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Guideline for allergological diagnosis of drug hypersensitivity reactions: S2k Guideline of the German Society for Allergology and Clinical Immunology (DGAKI) in cooperation with the German Dermatological Society (DDG), the Association of German Allergologists (ÄDA), the German Society for Pediatric Allergology (GPA), the German Contact Dermatitis Research Group (DKG), the German Society for Pneumology (DGP), the German Society of Otorhinolaryngology, Head and Neck Surgery, the Austrian Society of Allergology and Immunology (ÖGAI), the Austrian Society of Dermatology and Venereology (ÖGDV), the German Academy of Allergology and Environmental Medicine (DAAU), and the German Documentation Center for Severe Skin Reactions (dZh).
Brockow K, Wurpts G, Trautmann A, Pfützner W, Treudler R, Bircher AJ, Brehler R, Buhl T, Dickel H, Fuchs T, Jakob T, Kurz J, Kreft B, Lange L, Merk HF, Mockenhaupt M, Mülleneisen N, Ott H, Ring J, Ruëff F, Sachs B, Sitter H, Wedi B, Wöhrl S, Worm M, Zuberbier T. Brockow K, et al. Allergol Select. 2023 Aug 9;7:122-139. doi: 10.5414/ALX02422E. eCollection 2023. Allergol Select. 2023. PMID: 37705676 Free PMC article.
Alpha-Gal-containing biologics and anaphylaxis.
Chinuki Y, Morita E. Chinuki Y, et al. Allergol Int. 2019 Jul;68(3):296-300. doi: 10.1016/j.alit.2019.04.001. Epub 2019 Apr 30. Allergol Int. 2019. PMID: 31053502 Free article. Review.
Research has shown that the principal cause of cetuximab-induced anaphylaxis is anti-oligosaccharide IgE antibodies specific for galactose-alpha-1,3-galactose (alpha-Gal) oligosaccharide present on the mouse-derived Fab portion of the cetuximab heavy chain. . …
Research has shown that the principal cause of cetuximab-induced anaphylaxis is anti-oligosaccharide IgE antibodies specific f …
Basophil Activation Test Predicts Cetuximab Anaphylaxis Severity in Alpha-Gal IgE-Positive Patients.
Kopač P, Koren A, Bidovec-Stojkovič U, Košnik M, Dejanović L, Mesti T, Strojan P, Korošec P, Ocvirk J. Kopač P, et al. Diagnostics (Basel). 2024 Jul 1;14(13):1403. doi: 10.3390/diagnostics14131403. Diagnostics (Basel). 2024. PMID: 39001293 Free PMC article.
We prospectively recruited 38 patients and evaluated sIgE to alpha-gal in all patients before the first application of cetuximab. In all alpha-gal-sensitized patients, we evaluated skin tests to meat extracts, gelatine, and cetuximab and performed BAT with alpha-gal …
We prospectively recruited 38 patients and evaluated sIgE to alpha-gal in all patients before the first application of cetuximab. In …
Nationwide pharmacovigilance data for cetuximab-induced anaphylaxis and predictive model validation using prospective specific IgE detection.
Park KH, Lee J, Beom SH, Shin SJ, Ahn JB, Kim SR, Lee JH, Park JW. Park KH, et al. World Allergy Organ J. 2021 Jun 23;14(7):100553. doi: 10.1016/j.waojou.2021.100553. eCollection 2021 Jul. World Allergy Organ J. 2021. PMID: 34257795 Free PMC article.
In a single-center study, incidence of cetuximab-induced anaphylaxis was 1.1%. Most anaphylaxis occurred at first injection (93.3%), even under pretreatment with anti-allergic drugs. ...CONCLUSIONS: Specific IgE detection of cetuximab or alpha-gal can …
In a single-center study, incidence of cetuximab-induced anaphylaxis was 1.1%. Most anaphylaxis occurred at first injec …
The Immunology of Alpha-Gal Syndrome: History, Tick Bites, IgE, and Delayed Anaphylaxis to Mammalian Meat.
Platts-Mills TAE, Gangwar RS, Workman L, Wilson JM. Platts-Mills TAE, et al. Immunol Rev. 2025 Jul;332(1):e70035. doi: 10.1111/imr.70035. Immunol Rev. 2025. PMID: 40515672 Free PMC article. Review.
The primary features of the alpha-gal syndrome (AGS) are (i) The IgE ab that are causally related to anaphylaxis with infusions of Cetuximab are specific for galactose alpha-1,3-galactose. (ii) In the USA, this IgE ab is induced by bites of the tick Amblyomma americ …
The primary features of the alpha-gal syndrome (AGS) are (i) The IgE ab that are causally related to anaphylaxis with infusions of …
Fatal anaphylaxis due to alpha-gal syndrome after initial cetuximab administration: The first forensic case report.
Wen S, Unuma K, Chinuki Y, Hikino H, Uemura K. Wen S, et al. Leg Med (Tokyo). 2021 Jul;51:101878. doi: 10.1016/j.legalmed.2021.101878. Epub 2021 Apr 7. Leg Med (Tokyo). 2021. PMID: 33892262
Patients with alpha-gal syndrome may suffer from cetuximab-induced anaphylaxis at the first administration because of developed alpha-gal-specific IgE antibodies. ...Thus, we determined that the death was caused by cetuximab-induced anaphylaxis due to …
Patients with alpha-gal syndrome may suffer from cetuximab-induced anaphylaxis at the first administration because of develope …
[Red meat allergy].
Marchal O, Allali D. Marchal O, et al. Rev Med Suisse. 2020 Apr 8;16(689):684-687. Rev Med Suisse. 2020. PMID: 32270935 Review. French.
Common allergic reactions include isolated gastrointestinal symptoms but can potentially be life-threatening with severe anaphylaxis. Diagnosis relies on a thorough clinical history, skin-prick testing and the search for specific IgE. The management of meat allergy consist …
Common allergic reactions include isolated gastrointestinal symptoms but can potentially be life-threatening with severe anaphylaxis. …
Validation of an anti-alpha-Gal IgE fluoroenzyme-immunoassay for the screening of patients at risk of severe anaphylaxis to cetuximab.
Serrier J, Davy JB, Dupont B, Clarisse B, Parienti JJ, Petit G, Khoy K, Ollivier Y, Gervais R, Mariotte D, Le Mauff B. Serrier J, et al. BMC Cancer. 2023 Jan 9;23(1):32. doi: 10.1186/s12885-023-10501-5. BMC Cancer. 2023. PMID: 36624467 Free PMC article.
BACKGROUND: The link between immediate hypersensitivity reactions (HSR) following the first cetuximab infusion and the IgE sensitization against anti-galactose-alpha-1,3-galactose (alpha-Gal) is now well-established. ...It could help avoiding cetuximab-induced HSR b …
BACKGROUND: The link between immediate hypersensitivity reactions (HSR) following the first cetuximab infusion and the IgE sensitizat …
Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose.
Chung CH, Mirakhur B, Chan E, Le QT, Berlin J, Morse M, Murphy BA, Satinover SM, Hosen J, Mauro D, Slebos RJ, Zhou Q, Gold D, Hatley T, Hicklin DJ, Platts-Mills TA. Chung CH, et al. N Engl J Med. 2008 Mar 13;358(11):1109-17. doi: 10.1056/NEJMoa074943. N Engl J Med. 2008. PMID: 18337601 Free PMC article.
RESULTS: Among 76 cetuximab-treated subjects, 25 had a hypersensitivity reaction to the drug. IgE antibodies against cetuximab were found in pretreatment samples from 17 of these subjects; only 1 of 51 subjects who did not have a hypersensitivity reaction had such a …
RESULTS: Among 76 cetuximab-treated subjects, 25 had a hypersensitivity reaction to the drug. IgE antibodies against cetuximab …
85 results