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Page 1
The Role of TNF-alpha and Anti-TNF-alpha Agents during Preconception, Pregnancy, and Breastfeeding.
Romanowska-Próchnicka K, Felis-Giemza A, Olesińska M, Wojdasiewicz P, Paradowska-Gorycka A, Szukiewicz D. Romanowska-Próchnicka K, et al. Int J Mol Sci. 2021 Mar 13;22(6):2922. doi: 10.3390/ijms22062922. Int J Mol Sci. 2021. PMID: 33805757 Free PMC article. Review.
Tumor necrosis factor-alpha (TNF-alpha) is a multifunctional Th1 cytokine and one of the most important inflammatory cytokines. In pregnancy, TNF-alpha influences hormone synthesis, placental architecture, and embryonic development. ...Additionally, elevated TNF-alp …
Tumor necrosis factor-alpha (TNF-alpha) is a multifunctional Th1 cytokine and one of the most important inflammatory cytokines. In pregna …
Lack of placental transfer of certolizumab pegol during pregnancy: results from CRIB, a prospective, postmarketing, pharmacokinetic study.
Mariette X, Förger F, Abraham B, Flynn AD, Moltó A, Flipo RM, van Tubergen A, Shaughnessy L, Simpson J, Teil M, Helmer E, Wang M, Chakravarty EF. Mariette X, et al. Ann Rheum Dis. 2018 Feb;77(2):228-233. doi: 10.1136/annrheumdis-2017-212196. Epub 2017 Oct 13. Ann Rheum Dis. 2018. PMID: 29030361 Free PMC article. Clinical Trial.
OBJECTIVES: There is a need for effective and safe treatment during pregnancy in women with chronic inflammatory diseases. This study evaluated placental transfer of certolizumab pegol (CZP), an Fc-free anti-tumour necrosis factor drug, from CZP …
OBJECTIVES: There is a need for effective and safe treatment during pregnancy in women with chronic inflammatory diseases. This study …
Serious Infections in Offspring Exposed to Tumor Necrosis Factor Inhibitors During Pregnancy: Comparison of Timing During Pregnancy and Placental Transfer Ability.
Flatman LK, Bernatsky S, St-Pierre Y, Beauchamp ME, Malhamé I, Bérard A, Vinet É. Flatman LK, et al. Arthritis Rheumatol. 2026 Apr;78(4):976-984. doi: 10.1002/art.70000. Epub 2026 Jan 25. Arthritis Rheumatol. 2026. PMID: 41327834 Free PMC article.
TNFi exposure was defined as at least one filled prescription during pregnancy, further subdivided by trimesters and placental transfer. The event of interest was the time to first hospitalization with infection in the offspring's first year of life. ...Addit …
TNFi exposure was defined as at least one filled prescription during pregnancy, further subdivided by trimesters and placental …
Certolizumab pegol does not bind the neonatal Fc receptor (FcRn): Consequences for FcRn-mediated in vitro transcytosis and ex vivo human placental transfer.
Porter C, Armstrong-Fisher S, Kopotsha T, Smith B, Baker T, Kevorkian L, Nesbitt A. Porter C, et al. J Reprod Immunol. 2016 Aug;116:7-12. doi: 10.1016/j.jri.2016.04.284. Epub 2016 Apr 14. J Reprod Immunol. 2016. PMID: 27123565 Free article.
In contrast to other anti-TNFs, certolizumab pegol lacks an Fc-region. The objective of this study was to determine whether the structure of certolizumab pegol limits active placental transfer. ...Together these results support the hypoth …
In contrast to other anti-TNFs, certolizumab pegol lacks an Fc-region. The objective of this study was to determine whether th …
Pregnancy Outcomes After Exposure to Certolizumab Pegol: Updated Results From a Pharmacovigilance Safety Database.
Clowse MEB, Scheuerle AE, Chambers C, Afzali A, Kimball AB, Cush JJ, Cooney M, Shaughnessy L, Vanderkelen M, Förger F. Clowse MEB, et al. Arthritis Rheumatol. 2018 Sep;70(9):1399-1407. doi: 10.1002/art.40508. Epub 2018 Jul 22. Arthritis Rheumatol. 2018. PMID: 29623679 Free PMC article.
Certolizumab pegol (CZP), a PEGylated, Fc-free anti-TNF agent approved for the treatment of rheumatic diseases and/or Crohn's disease, has minimal to no active placental transfer. This analysis was undertaken to evaluate pregnancy outcomes in wo …
Certolizumab pegol (CZP), a PEGylated, Fc-free anti-TNF agent approved for the treatment of rheumatic diseases and/or Crohn's …
A Narrative Review on Anti-Tumor Necrosis Factor alpha Therapies in Inflammatory Bowel Disease During Pregnancy: Immunoglobulin Placental Translocation and its Impact.
Roseira J, Ramos J. Roseira J, et al. Acta Med Port. 2019 Apr 30;32(4):305-312. doi: 10.20344/amp.11482. Epub 2019 Apr 30. Acta Med Port. 2019. PMID: 31067425 Free article. Review.
However, there are concerns regarding treatment with these agents during pregnancy, as they actively cross the placental barrier. MATERIAL AND METHODS: Studies regarding anti-tumor necrosis factor alpha therapy during pregnancy were identified from PubMed fro …
However, there are concerns regarding treatment with these agents during pregnancy, as they actively cross the placental barri …
Certolizumab Pegol: A Review in Moderate to Severe Plaque Psoriasis.
Lee A, Scott LJ. Lee A, et al. BioDrugs. 2020 Apr;34(2):235-244. doi: 10.1007/s40259-020-00416-z. BioDrugs. 2020. PMID: 32207094 Review.
Certolizumab pegol (Cimzia( )) is a PEGylated, Fab'-only, recombinant humanized antibody against TNF-alpha. ...Certolizumab pegol is unique among the biologics, with the absence of an Fc fragment conferring pharmacokinetic advantages; most notably, its …
Certolizumab pegol (Cimzia( )) is a PEGylated, Fab'-only, recombinant humanized antibody against TNF-alpha. ...Certolizumab …
Management of psoriasis in pregnancy - a review of the evidence to date.
Ferreira C, Azevedo A, Nogueira M, Torres T. Ferreira C, et al. Drugs Context. 2020 Mar 9;9:2019-11-6. doi: 10.7573/dic.2019-11-6. eCollection 2020. Drugs Context. 2020. PMID: 32201494 Free PMC article. Review.
Although there are several pharmacological therapies available, pregnancy brings ethical concerns and any pharmacological approach must be well thought out. The data available in humans are limited, and further investigation on this matter is needed. Within biological ther …
Although there are several pharmacological therapies available, pregnancy brings ethical concerns and any pharmacological approach mu …
[Evolution of biological management during pregnancy: from uncertainty to evidence in rheumatoid arthritis].
Vinicki JP, Velasco Zamora JL. Vinicki JP, et al. Medicina (B Aires). 2025;85(4):778-784. Medicina (B Aires). 2025. PMID: 40793891 Free article. Spanish.
Over the last decade, the management of biologic therapies during pregnancy in rheumatoid arthritis (RA) patients has significantly evolved, shifting from uncertainty to robust evidence. ...Later studies demonstrated significant differences in placental transfer …
Over the last decade, the management of biologic therapies during pregnancy in rheumatoid arthritis (RA) patients has significantly e …
32 results