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Nonparaneoplastic autoimmune cerebellar ataxias.
Joubert B, Honnorat J. Joubert B, et al. Curr Opin Neurol. 2019 Jun;32(3):484-492. doi: 10.1097/WCO.0000000000000678. Curr Opin Neurol. 2019. PMID: 30694927 Review.
PURPOSE OF REVIEW: The current review develops the clinical presentations of nonparaneoplastic autoimmune cerebellar ataxia (ACA) and analyzes the association with autoantibodies. RECENT FINDINGS: Emerging evidence suggests that autoimmunity is involve …
PURPOSE OF REVIEW: The current review develops the clinical presentations of nonparaneoplastic autoimmune cerebellar ataxia …
Immune-Mediated Cerebellar Ataxia Associated With Neuronal Surface Antibodies.
Jia Y, Li M, Li D, Zhang M, Wang H, Jiao L, Huang Z, Ye J, Liu A, Wang Y. Jia Y, et al. Front Immunol. 2022 Feb 17;13:813926. doi: 10.3389/fimmu.2022.813926. eCollection 2022. Front Immunol. 2022. PMID: 35250990 Free PMC article.
BACKGROUND: Immune-mediated cerebellar ataxias (IMCAs) are common in paraneoplastic cerebellar degeneration (PCD) but rarely occur in patients with neuronal surface antibodies (NSAbs). Although cerebellar ataxias (CAs) associated with anti-NMDAR and anti-C …
BACKGROUND: Immune-mediated cerebellar ataxias (IMCAs) are common in paraneoplastic cerebellar degeneration (PCD) but rarely o …
Autoimmune Vestibulocerebellar Syndromes.
Narayan RN, McKeon A, Fife TD. Narayan RN, et al. Semin Neurol. 2020 Feb;40(1):97-115. doi: 10.1055/s-0039-3402061. Epub 2020 Jan 20. Semin Neurol. 2020. PMID: 31958862 Review.
Autoimmune disorders affecting the vestibular end organs, vestibular pathways, vestibular nuclei, and vestibulocerebellum are often underrecognized as a cause of chronic dizziness and ataxia. ...The vestibulocerebellar presentation is largely indistinguishable among …
Autoimmune disorders affecting the vestibular end organs, vestibular pathways, vestibular nuclei, and vestibulocerebellum are often u …
Novelties in Autoimmune and Paraneoplastic Cerebellar Ataxias: Twenty Years of Progresses.
Muñiz-Castrillo S, Vogrig A, Ciano-Petersen NL, Villagrán-García M, Joubert B, Honnorat J. Muñiz-Castrillo S, et al. Cerebellum. 2022 Aug;21(4):573-591. doi: 10.1007/s12311-021-01363-3. Epub 2022 Jan 12. Cerebellum. 2022. PMID: 35020135 Review.
Major advances in our knowledge concerning autoimmune and paraneoplastic cerebellar ataxias have occurred in the last 20 years. The discovery of several neural antibodies represents an undeniable contribution to this field, especially those serving as good biomarker …
Major advances in our knowledge concerning autoimmune and paraneoplastic cerebellar ataxias have occurred in the last 20 years …
Neuronal-specific antibody in patients with multiple system atrophy and progressive supranuclear palsy.
Fang MS, Tsai MC, Arlt FA, Li CH, Fan SP, Chen PS, Chang YY, Lan MY, Wu YR, Hsiao IT, Chiang HL, Chen CY, Lee TL, Chang HC, Hsu JL, Lu CS, McKeon A, Lin CH; Taiwan PSP/CBS consortium. Fang MS, et al. J Formos Med Assoc. 2026 Jun;125(6):711-715. doi: 10.1016/j.jfma.2025.10.036. Epub 2025 Oct 28. J Formos Med Assoc. 2026. PMID: 41152112 Free PMC article.
We observed one PSP-Richardson syndrome patient (0.74 %) was CASPR2-IgG positive, and one MSA-cerebellar subtype patient (3.33 %) showed GAD65 positivity with a hot-cross bun sign on MRI. ...These findings indicate that neuronal-specific antibodies may mimic …
We observed one PSP-Richardson syndrome patient (0.74 %) was CASPR2-IgG positive, and one MSA-cerebellar subtype patient (3.33 …