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137 results

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Page 1
Cetirizine more potently exerts mast cell-stabilizing property than diphenhydramine.
Fujimura R, Asada A, Aizawa M, Kazama I. Fujimura R, et al. Drug Discov Ther. 2022 Nov 20;16(5):245-250. doi: 10.5582/ddt.2022.01067. Epub 2022 Oct 19. Drug Discov Ther. 2022. PMID: 36261390 Free article.
This study provided in vitro evidence for the first time that cetirizine more potently inhibited the process of exocytosis in mast cells than diphenhydramine, indicating its higher potency as a mast cell-stabilizer. Such mast cell- …
This study provided in vitro evidence for the first time that cetirizine more potently inhibited the process of exocytosis in mast …
Idiopathic Anaphylaxis.
Ben-Shoshan M, Cem A, Cook VE, Khalaf R, Freigeh G. Ben-Shoshan M, et al. J Allergy Clin Immunol Pract. 2025 Dec;13(12):3165-3178.e1. doi: 10.1016/j.jaip.2025.08.019. Epub 2025 Aug 27. J Allergy Clin Immunol Pract. 2025. PMID: 40882893 Free article. Review.
Evaluation revealed elevated acute tryptase levels with a normal baseline, negative skin testing results, and negative galactose-alpha-1,3-galactose (alpha-gal) and KIT mutation analysis. The patient improved on daily cetirizine with no further reactions. IA remains a diag …
Evaluation revealed elevated acute tryptase levels with a normal baseline, negative skin testing results, and negative galactose-alpha-1,3-g …
[Cetirizine inhibits activation of JAK2-STAT3 pathway and mast cell activation in lung tissue of asthmatic mice].
Qu T, Huang B, Lei L, Luo S. Qu T, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2022 Mar;38(3):193-198. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2022. PMID: 35365983 Chinese.
Objective To investigate the effects of cetirizine on Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway and mast cell activation in asthmatic mice by establishing a mouse model of asthma. ...Conclusion Cetirizine in …
Objective To investigate the effects of cetirizine on Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) …
Mast cell function in prostate inflammation, fibrosis, and smooth muscle cell dysfunction.
Pattabiraman G, Bell-Cohn AJ, Murphy SF, Mazur DJ, Schaeffer AJ, Thumbikat P. Pattabiraman G, et al. Am J Physiol Renal Physiol. 2021 Oct 1;321(4):F466-F479. doi: 10.1152/ajprenal.00116.2021. Epub 2021 Aug 23. Am J Physiol Renal Physiol. 2021. PMID: 34423679 Free PMC article.
In both patients with LUTS and CP1-infected mice, we observed increased numbers and activation of mast cells and elevated levels of prostate fibrosis. Therapeutic inhibition of mast cells using a combination of a mast cell stabilizer, cro …
In both patients with LUTS and CP1-infected mice, we observed increased numbers and activation of mast cells and elevated leve …
Efficacy of Targeted Mast Cell Inhibition Therapy in Chronic Prostatitis/Chronic Pelvic Pain Syndrome.
Pattabiraman G, Engel G, Osborn CV, Murphy SF, Schaeffer AJ, Thumbikat P. Pattabiraman G, et al. Urology. 2023 Oct;180:200-208. doi: 10.1016/j.urology.2023.05.047. Epub 2023 Jul 12. Urology. 2023. PMID: 37442295 Free PMC article.
OBJECTIVE: To identify a subgroup of patients with mast cell dysfunction in chronic prostatitis/chronic pelvic pain syndrome and evaluate efficacy of mast cell-directed therapy. ...Marked reduction in CD45+ cells and specifically macrophages and …
OBJECTIVE: To identify a subgroup of patients with mast cell dysfunction in chronic prostatitis/chronic pelvic pain syndrome a …
Effect of cetirizine on mast cell-mediator release and cellular traffic during the cutaneous late-phase reaction.
Charlesworth EN, Kagey-Sobotka A, Norman PS, Lichtenstein LM. Charlesworth EN, et al. J Allergy Clin Immunol. 1989 May;83(5):905-12. doi: 10.1016/0091-6749(89)90104-8. J Allergy Clin Immunol. 1989. PMID: 2469708 Clinical Trial.
Histamine release was not altered by cetirizine treatment, but prostaglandin D2 (PGD2) production, which peaked at 3 to 5 hours, was clearly reduced by cetirizine treatment, being lower at all time points during the reaction; this was significant by analysis of vari …
Histamine release was not altered by cetirizine treatment, but prostaglandin D2 (PGD2) production, which peaked at 3 to 5 hours, was …
Antihistamines in asthma.
Holgate ST, Finnerty JP. Holgate ST, et al. J Allergy Clin Immunol. 1989 Feb;83(2 Pt 2):537-47. doi: 10.1016/0091-6749(89)90035-3. J Allergy Clin Immunol. 1989. PMID: 2563745 Review.
Histamine, a bronchoactive and vasoactive mediator, is released in patients with naturally occurring or allergen-induced asthma. It is clear that mast cells are activated as part of the asthmatic response, and they have now been implicated as effector cells o …
Histamine, a bronchoactive and vasoactive mediator, is released in patients with naturally occurring or allergen-induced asthma. It is clear …
Mast cell dependent vascular changes associated with an acute response to cold immersion in primary contact urticaria.
Meyer J, Gorbach AM, Liu WM, Medic N, Young M, Nelson C, Arceo S, Desai A, Metcalfe DD, Komarow HD. Meyer J, et al. PLoS One. 2013;8(2):e56773. doi: 10.1371/journal.pone.0056773. Epub 2013 Feb 22. PLoS One. 2013. PMID: 23451084 Free PMC article.
BACKGROUND: While a number of the consequences of mast cell degranulation within tissues have been documented including tissue-specific changes such as bronchospasm and the subsequent cellular infiltrate, there is little known about the immediate effects of mast …
BACKGROUND: While a number of the consequences of mast cell degranulation within tissues have been documented including tissue …
Mast Cell Changes the Phenotype of Microglia via Histamine and ATP.
Ramírez-Ponce MP, Sola-García A, Balseiro-Gómez S, Maldonado MD, Acosta J, Alés E, Flores JA. Ramírez-Ponce MP, et al. Cell Physiol Biochem. 2021 Jan 15;55(1):17-32. doi: 10.33594/000000324. Cell Physiol Biochem. 2021. PMID: 33443845 Free article.
Microglia help orchestrate the immunological response by interacting with others immune cells. Mast cells (MCs) are effector cells of the innate immune system distributed in all organs and vascularized tissues, brain included. ...Iba-1 fluorescence, …
Microglia help orchestrate the immunological response by interacting with others immune cells. Mast cells (MCs) are eff …
Antihistamines: topical vs oral administration.
Davies RJ, Bagnall AC, McCabe RN, Calderon MA, Wang JH. Davies RJ, et al. Clin Exp Allergy. 1996 May;26 Suppl 3:11-7. doi: 10.1111/j.1365-2222.1996.tb00653.x. Clin Exp Allergy. 1996. PMID: 8735853 Review.
The pathogenesis of allergic rhinitis is complex, involving not only histamine and mast cell-derived tryptase, but also eosinophil- and neutrophil-derived mediators, cytokines, and intercellular cell adhesion molecules (ICAM-1). ...In vitro studies have shown …
The pathogenesis of allergic rhinitis is complex, involving not only histamine and mast cell-derived tryptase, but also eosino …
137 results