, Schöls L, Szymanski S, van de Warrenburg BP, Dürr A, Klockgether T, Fancellu R. Schmitz-Hübsch T, et al. Neurology. 2006 Jun 13;66(11):1717-20. doi: 10.1212/01.wnl.0000219042.60538.92. Neurology. 2006. PMID: 16769946 Clinical Trial.
OBJECTIVE: To develop a reliable and valid clinical scale measuring the severity of ataxia. METHODS: The authors devised the Scale for the Assessment and Rating of Ataxia (SARA) and tested it in two trials of 167 and 119 patients with spinocereb …
OBJECTIVE: To develop a reliable and valid clinical scale measuring the severity of ataxia. METHODS: The authors devised the …
Goal-Directed Rehabilitation Versus Standard Care for Individuals with Hereditary Cerebellar Ataxia: A Multicenter, Single-Blind, Randomized Controlled Superiority Trial.
Milne SC, Roberts M, Williams S, Chua J, Grootendorst AC, Agostinelli G, Grobler AC, Ross HL, Robinson A, Grove K, Modderman G, Price A, Thomson M, Massey L, Liang C, Kumar KR, Dalziel K, Burns J, Sue CM, Pathirana PN, Horne M, Gelfand N, Curd H, Szmulewicz D, Corben LA, Delatycki MB. Milne SC, et al. Ann Neurol. 2025 Mar;97(3):409-424. doi: 10.1002/ana.27130. Epub 2024 Nov 9. Ann Neurol. 2025. PMID: 39520242 Clinical Trial.
OBJECTIVE: Rehabilitation is thought to reduce ataxia severity in individuals with hereditary cerebellar ataxia (HCA). This multicenter, randomized controlled superiority trial aimed to examine the efficacy of a 30-week goal-directed rehabilitation program co …
OBJECTIVE: Rehabilitation is thought to reduce ataxia severity in individuals with hereditary cerebellar ataxia (HCA). …
Efficacy and safety of N-acetyl-L-leucine in patients with ataxia telangiectasia: A randomized, double-blind, placebo-controlled, crossover clinical trial.
Beyraghi-Tousi M, Sahebkar A, Houra M, Sarvghadi P, Jamialahmadi T, Bagheri R, Tavallaie S, Gumpricht E, Saberi-Karimian M. Beyraghi-Tousi M, et al. Eur J Paediatr Neurol. 2024 May;50:57-63. doi: 10.1016/j.ejpn.2024.04.009. Epub 2024 Apr 22. Eur J Paediatr Neurol. 2024. PMID: 38669738 Clinical Trial.
BACKGROUND: Ataxia telangiectasia (AT) is an autosomal recessive multisystem disorder. Most patients have progressive cerebellar ataxia, oculocutaneous telangiectasia, frequent pulmonary infection, and an increased risk of malignancies. ...Subjects then had a …
BACKGROUND: Ataxia telangiectasia (AT) is an autosomal recessive multisystem disorder. Most patients have progressive cerebellar …
Transcranial alternating current stimulation for treating spinocerebellar ataxia type 3: A randomized controlled trial.
Chen X, Liu X, Lin W, Zhang L, Cheng X, Huang Z, Zhang W, Zeng H, Lian Y, Zhang Y, Li M, Chen N, Huang S, Wang Z, Wang X, Liu Z, Yuan R, Chen X, Ye Z, Cheng B, Zhang Y, Chen Q, Wang D, Ni J, Wang N, Fu Y, Gan S; OSCCAR Investigators. Chen X, et al. Cell Rep Med. 2025 Jun 17;6(6):102162. doi: 10.1016/j.xcrm.2025.102162. Cell Rep Med. 2025. PMID: 40532663 Free PMC article. Clinical Trial.
There are no specific treatments for spinocerebellar ataxia type 3 (SCA3), a neurodegenerative disease causing cerebellar dysfunction. Transcranial alternating current stimulation (tACS) can improve cerebellar motor functions, and it has been shown to be safe …
There are no specific treatments for spinocerebellar ataxia type 3 (SCA3), a neurodegenerative disease causing cerebellar dysf …
Video-Based Kinematic Analysis of Movement Quality in a Phase 3 Clinical Trial of Troriluzole in Adults with Spinocerebellar Ataxia: A Post Hoc Analysis.
L'Italien GJ, Oikonomou EK, Khera R, Potashman MH, Beiner MW, Maclaine GDH, Schmahmann JD, Perlman S, Coric V. L'Italien GJ, et al. Neurol Ther. 2024 Aug;13(4):1287-1301. doi: 10.1007/s40120-024-00625-6. Epub 2024 May 30. Neurol Ther. 2024. PMID: 38814532 Free PMC article.
INTRODUCTION: Traditional methods for assessing movement quality rely on subjective standardized scales and clinical expertise. This limitation creates challenges for assessing patients with spinocerebellar ataxia (SCA), in whom changes in mobility can be subtle and …
INTRODUCTION: Traditional methods for assessing movement quality rely on subjective standardized scales and clinical expertise. This …
Longitudinal changes of SARA scale in Friedreich ataxia: Strong influence of baseline score and age at onset.
Porcu L, Fichera M, Nanetti L, Rulli E, Giunti P, Parkinson MH, Durr A, Ewenczyk C, Boesch S, Nachbauer W, Indelicato E, Klopstock T, Stendel C, Rodríguez de Rivera FJ, Schöls L, Fleszar Z, Giordano I, Didszun C, Castaldo A, Rai M, Klockgether T, Pandolfo M, Schulz JB, Reetz K, Mariotti C; EFACTS Study Group. Porcu L, et al. Ann Clin Transl Neurol. 2023 Nov;10(11):2000-2012. doi: 10.1002/acn3.51886. Epub 2023 Aug 28. Ann Clin Transl Neurol. 2023. PMID: 37641437 Free PMC article.
BACKGROUND: The Scale for Assessment and Rating of Ataxia (SARA) is widely used in different types of ataxias and has been chosen as the primary outcome measure in the European natural history study for Friedreich ataxia (FA). ...INTERPRETATION: Analys …
BACKGROUND: The Scale for Assessment and Rating of Ataxia (SARA) is widely used in different types of ataxias and has b …
Cerebellar Transcranial Direct Current Stimulation in Spinocerebellar Ataxia Type 3: a Randomized, Double-Blind, Sham-Controlled Trial.
Maas RPPWM, Teerenstra S, Toni I, Klockgether T, Schutter DJLG, van de Warrenburg BPC. Maas RPPWM, et al. Neurotherapeutics. 2022 Jul;19(4):1259-1272. doi: 10.1007/s13311-022-01231-w. Epub 2022 May 2. Neurotherapeutics. 2022. PMID: 35501469 Free PMC article. Clinical Trial.
Repeated sessions of cerebellar anodal transcranial direct current stimulation (tDCS) have been suggested to modulate cerebellar-motor cortex (M1) connectivity and decrease ataxia severity. ...Change in Scale for the Assessment and Rating of Ataxia …
Repeated sessions of cerebellar anodal transcranial direct current stimulation (tDCS) have been suggested to modulate cerebellar …
Safety and Efficacy of Acetyl-DL-Leucine in Certain Types of Cerebellar Ataxia: The ALCAT Randomized Clinical Crossover Trial.
Feil K, Adrion C, Boesch S, Doss S, Giordano I, Hengel H, Jacobi H, Klockgether T, Klopstock T, Nachbauer W, Schöls L, Steiner KM, Stendel C, Timmann D, Naumann I, Mansmann U, Strupp M; ALCAT Study Group. Feil K, et al. JAMA Netw Open. 2021 Dec 1;4(12):e2135841. doi: 10.1001/jamanetworkopen.2021.35841. JAMA Netw Open. 2021. PMID: 34905009 Free PMC article. Clinical Trial.
IMPORTANCE: Cerebellar ataxia is a neurodegenerative disease impairing motor function characterized by ataxia of stance, gait, speech, and fine motor disturbances. ...Patients were aged at least 18 years and diagnosed with cerebellar ataxia of h …
IMPORTANCE: Cerebellar ataxia is a neurodegenerative disease impairing motor function characterized by ataxia of stance …
Assessment of the reliability, responsiveness, and meaningfulness of the scale for the assessment and rating of ataxia (SARA) for lysosomal storage disorders.
Park J, Bremova-Ertl T, Brands M, Foltan T, Gautschi M, Gissen P, Hahn A, Jones S, Arash-Kaps L, Kolnikova M, Patterson M, Perlman S, Ramaswami U, Reichmannová S, Rohrbach M, Schneider SA, Shaikh A, Sivananthan S, Synofzik M, Walterfarng M, Wibawa P, Martakis K, Manto M. Park J, et al. J Neurol. 2024 Oct;271(10):6888-6902. doi: 10.1007/s00415-024-12664-y. Epub 2024 Sep 3. J Neurol. 2024. PMID: 39225743 Free PMC article.
OBJECTIVE: To evaluate the reliability, responsiveness, and validity of the Scale for the Assessment and Rating of Ataxia (SARA) in patients with lysosomal storage disorders (LSDs) who present with neurological symptoms, and quantify the threshold for a clini …
OBJECTIVE: To evaluate the reliability, responsiveness, and validity of the Scale for the Assessment and Rating of Ataxia ( …
91 results